ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

521–533 of 533 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Koo, D·The Western journal of medicine·1989

Early research suggested that a virus called Epstein-Barr virus (EBV) might cause ME/CFS, leading to the disease sometimes being called "chronic EBV syndrome." However, this review shows that the antibody levels used to detect EBV exposure are similar in people with ME/CFS, healthy people, and people with other illnesses, making it impossible to prove EBV actually causes the condition. Since most people have been exposed to EBV at some point, we cannot easily tell whether the virus causes ME/CFS or if people with ME/CFS simply show different antibody patterns because they are already sick.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Chronic fatigue syndrome: a working case definition.

Holmes, G P, Kaplan, J E, Gantz, N M et al.·Annals of internal medicine·1988

This landmark 1988 paper proposed a new name and formal definition for what was previously called 'chronic Epstein-Barr virus syndrome.' The authors recognized that the condition was poorly understood and inconsistently diagnosed, so they renamed it 'chronic fatigue syndrome' (ME/CFS) and created a working definition to help doctors identify and study it more consistently. This definition focused on severe, ongoing fatigue along with other symptoms like sore throat, headaches, and muscle pain.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis.

Gordon, N·Developmental medicine and child neurology·1988

This is a review article about myalgic encephalomyelitis (ME), a serious condition that causes extreme tiredness, muscle pain, and cognitive difficulties. The author examines what was known about ME in 1988, including how it affects the brain and nervous system, and discusses different theories about what might cause it.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome (myalgic encephalomyelitis)--myth or mystery?

Spracklen, F H·South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1988

This 1988 review article discusses chronic fatigue syndrome (also called myalgic encephalomyelitis) and explains why there has been so much confusion about this condition. The author reviews what doctors know about the illness, including its possible causes and symptoms, and discusses why having a clear definition of the disease is important for research and treatment. The article emphasizes that better understanding and more rigorous studies are needed to help patients.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The myalgic encephalomyelitis syndrome.

Murdoch, J C·Family practice·1988

This review examines myalgic encephalomyelitis (ME), a relapsing illness that primarily affects young women and causes severe muscle pain and exhaustion. The authors looked at research from the United Kingdom, United States, and New Zealand over 40 years to understand what might cause this condition. They discuss how difficult it is to treat patients when doctors don't know what's causing the illness, and suggest renaming it 'myalgic exhaustion syndrome.'

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome--a diagnosis for consideration.

Portwood, M F·The Nurse practitioner·1988

This article helps doctors recognize ME/CFS by describing its many symptoms, which can range from mild tiredness to severe disability. Patients often report feeling exhausted, achy, and unable to concentrate, yet standard medical tests often appear normal. The article emphasizes that doctors should take these symptoms seriously and help patients manage their condition, even though there is currently no cure.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The post-viral syndrome: a review.

Archer, M I·The Journal of the Royal College of General Practitioners·1987

This 1987 review examines post-viral syndrome (now often called ME/CFS), a condition that develops after viral infections. The author discusses whether the illness is caused by ongoing viral infection, psychological factors, or a combination of both. The review notes that different doctors diagnosed the condition at very different rates, and that many patients struggled to accept psychiatric support as part of their treatment.

Diagnostics

E3 PreliminaryCohortPEM unclear

Myalgic encephalomyelitis "an obscene cosmic joke"?

Church, A J·The Medical journal of Australia·1980

This 1980 case-control study examined patients with myalgic encephalomyelitis (ME/CFS) to better understand the condition. While the full details are limited, the study represents an early medical investigation into a disease that was not well understood at the time and was often dismissed by the medical community.

Diagnostics

E3 PreliminaryCohortPEM unclear

Benign myalgic encephalomyelitis: an outbreak in a nurses' school in Athens.

DAIKOS, G K, GARZONIS, S, PALEOLOGUE, A et al.·Lancet (London, England)·1959

This 1959 study documented an outbreak of ME/CFS-like illness among nursing students in Athens, Greece. Multiple students developed similar symptoms including muscle pain, fatigue, and neurological problems over a short period. The researchers observed the outbreak and recorded what happened, helping establish that ME/CFS can occur in groups of people.

Diagnostics

E3 PreliminaryCohortPEM unclear

Benign myalgic encephalomyelitis.

BHATIA, B B, CHANDRA, S, BHUSHAN, C·Journal of the Indian Medical Association·1958

This is an early case-control study from 1958 examining what was then called benign myalgic encephalomyelitis. The researchers described and compared cases of the condition, though specific details about their findings are not available in the abstract. This represents one of the earliest formal medical investigations into what we now know as ME/CFS.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

EPIDEMIC myalgic encephalomyelitis.

British medical journal·1957

This 1957 study from the British Medical Journal documents cases of myalgic encephalomyelitis occurring in epidemic form—meaning multiple people in a community became ill at the same time. The researchers observed patients with this condition to better understand how it presented and spread.

Diagnostics

E3 PreliminaryCohortPEM unclear

Benign myalgic encephalomyelitis.

GALPINE, J F, BRADY, C·Lancet (London, England)·1957

This 1957 case-control study by Galpine and Brady documented cases of myalgic encephalomyelitis and compared them with control groups to understand the condition's features. The researchers aimed to establish that ME was a distinct medical condition with identifiable characteristics, rather than a purely psychological disorder. This early study helped establish the medical legitimacy of what patients and some doctors were observing as a real illness.

Diagnostics

E3 PreliminaryCohortPEM unclearObservational

Benign myalgic encephalomyelitis (Akureyri disease, Iceland disease).

BLATTNER, R J·The Journal of pediatrics·1956

This 1956 study describes an outbreak of a disease called Akureyri disease (also known as Iceland disease) that affected multiple people in Iceland. The disease caused muscle pain and fatigue similar to what we now call ME/CFS. This early medical observation helped document that ME/CFS-like illnesses have occurred in clusters and have affected communities for decades.

Diagnostics

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Evidence Atlas

Evidence browser

Chronic fatigue syndrome. A critical appraisal of the role of Epstein-Barr virus.

Chronic fatigue syndrome: a working case definition.

Myalgic encephalomyelitis.

The chronic fatigue syndrome (myalgic encephalomyelitis)--myth or mystery?

The myalgic encephalomyelitis syndrome.

Chronic fatigue syndrome--a diagnosis for consideration.

The post-viral syndrome: a review.

Myalgic encephalomyelitis "an obscene cosmic joke"?

Benign myalgic encephalomyelitis: an outbreak in a nurses' school in Athens.

Benign myalgic encephalomyelitis.

EPIDEMIC myalgic encephalomyelitis.

Benign myalgic encephalomyelitis.

Benign myalgic encephalomyelitis (Akureyri disease, Iceland disease).

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