ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5321–5340 of 6,188 studies

E3 PreliminaryBehavioralPEM not requiredCase-Control

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

Young, Joel L, Redmond, Judith C·Psychopharmacology bulletin·2007

This study looked at patients who came to a psychiatry clinic with ADHD symptoms and also had unexplained tiredness and widespread pain—conditions similar to ME/CFS or fibromyalgia. When doctors treated the ADHD with medication, some patients noticed their fatigue and pain improved along with their attention problems. The researchers suggest this might mean these conditions involve how the brain processes information rather than problems in muscles and joints.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

The hypothalamo-pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome.

Tanriverdi, F, Karaca, Z, Unluhizarci, K et al.·Stress (Amsterdam, Netherlands)·2007

This review examines how the stress response system (called the HPA axis) works differently in people with ME/CFS and fibromyalgia. The HPA axis is normally responsible for managing how your body responds to stress. Most studies show that in these conditions, the system is underactive and produces lower levels of cortisol (a stress hormone), though some studies have found different results.

Endocrine Disruption

E3 PreliminaryMechanismPEM unclearCross-Sectional

Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms.

Wyller, Vegard Bruun, Godang, Kristin, Mørkrid, Lars et al.·Pediatrics·2007

This study looked at how the body controls temperature in adolescents with ME/CFS compared to healthy teenagers. Researchers found that people with ME/CFS have abnormal responses to temperature changes, with their bodies struggling to regulate heat and cold properly. The study suggests this problem may be related to dysfunction in the nervous system's control of stress hormones like adrenaline.

Autonomic Nervous System

E3 PreliminaryPEM unclear

Chronic fatigue syndrome after Q fever.

Ledina, Dragan, Bradarić, Nikola, Milas, Ivo et al.·Medical science monitor : international medical journal of experimental and clinical research·2007

Q fever is an infection caused by bacteria that can spread from animals to people. While most people recover from acute Q fever, a few develop chronic fatigue that looks like ME/CFS. This report describes three patients who developed post-Q-fever fatigue syndrome and were treated with antibiotics, with mixed results—two improved but one did not.

E3 PreliminaryReviewPEM unclearReview-Narrative

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Appel, Shmuel, Chapman, Joab, Shoenfeld, Yehuda·Autoimmunity·2007

This review examines whether vaccinations might trigger ME/CFS, since infections can sometimes lead to the condition. The authors found some case reports of ME/CFS occurring after vaccination, but most studies did not find a reliable connection. A Canadian health organization concluded there is no strong evidence linking vaccinations to ME/CFS, though researchers agree more studies are needed.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

Klimas, Nancy G, Koneru, Anne O'Brien·Current rheumatology reports·2007

Researchers studied what causes ME/CFS by looking at genes, immune cells, and hormones in patients. They found that how severe someone's initial viral infection was predicted whether fatigue would last long-term, and that people with ongoing ME/CFS show signs of reactivated viruses and problems with energy-producing structures in their cells. The immune system dysfunction they observed involved specialized infection-fighting cells not working properly.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Considerations for the treatment of chronic fatigue syndrome].

Murakami, Masato·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how stress and emotional factors play a role in ME/CFS. The authors suggest that treating ME/CFS effectively requires addressing both the body and mind, not just physical symptoms. They discuss how antidepressants and certain herbal medicines may help reduce anxiety and depression, and emphasize that lifestyle changes and behavioral adjustments are important parts of recovery.

E3 PreliminaryCohortPEM not requiredCase-Control

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

Boimel, P, Check, J H, Katsoff, D·Clinical and experimental obstetrics & gynecology·2007

This case report describes one patient with ME/CFS who had severe stomach emptying problems (gastroparesis) that didn't respond to standard treatments. When she was given a stimulant medication called dextroamphetamine, her stomach symptoms improved significantly and stayed better for at least eight months. The authors suggest this type of medication might help some people with refractory gastroparesis, similar to how it may help other ME/CFS-related symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Autonomic function and child chronic fatigue syndrome].

Tanaka, Hidetaka·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined how the autonomic nervous system—the part of your nervous system that controls automatic functions like heart rate and blood pressure—might be involved in childhood ME/CFS. Researchers found that about one-third of children with ME/CFS had problems regulating their blood pressure and heart rate when standing up, a condition called orthostatic dysregulation. While some studies suggested increased sympathetic nervous system activity, the findings were not consistent across all research.

Autonomic Nervous System

E3 PreliminaryCommentaryPEM not requiredEditorial

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Tjørve, E, Tjørve, K M C, Olsen, J O et al.·Medical hypotheses·2007

Your body's cells may not respond properly to thyroid hormone even when blood tests show normal thyroid levels. This resistance to thyroid hormone can develop from various causes including infections, medications, toxins, or the immune system attacking thyroid proteins. The authors suggest this acquired resistance might be more common than previously thought and could explain why some patients feel hypothyroid symptoms despite normal blood tests.

E3 PreliminaryReviewPEM unclearReview-Narrative

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

Kasatkin, D S, Spirin, N N·Neuroscience and behavioral physiology·2007

This study examined why people with multiple sclerosis (MS) often experience severe fatigue. The researchers identified different types of fatigue—exhaustion at rest, excessive tiredness after activity, and worsening fatigue during MS flare-ups—and explored how brain chemistry, hormones, immune system problems, and sleep issues might all contribute to this fatigue.

Sleep

E3 PreliminaryMechanismPEM not requiredObservational

[Chronic fatigue syndrome and herpesvirus reactivation].

Kondo, Kazuhiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at whether two common viruses that hide dormant in our bodies (HHV-6 and HHV-7) wake up and become active during fatigue. Researchers found that healthy people shed more HHV-6 in their saliva when tired from work, but ME/CFS patients did not show this pattern. However, HHV-7 did increase in both groups, suggesting these viruses might be useful markers to measure fatigue objectively.

BiomarkersImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryGuidelinePEM not requiredGuideline

[Overview of medical treatment and management of chronic fatigue syndrome].

Yoshihara, Kazufumi, Kubo, Chiharu·Nihon rinsho. Japanese journal of clinical medicine·2007

This paper presents a comprehensive approach to treating ME/CFS that combines different types of therapies tailored to individual patients. The main treatments discussed include structured exercise programs (done gradually), lifestyle changes, and sometimes medications or mental health support when needed. The authors emphasize that doctors should carefully monitor patients throughout treatment and adjust their plan based on how well it's working.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

Fulle, Stefania, Pietrangelo, Tiziana, Mancinelli, Rosa et al.·Journal of muscle research and cell motility·2007

This paper explores whether muscle damage from unstable molecules called free radicals might contribute to ME/CFS. The researchers reviewed existing evidence suggesting that muscles in ME/CFS patients may experience harmful oxidative stress—a chemical imbalance that damages cells. While this is a theoretical discussion rather than a new experiment, it proposes that understanding this muscle damage could help explain why ME/CFS causes such severe fatigue.

E3 PreliminaryMechanismPEM not requiredObservational

[Sleep disturbance in chronic fatigue syndrome].

Kumano-go, Takayuki, Adachi, Hiroyoshi, Sugita, Yoshiro·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked at sleep problems in ME/CFS patients using a special laser device to measure blood flow patterns during sleep. The researchers found that different ME/CFS patients showed different types of abnormal sleep patterns, suggesting that ME/CFS may actually be several different conditions rather than one single illness. Sleep disturbances like insomnia, oversleeping, and irregular sleep-wake cycles are common in ME/CFS.

Sleep

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Aslakson, Eric, Vollmer-Conna, Uté, White, Peter D·Pharmacogenomics·2006

Researchers used statistical methods to identify distinct groups among people with chronic unexplained fatigue, including those with ME/CFS. They tested whether these groups were real and consistent by running their analysis multiple ways. They found that the groups they identified were valid and matched well with established ME/CFS diagnostic criteria, suggesting that ME/CFS is not one single condition but rather several related conditions with potentially different underlying causes.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

Engel, Charles C·CNS spectrums·2006

This paper discusses two different ways to approach studying and treating illnesses like ME/CFS that don't have a clear, well-understood cause. One approach focuses on finding the root cause in controlled settings; the other focuses on whether treatments actually work in real-world patient care. The authors argue that for conditions like ME/CFS, the practical approach—focusing on what helps patients in everyday life—may be more useful than searching for a single underlying cause.

Diagnostics

E3 PreliminaryPEM unclear

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Teitelbaum, Jacob E, Johnson, Clarence, St Cyr, John·Journal of alternative and complementary medicine (New York, N.Y.)·2006

Researchers gave 41 patients with ME/CFS or fibromyalgia a natural sugar called D-ribose to see if it could help their symptoms. Two-thirds of patients reported feeling noticeably better, with improvements in energy, sleep, mental clarity, pain, and overall well-being. The supplement was well-tolerated with no serious side effects reported.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredObservational

Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis.

Fostel, Jennifer, Boneva, Roumiana, Lloyd, Andrew·Pharmacogenomics·2006

Researchers used blood tests and symptom questionnaires to look for biological markers that could help identify ME/CFS. They found that ME/CFS involves multiple symptom patterns (fatigue and mood changes being most prominent) and identified 57 genes whose activity differed between people with severe symptoms and those with mild symptoms. However, no single gene or blood test on its own clearly identifies the disease.

Biomarkers

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Fibromylagia, chronic fatigue, and adult attention deficit hyperactivity disorder in the adult: a case study.

The hypothalamo-pituitary-adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome.

Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms.

Chronic fatigue syndrome after Q fever.

Infection and vaccination in chronic fatigue syndrome: myth or reality?

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

[Considerations for the treatment of chronic fatigue syndrome].

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

[Autonomic function and child chronic fatigue syndrome].

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

[Chronic fatigue syndrome and herpesvirus reactivation].

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

[Overview of medical treatment and management of chronic fatigue syndrome].

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

[Sleep disturbance in chronic fatigue syndrome].

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Explanatory and pragmatic perspectives regarding idiopathic physical symptoms and related syndromes.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research