ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5301–5320 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Van Houdenhove, B, Verheyen, L, Pardaens, K et al.·Clinical rehabilitation·2007

This paper proposes a new way to think about why people with ME/CFS have reduced physical ability. The authors suggest there may be two different problems: some patients may have low energy capacity (their bodies can't produce enough energy), while others may have reduced effort tolerance (their nervous system tells them to stop before their body actually reaches its limit). Understanding which problem a patient has could help doctors choose better treatments.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Galanopoulos, Ng, Kampakis, Gp, Ladopoulou, Kf·Psychiatrike = Psychiatriki·2007

This review discusses fibromyalgia and chronic fatigue syndrome (ME/CFS) in children and teenagers, noting that both conditions are fairly common in this age group. Patients with these conditions experience widespread muscle pain, exhaustion, depression, headaches, and sleep problems that can significantly impact school, family life, and overall development. The authors emphasize that early diagnosis and treatment combining medication, physical therapy, and psychological support are important for helping young people manage these conditions.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Tomoda, Akemi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines childhood chronic fatigue syndrome (CCFS), a serious condition where children experience extreme tiredness that cannot be explained by other medical or mental health problems. Children with CCFS often struggle with memory and concentration, sleep problems, and symptoms related to their nervous system. The authors suggest that CCFS may involve changes in how the brain functions, which could explain why patients experience fatigue, thinking difficulties, and memory problems.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Violence, stress, and somatic syndromes.

Crofford, Leslie J·Trauma, violence & abuse·2007

This review article examines how experiences of violence and stress may trigger or worsen conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome—illnesses that involve pain, exhaustion, mood changes, memory problems, and sleep issues. The authors explain that stress affects the brain and body's hormone and nervous system function, which may make people more vulnerable to developing these conditions. Understanding this connection could help us recognize how violence exposure affects long-term health.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryPEM not required

[Chronic fatigue syndrome in a 15-year-old girl].

Díaz-Caneja Greciano, A, Rodríguez Sosa, J T, Aguilera Albesa, S et al.·Anales de pediatria (Barcelona, Spain : 2003)·2007

This report describes a 15-year-old girl diagnosed with ME/CFS (chronic fatigue syndrome), a condition that causes severe tiredness and lack of energy without an obvious physical cause. The doctors emphasize that ME/CFS should be considered when young people have chronic fatigue along with other symptoms but medical tests don't reveal why. Treatment focused on rehabilitation with cognitive behavioral therapy (talking therapy to address thoughts and behaviors) combined with a gradual, structured increase in activity levels.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome and neurotransmitters].

Miwa, Soichi, Takikawa, Osamu·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how chemical messengers in the brain called neurotransmitters may be disrupted in ME/CFS. The researchers found that ME/CFS patients may have problems with serotonin and glutamate signaling, possibly triggered by viral infections or genetic differences. These imbalances could help explain why ME/CFS causes such persistent exhaustion.

Energy MetabolismImmune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of the influence of individual participant characteristics on formal consensus development.

Carpenter, James, Hutchings, Andrew, Raine, Rosalind et al.·International journal of technology assessment in health care·2007

This study looked at how different types of doctors and healthcare workers rate whether psychological treatments are appropriate for ME/CFS and other chronic conditions. Researchers had 346 people in 20 groups review mental health treatments and rate how suitable they were, testing whether factors like the doctors' specialty, age, and sex changed their opinions.

E3 PreliminaryBehavioralPEM not requiredLongitudinal

Post concussion syndrome ebb and flow: longitudinal effects and management.

Rees, Roger J, Bellon, Michelle L·NeuroRehabilitation·2007

This study followed 20 adults who had lasting symptoms after a head injury (concussion) for an average of 3.35 years. Participants experienced fatigue, difficulty concentrating, mood changes, and sensitivity to noise. When they received counseling and therapy over two years, some symptoms like irritability improved, but many people still felt fundamentally changed and struggled with feelings of helplessness.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Considerations for the treatment of chronic fatigue syndrome].

Murakami, Masato·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how stress and emotional factors play a role in ME/CFS. The authors suggest that treating ME/CFS effectively requires addressing both the body and mind, not just physical symptoms. They discuss how antidepressants and certain herbal medicines may help reduce anxiety and depression, and emphasize that lifestyle changes and behavioral adjustments are important parts of recovery.

E3 PreliminaryCohortPEM not requiredCase-Control

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

Boimel, P, Check, J H, Katsoff, D·Clinical and experimental obstetrics & gynecology·2007

This case report describes one patient with ME/CFS who had severe stomach emptying problems (gastroparesis) that didn't respond to standard treatments. When she was given a stimulant medication called dextroamphetamine, her stomach symptoms improved significantly and stayed better for at least eight months. The authors suggest this type of medication might help some people with refractory gastroparesis, similar to how it may help other ME/CFS-related symptoms.

Autonomic Nervous System

E3 PreliminaryGuidelinePEM not requiredGuideline

[Overview of medical treatment and management of chronic fatigue syndrome].

Yoshihara, Kazufumi, Kubo, Chiharu·Nihon rinsho. Japanese journal of clinical medicine·2007

This paper presents a comprehensive approach to treating ME/CFS that combines different types of therapies tailored to individual patients. The main treatments discussed include structured exercise programs (done gradually), lifestyle changes, and sometimes medications or mental health support when needed. The authors emphasize that doctors should carefully monitor patients throughout treatment and adjust their plan based on how well it's working.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Maes, Michael, Mihaylova, Ivanka, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study found that people with ME/CFS and depression have higher levels of specific immune proteins (IgM antibodies) that attack a substance called phosphatidyl inositol in their blood compared to healthy people. These antibody levels were linked to fatigue and depression symptoms, suggesting that an abnormal immune response against this substance might contribute to both conditions.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryCommentaryPEM not requiredEditorial

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Tjørve, E, Tjørve, K M C, Olsen, J O et al.·Medical hypotheses·2007

Your body's cells may not respond properly to thyroid hormone even when blood tests show normal thyroid levels. This resistance to thyroid hormone can develop from various causes including infections, medications, toxins, or the immune system attacking thyroid proteins. The authors suggest this acquired resistance might be more common than previously thought and could explain why some patients feel hypothyroid symptoms despite normal blood tests.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

Klimas, Nancy G, Koneru, Anne O'Brien·Current rheumatology reports·2007

Researchers studied what causes ME/CFS by looking at genes, immune cells, and hormones in patients. They found that how severe someone's initial viral infection was predicted whether fatigue would last long-term, and that people with ongoing ME/CFS show signs of reactivated viruses and problems with energy-producing structures in their cells. The immune system dysfunction they observed involved specialized infection-fighting cells not working properly.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Advances in the treatment of multiple sclerosis?].

Tackenberg, B, Himmerich, H, Wellek, A et al.·MMW Fortschritte der Medizin·2007

This article reviews advances in treating multiple sclerosis (MS), a different neurological disease from ME/CFS. It discusses how MS treatment has improved with new diagnostic tools, early treatment approaches, and various medications. The article notes that MS patients often experience chronic fatigue, depression, and other symptoms that require separate treatment alongside MS-specific therapies.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Update in Hepatitis C virus associated extrahepatic manifestations].

Sène, D, Saadoun, D, Limal, N et al.·La Revue de medecine interne·2007

This review examines how hepatitis C virus (HCV) can affect parts of the body beyond the liver. The authors discuss various conditions linked to HCV infection, including chronic fatigue, dry mouth and eyes, diabetes, and certain blood cancers. They note that while these connections are documented, scientists still don't fully understand the mechanisms behind them.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Clinical features of chronic fatigue syndrome--symptoms].

Ban, Nobutaro, Saiki, Takuya, Ko, Gyoshin et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

This review article summarizes the most common symptoms experienced by people with ME/CFS. The researchers identified and described the top 10 symptoms in detail, including severe fatigue, problems with memory and concentration, muscle pain, poor sleep, and headaches. Understanding these symptom patterns can help doctors recognize and diagnose ME/CFS more accurately.

Pain and SensitizationCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Cirrhotic cardiomyopathy].

Osipenko, M F, Bikbulatova, E A·Klinicheskaia meditsina·2007

This review examines how liver cirrhosis (severe liver disease) affects the heart. The study found that patients with cirrhosis develop heart problems including thickened heart walls and weakened heart function, especially during physical activity. These heart changes may contribute to fatigue and reduced ability to work, but importantly, these problems can improve significantly after a liver transplant.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM unclearCross-Sectional

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Edwards, Catherine R, Thompson, Andrew R, Blair, Alan·Journal of health psychology·2007

This study interviewed eight women with ME/CFS about how they learned to cope with their illness. Many felt overwhelmed at first and frustrated when doctors didn't believe or help them. Over time, women found ways to manage by learning more about their condition, getting support from others, and taking charge of their own care, which helped them feel more in control.

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Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

[School phobia and childhood chronic fatigue syndrome (CCFS)].

Violence, stress, and somatic syndromes.

[Chronic fatigue syndrome in a 15-year-old girl].

[Chronic fatigue syndrome and neurotransmitters].

An experimental study of the influence of individual participant characteristics on formal consensus development.

Post concussion syndrome ebb and flow: longitudinal effects and management.

[Considerations for the treatment of chronic fatigue syndrome].

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

[Overview of medical treatment and management of chronic fatigue syndrome].

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

[Advances in the treatment of multiple sclerosis?].

[Update in Hepatitis C virus associated extrahepatic manifestations].

[Clinical features of chronic fatigue syndrome--symptoms].

[Cirrhotic cardiomyopathy].

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

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