ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5641–5660 of 6,211 studies

E3 PreliminaryMechanismPEM unclearMechanistic

Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.

Pall, M L·Medical hypotheses·2001

This study proposes that ME/CFS, fibromyalgia, multiple chemical sensitivity, and PTSD may all share the same root cause: a buildup of harmful molecules called nitric oxide and peroxynitrite in the body. These molecules can create a self-perpetuating cycle that keeps the illness going once it starts, often triggered by a period of stress. The same biochemical problem appearing in different tissues might explain why these conditions overlap and share similar symptoms.

E3 PreliminaryMechanismPEM requiredObservational

Hormonal responses to exercise in chronic fatigue syndrome.

Ottenweller, J E, Sisto, S A, McCarty, R C et al.·Neuropsychobiology·2001

This study compared how the bodies of ME/CFS patients and healthy people respond to exercise, specifically looking at hormones—chemical messengers that regulate many body functions. Researchers found that ME/CFS patients had weaker responses in several key stress hormones (like adrenaline) immediately after exercise, but hormone levels returned to normal by the next day, suggesting that abnormal hormones may not be the main reason why ME/CFS patients feel worse after exertion.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Voluntary motor function in patients with chronic fatigue syndrome.

Davey, N J, Puri, B K, Nowicky, A V et al.·Journal of psychosomatic research·2001

This study tested whether ME/CFS patients have problems with the brain signals that control voluntary movement. Researchers used magnetic stimulation on the scalp to measure how well nerve signals traveled to hand muscles, and they also tested how quickly patients could react and move their hands. The main finding was that while patients moved more slowly than healthy people, the nerve pathways themselves worked normally, suggesting the slowness comes from somewhere else in the body or brain.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome].

Miike, T·Nihon rinsho. Japanese journal of clinical medicine·2001

This is a review article that examines what is known about chronic fatigue syndrome (ME/CFS). Rather than presenting new research data, the authors summarize existing knowledge about the condition, including its characteristics, how it affects patients, and what is understood about its causes. This type of article helps bring together information from many different studies to provide a comprehensive overview of the disease.

E3 PreliminaryMechanismPEM not requiredObservational

Abnormalities in response to vasopressin infusion in chronic fatigue syndrome.

Altemus, M, Dale, J K, Michelson, D et al.·Psychoneuroendocrinology·2001

This study tested how the bodies of ME/CFS patients respond to a hormone called vasopressin. Researchers compared 19 patients with ME/CFS to 19 healthy volunteers by giving them vasopressin infusions and measuring hormone levels in their blood. ME/CFS patients showed a weaker response in a key stress hormone called ACTH, suggesting their brain may not be producing enough of another hormone called CRH that helps control stress responses.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredObservational

Role of impaired lower-limb venous innervation in the pathogenesis of the chronic fatigue syndrome.

Streeten, D H·The American journal of the medical sciences·2001

This study found that people with ME/CFS have problems with how blood vessels in their feet respond to stress. When standing up, their blood pressure drops abnormally after a delay, and their foot veins don't tighten properly in response to a hormone (norepinephrine) that normally helps maintain blood pressure. This suggests that the nerves controlling blood vessels in the legs may not be working correctly in ME/CFS.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroendocrine mechanisms in fibromyalgia-chronic fatigue.

Buskila, D, Press, J·Best practice & research. Clinical rheumatology·2001

This review examines why fibromyalgia and ME/CFS cause such similar symptoms like fatigue, pain, and problems with the nervous system. Researchers found that both conditions involve problems with hormones, how the body processes pain, and how the autonomic nervous system (which controls automatic body functions) works. The study suggests these conditions may share the same underlying cause: dysfunction in the central nervous system.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome following a toxic exposure.

Racciatti, D, Vecchiet, J, Ceccomancini, A et al.·The Science of the total environment·2001

This study looked at five people who developed ME/CFS symptoms after being exposed to toxic substances—either through seafood poisoning or chemical fumes. Researchers compared them to people with ME/CFS that started after viral infections or depression to see if the cause mattered. They found that people whose ME/CFS followed toxic exposure had more significant problems with immune system function than the comparison groups.

Immune System

E3 PreliminaryPEM unclear

Narrative Identities and the Management of Personal Accountability in Talk about ME: A Discursive Psychology Approach to Illness Narrative.

Horton-Salway, M·Journal of health psychology·2001

This study examined how people with ME/CFS talk about their illness and explain what caused it. Researchers found that patients often describe working too hard before getting sick, but in doing so, they unintentionally suggest they might have caused their own illness—even while trying to prove ME is a real physical disease. The study shows how the words people choose and stories they tell can have complicated effects on how others understand their condition.

E3 PreliminaryBehavioralPEM not requiredObservational

[Use of local negative pressure in combination with electric sleep or Charcot's douche for treatment of erectile dysfunctions].

Karpukhin, I V·Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury·2001

This study looked at 43 men with erectile dysfunction linked to stress, anxiety, and chronic fatigue. Researchers combined three treatments: a device that uses negative pressure, electric sleep therapy, and a water treatment called Charcot's douche. The combination appeared to help improve sexual function in men whose problems were caused by psychological stress rather than physical causes.

Sleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Brainstem conundrum: the Chiari I malformation.

Mueller, D·Journal of the American Academy of Nurse Practitioners·2001

Chiari I Malformation is a condition where brain tissue extends into the spinal canal, causing various symptoms. This study reviews cases and explains why patients with this condition are often misdiagnosed with ME/CFS, fibromyalgia, or other illnesses, sometimes delaying proper diagnosis by months or years.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome and fibromyalgia.

Asbring, P·Journal of advanced nursing·2001

This study looked at how women with ME/CFS and fibromyalgia experience major changes to their sense of self and identity after becoming ill. Researchers interviewed 25 Swedish women about how they adjusted to these illnesses, and found that while the conditions caused significant disruption to their work and social lives, many women also discovered unexpected positive aspects of their new identity as they adapted.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Logan, A C, Wong, C·Alternative medicine review : a journal of clinical therapeutic·2001

This review examines how oxidative stress—damage caused by harmful molecules in the body—may contribute to ME/CFS symptoms. The authors suggest that certain dietary supplements with antioxidant properties, such as glutathione and alpha-lipoic acid, might help reduce this damage. They also discuss how food intolerances and undiagnosed celiac disease could play a role in ME/CFS, even when digestive symptoms are absent.

E3 PreliminaryCohortPEM not requiredCross-Sectional

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Jason, L A, Taylor, R R, Stepanek, Z et al.·Journal of health psychology·2001

This study found that what doctors and students call ME/CFS affects how they think about the condition. When it was called "myalgic encephalopathy," people were more likely to believe it had a physical cause in the body. The name used also influenced whether healthcare workers thought patients were truly ill or just depressed. This suggests that even the language we use to describe ME/CFS can shape people's beliefs about how serious it is and how it should be treated.

E3 PreliminaryMechanismPEM not requiredMechanistic

Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.

Visser, J, Lentjes, E, Haspels, I et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2001

Researchers found that immune cells from ME/CFS patients react more strongly to a stress hormone called dexamethasone (a type of glucocorticoid) than cells from healthy people. However, the cells have the same number of receptors for this hormone and bind it with the same strength, suggesting the heightened sensitivity comes from something happening inside the cells after the hormone attaches, rather than from problems with the receptors themselves.

Immune System

E3 PreliminaryCohortPEM not requiredLongitudinal

Dynamics of chronic active herpesvirus-6 infection in patients with chronic fatigue syndrome: data acquisition for computer modeling.

Krueger, G R, Koch, B, Hoffmann, A et al.·In vivo (Athens, Greece)·2001

This study followed 10 ME/CFS patients for two years to understand how a virus called HHV-6 might be involved in their illness. Researchers measured virus levels and immune cell counts in the patients' blood over time. They found that ME/CFS patients had slightly elevated virus levels and abnormal immune responses, different from what happens during acute HHV-6 infection.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Cytokines and chronic fatigue syndrome.

Patarca, R·Annals of the New York Academy of Sciences·2001

This study found that people with ME/CFS show signs of immune system activation (more active immune cells and elevated immune signaling molecules), yet paradoxically have weak immune function (poor natural killer cell activity and weak responses to infections). The immune system appears to be stuck in an imbalanced state, favoring certain types of inflammatory responses, which may relate to symptom cycles of improvement and worsening.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.

Hanson, S J, Gause, W, Natelson, B·Clinical and diagnostic laboratory immunology·2001

Researchers used advanced computer analysis to find immune system differences in ME/CFS patients that traditional statistical methods had missed. They discovered that ME/CFS patients have lower levels of certain immune cells and higher levels of a chemical messenger called interleukin-4, suggesting their immune system may be stuck in a particular type of response pattern.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

Tarello, W·Comparative immunology, microbiology and infectious diseases·2001

This study looked at 15 dogs and cats that had fatigue symptoms similar to ME/CFS and tested their blood for bacterial infections. Nine out of 15 animals had a type of bacteria called Staphylococcus in their blood. When these animals were treated with an antibiotic drug, all of them got completely better and the bacteria disappeared from their blood.

Biomarkers

E3 PreliminaryCommentaryPEM not requiredEditorial

[Fatigue].

Reinhart, W H, Fleisch, F·Praxis·2001

Fatigue is a very common symptom that doctors see in many patients. This editorial discusses how doctors should evaluate someone with fatigue by taking a careful history, doing a physical exam, and ordering appropriate tests. When other diseases are ruled out, chronic fatigue syndrome may be diagnosed, though its causes remain unknown. The most proven treatments are graded exercise, cognitive behavioral therapy, and antidepressants if depression or anxiety are present.

Diagnostics

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Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.

Hormonal responses to exercise in chronic fatigue syndrome.

Voluntary motor function in patients with chronic fatigue syndrome.

[Chronic fatigue syndrome].

Abnormalities in response to vasopressin infusion in chronic fatigue syndrome.

Role of impaired lower-limb venous innervation in the pathogenesis of the chronic fatigue syndrome.

Neuroendocrine mechanisms in fibromyalgia-chronic fatigue.

Chronic fatigue syndrome following a toxic exposure.

Narrative Identities and the Management of Personal Accountability in Talk about ME: A Discursive Psychology Approach to Illness Narrative.

[Use of local negative pressure in combination with electric sleep or Charcot's douche for treatment of erectile dysfunctions].

Brainstem conundrum: the Chiari I malformation.

Chronic illness -- a disruption in life: identity-transformation among women with chronic fatigue syndrome and fibromyalgia.

Chronic fatigue syndrome: oxidative stress and dietary modifications.

Attitudes regarding chronic fatigue syndrome: the importance of a name.

Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors.

Dynamics of chronic active herpesvirus-6 infection in patients with chronic fatigue syndrome: data acquisition for computer modeling.

Cytokines and chronic fatigue syndrome.

Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers.

Chronic Fatigue Syndrome (CFS) in 15 dogs and cats with specific biochemical and microbiological anomalies.

[Fatigue].

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