ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5261–5280 of 6,211 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

A precarious balance: using a self-regulation model to conceptualize and treat chronic fatigue syndrome.

Deary, Vincent·British journal of health psychology·2008

This study proposes a new way to understand ME/CFS by looking at how the body and mind try to adapt to living with the illness. The researchers suggest that people with ME/CFS develop a delicate balance with their condition, and when they try to fix things—like pushing through fatigue or avoiding activity—these efforts can sometimes backfire and make symptoms worse. The theory focuses on how physical sensations, emotions, and thoughts become tightly connected and reinforce each other in ME/CFS.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Teaching medical students about medically unexplained illnesses: a preliminary study.

Friedberg, Fred, Sohl, Stephanie J, Halperin, Peter J·Medical teacher·2008

Researchers taught 45 medical students about ME/CFS and fibromyalgia in a 90-minute class and then measured whether their attitudes changed. After the class, students had significantly more favorable views about ME/CFS—they were more likely to support research funding, believe employers should offer flexibility to patients, and recognize that ME/CFS is not primarily a psychological condition.

E3 PreliminaryReviewPEM unclearReview-Narrative

Contribution of proteomics to the study of the role of cytokeratins in disease and physiopathology.

Brouillard, Franck, Fritsch, Janine, Edelman, Aleksander et al.·Proteomics. Clinical applications·2008

This review article discusses cytokeratins, which are structural proteins found in cells throughout the body. Researchers used advanced laboratory techniques called proteomics to study how these proteins are involved in various diseases, including chronic fatigue syndrome (ME/CFS). The article summarizes what scientists have learned about cytokeratins' roles in disease and suggests these proteins might be useful targets for developing new treatments.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

A train-the-trainer education and promotion program: chronic fatigue syndrome--a diagnostic and management challenge.

Brimmer, Dana J, McCleary, K Kimberly, Lupton, Teresa A et al.·BMC medical education·2008

This study tested whether training primary care doctors about ME/CFS could help more patients get diagnosed and treated. Researchers trained 79 doctors and nurse practitioners to recognize and manage ME/CFS, and these trained providers then taught over 2,000 other healthcare workers. The training improved doctors' knowledge and confidence in diagnosing ME/CFS, showing that education programs can help address the problem of missed diagnoses.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Medication-induced mitochondrial damage and disease.

Neustadt, John, Pieczenik, Steve R·Molecular nutrition & food research·2008

Mitochondria are the energy-producing structures in our cells, and when they are damaged, they don't work properly. This review article explains that many common medications—including psychiatric drugs, cholesterol medications, and pain relievers like acetaminophen—can damage mitochondria, which may explain some of their harmful side effects. Since ME/CFS involves problems with energy production, understanding how medications damage mitochondria and how certain nutrients might help repair them could be important for patients.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

POTS versus deconditioning: the same or different?

Joyner, Michael J, Masuki, Shizue·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2008

This review article compares POTS (a condition where heart rate and blood pressure drop abnormally when standing) with the physical deconditioning that happens after long bed rest or spaceflight. The authors suggest that both conditions may share similar causes and that carefully structured exercise training might help patients with POTS, ME/CFS, and fibromyalgia, while acknowledging the medical community must remain empathetic to patients with these complex conditions.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Assessment of fibromyalgia & chronic fatigue syndrome: a new protocol designed to determine work capability--chronic pain abilities determination (CPAD).

Kelly, M, Gagne, R, Newman, J D et al.·Irish medical journal·2008

This study created a new testing system to help doctors objectively measure how much work someone with ME/CFS or fibromyalgia can do. The system combines patient interviews, standardized questionnaires about pain and fatigue, and several objective tests (including strength measurements, fitness tests, and cognitive assessments) to give a complete picture of someone's working abilities. The results are then compared to databases of normal working capacity to determine what kinds of work might be realistic.

E3 PreliminaryPEM not required

Using multiple sources of knowledge to reach clinical understanding of chronic fatigue syndrome.

Chew-Graham, Carolyn A, Cahill, Greg, Dowrick, Christopher et al.·Annals of family medicine·2008

This study looked at how ME/CFS patients and their family doctors understand the illness and talk about it during medical visits. Researchers interviewed 24 patients and 14 doctors in England and found that both groups use general knowledge from society and media—not just medical training—to make sense of ME/CFS. When they talk together, both patients and doctors use scientific language to be heard and trusted, which can help them work together better.

E3 PreliminaryCohortPEM unclearCross-Sectional

Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance.

Meeus, Mira, Nijs, Jo, McGregor, Neil et al.·In vivo (Athens, Greece)·2008

This study looked at three immune system proteins in people with ME/CFS to see if they were connected to each other and to patients' ability to do daily activities. Researchers found that these three proteins (RNase L, PKR, and elastase) were all linked together, and that higher levels of two of them (RNase L and elastase) were associated with greater difficulty doing everyday tasks. This suggests these immune abnormalities may play a real role in ME/CFS symptoms.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS), chronic Ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins.

Hokama, Yoshitsugi, Empey-Campora, Cara, Hara, Cynthia et al.·Journal of clinical laboratory analysis·2008

This study looked for specific molecules in the blood of ME/CFS patients that might be related to mitochondria (the energy-producing parts of cells). Researchers found that over 91% of ME/CFS patients had elevated levels of these molecules, similar to what was seen in people with other conditions linked to toxins. The study suggests these molecules might be a biological marker—like a sign—of ME/CFS, comparable to well-known inflammation markers in other diseases.

Immune System

E3 PreliminaryBehavioralPEM unclear

Association of chronic fatigue syndrome and acute psychotic episode: is it coincidental?

Kornreich, Charles, Szombat, Maya, Vandriette, Yun-Marie et al.·Primary care companion to the Journal of clinical psychiatry·2008

This study looked at whether ME/CFS and sudden onset of psychotic symptoms (like hallucinations or delusions) occur together by chance or if there might be a connection between them. The researchers examined case reports to explore whether patients with ME/CFS experienced psychotic episodes more often than would be expected. This small study helps raise awareness that mental health symptoms can sometimes accompany ME/CFS and deserve clinical attention.

E3 PreliminaryBehavioralPEM not requiredObservational

Open-label study of s-citalopram therapy of chronic fatigue syndrome and co-morbid major depressive disorder.

Amsterdam, Jay D, Shults, Justine, Rutherford, Nancy·Progress in neuro-psychopharmacology & biological psychiatry·2008

This study tested whether an antidepressant medication called s-citalopram could help people with ME/CFS who also had depression. Sixteen patients took the medication for up to 12 weeks, and researchers measured changes in fatigue, pain, sleep, and mood using standard questionnaires. The results showed improvements in fatigue severity, several ME/CFS symptoms, and depression scores during treatment.

Post-Exertional Malaise

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of significant genes in genomics using Bayesian variable selection methods.

Lin, Eugene, Huang, Lung-Cheng·Advances and applications in bioinformatics and chemistry : AABC·2008

Researchers developed a new mathematical method to find which genes are most important in ME/CFS by sorting through large amounts of genetic data. Instead of looking at every gene equally, this approach helps identify a smaller group of genes that appear to have the strongest connection to the disease. This method could help scientists focus their research on the most promising genetic leads.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan.

Tanaka, Masaaki, Fukuda, Sanae, Mizuno, Kei et al.·Psychological reports·2008

This study tested whether a fatigue measurement tool called the Chalder Fatigue Scale works well in Japanese. Researchers gave the scale to healthy schoolchildren and young people with childhood chronic fatigue syndrome to see if it could reliably measure how tired they were. The tool performed reasonably well and was able to tell the difference between healthy children and those with severe fatigue.

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'That was my old life; it's almost like a past-life now': identity crisis, loss and adjustment amongst people living with Chronic Fatigue Syndrome.

Dickson, Adele, Knussen, Christina, Flowers, Paul·Psychology & health·2008

This study asked 14 people with ME/CFS about their personal experiences living with the condition. Participants described feeling a loss of identity and control over their lives, struggling with not being able to plan for the future, and feeling worthless. They also mentioned how disbelief from others made these feelings worse. The study found that learning to accept the illness and adapt to their new life helped people cope better.

E3 PreliminaryReviewPEM unclearReview-Narrative

The potential toxicity of artificial sweeteners.

Whitehouse, Christina R, Boullata, Joseph, McCauley, Linda A·AAOHN journal : official journal of the American Association of Occupational Health Nurses·2008

This article reviews what we know about artificial sweeteners—sugar substitutes used in diet drinks and other products. Scientists have debated whether these sweeteners are safe, and some have suggested links to various diseases including chronic fatigue syndrome, though the evidence is mixed. The authors provide an overview of different types of sweeteners, how they work in the body, and what research shows so far.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years.

Allen, Peggy Rosati·Journal of midwifery & women's health·2008

This review examines what happens to women with ME/CFS when they become pregnant, give birth, and recover after having a baby. The authors looked at existing research and expert knowledge to understand how ME/CFS affects pregnancy and provide guidance for doctors and midwives caring for these women. The study highlights that very little research has been done on this important topic, even though millions of women with ME/CFS may experience pregnancy.

E3 PreliminaryMechanismPEM not requiredMechanistic

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome.

Kumar, Anil, Garg, Ruchika, Kumar, Puneet·Pharmacological reports : PR·2008

This study tested whether a medication called trazodone could help mice recover from fatigue caused by repeated physical stress. Researchers found that trazodone did reduce fatigue-like behavior and improved activity levels in stressed mice. The protective effect seemed to involve a chemical messenger in the body called nitric oxide, suggesting this might be one way trazodone works to improve symptoms.

E3 PreliminaryPEM unclear

Individuals' experience of chronic fatigue syndrome/myalgic encephalomyelitis: an interpretative phenomenological analysis.

Arroll, Megan A, Senior, Victoria·Psychology & health·2008

This study asked eight people with ME/CFS to describe their personal experience of the illness through telephone interviews. Researchers found that patients experience their symptoms in complex ways, with fatigue, pain, and other problems affecting their daily lives in varying patterns. An important discovery was that receiving a diagnosis, while helpful, didn't necessarily make the journey easier—patients continued to struggle with understanding and managing their condition.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis.

Hollingsworth, Kieren G, Newton, Julia L, Taylor, Roy et al.·Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2008

This study examined how muscles produce and use energy in patients with primary biliary cirrhosis (PBC), a liver disease where the immune system attacks mitochondria—the energy factories inside cells. Using a special MRI technique, researchers measured how quickly muscles recovered after exercise and found that PBC patients had problems with this energy recovery process. The study also included people with ME/CFS and found that how quickly muscles can clear acid buildup after exercise may determine whether patients feel severely fatigued.

Post-Exertional Malaise

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Evidence browser

A precarious balance: using a self-regulation model to conceptualize and treat chronic fatigue syndrome.

Teaching medical students about medically unexplained illnesses: a preliminary study.

Contribution of proteomics to the study of the role of cytokeratins in disease and physiopathology.

A train-the-trainer education and promotion program: chronic fatigue syndrome--a diagnostic and management challenge.

Medication-induced mitochondrial damage and disease.

POTS versus deconditioning: the same or different?

Assessment of fibromyalgia & chronic fatigue syndrome: a new protocol designed to determine work capability--chronic pain abilities determination (CPAD).

Using multiple sources of knowledge to reach clinical understanding of chronic fatigue syndrome.

Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance.

Acute phase phospholipids related to the cardiolipin of mitochondria in the sera of patients with chronic fatigue syndrome (CFS), chronic Ciguatera fish poisoning (CCFP), and other diseases attributed to chemicals, Gulf War, and marine toxins.

Association of chronic fatigue syndrome and acute psychotic episode: is it coincidental?

Open-label study of s-citalopram therapy of chronic fatigue syndrome and co-morbid major depressive disorder.

Identification of significant genes in genomics using Bayesian variable selection methods.

Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan.

'That was my old life; it's almost like a past-life now': identity crisis, loss and adjustment amongst people living with Chronic Fatigue Syndrome.

The potential toxicity of artificial sweeteners.

Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years.

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome.

Individuals' experience of chronic fatigue syndrome/myalgic encephalomyelitis: an interpretative phenomenological analysis.

Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis.

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