ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5701–5720 of 6,211 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

[Physical activity for mental health].

Martinsen, E W·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2000

This review examined whether exercise can help treat mental health conditions like depression and anxiety. The research found that exercise works best for mild to moderate depression and chronic fatigue syndrome, and may also help with panic disorder, anxiety, and other conditions. Exercise appears to be a useful, affordable alternative or addition to standard treatments like medication and therapy.

Interventions

E3 PreliminaryCohortPEM not requiredCase-Control

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Takahashi, Y, Ohta, S, Sano, A et al.·Clinical nephrology·2000

Researchers found that 9 children with chronic fatigue all had a rare blood vessel condition called nutcracker phenomenon, where a vein gets compressed and restricts blood flow. These children also had symptoms of autonomic dysfunction (problems with automatic body functions like heart rate and blood pressure) and were originally thought to have psychological problems. The study suggests that this vascular compression might be connected to their fatigue and other symptoms.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Bradley, L A, McKendree-Smith, N L, Alarcón, G S·Current review of pain·2000

Both fibromyalgia (FM) and ME/CFS cause muscle and joint pain, but the underlying reasons differ between these conditions. People with FM alone have unusually sensitive pain responses to light touch or mild pressure (called allodynia), while people with ME/CFS do not typically show this. This study examined what brain and hormone system differences might explain why these two conditions cause pain in different ways.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report.

Redman, D A·Journal of alternative and complementary medicine (New York, N.Y.)·2000

Many people with ME/CFS experience orthostatic hypotension—a sudden drop in blood pressure when standing up—which can be severely disabling. This paper reviews why existing medications for this condition often don't work well and proposes that Ruscus aculeatus (butcher's broom), a plant-based supplement used in Europe, might help by improving blood vessel function and preventing blood from pooling in the legs.

Autonomic Nervous System

E3 PreliminaryCommentaryPEM not requiredEditorial

The biopsychosocial model--a tool for rheumatologists.

Ferrari, R·Bailliere's best practice & research. Clinical rheumatology·2000

This article discusses how doctors can better understand and treat ME/CFS and similar conditions by moving away from the traditional debate of whether symptoms are 'all in your head' or entirely physical. Instead, it suggests using the biopsychosocial model, which recognizes that physical symptoms, thoughts, emotions, and life circumstances all play a role. The article explains how doctors can use patient education and help patients change unhelpful illness behaviors to improve treatment outcomes.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Aspects of occupational disability in psychosomatic disorders].

Huber, M·Versicherungsmedizin·2000

This 2000 review describes how psychosomatic illnesses—conditions where physical and emotional health are closely connected—were a major reason people went on disability leave in the 1990s. The article discusses several conditions including chronic fatigue syndrome, fibromyalgia, and chronic pain disorders, and suggests that the best approach to help these patients is through teamwork between physical medicine doctors and mental health professionals early in the illness.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.

Stewart, J M·Pediatric research·2000

This study looked at how the nervous system controls heart rate and blood pressure in adolescents with ME/CFS and POTS when they stand up or tilt their head upward. Researchers found that both groups had similar problems: their bodies couldn't properly regulate heart rate through the vagus nerve (which normally helps calm the heart), and their blood vessels were overly tense. This mismatch may explain why these patients experience dizziness, rapid heartbeat, and fatigue when standing.

Autonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome.

Korszun, A, Young, E A, Engleberg, N C et al.·The Journal of rheumatology·2000

Researchers tested whether women with fibromyalgia (FM) and chronic fatigue syndrome (CFS) have imbalances in hormones related to reproduction and the menstrual cycle. They collected blood samples every 10 minutes over 12 hours from women with FM, women with CFS, and healthy controls during the first part of the menstrual cycle. They found no significant differences in hormone levels or patterns between the patient groups and healthy women.

E3 PreliminaryCohortPEM unclearCross-Sectional

Search for Borna disease virus in Danish fibromyalgia patients.

Wittrup, I H, Christensen, L S, Jensen, B et al.·Scandinavian journal of rheumatology·2000

Researchers tested 18 patients with fibromyalgia (a condition causing widespread pain and fatigue) to see if they had a virus called Borna disease virus (BDV). This virus affects animals and had been suggested as a possible cause of chronic fatigue syndrome. The tests came back negative—BDV was not found in any of the patients' blood or spinal fluid samples.

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Neeck, G, Crofford, L J·Rheumatic diseases clinics of North America·2000

This review examines how hormone systems work differently in people with ME/CFS and fibromyalgia. In ME/CFS, the stress hormone system appears to be underactive, possibly due to problems in the brain. In fibromyalgia, the opposite seems true—the stress hormone system appears overactive, likely as the body's response to chronic pain. Understanding these differences could help explain why these conditions feel so different and might guide better treatments.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Sympathetic nervous system function in fibromyalgia.

Petzke, F, Clauw, D J·Current rheumatology reports·2000

This review examines how the sympathetic nervous system—the part that controls your 'fight or flight' stress response—works differently in fibromyalgia patients. Researchers looked at various ways to measure sympathetic function, including heart rate changes, stress hormone levels, and physical responses to stress. The authors also compared findings in fibromyalgia to similar conditions like ME/CFS, irritable bowel syndrome, and migraine to identify common patterns.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia in the year 2000].

Maquet, D, Croisier, J L, Crielaard, J M·Revue medicale de Liege·2000

This review article examines fibromyalgia (FM), a condition causing widespread muscle pain that affects about 2% of people. While doctors can diagnose fibromyalgia using a specific test (checking for tenderness at 18 specific body points), scientists still don't fully understand what causes it. This article summarizes what researchers knew in 2000 about how fibromyalgia develops and how doctors treat it.

Pain and Sensitization

E3 PreliminaryPEM not required

Chronic fatigue syndrome in childhood.

Tomoda, A, Miike, T, Yamada, E et al.·Brain & development·2000

This study looked at three children (ages 11-13) with ME/CFS and used special brain imaging scans to measure blood flow and chemical activity in their brains. The scans showed differences in brain blood flow and metabolism compared to healthy children, suggesting that ME/CFS may involve changes in how the brain is functioning, not just a psychological problem.

E3 PreliminaryCohortPEM not requiredObservational

Fatigue in chronic fatigue syndrome: a discourse analysis of women's experiential narratives.

Hart, B, Grace, V M·Health care for women international·2000

This study interviewed 11 women with ME/CFS in New Zealand to understand how they experience and describe fatigue. The women often talked about fatigue as something missing or absent—a lack of energy or ability—rather than as a specific physical symptom doctors could identify. The researchers suggest that healthcare approaches need to recognize how complex and personal the experience of fatigue is for each person.

E3 PreliminaryCohortPEM not requiredCase-Control

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

Foltán, R, Sonka, K·Sbornik lekarsky·2000

This case report describes a 68-year-old woman with severe sleep apnea (a condition where breathing repeatedly stops during sleep) who also had symptoms of chronic fatigue, daytime sleepiness, and morning headaches. Because she couldn't tolerate the standard breathing mask treatment due to anxiety, she had surgery to widen her airway. After surgery, her sleep apnea improved significantly and her fatigue and other symptoms improved.

Sleep

E3 PreliminaryMechanismPEM not requiredObservational

The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome.

Streeten, D H, Thomas, D, Bell, D S·The American journal of the medical sciences·2000

This study found that many ME/CFS patients experience a sudden drop in blood pressure and abnormal heart rate acceleration when standing up, along with symptoms like dizziness. The researchers discovered that low red blood cell volume was present in most patients tested, and that wearing inflatable compression pants could quickly reverse these standing problems. This suggests that problems with blood pooling in the legs when upright may contribute to ME/CFS symptoms.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

Gelman, I H, Unger, E R, Mawle, A C et al.·Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology·2000

Researchers investigated whether a virus called endogenous retroviral p15E might be involved in causing ME/CFS. They tested blood samples from people with ME/CFS and compared them to healthy controls. The study found no evidence that this viral protein was present in higher amounts in ME/CFS patients, suggesting it is not responsible for the disease.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Nutritional strategies for treating chronic fatigue syndrome.

Werbach, M R·Alternative medicine review : a journal of clinical therapeutic·2000

This review examines whether nutritional deficiencies might play a role in ME/CFS and suggests that patients may benefit from supplementation. The authors identified several nutrients—including B vitamins, vitamin C, magnesium, and others—that appear to be lower in ME/CFS patients, likely due to the illness itself rather than poor diet. They recommend considering vitamin and mineral supplements as a trial treatment, since these supplements are generally safe and may help with both symptoms and recovery.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system.

Elenkov, I J, Wilder, R L, Chrousos, G P et al.·Pharmacological reviews·2000

Your brain and immune system communicate constantly to keep your body healthy, and your nervous system plays a key role in this conversation. This review explains how nerve signals release chemicals called norepinephrine and epinephrine that can either calm down or activate your immune system depending on where in your body they act. Understanding this communication system may help explain why chronic conditions like fatigue syndromes involve both nervous system and immune system problems.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

Visser, J T, De Kloet, E R, Nagelkerken, L·Annals of the New York Academy of Sciences·2000

This study explores how stress hormones called glucocorticoids affect the immune system in ME/CFS patients. The researchers found evidence suggesting that in ME/CFS, these stress hormones may be shifting the immune system's balance in an unhelpful way—boosting certain types of immune responses while weakening others. This could help explain why ME/CFS patients experience ongoing immune system problems.

Immune System

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Evidence browser

[Physical activity for mental health].

Does severe nutcracker phenomenon cause pediatric chronic fatigue?

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.

Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report.

The biopsychosocial model--a tool for rheumatologists.

[Aspects of occupational disability in psychosomatic disorders].

Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion.

Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome.

Search for Borna disease virus in Danish fibromyalgia patients.

Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Sympathetic nervous system function in fibromyalgia.

[Fibromyalgia in the year 2000].

Chronic fatigue syndrome in childhood.

Fatigue in chronic fatigue syndrome: a discourse analysis of women's experiential narratives.

[Genioglossal advancement in the surgical treatment of obstructive sleep apnea syndrome in adults].

The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome.

Chronic fatigue syndrome is not associated with expression of endogenous retroviral p15E.

Nutritional strategies for treating chronic fatigue syndrome.

The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system.

Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome.

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