ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5621–5640 of 6,211 studies

E3 PreliminaryCommentaryPEM unclearEditorial

Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.

Durlach, J, Pagès, N, Bac, P et al.·Magnesium research·2002

This paper suggests that low magnesium levels may disrupt the body's internal clock (circadian rhythm) in two opposite ways. In one pattern, the clock runs too fast, causing depression, nighttime headaches, and fatigue—similar to symptoms in ME/CFS and fibromyalgia. In the other pattern, the clock runs too slow, causing anxiety, migraines, and sleep problems. The authors propose that measuring melatonin levels could help distinguish between these two patterns and guide treatment.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes.

Freeman, Roy·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2002

This review article examines whether ME/CFS might be caused by problems with the autonomic nervous system—the part of your body that controls automatic functions like heart rate and blood pressure. The author, Dr. Roy Freeman, discusses evidence suggesting that some ME/CFS patients do show signs of autonomic dysfunction, but emphasizes that this is not true for all patients with the condition.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Evaluating attributions for an illness based upon the name: chronic fatigue syndrome, myalgic encephalopathy and Florence Nightingale disease.

Jason, Leonard A, Taylor, Renee R, Plioplys, Sigita et al.·American journal of community psychology·2002

This study asked medical trainees to read about a patient with ME/CFS symptoms, but gave different groups different names for the illness: "chronic fatigue syndrome," "myalgic encephalopathy," or "Florence Nightingale disease." Researchers found that the name used affected how seriously the trainees thought about the illness—specifically, "myalgic encephalopathy" sounded more serious than "chronic fatigue syndrome." This suggests that what doctors call a disease can influence how much they respect and understand it.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. Symptom relief is primary goal.

Hoffman, Diane B·Advance for nurse practitioners·2002

This article discusses chronic fatigue syndrome (ME/CFS) and emphasizes that helping patients feel better is the main goal of treatment. The author, writing for nurse practitioners, focuses on practical approaches to managing symptoms and improving patients' quality of life.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chiari type I malformation revisited: diagnosis and treatment.

Cheng, Joseph S, Nash, John, Meyer, Glenn A·The neurologist·2002

Chiari type I is a condition where brain tissue (cerebellar tonsils) extends into the spinal canal, potentially compressing the lower brain and upper spinal cord. This article reviews how doctors diagnose and treat this condition, and discusses possible links between Chiari I and ME/CFS, fibromyalgia, and other neurological symptoms. The authors note that in severe cases, Chiari I can cause permanent nerve damage, but better imaging and treatments are being developed.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Connecting cytokines and brain: a review of current issues.

Quan, N, Herkenham, M·Histology and histopathology·2002

This review examines how immune molecules called cytokines communicate with the brain and affect how it works. Scientists have found that cytokines can trigger fatigue, changes in mood and behavior, and problems with the nervous system. The authors suggest that cytokines may play a role in several brain-related conditions, including chronic fatigue syndrome.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: probable pathogenesis and possible treatments.

Evengård, Birgitta, Klimas, Nancy·Drugs·2002

ME/CFS is a serious illness affecting about 1 in 200 people in Western countries, causing extreme tiredness that lasts at least 6 months along with problems thinking clearly, poor sleep, and pain. While doctors don't yet know exactly what causes it, research shows the immune system is overactive and certain brain functions are disrupted. Currently, talking therapy (cognitive behavioural therapy) can help improve quality of life, but scientists are still searching for more effective treatments.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

Slavkin, Harold C·Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2002

This article examines how men and women differ in their health, including oral health and overall diseases. The authors note that women and men have different genetics, body chemistry, and hormones, which leads to different rates of certain illnesses like autoimmune diseases, osteoporosis, and chronic fatigue syndrome. Understanding these gender differences can help doctors provide better, more personalized care for women.

E3 PreliminaryReviewPEM unclearReview-Narrative

Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion.

Durlach, Jean, Pagès, Nicole, Bac, Pierre et al.·Magnesium research·2002

This paper proposes that magnesium deficiency may be linked to disrupted circadian rhythms (biological clocks) and could contribute to several conditions including ME/CFS, fibromyalgia, and sleep problems. The authors suggest that light therapy, dark therapy, and magnesium supplementation may help by affecting the body's internal clock and natural sleep hormone production.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Psychiatric management of severe somatoform disorders in childhood and adolescence.

Garralda, M Elena·Acta neuropsychiatrica·2002

This review examined how doctors can help children with unexplained medical symptoms, including chronic fatigue syndrome. The authors looked at different treatment approaches, particularly psychological and behavioral therapies, and found that many children improved with these methods. However, they note that more rigorous research is needed to confirm which treatments work best.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

Gaab, Jens, Hüster, Dominik, Peisen, Renate et al.·Psychosomatic medicine·2002

This study looked at how the stress-response system (a hormone system in the brain called the HPA axis) works in ME/CFS patients compared to healthy people. Researchers exposed both groups to different types of stress—mental stress, exercise, and a hormone test—and measured how their bodies responded. ME/CFS patients showed lower levels of a stress hormone called ACTH at baseline and during stress tests, but their cortisol levels were mostly normal, suggesting their stress system works differently rather than being broken.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[On the history of the concept neurasthenia and its modern variants chronic-fatigue-syndrome, fibromyalgia and multiple chemical sensitivities].

Schäfer, M L·Fortschritte der Neurologie-Psychiatrie·2002

This article traces the history of a medical term called 'neurasthenia' that was used in the 1800s to describe people with severe tiredness and weakness. The author explains how this old concept disappeared from Western medicine but has reappeared in modern times under new names like Chronic Fatigue Syndrome, fibromyalgia, and multiple chemical sensitivities. The article suggests that cultural and social factors influence how these illnesses are recognized and named in different parts of the world.

E3 PreliminaryReviewPEM unclearReview-Narrative

Information from your family doctor. Chronic fatigue syndrome: how to help yourself.

American family physician·2002

This article from American Family Physician provides practical guidance for people with ME/CFS and their doctors about self-help strategies. It offers information to help patients understand their condition better and suggests ways they can manage their symptoms with support from their healthcare provider.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The case definition of chronic fatigue syndrome.

Tan, Eng M, Sugiura, Kazumitsu, Gupta, Sudhir·Journal of clinical immunology·2002

This review discusses how ME/CFS is currently diagnosed using symptom-based criteria from 1994, which doesn't account for the fact that different patients have very different experiences. The authors suggest that ME/CFS might actually be four distinct subtypes based on which body system is most affected: nervous system (memory problems, headaches), endocrine system (poor sleep, post-exertion crashes), musculoskeletal system (muscle and joint pain), or immune/infection-related (sore throat, swollen lymph nodes). If researchers studied more similar groups of patients separately instead of mixing everyone together, they might get clearer and more consistent results.

Post-Exertional Malaise

E3 PreliminaryPEM unclear

Intravenous nutrient therapy: the "Myers' cocktail".

Gaby, Alan R·Alternative medicine review : a journal of clinical therapeutic·2002

This study describes a intravenous nutrient mixture called the "Myers' cocktail," containing magnesium, calcium, B vitamins, and vitamin C, used to treat various conditions including chronic fatigue syndrome. The author reports clinical experiences suggesting this treatment may help reduce fatigue and other symptoms. The paper reviews why these nutrients might be helpful and discusses safety considerations.

E3 PreliminaryMechanismPEM not requiredMechanistic

Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.

Shetzline, Susan E, Martinand-Mari, Camille, Reichenbach, Nancy L et al.·Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2002

Researchers found that ME/CFS patients have a smaller, altered form of a protein called RNase L in their immune cells compared to healthy people. This smaller protein (37-kDa) appears to work similarly to the normal-sized protein (80-kDa) in healthy controls, particularly in how it binds to immune signaling molecules. This discovery suggests that ME/CFS may involve a structural change in this immune system protein.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.

Bested, A C, Saunders, P R, Logan, A C·Medical hypotheses·2001

This study proposes that ME/CFS symptoms may be caused by a breakdown in the blood-brain barrier (BBB), a protective layer that normally keeps harmful substances out of the brain. The researchers reviewed scientific literature to identify factors that could damage this barrier in ME/CFS patients, including viral infections, stress, and certain chemical imbalances. They suggest that if this protective barrier becomes leaky, it could allow harmful substances into the brain and disrupt normal nerve function, potentially explaining many ME/CFS symptoms.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearCross-Sectional

Delayed-type hypersensitivity and chronic fatigue syndrome: the usefulness of assessing T-cell activation by flow cytometry--preliminary study.

Brunet, J L, Liaudet, A P, Later, R et al.·Allergie et immunologie·2001

This small study looked at whether people with ME/CFS have exaggerated immune reactions to common substances like yeast (Candida). Researchers tested this by applying yeast extract under the skin and watching for delayed reactions, then measuring immune cell activity in blood samples. About half of the ME/CFS patients showed these exaggerated reactions, suggesting the immune system may be responding unusually to everyday germs.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Torpy, D J, Bachmann, A W, Grice, J E et al.·The Journal of clinical endocrinology and metabolism·2001

This study examined a family with a genetic mutation affecting a protein called corticosteroid-binding globulin (CBG), which helps transport the stress hormone cortisol in the blood. People with this mutation had unusually low blood pressure and chronic fatigue—in fact, 86% of affected adults met criteria for chronic fatigue syndrome. The findings suggest that problems with how the body handles cortisol may contribute to fatigue disorders.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Mullington, J M, Hinze-Selch, D, Pollmächer, T·Annals of the New York Academy of Sciences·2001

This study explores how the body's immune system and sleep are connected, and how this connection might explain the severe fatigue in ME/CFS. Researchers found that when the immune system is activated, it releases chemical messengers called cytokines that can affect sleep quality and cause fatigue. The study suggests that abnormal levels of these immune chemicals in ME/CFS patients could be responsible for the debilitating tiredness that characterizes the condition.

Immune System

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Chronopathological forms of magnesium depletion with hypofunction or with hyperfunction of the biological clock.

The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes.

Evaluating attributions for an illness based upon the name: chronic fatigue syndrome, myalgic encephalopathy and Florence Nightingale disease.

Chronic fatigue syndrome. Symptom relief is primary goal.

Chiari type I malformation revisited: diagnosis and treatment.

Connecting cytokines and brain: a review of current issues.

Chronic fatigue syndrome: probable pathogenesis and possible treatments.

Distinguishing Mars from Venus: emergence of gender biology differences in oral health and systemic disease.

Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion.

Psychiatric management of severe somatoform disorders in childhood and adolescence.

Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

[On the history of the concept neurasthenia and its modern variants chronic-fatigue-syndrome, fibromyalgia and multiple chemical sensitivities].

Information from your family doctor. Chronic fatigue syndrome: how to help yourself.

The case definition of chronic fatigue syndrome.

Intravenous nutrient therapy: the "Myers' cocktail".

Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.

Delayed-type hypersensitivity and chronic fatigue syndrome: the usefulness of assessing T-cell activation by flow cytometry--preliminary study.

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

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