ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5641–5660 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Problems of chronic fatigue].

Kovaleva, A I, Pyshnov, G Iu·Meditsina truda i promyshlennaia ekologiia·2001

This review examines chronic fatigue syndrome and related conditions like burnout and caroshi (a Japanese term for work-related exhaustion), looking at them as forms of extreme tiredness. The authors suggest these conditions may be linked to workplace stress and occupational demands. The paper considers what these different conditions have in common and how they develop.

E3 PreliminaryBehavioralPEM not requiredObservational

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Sachs, L·Medical anthropology·2001

This study explored how receiving a CFS diagnosis affects people's lives and sense of self. Researchers interviewed 21 people with CFS to understand how they experience being diagnosed with an illness that doesn't show up on standard medical tests. The study found that a diagnosis can be both helpful and complicated—it validates that suffering is real, but it can also change how people see themselves and their future.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Evaluation of a recombinant line blot for diagnosis of Epstein-Barr Virus compared with ELISA, using immunofluorescence as reference method.

Gärtner, B C, Fischinger, J M, Roemer, K et al.·Journal of virological methods·2001

This study compared three different blood tests for detecting Epstein-Barr virus (EBV) infection: a newer line blot test, a standard ELISA test, and an older reference test called immunofluorescence. The researchers found that all three tests worked well at identifying new infections and past infections, but the line blot and ELISA were less reliable at detecting EBV reactivation (when the virus becomes active again in people with weakened immune systems).

E3 PreliminaryMechanismPEM not requiredMechanistic

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Torpy, D J, Bachmann, A W, Grice, J E et al.·The Journal of clinical endocrinology and metabolism·2001

This study examined a family with a genetic mutation affecting a protein called corticosteroid-binding globulin (CBG), which helps transport the stress hormone cortisol in the blood. People with this mutation had unusually low blood pressure and chronic fatigue—in fact, 86% of affected adults met criteria for chronic fatigue syndrome. The findings suggest that problems with how the body handles cortisol may contribute to fatigue disorders.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients.

Valentine, A D, Meyers, C A·Cancer·2001

This review discusses how fatigue, brain fog, and depression are connected in cancer patients and how they may cause or worsen each other. The authors suggest that understanding these connections might help doctors develop better, more personalized treatments that address the specific needs of each patient.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Patarca-Montero, R, Antoni, M, Fletcher, M A et al.·Applied neuropsychology·2001

This study looked at immune system markers in ME/CFS patients and found that their immune cells show signs of being overactive, with abnormal patterns of immune signaling molecules called cytokines. The researchers propose that when stress and difficult emotions interact with this immune dysfunction, they can perpetuate the cycle of fatigue, cognitive problems, and other symptoms seen in ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Buskila, D·Current opinion in rheumatology·2001

This review examined fibromyalgia (FM), chronic fatigue syndrome (CFS), and related pain conditions across different countries. Researchers found that pain sensitivity involves brain chemistry (including a system called NMDA), hormone imbalances, and nervous system problems. CFS was found in about 0.4% of a large community sample, with many children recovering well, though the study notes that no major new treatments were tested during this period.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCommentaryPEM unclearEditorial

Potential mechanisms in chemical intolerance and related conditions.

Clauw, D J·Annals of the New York Academy of Sciences·2001

Many people with ME/CFS, fibromyalgia, and related conditions experience chemical intolerance alongside other symptoms like pain and fatigue. This study reviews research suggesting that these conditions share common biological problems, particularly in how the nervous system processes sensory information—making everyday smells, sounds, or lights feel unusually unpleasant or overwhelming. While stress and worry can sometimes make symptoms worse, the evidence shows that physical changes in the body's sensory processing are doing much of the heavy lifting in causing symptoms.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclear

Recovery from chronic fatigue syndrome associated with changes in neuroendocrine function.

Sharma, A, Oyebode, F, Kendall, M J et al.·Journal of the Royal Society of Medicine·2001

This study looked at whether people who recovered from ME/CFS showed changes in their body's hormone and nervous system function compared to those still sick and healthy controls. The researchers examined whether normalizing these biological systems was connected to getting better from the illness.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.

Bested, A C, Saunders, P R, Logan, A C·Medical hypotheses·2001

This study proposes that ME/CFS symptoms may be caused by a breakdown in the blood-brain barrier (BBB), a protective layer that normally keeps harmful substances out of the brain. The researchers reviewed scientific literature to identify factors that could damage this barrier in ME/CFS patients, including viral infections, stress, and certain chemical imbalances. They suggest that if this protective barrier becomes leaky, it could allow harmful substances into the brain and disrupt normal nerve function, potentially explaining many ME/CFS symptoms.

Neuroinflammation

E3 PreliminaryReviewPEM not requiredReview-Narrative

The role of gender in fibromyalgia syndrome.

Yunus, M B·Current rheumatology reports·2001

This review examined why fibromyalgia syndrome (FMS) affects far more women than men—about 9 women for every 1 man. Researchers found that women with FMS tend to experience more fatigue, more tender points throughout their body, and more associated symptoms like irritable bowel syndrome compared to men. Interestingly, the severity of pain and depression levels were similar between men and women, suggesting gender differences involve complex interactions between biology, psychology, and social factors.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Assessing attitudes toward new names for chronic fatigue syndrome.

Jason, L A, Eisele, H, Taylor, R R·Evaluation & the health professions·2001

Researchers asked 432 people with ME/CFS and medical professionals what they thought about changing the disease's name from 'chronic fatigue syndrome.' Most people surveyed (86%) agreed a name change was needed, with patients being more supportive than doctors. However, people disagreed about what the new name should be—some preferred 'myalgic encephalopathy' while others favored 'neuro-endocrine immune disorder,' and very few people liked both options equally.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Mullington, J M, Hinze-Selch, D, Pollmächer, T·Annals of the New York Academy of Sciences·2001

This study explores how the body's immune system and sleep are connected, and how this connection might explain the severe fatigue in ME/CFS. Researchers found that when the immune system is activated, it releases chemical messengers called cytokines that can affect sleep quality and cause fatigue. The study suggests that abnormal levels of these immune chemicals in ME/CFS patients could be responsible for the debilitating tiredness that characterizes the condition.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Vassallo, C M, Feldman, E, Peto, T et al.·Psychological medicine·2001

This study examined whether people with ME/CFS have oversensitive serotonin receptors in the brain, which could explain some of their symptoms. Researchers gave patients and healthy people a drug that directly activates serotonin receptors and measured the response. They found that both groups responded similarly, suggesting the problem in ME/CFS is not overly sensitive receptors but rather increased serotonin activity from nerve cells themselves. Interestingly, people with ME/CFS had lower levels of tryptophan (a building block for serotonin) in their blood.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

DHEA. Monograph.

Alternative medicine review : a journal of clinical therapeutic·2001

This article reviews DHEA, a hormone naturally produced by your body that decreases as you age. Research suggests that lower DHEA levels may be connected to several conditions, including ME/CFS, heart disease, diabetes, and autoimmune diseases like lupus and rheumatoid arthritis. DHEA acts as a 'buffer hormone' that can be converted into other important hormones like estrogen and testosterone.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Delayed-type hypersensitivity and chronic fatigue syndrome: the usefulness of assessing T-cell activation by flow cytometry--preliminary study.

Brunet, J L, Liaudet, A P, Later, R et al.·Allergie et immunologie·2001

This small study looked at whether people with ME/CFS have exaggerated immune reactions to common substances like yeast (Candida). Researchers tested this by applying yeast extract under the skin and watching for delayed reactions, then measuring immune cell activity in blood samples. About half of the ME/CFS patients showed these exaggerated reactions, suggesting the immune system may be responding unusually to everyday germs.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study looked at 15 dogs and cats that had fatigue symptoms similar to ME/CFS and tested their blood for bacterial infections. Nine out of 15 animals had a type of bacteria called Staphylococcus in their blood. When these animals were treated with an antibiotic drug, all of them got completely better and the bacteria disappeared from their blood.

Biomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Brainstem conundrum: the Chiari I malformation.

Mueller, D·Journal of the American Academy of Nurse Practitioners·2001

Chiari I Malformation is a condition where brain tissue extends into the spinal canal, causing various symptoms. This study reviews cases and explains why patients with this condition are often misdiagnosed with ME/CFS, fibromyalgia, or other illnesses, sometimes delaying proper diagnosis by months or years.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCase-Control

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

Zaman, R, Puri, B K, Main, J et al.·Experimental physiology·2001

This study used a brain stimulation technique called TMS to test whether the motor control systems in ME/CFS patients work differently than in healthy people. Researchers found that the brain's ability to inhibit (turn off) muscle activity was normal in ME/CFS patients, even though these patients moved more slowly and took longer to react to simple tasks. This suggests that the fatigue and slowness experienced in ME/CFS may not be caused by problems in how the brain controls muscles.

E3 PreliminaryBehavioralPEM not requiredObservational

[Use of local negative pressure in combination with electric sleep or Charcot's douche for treatment of erectile dysfunctions].

Karpukhin, I V·Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury·2001

This study looked at 43 men with erectile dysfunction linked to stress, anxiety, and chronic fatigue. Researchers combined three treatments: a device that uses negative pressure, electric sleep therapy, and a water treatment called Charcot's douche. The combination appeared to help improve sexual function in men whose problems were caused by psychological stress rather than physical causes.

Sleep

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Evidence browser

[Problems of chronic fatigue].

From a lived body to a medicalized body: diagnostic transformation and chronic fatigue syndrome.

Evaluation of a recombinant line blot for diagnosis of Epstein-Barr Virus compared with ELISA, using immunofluorescence as reference method.

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients.

Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Potential mechanisms in chemical intolerance and related conditions.

Recovery from chronic fatigue syndrome associated with changes in neuroendocrine function.

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.

The role of gender in fibromyalgia syndrome.

Assessing attitudes toward new names for chronic fatigue syndrome.

Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

DHEA. Monograph.

Delayed-type hypersensitivity and chronic fatigue syndrome: the usefulness of assessing T-cell activation by flow cytometry--preliminary study.

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Brainstem conundrum: the Chiari I malformation.

Corticospinal inhibition appears normal in patients with chronic fatigue syndrome.

[Use of local negative pressure in combination with electric sleep or Charcot's douche for treatment of erectile dysfunctions].

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