ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5321–5340 of 6,165 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Neuropsychiatric symptoms related to interferon alpha].

Małyszczak, Krzysztof, Inglot, Małgorzata, Pawłowski, Tomasz et al.·Psychiatria polska·2006

Interferon alpha, a medication used to treat hepatitis C and B, cancer, and other serious illnesses, commonly causes psychiatric and neurological side effects including depression, fatigue, anxiety, and cognitive problems in up to half of patients. These symptoms occur because interferon directly affects the brain and triggers a cascade of chemical changes, including alterations to serotonin and other neurotransmitters. The good news is that these symptoms can often be managed with antidepressants, therapy, and behavioral support.

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Ablin, Jacob N, Shoenfeld, Yehuda, Buskila, Dan·Journal of autoimmunity·2006

This review examines whether infections and vaccinations might trigger fibromyalgia and related conditions like chronic fatigue syndrome. Researchers found that certain infections (like Lyme disease and hepatitis C) have been linked to fibromyalgia, and some people report symptoms starting after vaccinations, but antibiotics and antivirals don't appear to help treat fibromyalgia effectively. The authors suggest that vaccinations might act as one trigger among several factors that together cause these conditions.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Craddock, R Cameron, Taylor, Renee, Broderick, Gordon et al.·Pharmacogenomics·2006

Researchers tested a new statistical method called the entropy correlation coefficient to identify which ME/CFS symptoms and test results are related to each other. They studied 130 women and found that fatigue-related measures were strongly connected to each other, as were general quality-of-life measures and depression scores. Importantly, they discovered some relationships between cognitive test results and ME/CFS that hadn't been found with traditional statistical methods.

Cognitive Impairment

E3 PreliminaryCohortPEM unclearCase-Control

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Toda, Katsuhiro, Kimura, Hiroaki·Hiroshima journal of medical sciences·2006

This case report describes one 28-year-old man with ME/CFS who was treated with a medication called Neurotropin (four tablets daily). His fatigue and widespread pain began improving within a week, and his sleep, focus, and memory improved within two weeks. He stopped taking the medication after 11 weeks and remained symptom-free for at least 5 months afterward.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

Takahashi, Takashi, Yu, Fei, Zhu, Shi-Jie et al.·Evidence-based complementary and alternative medicine : eCAM·2006

Researchers gave mice a brewer's yeast extract to see if it could help restore activity levels in a mouse model of ME/CFS. Mice treated with the yeast extract showed significantly better activity levels compared to untreated mice, and the treated mice also had better survival rates. The study suggests that brewer's yeast extract may help by adjusting immune system responses that become imbalanced in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

Kasatkin, D S, Spirin, N N·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2006

This review describes how fatigue in multiple sclerosis (MS) can happen in different ways: tiredness even at rest, exhaustion during activity, and fatigue linked to MS flare-ups. The authors explain that fatigue likely involves both brain-based and body-based mechanisms, and often occurs alongside depression and sleep problems, suggesting these conditions may share common biological causes related to brain chemicals like serotonin.

NeuroinflammationPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.

Chalmers, Ronald A, Jones, Mark G, Goodwin, C Stewart et al.·Clinica chimica acta; international journal of clinical chemistry·2006

An earlier study claimed to find two special markers in the urine of ME/CFS patients that could help diagnose the condition. This study re-examined those findings and discovered that these supposed markers were actually just artifacts—unintended byproducts created by the way the urine samples were prepared in the lab, not real biological differences between patients and healthy people.

Biomarkers

E3 PreliminaryCohortPEM unclearObservational

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

Whitehead, Lisa Claire·Social science & medicine (1982)·2006

This study looked at how 17 people with ME/CFS describe their illness and make sense of it. Researchers found that people often go through different ways of telling their story: first trying to get back to normal (restitution), then feeling overwhelmed by chaos, and eventually finding new meaning in their lives (quest narrative). Understanding these patterns helps explain how people cope with a long-term illness that's hard to diagnose and often misunderstood.

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Aslakson, Eric, Vollmer-Conna, Uté, White, Peter D·Pharmacogenomics·2006

Researchers used statistical methods to identify distinct groups among people with chronic unexplained fatigue, including those with ME/CFS. They tested whether these groups were real and consistent by running their analysis multiple ways. They found that the groups they identified were valid and matched well with established ME/CFS diagnostic criteria, suggesting that ME/CFS is not one single condition but rather several related conditions with potentially different underlying causes.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis.

Ito, N, Nagai, T, Yabe, T et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology·2006

This study tested whether Koso-san, a traditional Japanese herbal medicine, could help reduce depression-like symptoms in mice exposed to stress. Mice given Koso-san showed improved behavior in stress tests, and the herb appeared to normalize stress hormone systems in their brains that were overactive due to the stress exposure.

Endocrine Disruption

E3 PreliminaryBehavioralPEM unclearLongitudinal

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

Whitehead, Lisa·International journal of nursing studies·2006

This study followed 17 people with ME/CFS over time to understand how the illness changed how they saw themselves. The researchers found that people's sense of identity shifted depending on how sick they were and how others treated them. Over the long term, most people developed ways to cope that helped them build a more stable sense of who they were, even while managing their illness.

E3 PreliminaryReviewPEM unclearReview-Narrative

The debate: myalgic encephalomyelitis and chronic fatigue syndrome.

Shepherd, Charles·British journal of nursing (Mark Allen Publishing)·2006

This article discusses the ongoing disagreement among doctors and researchers about ME/CFS, including what causes it and how to treat it. The author explains that while we still don't fully understand what causes the illness, we are learning more about the factors that may trigger or worsen it. Good news: doctors now have treatments available that can help reduce symptoms and improve quality of life for patients, rather than simply accepting the illness as untreatable.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Maoz, Daniel, Shoenfeld, Yehuda·Harefuah·2006

ME/CFS is a serious illness that causes extreme tiredness and other symptoms that interfere with daily life. Doctors often fail to diagnose it correctly, and we still don't fully understand what causes it. This review suggests that ME/CFS likely results from multiple different factors working together, and that two treatments—cognitive behavioral therapy and graded exercise therapy—might help some patients.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The problem of fatigue in neurological disorders].

Kumor, Klaudiusz, Pierzchała, Krystyna·Wiadomosci lekarskie (Warsaw, Poland : 1960)·2006

Fatigue is an extremely common and often severely disabling symptom in many neurological disorders, affecting 40–90% of patients with conditions like multiple sclerosis, Parkinson's disease, and stroke. This review explains that fatigue is a real medical symptom that should be carefully distinguished from depression, weakness, and sleepiness, though these conditions often occur together. Currently, doctors assess fatigue mainly through patient questionnaires, and there is no clear biological test or proven cure—treatments focus on addressing the underlying disease and using behavioral and psychological approaches.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--exercise and physical activity].

Greenberg, Shai, Frid, Mordechai·Harefuah·2006

People with ME/CFS often feel extremely tired and struggle with physical activity, experiencing worsening symptoms even after light exercise. This review found that ME/CFS patients typically have lower fitness levels, their hearts work harder during normal activity, and they take longer to recover than healthy people. The good news is that carefully guided exercise programs appear to be the most helpful treatment for improving energy levels, physical function, and daily life activities.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Identifying illness parameters in fatiguing syndromes using classical projection methods.

Broderick, Gordon, Craddock, R Cameron, Whistler, Toni et al.·Pharmacogenomics·2006

Researchers studied 111 women to find common patterns that distinguish ME/CFS patients from healthy controls by looking at both their symptoms and gene activity in blood cells. They used a statistical method to combine multiple pieces of information—like fatigue scores, quality of life measures, and which genes were active—rather than looking at single factors alone. The analysis identified key differences related to stress in cells, immune problems, and imbalanced minerals, particularly reflected in abnormal heart rate patterns during sleep.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Challenges for molecular profiling of chronic fatigue syndrome.

Vernon, Suzanne D, Whistler, Toni, Aslakson, Eric et al.·Pharmacogenomics·2006

This paper discusses why it's been difficult for scientists to find reliable blood tests (biomarkers) to diagnose ME/CFS and develop treatments. The authors explain that ME/CFS is complex because it affects many body systems at once, and each researcher may focus on different areas based on their expertise. They suggest that blood tests show promise for understanding ME/CFS and that combining genetic information, protein data, and information about patients' environments and behaviors could help researchers better understand why different patients experience the illness differently.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Iasiukiavichene, L, Vasiliauskas, D·Kardiologiia·2006

This review examines why people with heart disease often experience severe fatigue and how the body's stress response system may be involved. The authors explain that chronic fatigue is a condition affecting the immune system, hormones, and nervous system, and can be triggered by stress, surgery, infections, or other illnesses. They suggest that measuring a stress hormone called cortisol could help doctors identify and treat fatigue in heart patients.

Endocrine Disruption

E3 PreliminaryCommentaryPEM not requiredEditorial

Psychomotor speed: possibly a new marker for overtraining syndrome.

Nederhof, Esther, Lemmink, Koen A P M, Visscher, Chris et al.·Sports medicine (Auckland, N.Z.)·2006

This study proposes that measuring how quickly someone can respond to mental tasks (psychomotor speed) might help identify athletes who are overtraining before serious problems develop. The researchers noticed that overtraining syndrome shares some features with chronic fatigue syndrome and depression, both of which involve slowed mental processing, and suggest this slowness could be an early warning sign.

Cognitive Impairment

E3 PreliminaryPEM unclear

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

Teitelbaum, Jacob E, Johnson, Clarence, St Cyr, John·Journal of alternative and complementary medicine (New York, N.Y.)·2006

Researchers gave 41 patients with ME/CFS or fibromyalgia a natural sugar called D-ribose to see if it could help their symptoms. Two-thirds of patients reported feeling noticeably better, with improvements in energy, sleep, mental clarity, pain, and overall well-being. The supplement was well-tolerated with no serious side effects reported.

Energy Metabolism

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Evidence browser

[Neuropsychiatric symptoms related to interferon alpha].

Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle.

Exploration of statistical dependence between illness parameters using the entropy correlation coefficient.

Efficacy of neurotropin in chronic fatigue syndrome: a case report.

Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.

[Possible mechanisms of chronic fatigue syndrome in multiple sclerosis].

CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.

Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis.

The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue.

Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis.

Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study.

The debate: myalgic encephalomyelitis and chronic fatigue syndrome.

[Chronic fatigue syndrome].

[The problem of fatigue in neurological disorders].

[Chronic fatigue syndrome--exercise and physical activity].

Identifying illness parameters in fatiguing syndromes using classical projection methods.

Challenges for molecular profiling of chronic fatigue syndrome.

[Chronic fatigue syndrome in cardiology neurohumoral changes].

Psychomotor speed: possibly a new marker for overtraining syndrome.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.

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