ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5601–5620 of 6,211 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: psychiatric perspectives].

Youssefi, M, Linkowski, P·Revue medicale de Bruxelles·2002

This review examines ME/CFS from a psychiatric perspective, looking at how mental health symptoms often occur alongside the physical illness. Many people with ME/CFS also experience depression, anxiety, or other mood problems, though it's unclear whether these conditions cause ME/CFS or develop because of living with a serious chronic illness. The authors discuss treatments that have shown promise, including talking therapy, exercise programs, and antidepressants when appropriate, while emphasizing that a supportive doctor-patient relationship is essential.

E3 PreliminaryMechanismPEM not requiredMechanistic

Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Demettre, Edith, Bastide, Lionel, D'Haese, Anne et al.·The Journal of biological chemistry·2002

Researchers found that immune cells from ME/CFS patients show abnormally high breakdown of a protein called RNase L, which normally helps fight viral infections. Instead of remaining whole, this protein is being cut into smaller pieces (37 kDa and 30 kDa fragments), yet these fragments can still work together to fight infections. This abnormal protein breakdown pattern could potentially be used as a marker to help diagnose ME/CFS.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Homeopathic treatment of Chronic Fatigue Syndrome: three case studies using Jan Scholten's methodology.

Geraghty, J·Homeopathy : the journal of the Faculty of Homeopathy·2002

This study looked at three young people with ME/CFS that developed after a viral infection, and tried treating them with homeopathic remedies based on a specific system of selecting remedies. The researchers describe how they chose three different phosphate-based homeopathic medicines and claim that patients experienced improvement, though the study is very small and doesn't use a comparison group.

E3 PreliminaryCohortPEM not requiredCase-Control

The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report.

Logan, Alan C, Beaulne, Tracey M·Alternative medicine review : a journal of clinical therapeutic·2002

This study describes one patient who had too many bacteria growing in their small intestine and was experiencing IBS-like symptoms. When treated with enteric-coated peppermint oil (a special form of peppermint that reaches the small intestine), the patient felt significantly better and had measurable improvements in digestive gas production. This suggests peppermint oil might work by reducing harmful bacteria in the gut.

E3 PreliminaryMechanismPEM not requiredCase-Control

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Arnold, M C, Papanicolaou, D A, O'Grady, J A et al.·Psychological medicine·2002

Researchers gave ME/CFS patients and healthy people a substance called interleukin-6 to temporarily trigger flu-like symptoms. They then tested how well both groups could think and remember during this induced illness. ME/CFS patients reported more overall sickness symptoms, but surprisingly, both groups performed equally well on memory and thinking tests, suggesting that the temporary immune activation didn't impair cognitive abilities in either group.

Immune System

E3 PreliminaryMechanismPEM requiredMechanistic

Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome.

Ohashi, Kyoko, Yamamoto, Yoshiharu, Natelson, Benjamin H·Physiology & behavior·2002

This study looked at whether exhausting exercise disrupts the body's internal daily rhythm in people with ME/CFS. Researchers measured activity patterns in ME/CFS patients and healthy controls before and after a strenuous treadmill test. They found that ME/CFS patients' activity rhythms became abnormally lengthened (longer than 24 hours) after exercise, while healthy people's rhythms stayed normal—suggesting the body loses its ability to keep time after strenuous activity in ME/CFS.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.

Kipen, Howard M, Fiedler, Nancy·Environmental health perspectives·2002

This paper discusses how many patients experience symptoms that doctors cannot easily explain, and how these symptoms sometimes get organized into syndrome names like chronic fatigue syndrome. The authors note that these syndromes are defined only by how patients feel, not by medical tests, and that arguments continue about whether environmental factors cause them. They call for better research and clearer definitions to help both doctors and patients understand these conditions.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Somatization, sensitization, and functional dyspepsia.

Wilhelmsen, Ingvard·Scandinavian journal of psychology·2002

This study explores why people with conditions like ME/CFS, fibromyalgia, and functional dyspepsia experience overlapping symptoms such as fatigue, headaches, muscle pain, and sleep problems. The researchers suggest these different conditions may share a common underlying process where the nervous system becomes overly sensitive to pain and discomfort signals, leading the body to experience and report multiple symptoms across different areas.

Pain and Sensitization

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

Characteristics of patients with persistent severe disability and medically unexplained neurological symptoms: a pilot study.

Allanson, J, Bass, C, Wade, D T·Journal of neurology, neurosurgery, and psychiatry·2002

This study looked at 25 patients with severe disability and neurological symptoms that doctors couldn't explain with standard tests. Most patients were in wheelchairs and very limited in daily activities, though they had been given different diagnoses—some psychiatric, some neurological. The researchers found that many of these patients had experienced trauma, had received psychiatric treatment, or had switched from self-harm to physical disability around the same time.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Does graded activity increase activity? A case study of chronic fatigue syndrome.

Friedberg, Fred·Journal of behavior therapy and experimental psychiatry·2002

This study looked at one patient with ME/CFS who received treatment aimed at gradually increasing physical activity. Surprisingly, while the patient reported doing more walking and felt much better overall, a step counter showed he was actually taking fewer steps per week by the end of treatment. The improvement seemed to come from doing activities that made him feel better emotionally, rather than from simply moving more.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Generation of classification criteria for chronic fatigue syndrome using an artificial neural network and traditional criteria set.

Linder, R, Dinser, R, Wagner, M et al.·In vivo (Athens, Greece)·2002

Researchers tested whether a computer program called an artificial neural network could help doctors better identify ME/CFS by looking at patient symptoms and comparing them to two other conditions that also cause fatigue: lupus and fibromyalgia. The computer program was very accurate—correctly identifying ME/CFS about 95% of the time—and worked better than traditional statistical methods for creating diagnostic rules.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

The intelligent body and its discontents.

Hyland, Michael E·Journal of health psychology·2002

This paper proposes that the whole body—not just the brain—can learn and process information like a complex computer system. When this body-wide system malfunctions, it can create widespread health problems distributed throughout the body rather than in one location. The authors suggest ME/CFS is an example of this type of whole-body dysfunction and may require different treatment approaches than traditional medicine typically offers.

E3 PreliminaryBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome and eating disorders: concurrence or coincidence?

Fisher, Martin, Krilov, Leonard R, Ovadia, Marc·International journal of adolescent medicine and health·2002

This study looked at four adolescent patients who had both an eating disorder and ME/CFS at the same time. In all four cases, the eating disorder appeared first, followed later by ME/CFS symptoms. The authors explored whether these two conditions might be related through common causes, whether an eating disorder could trigger ME/CFS, or whether they simply occurred together by chance.

Autonomic Nervous System

E3 PreliminaryCohortPEM unclearCase-Control

Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report.

Panerai, Alberto E, Vecchiet, Jacopo, Panzeri, Paolo et al.·The Clinical journal of pain·2002

This study measured a natural pain-relieving substance called beta-endorphin in immune cells from people with ME/CFS, fibromyalgia, depression, and healthy controls. The researchers found that people with ME/CFS and fibromyalgia had significantly lower levels of beta-endorphin than healthy people and those with depression. This suggests the immune systems of people with ME/CFS and fibromyalgia may be working differently than in other conditions.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

Women's experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia.

Asbring, Pia, Närvänen, Anna-Liisa·Qualitative health research·2002

This study interviewed 25 women with ME/CFS or fibromyalgia about their experiences with stigma—being doubted, judged, or not taken seriously. Women reported that stigma was most common before they received a diagnosis, and that having many different symptoms made it harder for others to believe they were truly ill. People sometimes questioned whether the illnesses were real or blamed them on emotional problems rather than physical causes.

Diagnostics

E3 PreliminaryCommentaryPEM unclearEditorial

Chronic fatigue syndrome in the psychiatric practice.

Van Duyse, A, Mariman, A, Poppe, C et al.·Acta neuropsychiatrica·2002

This review examines how psychiatric symptoms interact with ME/CFS. Many people with ME/CFS also experience depression, anxiety, or sleep problems, and doctors often miss these conditions. The study found that while antidepressant medications help with mood and social functioning, they don't improve fatigue itself. Cognitive behavioral therapy and graded exercise were the only treatments shown to actually improve fatigue and other ME/CFS symptoms.

Endocrine Disruption

E3 PreliminaryBehavioralPEM not requiredCase-Control

[Symptom or illness? The exhausting life of an adolescent with chronic fatigue syndrome].

Di Gallo, A·Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie·2002

This study describes the medical experience of a teenage boy diagnosed with chronic fatigue syndrome (CFS). The doctors examined questions about what causes CFS, how it develops, how to diagnose it, and what treatments might help. The case provides a detailed look at one patient's journey with this complex illness.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: evaluation and treatment.

Craig, Timothy, Kakumanu, Sujani·American family physician·2002

ME/CFS is a serious condition marked by extreme tiredness that doesn't go away, along with muscle pain, swollen lymph nodes, and feeling worse after physical activity. Doctors diagnose it mainly by ruling out other illnesses, since there's no single blood test or physical sign that definitively confirms it. Treatment is personalized and may include exercise, sleep improvements, diet changes, and medications like antidepressants.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Role of fatigue in limiting physical activities in humans with neuromuscular diseases.

Miller, Robert G·American journal of physical medicine & rehabilitation·2002

Fatigue in people with muscle and nerve diseases works differently than tiredness in healthy people, and scientists are now developing better tools to measure it. This paper reviews what we know about two types of fatigue: one that comes from the brain and nervous system (central fatigue) and one that comes from the muscles themselves (peripheral fatigue). The authors explain how these different types of fatigue affect people with conditions like ME/CFS, post-polio syndrome, and other neuromuscular diseases.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Methodologic aspects of the study of modern-age diseases: the example of sick-building syndrome.

Thörn, Ake·International journal of occupational and environmental health·2002

This paper discusses challenges in studying conditions like ME/CFS that have many different symptoms but no clear physical test to diagnose them. The authors suggest that studying how these illnesses develop over time, through detailed interviews and case studies, may help us understand them better than traditional research methods that count statistics across large groups.

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[Chronic fatigue syndrome: psychiatric perspectives].

Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.

Homeopathic treatment of Chronic Fatigue Syndrome: three case studies using Jan Scholten's methodology.

The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report.

Using an interleukin-6 challenge to evaluate neuropsychological performance in chronic fatigue syndrome.

Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome.

Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.

Somatization, sensitization, and functional dyspepsia.

Characteristics of patients with persistent severe disability and medically unexplained neurological symptoms: a pilot study.

Does graded activity increase activity? A case study of chronic fatigue syndrome.

Generation of classification criteria for chronic fatigue syndrome using an artificial neural network and traditional criteria set.

The intelligent body and its discontents.

Chronic fatigue syndrome and eating disorders: concurrence or coincidence?

Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report.

Women's experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia.

Chronic fatigue syndrome in the psychiatric practice.

[Symptom or illness? The exhausting life of an adolescent with chronic fatigue syndrome].

Chronic fatigue syndrome: evaluation and treatment.

Role of fatigue in limiting physical activities in humans with neuromuscular diseases.

Methodologic aspects of the study of modern-age diseases: the example of sick-building syndrome.

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