ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5281–5300 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of psychiatric therapy for chronic fatigue syndrome].

Yamadera, Wataru, Itoh, Hiroshi·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines how talking therapies, particularly cognitive behavioral therapy (CBT), can help people with ME/CFS. CBT focuses on identifying unhelpful thinking patterns and behaviors—like perfectionism, avoidance, and constantly searching for physical causes—that may be making fatigue worse. The approach involves keeping steady activity levels and making small, planned increases over time, rather than pushing hard and then collapsing.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Vitamin d and rehabilitation: improving functional outcomes.

Shinchuk, Leonid M, Holick, Michael F·Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2007

Vitamin D deficiency is very common in people undergoing rehabilitation and can cause bone pain, muscle weakness, and poor balance. This review explains that maintaining healthy vitamin D levels (measured as 30–60 ng/mL in the blood) through sunlight exposure, diet, or supplements can help prevent fractures and improve muscle function. Because vitamin D deficiency can mimic or worsen symptoms of ME/CFS, fibromyalgia, and other conditions, doctors should check vitamin D levels in patients with these problems.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome.

Jerjes, Walid K, Taylor, Norman F, Wood, Peter J et al.·Psychoneuroendocrinology·2007

This study tested how the bodies of ME/CFS patients respond to a small dose of a steroid medication called prednisolone. Researchers found that people with ME/CFS showed a stronger suppression of cortisol (a stress hormone) after taking the medication compared to healthy controls, suggesting their bodies may be overly sensitive to this type of feedback signal from the steroid.

Endocrine Disruption

E3 PreliminaryBehavioralPEM unclearCross-Sectional

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

Edwards, Catherine R, Thompson, Andrew R, Blair, Alan·Journal of health psychology·2007

This study interviewed eight women with ME/CFS about how they learned to cope with their illness. Many felt overwhelmed at first and frustrated when doctors didn't believe or help them. Over time, women found ways to manage by learning more about their condition, getting support from others, and taking charge of their own care, which helped them feel more in control.

E3 PreliminaryBehavioralPEM not requiredCase-Control

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

Oki, Junichi, Okubo, Jun·Nihon rinsho. Japanese journal of clinical medicine·2007

This small study looked at growth charts from three young people with chronic fatigue syndrome to see if the charts could help identify what triggered their illness. The researchers found that life events—like overexercise, family stress, or infection—appeared before symptoms like extreme tiredness, nausea, and sleep problems started. While growth charts alone cannot predict who will develop ME/CFS, they may help doctors spot important life changes that happened around the time symptoms began.

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryTrialPEM not requiredRCT

Effects of elevated plasma tryptophan on brain activation associated with the Stroop task.

Morgan, Rhian M, Parry, Allyson M M, Arida, Ricardo M et al.·Psychopharmacology·2007

This study looked at how a dietary supplement called tryptophan affects the brain's activity during mental tasks in people experiencing central fatigue (like in ME/CFS). Researchers used brain imaging to watch what happens when people take tryptophan versus a placebo while doing a challenging attention test. They found that tryptophan slowed down responses and changed brain activity patterns in several regions, particularly in areas related to awareness and processing information.

Cognitive Impairment

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Hyperventilation in patients with chronic fatigue syndrome: the role of coping strategies.

Bogaerts, Katleen, Hubin, Morgane, Van Diest, Ilse et al.·Behaviour research and therapy·2007

This study looked at how people with ME/CFS breathe differently depending on how they mentally cope with their illness. Researchers found that when patients imagined resisting or fighting against their illness, their breathing changed in ways that made their symptoms worse. In contrast, when patients imagined accepting their illness, their breathing stayed more stable and symptoms improved. This suggests that our psychological response to ME/CFS may directly affect how our body breathes and which symptoms we experience.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The thoughts and methods for clinical research on acupuncture treatment of chronic fatigue syndrome.

Yao, Renmin·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2007

This paper presents acupuncture treatment guidelines for chronic fatigue syndrome (ME/CFS), focusing on how acupuncture might restore balance to the body's energy systems according to traditional Chinese medicine. The authors discuss important considerations like which patients are most suitable for treatment, which acupuncture points to use, and how to measure whether the treatment is working.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Galanopoulos, Ng, Kampakis, Gp, Ladopoulou, Kf·Psychiatrike = Psychiatriki·2007

This review discusses fibromyalgia and chronic fatigue syndrome (ME/CFS) in children and teenagers, noting that both conditions are fairly common in this age group. Patients with these conditions experience widespread muscle pain, exhaustion, depression, headaches, and sleep problems that can significantly impact school, family life, and overall development. The authors emphasize that early diagnosis and treatment combining medication, physical therapy, and psychological support are important for helping young people manage these conditions.

Pain and SensitizationSleep

E3 PreliminaryCohortPEM not requiredCase-Control

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Maes, Michael, Coucke, Francis, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study describes a teenage girl with ME/CFS who had damage to her gut lining, allowing bacterial toxins to leak into her bloodstream. When she was treated with antioxidants, dietary changes to repair her gut, and immune support therapy, the leaky gut improved and her ME/CFS symptoms disappeared. The findings suggest that gut damage may play a role in some ME/CFS cases.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

Chung, Yujin, Lee, Seung Yeoun, Elston, Robert C et al.·Bioinformatics (Oxford, England)·2007

This study presents a new computational tool called OR MDR that helps scientists find combinations of genes that might increase the risk of developing diseases like ME/CFS. Unlike older methods that simply sort gene combinations into two groups (high-risk or low-risk), this new tool provides more detailed information about exactly how much each gene combination increases disease risk, including ranges of uncertainty around those estimates.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

Kuratsune, Hirohiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examines ME/CFS as a real medical condition affecting the nervous system, immune system, and stress response. While researchers have found many different abnormalities in ME/CFS patients—including viral reactivation, immune problems, and chemical imbalances in the brain—no single cause has been identified in everyone with the condition. The authors suggest that ME/CFS likely results from a combination of genetic factors and life stress that disrupts how the body's immune and hormone systems work together.

Immune System

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Brief report: The accuracy of parents for the thoughts and feelings of their adolescent suffering from chronic fatigue: a preliminary study of empathy.

Vervoort, Tine, Crombez, Geert, Buysse, Ann et al.·Journal of pediatric psychology·2007

This study looked at whether parents of teenagers with ME/CFS could accurately understand what their child was thinking and feeling. Researchers found that parents were less able to understand their teenager's thoughts and feelings about ME/CFS itself compared to other life situations. Interestingly, teenagers thought their mothers understood them better than their fathers did, even though fathers were actually just as accurate in understanding them.

E3 PreliminaryPEM not required

[Chronic fatigue syndrome in a 15-year-old girl].

Díaz-Caneja Greciano, A, Rodríguez Sosa, J T, Aguilera Albesa, S et al.·Anales de pediatria (Barcelona, Spain : 2003)·2007

This report describes a 15-year-old girl diagnosed with ME/CFS (chronic fatigue syndrome), a condition that causes severe tiredness and lack of energy without an obvious physical cause. The doctors emphasize that ME/CFS should be considered when young people have chronic fatigue along with other symptoms but medical tests don't reveal why. Treatment focused on rehabilitation with cognitive behavioral therapy (talking therapy to address thoughts and behaviors) combined with a gradual, structured increase in activity levels.

Diagnostics

E3 PreliminaryCohortPEM not requiredCase-Control

[A new treatment: thermal therapy for chronic fatigue syndrome].

Masuda, Akinori, Munemoto, Takao, Tei, Chuwa·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested far-infrared sauna therapy on 13 ME/CFS patients. Two patients experienced dramatic improvements in fatigue, pain, and fever, and were able to stop taking prednisolone and return to normal activities within 6 months. The remaining 11 patients also reported improvements in fatigue and pain, with additional benefits including relaxation and reduced depression symptoms.

E3 PreliminaryCohortPEM not requiredCase-Control

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

Boimel, P, Check, J H, Katsoff, D·Clinical and experimental obstetrics & gynecology·2007

This case report describes one patient with ME/CFS who had severe stomach emptying problems (gastroparesis) that didn't respond to standard treatments. When she was given a stimulant medication called dextroamphetamine, her stomach symptoms improved significantly and stayed better for at least eight months. The authors suggest this type of medication might help some people with refractory gastroparesis, similar to how it may help other ME/CFS-related symptoms.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

An experimental study of the influence of individual participant characteristics on formal consensus development.

Carpenter, James, Hutchings, Andrew, Raine, Rosalind et al.·International journal of technology assessment in health care·2007

This study looked at how different types of doctors and healthcare workers rate whether psychological treatments are appropriate for ME/CFS and other chronic conditions. Researchers had 346 people in 20 groups review mental health treatments and rate how suitable they were, testing whether factors like the doctors' specialty, age, and sex changed their opinions.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Van Houdenhove, B, Verheyen, L, Pardaens, K et al.·Clinical rehabilitation·2007

This paper proposes a new way to think about why people with ME/CFS have reduced physical ability. The authors suggest there may be two different problems: some patients may have low energy capacity (their bodies can't produce enough energy), while others may have reduced effort tolerance (their nervous system tells them to stop before their body actually reaches its limit). Understanding which problem a patient has could help doctors choose better treatments.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Violence, stress, and somatic syndromes.

Crofford, Leslie J·Trauma, violence & abuse·2007

This review article examines how experiences of violence and stress may trigger or worsen conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome—illnesses that involve pain, exhaustion, mood changes, memory problems, and sleep issues. The authors explain that stress affects the brain and body's hormone and nervous system function, which may make people more vulnerable to developing these conditions. Understanding this connection could help us recognize how violence exposure affects long-term health.

Pain and SensitizationSleepCognitive Impairment

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

[Overview of psychiatric therapy for chronic fatigue syndrome].

Vitamin d and rehabilitation: improving functional outcomes.

Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome.

An 'overwhelming illness': women's experiences of learning to live with chronic fatigue syndrome/myalgic encephalomyelitis.

[Usefulness of growth chart in children and adolescents with chronic fatigue syndrome].

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Effects of elevated plasma tryptophan on brain activation associated with the Stroop task.

Hyperventilation in patients with chronic fatigue syndrome: the role of coping strategies.

The thoughts and methods for clinical research on acupuncture treatment of chronic fatigue syndrome.

[Fibromyalgia and chronic fatigue syndrome in children and adolescents].

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions.

[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria].

Brief report: The accuracy of parents for the thoughts and feelings of their adolescent suffering from chronic fatigue: a preliminary study of empathy.

[Chronic fatigue syndrome in a 15-year-old girl].

[A new treatment: thermal therapy for chronic fatigue syndrome].

Sympathomimetic amine therapy may improve refractory gastroparesis similar to its effect on chronic pelvic pain--case report.

An experimental study of the influence of individual participant characteristics on formal consensus development.

Rehabilitation of decreased motor performance in patients with chronic fatigue syndrome: should we treat low effort capacity or reduced effort tolerance?

Violence, stress, and somatic syndromes.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research