ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5661–5680 of 6,188 studies

E3 PreliminaryCommentaryPEM unclearEditorial

Potential mechanisms in chemical intolerance and related conditions.

Clauw, D J·Annals of the New York Academy of Sciences·2001

Many people with ME/CFS, fibromyalgia, and related conditions experience chemical intolerance alongside other symptoms like pain and fatigue. This study reviews research suggesting that these conditions share common biological problems, particularly in how the nervous system processes sensory information—making everyday smells, sounds, or lights feel unusually unpleasant or overwhelming. While stress and worry can sometimes make symptoms worse, the evidence shows that physical changes in the body's sensory processing are doing much of the heavy lifting in causing symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredMechanistic

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Torpy, D J, Bachmann, A W, Grice, J E et al.·The Journal of clinical endocrinology and metabolism·2001

This study examined a family with a genetic mutation affecting a protein called corticosteroid-binding globulin (CBG), which helps transport the stress hormone cortisol in the blood. People with this mutation had unusually low blood pressure and chronic fatigue—in fact, 86% of affected adults met criteria for chronic fatigue syndrome. The findings suggest that problems with how the body handles cortisol may contribute to fatigue disorders.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCase-Control

Chronic fatigue syndrome following a toxic exposure.

Racciatti, D, Vecchiet, J, Ceccomancini, A et al.·The Science of the total environment·2001

This study looked at five people who developed ME/CFS symptoms after being exposed to toxic substances—either through seafood poisoning or chemical fumes. Researchers compared them to people with ME/CFS that started after viral infections or depression to see if the cause mattered. They found that people whose ME/CFS followed toxic exposure had more significant problems with immune system function than the comparison groups.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Sensitization, subjective health complaints, and sustained arousal.

Ursin, H, Eriksen, H R·Annals of the New York Academy of Sciences·2001

This study proposes that a process called 'sensitization'—where the body becomes increasingly reactive to triggers over time—may underlie many chronic conditions including ME/CFS, fibromyalgia, and chemical sensitivities. The authors suggest that prolonged stress and sustained arousal (keeping your nervous system in a heightened alert state) may make the body more likely to develop this sensitization, particularly affecting muscles and pain perception.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome].

Miike, T·Nihon rinsho. Japanese journal of clinical medicine·2001

This is a review article that examines what is known about chronic fatigue syndrome (ME/CFS). Rather than presenting new research data, the authors summarize existing knowledge about the condition, including its characteristics, how it affects patients, and what is understood about its causes. This type of article helps bring together information from many different studies to provide a comprehensive overview of the disease.

E3 PreliminaryMechanismPEM unclearMechanistic

Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.

Pall, M L·Medical hypotheses·2001

This study proposes that ME/CFS, fibromyalgia, multiple chemical sensitivity, and PTSD may all share the same root cause: a buildup of harmful molecules called nitric oxide and peroxynitrite in the body. These molecules can create a self-perpetuating cycle that keeps the illness going once it starts, often triggered by a period of stress. The same biochemical problem appearing in different tissues might explain why these conditions overlap and share similar symptoms.

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

Gelman, I H, Unger, E R, Mawle, A C et al.·Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology·2000

Researchers investigated whether a virus called endogenous retroviral p15E might be involved in causing ME/CFS. They tested blood samples from people with ME/CFS and compared them to healthy controls. The study found no evidence that this viral protein was present in higher amounts in ME/CFS patients, suggesting it is not responsible for the disease.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome].

Kuratsune, H·Ryoikibetsu shokogun shirizu·2000

This is a review article that summarizes what was known about chronic fatigue syndrome (ME/CFS) around the year 2000. Rather than conducting a new experiment, the author examined existing research to provide an overview of the condition. It helps explain what ME/CFS is and what scientists understood about it at that time.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Controversies in neurological infectious diseases.

Greenlee, J E, Rose, J W·Seminars in neurology·2000

This is a review article that discusses six controversial topics in infections affecting the nervous system. One of these topics is whether viruses might play a role in chronic fatigue syndrome (ME/CFS). The authors examine what scientists know and disagree about regarding these infections and their treatments.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--the disease and approaches to treatment].

Apel-Paz, M, Lior, B, Shemesh-Kigli, R·Harefuah·2000

This review article examines ME/CFS, describing what the disease is and discussing different treatment approaches. The authors provide an overview of the condition and explore various ways doctors have tried to help patients manage their symptoms. This type of review helps bring together existing knowledge about the illness and its management.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sleep and circadian rhythm disorders in fibromyalgia.

Korszun, A·Current rheumatology reports·2000

Fibromyalgia is a condition causing widespread muscle pain along with sleep problems and extreme tiredness. This review examines how broken sleep patterns and disrupted body clocks (which control things like stress hormones) play a role in fibromyalgia. The authors suggest that treating sleep disorders, depression, and improving sleep habits—along with careful use of medications—may help relieve symptoms.

Sleep

E3 PreliminaryCohortPEM unclearCase-Control

An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon.

Takahashi, Y, Sano, A, Matsuo, M·Clinical nephrology·2000

This case report describes a small number of children with chronic fatigue syndrome who also had a rare blood vessel condition called 'nutcracker phenomenon,' where a vein becomes compressed. The researchers tried a procedure called balloon angioplasty (widening the compressed vessel) to see if it could help reduce fatigue symptoms. The study suggests this treatment may have helped some patients, but it involved only a few cases.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The challenge of evaluating fatigue.

Rodriguez, T·Journal of the American Academy of Nurse Practitioners·2000

This article helps doctors and nurse practitioners understand how to properly evaluate fatigue in patients. It explains that fatigue can have many different causes and can be either short-term or long-term, and it's important to distinguish chronic fatigue from ME/CFS. The article suggests using specific tools and checklists to help identify what might be causing someone's fatigue so it can be properly treated.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Traumatic stress disorders: a classification with implications for prevention and management.

Pearn, J·Military medicine·2000

This article reviews different types of stress disorders that can develop after traumatic events, particularly in military personnel. It describes how these conditions are classified and discusses different ways they can be prevented and treated. The article notes that chronic fatigue syndrome is mentioned as one potential long-term stress-related condition that may develop after trauma.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Physical activity for mental health].

Martinsen, E W·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2000

This review examined whether exercise can help treat mental health conditions like depression and anxiety. The research found that exercise works best for mild to moderate depression and chronic fatigue syndrome, and may also help with panic disorder, anxiety, and other conditions. Exercise appears to be a useful, affordable alternative or addition to standard treatments like medication and therapy.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Bradley, L A, McKendree-Smith, N L, Alarcón, G S·Current review of pain·2000

Both fibromyalgia (FM) and ME/CFS cause muscle and joint pain, but the underlying reasons differ between these conditions. People with FM alone have unusually sensitive pain responses to light touch or mild pressure (called allodynia), while people with ME/CFS do not typically show this. This study examined what brain and hormone system differences might explain why these two conditions cause pain in different ways.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Sympathetic nervous system function in fibromyalgia.

Petzke, F, Clauw, D J·Current rheumatology reports·2000

This review examines how the sympathetic nervous system—the part that controls your 'fight or flight' stress response—works differently in fibromyalgia patients. Researchers looked at various ways to measure sympathetic function, including heart rate changes, stress hormone levels, and physical responses to stress. The authors also compared findings in fibromyalgia to similar conditions like ME/CFS, irritable bowel syndrome, and migraine to identify common patterns.

Autonomic Nervous System

E3 PreliminaryCohortPEM not requiredCase-Control

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Takahashi, Y, Ohta, S, Sano, A et al.·Clinical nephrology·2000

Researchers found that 9 children with chronic fatigue all had a rare blood vessel condition called nutcracker phenomenon, where a vein gets compressed and restricts blood flow. These children also had symptoms of autonomic dysfunction (problems with automatic body functions like heart rate and blood pressure) and were originally thought to have psychological problems. The study suggests that this vascular compression might be connected to their fatigue and other symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Physical activity for the chronically ill and disabled.

Durstine, J L, Painter, P, Franklin, B A et al.·Sports medicine (Auckland, N.Z.)·2000

This review article examines how exercise should be prescribed differently for people with chronic illnesses and disabilities compared to healthy people. The authors note that while exercise guidelines exist for conditions like heart disease, many chronic conditions—including ME/CFS—have received little scientific attention regarding safe and effective exercise recommendations. The key idea is that exercise plans need to be customized based on each person's individual health status rather than using one-size-fits-all approaches.

E3 PreliminaryPEM not required

Chronic fatigue syndrome in childhood.

Tomoda, A, Miike, T, Yamada, E et al.·Brain & development·2000

This study looked at three children (ages 11-13) with ME/CFS and used special brain imaging scans to measure blood flow and chemical activity in their brains. The scans showed differences in brain blood flow and metabolism compared to healthy children, suggesting that ME/CFS may involve changes in how the brain is functioning, not just a psychological problem.

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Evidence browser

Potential mechanisms in chemical intolerance and related conditions.

Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension.

Chronic fatigue syndrome following a toxic exposure.

Sensitization, subjective health complaints, and sustained arousal.

[Chronic fatigue syndrome].

Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

[Chronic fatigue syndrome].

Controversies in neurological infectious diseases.

[Chronic fatigue syndrome--the disease and approaches to treatment].

Sleep and circadian rhythm disorders in fibromyalgia.

An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon.

The challenge of evaluating fatigue.

Traumatic stress disorders: a classification with implications for prevention and management.

[Physical activity for mental health].

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Sympathetic nervous system function in fibromyalgia.

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Physical activity for the chronically ill and disabled.

Chronic fatigue syndrome in childhood.

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