ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5681–5700 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Aspects of occupational disability in psychosomatic disorders].

Huber, M·Versicherungsmedizin·2000

This 2000 review describes how psychosomatic illnesses—conditions where physical and emotional health are closely connected—were a major reason people went on disability leave in the 1990s. The article discusses several conditions including chronic fatigue syndrome, fibromyalgia, and chronic pain disorders, and suggests that the best approach to help these patients is through teamwork between physical medicine doctors and mental health professionals early in the illness.

E3 PreliminaryPEM not required

Chronic fatigue syndrome in childhood.

Tomoda, A, Miike, T, Yamada, E et al.·Brain & development·2000

This study looked at three children (ages 11-13) with ME/CFS and used special brain imaging scans to measure blood flow and chemical activity in their brains. The scans showed differences in brain blood flow and metabolism compared to healthy children, suggesting that ME/CFS may involve changes in how the brain is functioning, not just a psychological problem.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.

Stewart, J M·Pediatric research·2000

This study looked at how the nervous system controls heart rate and blood pressure in adolescents with ME/CFS and POTS when they stand up or tilt their head upward. Researchers found that both groups had similar problems: their bodies couldn't properly regulate heart rate through the vagus nerve (which normally helps calm the heart), and their blood vessels were overly tense. This mismatch may explain why these patients experience dizziness, rapid heartbeat, and fatigue when standing.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia in the year 2000].

Maquet, D, Croisier, J L, Crielaard, J M·Revue medicale de Liege·2000

This review article examines fibromyalgia (FM), a condition causing widespread muscle pain that affects about 2% of people. While doctors can diagnose fibromyalgia using a specific test (checking for tenderness at 18 specific body points), scientists still don't fully understand what causes it. This article summarizes what researchers knew in 2000 about how fibromyalgia develops and how doctors treat it.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Sympathetic nervous system function in fibromyalgia.

Petzke, F, Clauw, D J·Current rheumatology reports·2000

This review examines how the sympathetic nervous system—the part that controls your 'fight or flight' stress response—works differently in fibromyalgia patients. Researchers looked at various ways to measure sympathetic function, including heart rate changes, stress hormone levels, and physical responses to stress. The authors also compared findings in fibromyalgia to similar conditions like ME/CFS, irritable bowel syndrome, and migraine to identify common patterns.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Controversies in neurological infectious diseases.

Greenlee, J E, Rose, J W·Seminars in neurology·2000

This is a review article that discusses six controversial topics in infections affecting the nervous system. One of these topics is whether viruses might play a role in chronic fatigue syndrome (ME/CFS). The authors examine what scientists know and disagree about regarding these infections and their treatments.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The challenge of evaluating fatigue.

Rodriguez, T·Journal of the American Academy of Nurse Practitioners·2000

This article helps doctors and nurse practitioners understand how to properly evaluate fatigue in patients. It explains that fatigue can have many different causes and can be either short-term or long-term, and it's important to distinguish chronic fatigue from ME/CFS. The article suggests using specific tools and checklists to help identify what might be causing someone's fatigue so it can be properly treated.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Feminist perspectives on the social construction of chronic fatigue syndrome.

Richman, J A, Jason, L A, Taylor, R R et al.·Health care for women international·2000

This study compares how doctors have historically viewed ME/CFS with how patients themselves understand the illness. The researchers found that when medical science couldn't find a viral cause for ME/CFS, doctors increasingly blamed psychiatric or social factors instead of looking for biological explanations. The authors argue that discovering biological markers (measurable signs of disease) could help restore ME/CFS's credibility as a real medical condition, similar to how multiple sclerosis gained recognition.

Diagnostics

E3 PreliminaryMechanismPEM not requiredObservational

The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome.

Streeten, D H, Thomas, D, Bell, D S·The American journal of the medical sciences·2000

This study found that many ME/CFS patients experience a sudden drop in blood pressure and abnormal heart rate acceleration when standing up, along with symptoms like dizziness. The researchers discovered that low red blood cell volume was present in most patients tested, and that wearing inflatable compression pants could quickly reverse these standing problems. This suggests that problems with blood pooling in the legs when upright may contribute to ME/CFS symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Motor cortex excitability in chronic fatigue syndrome.

Starr, A, Scalise, A, Gordon, R et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2000

This study used a technique called transcranial magnetic stimulation (TMS) to measure how the motor cortex—the part of the brain that controls movement—behaves in people with ME/CFS. Patients and healthy controls performed finger movements while researchers measured brain responses before, during, and after the exercise. People with ME/CFS showed abnormal brain responses compared to healthy people, suggesting their brains may not adapt normally to physical activity.

E3 PreliminaryCommentaryPEM not requiredEditorial

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

Visser, J T, De Kloet, E R, Nagelkerken, L·Annals of the New York Academy of Sciences·2000

This study explores how stress hormones called glucocorticoids affect the immune system in ME/CFS patients. The researchers found evidence suggesting that in ME/CFS, these stress hormones may be shifting the immune system's balance in an unhelpful way—boosting certain types of immune responses while weakening others. This could help explain why ME/CFS patients experience ongoing immune system problems.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Search for Borna disease virus in Danish fibromyalgia patients.

Wittrup, I H, Christensen, L S, Jensen, B et al.·Scandinavian journal of rheumatology·2000

Researchers tested 18 patients with fibromyalgia (a condition causing widespread pain and fatigue) to see if they had a virus called Borna disease virus (BDV). This virus affects animals and had been suggested as a possible cause of chronic fatigue syndrome. The tests came back negative—BDV was not found in any of the patients' blood or spinal fluid samples.

E3 PreliminaryCommentaryPEM not requiredEditorial

The biopsychosocial model--a tool for rheumatologists.

Ferrari, R·Bailliere's best practice & research. Clinical rheumatology·2000

This article discusses how doctors can better understand and treat ME/CFS and similar conditions by moving away from the traditional debate of whether symptoms are 'all in your head' or entirely physical. Instead, it suggests using the biopsychosocial model, which recognizes that physical symptoms, thoughts, emotions, and life circumstances all play a role. The article explains how doctors can use patient education and help patients change unhelpful illness behaviors to improve treatment outcomes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Nutritional strategies for treating chronic fatigue syndrome.

Werbach, M R·Alternative medicine review : a journal of clinical therapeutic·2000

This review examines whether nutritional deficiencies might play a role in ME/CFS and suggests that patients may benefit from supplementation. The authors identified several nutrients—including B vitamins, vitamin C, magnesium, and others—that appear to be lower in ME/CFS patients, likely due to the illness itself rather than poor diet. They recommend considering vitamin and mineral supplements as a trial treatment, since these supplements are generally safe and may help with both symptoms and recovery.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

Sleep and circadian rhythm disorders in fibromyalgia.

Korszun, A·Current rheumatology reports·2000

Fibromyalgia is a condition causing widespread muscle pain along with sleep problems and extreme tiredness. This review examines how broken sleep patterns and disrupted body clocks (which control things like stress hormones) play a role in fibromyalgia. The authors suggest that treating sleep disorders, depression, and improving sleep habits—along with careful use of medications—may help relieve symptoms.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Neeck, G, Crofford, L J·Rheumatic diseases clinics of North America·2000

This review examines how hormone systems work differently in people with ME/CFS and fibromyalgia. In ME/CFS, the stress hormone system appears to be underactive, possibly due to problems in the brain. In fibromyalgia, the opposite seems true—the stress hormone system appears overactive, likely as the body's response to chronic pain. Understanding these differences could help explain why these conditions feel so different and might guide better treatments.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report.

Redman, D A·Journal of alternative and complementary medicine (New York, N.Y.)·2000

Many people with ME/CFS experience orthostatic hypotension—a sudden drop in blood pressure when standing up—which can be severely disabling. This paper reviews why existing medications for this condition often don't work well and proposes that Ruscus aculeatus (butcher's broom), a plant-based supplement used in Europe, might help by improving blood vessel function and preventing blood from pooling in the legs.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Buskila, D·Current opinion in rheumatology·2000

This review article examines the connections between fibromyalgia, chronic fatigue syndrome (ME/CFS), and myofascial pain syndrome. Researchers found that people with these conditions often have tender points in their muscles, hormonal imbalances affecting stress response, and possible immune system involvement. The study suggests that talking therapies like cognitive behavioral therapy may help manage chronic pain in these conditions, and that children and adolescents with these illnesses often improve over time.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCohortPEM not requiredCross-Sectional

"I could not lift my arm holding the fork...". Living with chronic fatigue syndrome.

Söderlund, A, Skoge, A M, Malterud, K·Scandinavian journal of primary health care·2000

This study asked 12 people with ME/CFS to describe what living with the illness is really like. They reported extreme exhaustion that goes far beyond normal tiredness, along with muscle weakness, pain, memory problems, sleep issues, and heightened sensitivity to light, sound, and smells. These symptoms made everyday activities like cooking, talking, and housework unpredictably difficult, which disrupted their social lives and relationships.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome--old wine in new bottles].

Leonhardt, T·Lakartidningen·2000

This 2000 article examines chronic fatigue syndrome (ME/CFS) and discusses how the condition may be understood through existing medical knowledge rather than as a completely new disease. The author explores what we already know about ME/CFS and how current medical frameworks apply to this complex illness.

Diagnostics

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[Aspects of occupational disability in psychosomatic disorders].

Chronic fatigue syndrome in childhood.

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.

[Fibromyalgia in the year 2000].

Sympathetic nervous system function in fibromyalgia.

Controversies in neurological infectious diseases.

The challenge of evaluating fatigue.

Feminist perspectives on the social construction of chronic fatigue syndrome.

The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome.

Motor cortex excitability in chronic fatigue syndrome.

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

Search for Borna disease virus in Danish fibromyalgia patients.

The biopsychosocial model--a tool for rheumatologists.

Nutritional strategies for treating chronic fatigue syndrome.

Sleep and circadian rhythm disorders in fibromyalgia.

Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

"I could not lift my arm holding the fork...". Living with chronic fatigue syndrome.

[Chronic fatigue syndrome--old wine in new bottles].

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