ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5261–5280 of 6,188 studies

E3 PreliminaryBehavioralPEM not requiredObservational

Open-label study of s-citalopram therapy of chronic fatigue syndrome and co-morbid major depressive disorder.

Amsterdam, Jay D, Shults, Justine, Rutherford, Nancy·Progress in neuro-psychopharmacology & biological psychiatry·2008

This study tested whether an antidepressant medication called s-citalopram could help people with ME/CFS who also had depression. Sixteen patients took the medication for up to 12 weeks, and researchers measured changes in fatigue, pain, sleep, and mood using standard questionnaires. The results showed improvements in fatigue severity, several ME/CFS symptoms, and depression scores during treatment.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Assessment of fibromyalgia & chronic fatigue syndrome: a new protocol designed to determine work capability--chronic pain abilities determination (CPAD).

Kelly, M, Gagne, R, Newman, J D et al.·Irish medical journal·2008

This study created a new testing system to help doctors objectively measure how much work someone with ME/CFS or fibromyalgia can do. The system combines patient interviews, standardized questionnaires about pain and fatigue, and several objective tests (including strength measurements, fitness tests, and cognitive assessments) to give a complete picture of someone's working abilities. The results are then compared to databases of normal working capacity to determine what kinds of work might be realistic.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Medication-induced mitochondrial damage and disease.

Neustadt, John, Pieczenik, Steve R·Molecular nutrition & food research·2008

Mitochondria are the energy-producing structures in our cells, and when they are damaged, they don't work properly. This review article explains that many common medications—including psychiatric drugs, cholesterol medications, and pain relievers like acetaminophen—can damage mitochondria, which may explain some of their harmful side effects. Since ME/CFS involves problems with energy production, understanding how medications damage mitochondria and how certain nutrients might help repair them could be important for patients.

Energy Metabolism

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan.

Tanaka, Masaaki, Fukuda, Sanae, Mizuno, Kei et al.·Psychological reports·2008

This study tested whether a fatigue measurement tool called the Chalder Fatigue Scale works well in Japanese. Researchers gave the scale to healthy schoolchildren and young people with childhood chronic fatigue syndrome to see if it could reliably measure how tired they were. The tool performed reasonably well and was able to tell the difference between healthy children and those with severe fatigue.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Gamma-aminobutyric acid--metabolism and its disorders].

Kowalski, Antoni, Rebas, Elzbieta, Zylińska, Ludmiła·Postepy biochemii·2007

Your brain uses a chemical messenger called GABA to calm nerve signals and prevent them from becoming overactive. When three key enzymes that control GABA levels don't work properly, it can cause various neurological problems including chronic fatigue syndrome, anxiety, seizures, and stiff-person syndrome. This article reviews what happens when GABA metabolism breaks down and how it affects the nervous system.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Kawai, Tomoko, Rokutan, Kazuhito·Nihon rinsho. Japanese journal of clinical medicine·2007

This study looked for genetic markers (differences in how genes are expressed) that could help doctors diagnose ME/CFS with a blood test. The researchers identified 9 genes that were expressed differently in ME/CFS patients compared to healthy people, and showed these genes could potentially be used to distinguish ME/CFS from other conditions.

Biomarkers

E3 PreliminaryMechanismPEM not requiredMechanistic

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Perrin, Raymond N·The Journal of the American Osteopathic Association·2007

This study proposes that ME/CFS may be connected to problems with how fluid drains from the brain and spinal cord. The author suggests that the cranial rhythmic impulse—a subtle body rhythm that practitioners can feel—reflects cerebrospinal fluid drainage and lymphatic system activity controlled by the nervous system. When this drainage process becomes disrupted, the author argues it could cause the fatigue and other symptoms of ME/CFS.

Neuroinflammation

E3 PreliminaryCommentaryPEM unclearEditorial

Mitochondrial dysfunction and molecular pathways of disease.

Pieczenik, Steve R, Neustadt, John·Experimental and molecular pathology·2007

This article explains that many different diseases—including chronic fatigue syndrome—may share a common problem: damage to mitochondria, the energy-producing parts of our cells. When mitochondria don't work properly, they produce harmful molecules called reactive oxygen species that can further damage cells. The authors suggest that antioxidant treatments and specific urine tests might help doctors treat these conditions more effectively.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Clinical features of chronic fatigue syndrome--symptoms].

Ban, Nobutaro, Saiki, Takuya, Ko, Gyoshin et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

This review article summarizes the most common symptoms experienced by people with ME/CFS. The researchers identified and described the top 10 symptoms in detail, including severe fatigue, problems with memory and concentration, muscle pain, poor sleep, and headaches. Understanding these symptom patterns can help doctors recognize and diagnose ME/CFS more accurately.

Pain and SensitizationCognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

Klimas, Nancy G, Koneru, Anne O'Brien·Current rheumatology reports·2007

Researchers studied what causes ME/CFS by looking at genes, immune cells, and hormones in patients. They found that how severe someone's initial viral infection was predicted whether fatigue would last long-term, and that people with ongoing ME/CFS show signs of reactivated viruses and problems with energy-producing structures in their cells. The immune system dysfunction they observed involved specialized infection-fighting cells not working properly.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

Tjørve, E, Tjørve, K M C, Olsen, J O et al.·Medical hypotheses·2007

Your body's cells may not respond properly to thyroid hormone even when blood tests show normal thyroid levels. This resistance to thyroid hormone can develop from various causes including infections, medications, toxins, or the immune system attacking thyroid proteins. The authors suggest this acquired resistance might be more common than previously thought and could explain why some patients feel hypothyroid symptoms despite normal blood tests.

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

Belotti, L, Bigoni, F, Pezzoli, F et al.·Giornale italiano di medicina del lavoro ed ergonomia·2007

This study describes the case of a physiotherapist who developed ME/CFS and faced challenges staying in their job. The medical team had to evaluate whether the patient could continue working and eventually helped them obtain disability benefits. The case illustrates the real-world workplace challenges that people with ME/CFS encounter.

E3 PreliminaryMechanismPEM not requiredCase-Control

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

Armitage, Roseanne, Landis, Carol, Hoffmann, Robert et al.·Sleep·2007

This study looked at how the brain's sleep patterns differ between people with ME/CFS and their healthy twins. Researchers kept twins awake 4 hours later than usual and then let them sleep normally. They found that people with ME/CFS showed weaker deep sleep activity when recovering from the sleep delay, suggesting their bodies may have trouble responding normally to sleep pressure.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Childhood chronic fatigue syndrome].

Miike, Teruhisa·Nihon rinsho. Japanese journal of clinical medicine·2007

This review discusses chronic fatigue syndrome (CFS) in children and teenagers, a serious condition affecting 3-5% of young people. Children with CFS experience extreme tiredness, sleep problems, trouble learning and remembering, and immune system issues. While routine blood tests often look normal, special testing can reveal abnormalities in how their bodies handle energy, regulate temperature, and control hormones.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Maes, Michael, Mihaylova, Ivanka, Leunis, Jean-Claude·Neuro endocrinology letters·2007

This study found that people with ME/CFS and depression have higher levels of specific immune proteins (IgM antibodies) that attack a substance called phosphatidyl inositol in their blood compared to healthy people. These antibody levels were linked to fatigue and depression symptoms, suggesting that an abnormal immune response against this substance might contribute to both conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

Kasatkin, D S, Spirin, N N·Neuroscience and behavioral physiology·2007

This study examined why people with multiple sclerosis (MS) often experience severe fatigue. The researchers identified different types of fatigue—exhaustion at rest, excessive tiredness after activity, and worsening fatigue during MS flare-ups—and explored how brain chemistry, hormones, immune system problems, and sleep issues might all contribute to this fatigue.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

Fulle, Stefania, Pietrangelo, Tiziana, Mancinelli, Rosa et al.·Journal of muscle research and cell motility·2007

This paper explores whether muscle damage from unstable molecules called free radicals might contribute to ME/CFS. The researchers reviewed existing evidence suggesting that muscles in ME/CFS patients may experience harmful oxidative stress—a chemical imbalance that damages cells. While this is a theoretical discussion rather than a new experiment, it proposes that understanding this muscle damage could help explain why ME/CFS causes such severe fatigue.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The chronic fatigue syndrome: a comparative pathway analysis.

Emmert-Streib, Frank·Journal of computational biology : a journal of computational molecular cell biology·2007

This study developed a new method to find biological pathways that go wrong in ME/CFS, rather than just looking at individual genes. The researchers compared how biological systems work differently in sick versus healthy people using computer analysis of gene expression data. This approach helps scientists understand ME/CFS as a disease of interconnected biological processes.

E3 PreliminaryCohortPEM not requiredCase-Control

[A new treatment: thermal therapy for chronic fatigue syndrome].

Masuda, Akinori, Munemoto, Takao, Tei, Chuwa·Nihon rinsho. Japanese journal of clinical medicine·2007

Researchers tested far-infrared sauna therapy on 13 ME/CFS patients. Two patients experienced dramatic improvements in fatigue, pain, and fever, and were able to stop taking prednisolone and return to normal activities within 6 months. The remaining 11 patients also reported improvements in fatigue and pain, with additional benefits including relaxation and reduced depression symptoms.

E3 PreliminaryGuidelinePEM not requiredGuideline

[Overview of medical treatment and management of chronic fatigue syndrome].

Yoshihara, Kazufumi, Kubo, Chiharu·Nihon rinsho. Japanese journal of clinical medicine·2007

This paper presents a comprehensive approach to treating ME/CFS that combines different types of therapies tailored to individual patients. The main treatments discussed include structured exercise programs (done gradually), lifestyle changes, and sometimes medications or mental health support when needed. The authors emphasize that doctors should carefully monitor patients throughout treatment and adjust their plan based on how well it's working.

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Evidence browser

Open-label study of s-citalopram therapy of chronic fatigue syndrome and co-morbid major depressive disorder.

Assessment of fibromyalgia & chronic fatigue syndrome: a new protocol designed to determine work capability--chronic pain abilities determination (CPAD).

Medication-induced mitochondrial damage and disease.

Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan.

[Gamma-aminobutyric acid--metabolism and its disorders].

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

Lymphatic drainage of the neuraxis in chronic fatigue syndrome: a hypothetical model for the cranial rhythmic impulse.

Mitochondrial dysfunction and molecular pathways of disease.

[Clinical features of chronic fatigue syndrome--symptoms].

Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions.

On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

[Chronic fatigue syndrome: from misunderstood illness to cause of job fitness management problem and of work total disability in a physiotherapist. Case report].

The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome.

[Childhood chronic fatigue syndrome].

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression.

Possible mechanisms of the formation of chronic fatigue syndrome in the clinical picture of multiple sclerosis.

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis.

The chronic fatigue syndrome: a comparative pathway analysis.

[A new treatment: thermal therapy for chronic fatigue syndrome].

[Overview of medical treatment and management of chronic fatigue syndrome].

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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