ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4661–4680 of 6,163 studies

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development.

Hughes, Alicia M, Gordon, Rola, Chalder, Trudie et al.·British journal of health psychology·2016

This paper is a guide for researchers on how to properly design experiments that test whether people with conditions like ME/CFS have unconscious biases in how they pay attention to and interpret information about their illness. The authors explain that many past studies used different, untested materials, making it hard to compare results. They provide a step-by-step process and practical tools to help researchers create better, standardized materials for these types of studies.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Investigation of the effects of vanilloids in chronic fatigue syndrome.

Sarvaiya, Kuldeep, Goswami, Sunita·Brain research bulletin·2016

This study tested whether compounds that affect a pain-sensing protein called TRPV1 could help reduce fatigue and related symptoms in an animal model of ME/CFS. Rats that were stressed through repeated swimming showed improvements in fatigue, muscle strength, mood, and stress hormone levels when treated with these compounds, suggesting that TRPV1 may play a role in ME/CFS symptoms.

Immune System

E3 PreliminaryDiagnosticPEM unclearObservational

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Brady, Ellen, Segar, Julia, Sanders, Caroline·Journal of medical Internet research·2016

This study asked 20 people with ME/CFS and 21 people with diabetes about how they share information on online health forums and what privacy means to them. The researchers found that people carefully decide what personal details to share online, changing their approach depending on the situation and who they're talking to. Rather than having simple rules about what's private or public, people make complex, individual decisions about how much of themselves to reveal.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Potential use of visible and near-infrared spectroscopy for the analysis and diagnosis of chronic fatigue syndrome (Review).

Sakudo, Akikazu·Molecular medicine reports·2016

This review examines whether a special type of light-based scanning called visible and near-infrared spectroscopy could help diagnose ME/CFS objectively. Currently, doctors diagnose ME/CFS only by listening to patient symptoms, with no blood test or physical measurement available. Researchers found that this light-scanning technique can detect differences in blood samples and thumb tissue between people with ME/CFS and healthy people, suggesting it might identify biological markers of the disease.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatifue syndrome.].

Holecek, V, Rokyta, R·Ceskoslovenska fysiologie·2016

This review article provides an overview of ME/CFS, explaining what it is, how common it is, and how doctors diagnose and treat it. The condition lasts about 6 months or longer in adults and at least 3 months in children, causing persistent fatigue and other symptoms. The article covers multiple possible causes including biological, genetic, infectious, and psychological factors, as well as the economic impact of the disease.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine Gammaherpesvirus Infection.

Trammell, Rita A, Toth, Linda A·Comparative medicine·2016

This study examined how disrupted sleep-wake cycles (like those from shift work) affect mice infected with a dormant virus, especially when their immune systems are weakened. Researchers found that mice exposed to disrupted schedules who then experienced inflammation had higher levels of reactivated virus in their lungs. This suggests that combining poor sleep patterns with immune challenges might trigger symptom flare-ups similar to those seen in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients.

Nguyen, T, Staines, D, Nilius, B et al.·Biological research·2016

This study looked at special channels called TRPM3 on immune cells (natural killer cells and B cells) that help control calcium flow inside cells. Researchers found that people with ME/CFS have fewer of these channels on certain immune cells and problems with calcium movement compared to healthy people. This suggests that broken calcium control in immune cells might play a role in ME/CFS, though much more research is needed to understand what this means for the illness.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Choi, Hyun Ho, Cho, Young-Seok·Clinical endoscopy·2016

This article reviews fecal microbiota transplantation (FMT), a treatment where healthy gut bacteria from a donor are transferred into a patient's digestive system to treat disease. The procedure can be done several different ways and has shown promise for treating many conditions, including chronic fatigue syndrome. However, many important questions remain unanswered about who should donate, how to do it safely long-term, and how to regulate it properly.

E3 PreliminaryCohortPEM unclearCase-Control

Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.

Sukocheva, Olga A, Manavis, Jim, Kok, Tuck-Weng et al.·BMC infectious diseases·2016

This case report describes a young woman who developed severe, long-lasting illness after a Q fever infection and died 10 years later. After her death, researchers examined her tissues and found pieces of the bacteria (Coxiella burnetii) and its DNA still present in multiple organs, including her brain, heart, lungs, and spleen. This suggests that Q fever bacteria can persist in the body in a dormant or inactive form, potentially triggering ongoing illness.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

ILLNESS IS WORK: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS.

Grue, Jan·Health (London, England : 1997)·2016

This study explores how people with ME/CFS manage their identity and daily life while dealing with an illness that society doesn't fully recognize or understand. The researchers use the concept of "illness as work" to show that patients are actively doing important identity work—constantly adapting to their condition, navigating medical systems, and coping with a stigmatized illness. This framework helps validate the real effort and agency that ME/CFS patients demonstrate every day.

E3 PreliminaryBehavioralPEM not requiredLongitudinal

Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions.

Cvejic, Erin, Lloyd, Andrew R, Vollmer-Conna, Uté·Comprehensive psychiatry·2016

This study tested whether a 12-week program combining graded activity and cognitive training could help ME/CFS patients with thinking and memory problems. Researchers measured improvements in two ways: by asking patients how they felt, and by giving them objective tests of mental performance. They found that patients showed real, measurable improvements in processing speed and accuracy on cognitive tests, and their stress response (measured by heart rate patterns) also improved.

Cognitive Impairment

E3 PreliminaryPEM unclear

Nutritional advice for community patients: insights from a panel discussion.

Thomas, Linda V, Jenkins, Gill, Belton, Julie et al.·British journal of community nursing·2016

A group of nursing and nutrition experts discussed how to help patients with conditions like chronic fatigue syndrome, irritable bowel syndrome, and depression through better nutrition and lifestyle choices. They reviewed real patient examples and recommended that nurses use supportive conversation techniques to understand what patients need, and refer patients to registered dietitians when major diet changes are being considered.

E3 PreliminaryMechanismPEM unclearMechanistic

Gene Expression in Response to Exercise in Patients with Chronic Fatigue Syndrome: A Pilot Study.

Keech, Andrew, Vollmer-Conna, Ute, Barry, Benjamin K et al.·Frontiers in physiology·2016

Researchers studied whether a single 25-minute exercise session changed the activity of specific genes in white blood cells of ME/CFS patients compared to healthy people. Although ME/CFS patients reported significantly worsened fatigue after exercise, the researchers found no major changes in the 19 genes they measured in either group, suggesting that post-exertional fatigue may not be caused by these particular genes switching on or off.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

Working with uncertainty: A grounded theory study of health-care professionals' experiences of working with children and adolescents with chronic fatigue syndrome.

Marks, Megan R, Huws, Jaci C, Whitehead, Liz·Journal of health psychology·2016

This study interviewed 10 healthcare professionals who treat children and teenagers with ME/CFS to understand how they approach the condition. Because ME/CFS is not yet fully understood scientifically, doctors often rely on their past experiences to decide how to treat young patients. What doctors believe about ME/CFS can affect the labels they give patients and what treatments they recommend.

E3 PreliminaryMechanismPEM not requiredMechanistic

Moxibustion upregulates hippocampal progranulin expression.

Yi, Tao, Qi, Li, Li, Ji et al.·Neural regeneration research·2016

This study tested whether moxibustion, a traditional Chinese medicine technique using heat from burning herbs, could help rats with chronic fatigue syndrome. Researchers found that moxibustion reduced stress hormone levels and increased a protective protein in the brain called progranulin, which appeared to improve the rats' symptoms of fatigue and low mood.

Neuroinflammation

E3 PreliminaryPEM unclear

Caring for people with severe myalgic encephalomyelitis: An interpretative phenomenological analysis of parents' experiences.

Mihelicova, Martina, Siegel, Zachary, Evans, Meredyth et al.·Journal of health psychology·2016

This study listened to parents who care for severely ill ME/CFS patients and asked about their experiences. Researchers found that parents often feel their identity has changed, experience guilt, feel isolated from others, deal with uncertainty about the future, and develop ways to cope with the demands of caregiving. The study provides important insights that could help healthcare providers better support and understand these caregivers.

Interventions

E3 PreliminaryMechanismPEM not requiredMechanistic

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME).

Petty, Robert D, McCarthy, Neil E, Le Dieu, Rifca et al.·PloS one·2016

This study examined tiny molecules called microRNAs in immune cells from ME/CFS patients and healthy people. Researchers found that four specific microRNAs were abnormally high in patients' blood, particularly in natural killer (NK) immune cells. When they tested these microRNAs in the lab, they found they affected how NK cells work, suggesting this might contribute to ME/CFS symptoms.

BiomarkersImmune System

E3 PreliminaryCohortPEM unclearCase-Control

[Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].

Beretta, Pablo·Vertex (Buenos Aires, Argentina)·2016

This study suggests that people with fibromyalgia and ME/CFS may have problems with how their muscles use oxygen. The authors found that patients' symptoms worsened in low-oxygen environments (like high altitudes or low air pressure) and improved with treatments that increase oxygen availability, including hyperbaric oxygen therapy and coenzyme Q10 supplements. Based on three patient cases that improved with medical oxygen treatment, the authors propose that oxygen therapy might help people experiencing severe symptom flare-ups.

E3 PreliminaryMechanismPEM not requiredMechanistic

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

Lee, Ji Hoon, Kim, Jong-Eun, Jang, Young Jin et al.·Molecular carcinogenesis·2016

This study examined a compound called dehydroglyasperin C (DGC) found in licorice root to see if it could prevent cancer by blocking harmful cell changes. Researchers used laboratory mouse cells and found that DGC stopped cells from transforming into cancer cells by interfering with two specific protein pathways (MKK4 and PI3K) that drive this process.

E3 PreliminaryCohortPEM unclearCross-Sectional

Implementing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in primary care: A qualitative study.

Bayliss, Kerin, Riste, Lisa, Band, Rebecca et al.·BMC family practice·2016

This study looked at whether special training and information resources for GPs could help them better diagnose and manage ME/CFS. Researchers interviewed patients and doctors in North West England and found that while the resources were helpful when used properly, most GPs didn't actually use them—either because they were too busy, didn't see enough ME/CFS patients to remember the training, or thought the condition should only be managed by specialists.

Diagnostics

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Evidence browser

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development.

Investigation of the effects of vanilloids in chronic fatigue syndrome.

"I Always Vet Things": Navigating Privacy and the Presentation of Self on Health Discussion Boards Among Individuals with Long-Term Conditions.

Potential use of visible and near-infrared spectroscopy for the analysis and diagnosis of chronic fatigue syndrome (Review).

[Chronic fatifue syndrome.].

Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine Gammaherpesvirus Infection.

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients.

Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.

ILLNESS IS WORK: Revisiting the concept of illness careers and recognizing the identity work of patients with ME/CFS.

Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions.

Nutritional advice for community patients: insights from a panel discussion.

Gene Expression in Response to Exercise in Patients with Chronic Fatigue Syndrome: A Pilot Study.

Working with uncertainty: A grounded theory study of health-care professionals' experiences of working with children and adolescents with chronic fatigue syndrome.

Moxibustion upregulates hippocampal progranulin expression.

Caring for people with severe myalgic encephalomyelitis: An interpretative phenomenological analysis of parents' experiences.

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME).

[Fibromyalgia and myalgic encephalomyelitis: The oxygen clue].

Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.

Implementing resources to support the diagnosis and management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in primary care: A qualitative study.

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