ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5981–6000 of 6,188 studies

E3 PreliminaryCohortPEM not requiredCase-Control

Consideration of narcolepsy in the differential diagnosis of chronic fatigue syndrome.

Ambrogetti, A, Olson, L G·The Medical journal of Australia·1994

This study describes four patients who were initially diagnosed with chronic fatigue syndrome (CFS) but actually had a different condition called narcolepsy, which causes extreme daytime sleepiness. When these patients were properly diagnosed with narcolepsy and treated with a medication called methylphenidate, their symptoms improved significantly or resolved completely. The authors suggest that doctors should carefully check for narcolepsy in patients with CFS who report severe daytime sleepiness.

Sleep

E3 PreliminaryCommentaryPEM not requiredEditorial

Somatization, illness attribution and the sociocultural psychiatry of chronic fatigue syndrome.

Abbey, S E·Ciba Foundation symposium·1993

This paper explores how psychological factors, personal beliefs about illness, and social influences may play a role in ME/CFS. The author examines how things like perfectionism, how people cope with stress, and the way doctors and media talk about ME/CFS can affect whether someone develops the condition or how severe their symptoms become.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Amma therapy: a holistic approach to chronic fatigue syndrome.

Young, A·Journal of holistic nursing : official journal of the American Holistic Nurses' Association·1993

This study looked at Amma Therapy, a hands-on healing practice, as a possible way to help people with ME/CFS who feel frustrated with traditional medical care. The researcher examined how this holistic approach might benefit patients with chronic fatigue. The study suggests that some people with ME/CFS may find relief through this alternative therapy.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pharmacological approaches to the therapy of chronic fatigue syndrome.

McCluskey, D R·Ciba Foundation symposium·1993

This study examined various medications used to treat ME/CFS and found that none completely resolved symptoms. The researchers suggest that ME/CFS may be caused by a sleep regulation problem in the brain, which leads to not only extreme tiredness but also pain sensitivity, temperature control issues, and mood problems. They propose that medications affecting brain chemicals, especially serotonin, might help and should be tested in larger clinical trials.

Sleep

E3 PreliminaryMechanismPEM not requiredCase-Control

Exercise performance and fatiguability in patients with chronic fatigue syndrome.

Gibson, H, Carroll, N, Clague, J E et al.·Journal of neurology, neurosurgery, and psychiatry·1993

This study compared how muscles work in people with ME/CFS and healthy controls during and after exercise. Researchers found that the muscles themselves functioned normally, but people with ME/CFS reported feeling much more tired and exhausted during exercise relative to their heart rate compared to controls. This suggests that the fatigue comes from how the brain perceives effort rather than from actual muscle damage or weakness.

E3 PreliminaryCohortPEM unclearCase-Control

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Bojić, I, Mijusković, P, Lilić, D et al.·Vojnosanitetski pregled·1993

This 1993 study examined whether Epstein-Barr virus (EBV)—a common virus that causes mononucleosis—might be connected to chronic fatigue syndrome (ME/CFS). Researchers compared a group of people with ME/CFS to a control group to see if EBV infection patterns differed between them. The study aimed to explore whether EBV could play a role in developing or maintaining ME/CFS symptoms.

E3 PreliminaryCohortPEM unclearCase-Control

[The "anti-Ki" syndrome: major clinical features].

Matsunaga, K·Rinsho byori. The Japanese journal of clinical pathology·1993

Researchers found that four patients with autoimmune diseases had high levels of anti-Ki antibodies, a type of immune marker. These patients shared several symptoms including hair loss, severe fatigue, muscle weakness, joint inflammation, dry mouth, and blood sugar problems. The study suggests that this antibody pattern may be related to conditions like chronic fatigue syndrome and fibromyalgia.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Is chronic fatigue syndrome an infectious disease?

Mawle, A C, Reyes, M, Schmid, D S·Infectious agents and disease·1993

This 1993 paper examines whether chronic fatigue syndrome (ME/CFS) might be caused by an infection. The authors reviewed evidence about infectious agents and their possible role in ME/CFS development. While the study explores this connection, it does not provide definitive answers about whether an infection causes the illness.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Analysis of neuropsychological functioning in patients with chronic fatigue syndrome.

Grafman, J, Schwartz, V, Dale, J K et al.·Journal of neurology, neurosurgery, and psychiatry·1993

This study tested memory and thinking skills in 20 people with ME/CFS who reported memory problems. The researchers found that patients did have mild difficulty with memory tasks that required deep thinking and organization of information, but performed normally on other types of memory tests. Importantly, the severity of fatigue and other physical findings did not predict how well people performed on memory tests.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Barnes, P R, Taylor, D J, Kemp, G J et al.·Journal of neurology, neurosurgery, and psychiatry·1993

Researchers used a special type of MRI scan to measure how muscles use energy in ME/CFS patients compared to healthy people. They found that most patients had normal muscle energy use, but about a quarter showed unusual patterns in how their muscles handled acid buildup during exercise. This suggests muscle metabolism problems may exist in some, but not all, ME/CFS patients.

Biomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: signs and symptoms.

Stern, K·CDS review·1993

This review article examines the signs and symptoms that people with chronic fatigue syndrome (ME/CFS) commonly experience. The study helps identify what doctors should look for when evaluating patients who may have this condition. Understanding these key features is important for recognizing ME/CFS and distinguishing it from other illnesses.

E3 PreliminaryBehavioralPEM unclearConference-Abstract

Muscle histopathology and physiology in chronic fatigue syndrome.

Edwards, R H, Gibson, H, Clague, J E et al.·Ciba Foundation symposium·1993

Researchers examined muscle tissue from 108 ME/CFS patients and 22 healthy people using microscopes to look for structural damage, and tested muscle strength before and after exercise. They found no consistent muscle damage that explained fatigue symptoms, and muscle strength worked normally even after exercise. The study suggests ME/CFS is not caused by a primary muscle disease.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Treatment of the chronic fatigue syndrome. A review and practical guide.

Blondel-Hill, E, Shafran, S D·Drugs·1993

This 1993 guide explains that ME/CFS is a real illness defined by severe, disabling fatigue along with other physical and mental symptoms, though its exact cause remains unknown. The main treatment is getting a proper diagnosis, learning about the condition, and working with a caring doctor who understands it. Some patients may benefit from antidepressant medications even without depression, though no single treatment has been proven to work reliably for everyone.

Diagnostics

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Service delivery for people with chronic fatigue syndrome: a pilot action research study.

Denz-Penhey, H, Murdoch, J C·Family practice·1993

This study looked at how general practices (family doctors' offices) could better serve patients with ME/CFS. Researchers worked with doctors and patients over time to find ways of talking about the condition and organizing services that felt acceptable and helpful to both. The goal was to develop self-management approaches that encouraged the body's natural healing abilities while fitting within what doctors' offices could realistically offer.

E3 PreliminaryCohortPEM unclear

[A case from practice (279). 1. Chronic fatigue syndrome (CFS). 2. Psychosocial problems].

Kiener, S·Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis·1993

This is a case report from a Swiss medical practice describing a patient with chronic fatigue syndrome (CFS) and the psychological and social problems that came along with the condition. The doctor documented how CFS affected this patient's daily life, relationships, and mental health. This type of case study helps doctors recognize CFS in their own patients and understand the broader impact it has beyond just physical symptoms.

Diagnostics

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

JAMA·1993

In the early 1990s, researchers tested whether retroviruses (a type of virus) could be identified in people with ME/CFS using available blood tests. The CDC study found that these retroviral tests could not reliably identify or confirm ME/CFS in patients. This helped clarify that ME/CFS was not caused by the retroviruses being tested at that time.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of viral infection in polymyositis, dermatomyositis and chronic fatigue syndrome.

Behan, W M, Behan, P O·Bailliere's clinical neurology·1993

This review examines whether viral infections might be responsible for causing three conditions: polymyositis, dermatomyositis, and ME/CFS. The authors looked at evidence connecting viruses to these diseases, which cause muscle weakness and persistent fatigue. Understanding these potential links could help explain why some people develop ME/CFS after infections.

Immune System

E3 PreliminaryReviewPEM requiredReview-Narrative

Clinical presentation of chronic fatigue syndrome.

Komaroff, A L·Ciba Foundation symposium·1993

ME/CFS is a long-lasting illness that causes severe tiredness lasting at least six months, along with other symptoms like fever, sore throat, joint pain, and worsening after physical activity. While some symptoms can look like mental health conditions, ME/CFS has physical features—like sudden onset following a flu-like illness and post-exertional exhaustion—that suggest it involves real biological problems. This condition significantly impacts people's ability to work, study, and care for themselves.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Ewig, S·Deutsche medizinische Wochenschrift (1946)·1993

This is a review article about chronic fatigue syndrome (ME/CFS) published in a German medical journal. The author summarizes existing knowledge about the condition to help doctors and patients understand what was known about this illness in the early 1990s.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a critical review].

Cathébras, P, Bouchou, K, Charmion, S et al.·La Revue de medecine interne·1993

ME/CFS is a debilitating condition characterized mainly by extreme tiredness of unknown cause. Current diagnostic criteria don't clearly identify a single uniform group of patients, and no clear infectious or immune cause has been definitively proven, though some viruses and immune changes may play a role in some cases. Treatment options are limited but may include antidepressants and cognitive-behavioral therapy.

Diagnostics

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Consideration of narcolepsy in the differential diagnosis of chronic fatigue syndrome.

Somatization, illness attribution and the sociocultural psychiatry of chronic fatigue syndrome.

Amma therapy: a holistic approach to chronic fatigue syndrome.

Pharmacological approaches to the therapy of chronic fatigue syndrome.

Exercise performance and fatiguability in patients with chronic fatigue syndrome.

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

[The "anti-Ki" syndrome: major clinical features].

Is chronic fatigue syndrome an infectious disease?

Analysis of neuropsychological functioning in patients with chronic fatigue syndrome.

Skeletal muscle bioenergetics in the chronic fatigue syndrome.

Chronic fatigue syndrome: signs and symptoms.

Muscle histopathology and physiology in chronic fatigue syndrome.

Treatment of the chronic fatigue syndrome. A review and practical guide.

Service delivery for people with chronic fatigue syndrome: a pilot action research study.

[A case from practice (279). 1. Chronic fatigue syndrome (CFS). 2. Psychosocial problems].

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

The role of viral infection in polymyositis, dermatomyositis and chronic fatigue syndrome.

Clinical presentation of chronic fatigue syndrome.

[The chronic fatigue syndrome].

[Chronic fatigue syndrome: a critical review].

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