ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5281–5300 of 6,164 studies

E3 PreliminaryCommentaryPEM not requiredEditorial

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

Cecchini, Marie, LoPresti, Vincent·Medical hypotheses·2007

This paper proposes that medications and drugs can accumulate in body fat over time and potentially cause long-term health problems even after someone stops taking them. The authors suggest that a treatment program involving exercise, sauna use, and vitamins might help remove these stored substances from the body and improve symptoms in conditions like ME/CFS.

Endocrine Disruption

E3 PreliminaryPEM unclear

Chronic fatigue syndrome after Q fever.

Ledina, Dragan, Bradarić, Nikola, Milas, Ivo et al.·Medical science monitor : international medical journal of experimental and clinical research·2007

Q fever is an infection caused by bacteria that can spread from animals to people. While most people recover from acute Q fever, a few develop chronic fatigue that looks like ME/CFS. This report describes three patients who developed post-Q-fever fatigue syndrome and were treated with antibiotics, with mixed results—two improved but one did not.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms.

Wyller, Vegard Bruun, Godang, Kristin, Mørkrid, Lars et al.·Pediatrics·2007

This study looked at how the body controls temperature in adolescents with ME/CFS compared to healthy teenagers. Researchers found that people with ME/CFS have abnormal responses to temperature changes, with their bodies struggling to regulate heat and cold properly. The study suggests this problem may be related to dysfunction in the nervous system's control of stress hormones like adrenaline.

Autonomic Nervous System

E3 PreliminaryBehavioralPEM not requiredObservational

Orthostatic panic attacks among Vietnamese refugees.

Hinton, Devon E, Hinton, Ladson, Tran, Minh et al.·Transcultural psychiatry·2007

This study looked at Vietnamese refugees who experienced panic attacks triggered by standing up quickly from a sitting or lying position (orthostatic dizziness). The researchers found that these panic attacks were common among this group and were often linked to trauma memories and cultural beliefs about health. The study suggests that doctors treating Vietnamese refugees should check for and treat these specific panic attacks as part of their care.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability.

Gupta, Shakti, Aslakson, Eric, Gurbaxani, Brian M et al.·Theoretical biology & medical modelling·2007

This study created a mathematical model of the body's stress-response system (the HPA axis) that helps explain why some people with chronic stress develop low cortisol levels. The model shows that when stress is repeated over a long time, the body can get 'stuck' in a low-cortisol state, similar to what happens in ME/CFS. The research suggests this happens because of how cortisol's receptor proteins build up and change how the stress system works.

E3 PreliminaryReviewPEM unclearReview-Narrative

Violence, stress, and somatic syndromes.

Crofford, Leslie J·Trauma, violence & abuse·2007

This review article examines how experiences of violence and stress may trigger or worsen conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome—illnesses that involve pain, exhaustion, mood changes, memory problems, and sleep issues. The authors explain that stress affects the brain and body's hormone and nervous system function, which may make people more vulnerable to developing these conditions. Understanding this connection could help us recognize how violence exposure affects long-term health.

Pain and SensitizationSleepCognitive Impairment

E3 PreliminaryPEM not required

[Chronic fatigue syndrome in a 15-year-old girl].

Díaz-Caneja Greciano, A, Rodríguez Sosa, J T, Aguilera Albesa, S et al.·Anales de pediatria (Barcelona, Spain : 2003)·2007

This report describes a 15-year-old girl diagnosed with ME/CFS (chronic fatigue syndrome), a condition that causes severe tiredness and lack of energy without an obvious physical cause. The doctors emphasize that ME/CFS should be considered when young people have chronic fatigue along with other symptoms but medical tests don't reveal why. Treatment focused on rehabilitation with cognitive behavioral therapy (talking therapy to address thoughts and behaviors) combined with a gradual, structured increase in activity levels.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCase-Control

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Sleep·2007

This study looked at how the brain's sleep patterns differ between people with ME/CFS and their healthy twins. Researchers kept twins awake 4 hours later than usual and then let them sleep normally. They found that people with ME/CFS showed weaker deep sleep activity when recovering from the sleep delay, suggesting their bodies may have trouble responding normally to sleep pressure.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Childhood chronic fatigue syndrome].

Miike, Teruhisa·Nihon rinsho. Japanese journal of clinical medicine·2007

This review discusses chronic fatigue syndrome (CFS) in children and teenagers, a serious condition affecting 3-5% of young people. Children with CFS experience extreme tiredness, sleep problems, trouble learning and remembering, and immune system issues. While routine blood tests often look normal, special testing can reveal abnormalities in how their bodies handle energy, regulate temperature, and control hormones.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The chronic fatigue syndrome: a comparative pathway analysis.

Emmert-Streib, Frank·Journal of computational biology : a journal of computational molecular cell biology·2007

This study developed a new method to find biological pathways that go wrong in ME/CFS, rather than just looking at individual genes. The researchers compared how biological systems work differently in sick versus healthy people using computer analysis of gene expression data. This approach helps scientists understand ME/CFS as a disease of interconnected biological processes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of psychiatric therapy for chronic fatigue syndrome].

Yamadera, Wataru, Itoh, Hiroshi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how talking therapies, particularly cognitive behavioral therapy (CBT), can help people with ME/CFS. CBT focuses on identifying unhelpful thinking patterns and behaviors—like perfectionism, avoidance, and constantly searching for physical causes—that may be making fatigue worse. The approach involves keeping steady activity levels and making small, planned increases over time, rather than pushing hard and then collapsing.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mechanisms of cancer-related fatigue.

Ryan, Julie L, Carroll, Jennifer K, Ryan, Elizabeth P et al.·The oncologist·2007

Cancer-related fatigue is extreme tiredness that happens during and after cancer treatment and significantly impacts quality of life, but doctors don't fully understand why it occurs. This review examines several possible causes, including problems with brain chemicals, muscle metabolism, hormonal balance, sleep-wake cycles, and inflammation in the body. Understanding these mechanisms could help develop better treatments for this distressing symptom.

Energy Metabolism

E3 PreliminaryCommentaryPEM unclearEditorial

Mitochondrial dysfunction and molecular pathways of disease.

Pieczenik, Steve R, Neustadt, John·Experimental and molecular pathology·2007

This article explains that many different diseases—including chronic fatigue syndrome—may share a common problem: damage to mitochondria, the energy-producing parts of our cells. When mitochondria don't work properly, they produce harmful molecules called reactive oxygen species that can further damage cells. The authors suggest that antioxidant treatments and specific urine tests might help doctors treat these conditions more effectively.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

[Advances in the treatment of multiple sclerosis?].

Tackenberg, B, Himmerich, H, Wellek, A et al.·MMW Fortschritte der Medizin·2007

This article reviews advances in treating multiple sclerosis (MS), a different neurological disease from ME/CFS. It discusses how MS treatment has improved with new diagnostic tools, early treatment approaches, and various medications. The article notes that MS patients often experience chronic fatigue, depression, and other symptoms that require separate treatment alongside MS-specific therapies.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Kawai, Tomoko, Rokutan, Kazuhito·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked for genetic markers (differences in how genes are expressed) that could help doctors diagnose ME/CFS with a blood test. The researchers identified 9 genes that were expressed differently in ME/CFS patients compared to healthy people, and showed these genes could potentially be used to distinguish ME/CFS from other conditions.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Perrin, Raymond N·The Journal of the American Osteopathic Association·2007

This study proposes that ME/CFS may be connected to problems with how fluid drains from the brain and spinal cord. The author suggests that the cranial rhythmic impulse—a subtle body rhythm that practitioners can feel—reflects cerebrospinal fluid drainage and lymphatic system activity controlled by the nervous system. When this drainage process becomes disrupted, the author argues it could cause the fatigue and other symptoms of ME/CFS.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Update in Hepatitis C virus associated extrahepatic manifestations].

Sène, D, Saadoun, D, Limal, N et al.·La Revue de medecine interne·2007

This review examines how hepatitis C virus (HCV) can affect parts of the body beyond the liver. The authors discuss various conditions linked to HCV infection, including chronic fatigue, dry mouth and eyes, diabetes, and certain blood cancers. They note that while these connections are documented, scientists still don't fully understand the mechanisms behind them.

Immune System

E3 PreliminaryGuidelinePEM requiredGuideline

Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works.

Carruthers, B M·Journal of clinical pathology·2007

This article discusses how doctors should define and diagnose ME/CFS, emphasizing that clear, consistent definitions help doctors recognize the condition and understand how severely it affects individual patients. The authors argue that good clinical guidelines are essential so doctors can properly diagnose ME/CFS, predict how it will progress, and develop appropriate treatments. They stress that combining what doctors learn from individual patients with scientific research findings creates the best foundation for patient care.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Gamma-aminobutyric acid--metabolism and its disorders].

Kowalski, Antoni, Rebas, Elzbieta, Zylińska, Ludmiła·Postepy biochemii·2007

Your brain uses a chemical messenger called GABA to calm nerve signals and prevent them from becoming overactive. When three key enzymes that control GABA levels don't work properly, it can cause various neurological problems including chronic fatigue syndrome, anxiety, seizures, and stiff-person syndrome. This article reviews what happens when GABA metabolism breaks down and how it affects the nervous system.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Chung, Yujin, Lee, Seung Yeoun, Elston, Robert C et al.·Bioinformatics (Oxford, England)·2007

This study presents a new computational tool called OR MDR that helps scientists find combinations of genes that might increase the risk of developing diseases like ME/CFS. Unlike older methods that simply sort gene combinations into two groups (high-risk or low-risk), this new tool provides more detailed information about exactly how much each gene combination increases disease risk, including ranges of uncertainty around those estimates.

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Evidence browser

Drug residues store in the body following cessation of use: impacts on neuroendocrine balance and behavior--use of the Hubbard sauna regimen to remove toxins and restore health.

Chronic fatigue syndrome after Q fever.

Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms.

Orthostatic panic attacks among Vietnamese refugees.

Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability.

Violence, stress, and somatic syndromes.

[Chronic fatigue syndrome in a 15-year-old girl].

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

[Childhood chronic fatigue syndrome].

The chronic fatigue syndrome: a comparative pathway analysis.

[Overview of psychiatric therapy for chronic fatigue syndrome].

Mechanisms of cancer-related fatigue.

Mitochondrial dysfunction and molecular pathways of disease.

[Advances in the treatment of multiple sclerosis?].

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

[Update in Hepatitis C virus associated extrahepatic manifestations].

Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works.

[Gamma-aminobutyric acid--metabolism and its disorders].

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research