ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6001–6020 of 6,211 studies

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

Patarca, R, Klimas, N G, Lugtendorf, S et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study tested blood samples from 70 ME/CFS patients and compared them to healthy people. Researchers found that about 60% of ME/CFS patients had unusually high levels of immune chemicals called cytokines, particularly two types called TNF-alpha and TNF-beta. These chemicals are normally released by the body to fight infections, but in ME/CFS patients they appeared to be abnormally activated even without an active infection.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Artsimovich, N G, Chugunov, V S, Kornev, A V et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·1994

ME/CFS is a serious condition that causes extreme tiredness, brain fog, and flu-like symptoms that can last for months or years. The condition affects people of all ages, but is most common in women under 45. Researchers believe the immune system is not working properly in people with ME/CFS, though the exact problem is still unclear.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Women's health issues: a review of the current literature in the social work journals, 1985-1992.

Millner, L, Widerman, E·Social work in health care·1994

This study reviewed social work journal articles published between 1985-1992 to see how the profession was addressing women's health issues. Researchers found 36 articles, most focusing on reproduction and pregnancy, with fewer articles on illnesses like chronic fatigue syndrome. The study concluded that social work was overlooking important structural factors that affect women's health, such as employment and childcare access.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a defined unity?].

Rasmussen, A K, Andersen, V, Nielsen, H et al.·Ugeskrift for laeger·1994

This 1994 review examined what scientists knew about ME/CFS at that time, looking at whether a persistent virus or immune system problem caused the condition. The authors found that existing research did not consistently support either explanation, and that different studies often contradicted each other. They concluded that more careful research was needed to understand what actually causes ME/CFS and how to tell it apart from other illnesses.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

JAMA·1993

In the early 1990s, researchers tested whether retroviruses (a type of virus) could be identified in people with ME/CFS using available blood tests. The CDC study found that these retroviral tests could not reliably identify or confirm ME/CFS in patients. This helped clarify that ME/CFS was not caused by the retroviruses being tested at that time.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Jason, L A·The journal of primary prevention·1993

This 1993 paper explores how the mind, nervous system, and immune system are connected in ME/CFS, and how community support might help with recovery. The authors use a real patient's story to show how understanding these connections and building supportive relationships could be helpful for people struggling with this illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: a critical review].

Cathébras, P, Bouchou, K, Charmion, S et al.·La Revue de medecine interne·1993

ME/CFS is a debilitating condition characterized mainly by extreme tiredness of unknown cause. Current diagnostic criteria don't clearly identify a single uniform group of patients, and no clear infectious or immune cause has been definitively proven, though some viruses and immune changes may play a role in some cases. Treatment options are limited but may include antidepressants and cognitive-behavioral therapy.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Central basis of muscle fatigue in chronic fatigue syndrome.

Kent-Braun, J A, Sharma, K R, Weiner, M W et al.·Neurology·1993

Researchers tested whether muscle fatigue in ME/CFS patients was caused by problems within the muscle itself or in the brain's ability to control muscles. They found that the muscles worked normally and used energy normally during exercise, but the patients' brains were unable to fully activate their muscles during hard, sustained work. This suggests the primary problem may be in how the nervous system controls muscles rather than in the muscles themselves.

E3 PreliminaryReviewPEM requiredReview-Narrative

Clinical presentation of chronic fatigue syndrome.

Komaroff, A L·Ciba Foundation symposium·1993

ME/CFS is a long-lasting illness that causes severe tiredness lasting at least six months, along with other symptoms like fever, sore throat, joint pain, and worsening after physical activity. While some symptoms can look like mental health conditions, ME/CFS has physical features—like sudden onset following a flu-like illness and post-exertional exhaustion—that suggest it involves real biological problems. This condition significantly impacts people's ability to work, study, and care for themselves.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: signs and symptoms.

Stern, K·CDS review·1993

This review article examines the signs and symptoms that people with chronic fatigue syndrome (ME/CFS) commonly experience. The study helps identify what doctors should look for when evaluating patients who may have this condition. Understanding these key features is important for recognizing ME/CFS and distinguishing it from other illnesses.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothesis: the nasal fatigue reflex.

Chester, A C·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1993

This paper proposes a new theory: that extreme fatigue in ME/CFS and related conditions might be the body's protective reflex triggered by nasal or sinus problems. The idea is that in our evolutionary past, when a good sense of smell was crucial for survival, fatigue would have kept sick animals resting safely at home while their nose healed. The author suggests this ancient reflex may still be active in humans today.

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Ewig, S·Deutsche medizinische Wochenschrift (1946)·1993

This is a review article about chronic fatigue syndrome (ME/CFS) published in a German medical journal. The author summarizes existing knowledge about the condition to help doctors and patients understand what was known about this illness in the early 1990s.

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Ways of coping with chronic fatigue syndrome: development of an illness management questionnaire.

Ray, C, Weir, W, Stewart, D et al.·Social science & medicine (1982)·1993

Researchers created a questionnaire to understand how people with ME/CFS cope with their illness and manage day-to-day life. They found that patients use four main coping strategies: trying to stay active, adjusting to the illness, focusing on symptoms, and seeking information. These coping approaches were linked to how well patients functioned and their levels of anxiety and depression.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is juvenile diabetes a viral disease?

Fohlman, J, Friman, G·Annals of medicine·1993

This review examines whether viruses—particularly enteroviruses like Coxsackie and ECHO viruses—might trigger type 1 diabetes in children. The authors suggest that a person can catch one of these viruses, and even though the initial infection may go unnoticed, the virus can persist in the body and potentially trigger the immune system to attack the insulin-producing cells in the pancreas. Interestingly, the authors mention that similar persistent viral infections might also play a role in chronic fatigue syndrome.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Bojić, I, Mijusković, P, Lilić, D et al.·Vojnosanitetski pregled·1993

This 1993 study examined whether Epstein-Barr virus (EBV)—a common virus that causes mononucleosis—might be connected to chronic fatigue syndrome (ME/CFS). Researchers compared a group of people with ME/CFS to a control group to see if EBV infection patterns differed between them. The study aimed to explore whether EBV could play a role in developing or maintaining ME/CFS symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Low NK syndrome and its relationship to chronic fatigue syndrome.

Aoki, T, Miyakoshi, H, Usuda, Y et al.·Clinical immunology and immunopathology·1993

This study examined whether people with chronic fatigue syndrome (ME/CFS) have lower numbers or reduced function of natural killer (NK) cells, which are part of the immune system that helps fight infections and abnormal cells. The researchers found that some ME/CFS patients showed low NK cell levels or activity, suggesting the immune system may not be working normally in this condition. This finding could help explain why people with ME/CFS experience persistent exhaustion and infections.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

[The "anti-Ki" syndrome: major clinical features].

Matsunaga, K·Rinsho byori. The Japanese journal of clinical pathology·1993

Researchers found that four patients with autoimmune diseases had high levels of anti-Ki antibodies, a type of immune marker. These patients shared several symptoms including hair loss, severe fatigue, muscle weakness, joint inflammation, dry mouth, and blood sugar problems. The study suggests that this antibody pattern may be related to conditions like chronic fatigue syndrome and fibromyalgia.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pharmacological approaches to the therapy of chronic fatigue syndrome.

McCluskey, D R·Ciba Foundation symposium·1993

This study examined various medications used to treat ME/CFS and found that none completely resolved symptoms. The researchers suggest that ME/CFS may be caused by a sleep regulation problem in the brain, which leads to not only extreme tiredness but also pain sensitivity, temperature control issues, and mood problems. They propose that medications affecting brain chemicals, especially serotonin, might help and should be tested in larger clinical trials.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

Is chronic fatigue syndrome an infectious disease?

Mawle, A C, Reyes, M, Schmid, D S·Infectious agents and disease·1993

This 1993 paper examines whether chronic fatigue syndrome (ME/CFS) might be caused by an infection. The authors reviewed evidence about infectious agents and their possible role in ME/CFS development. While the study explores this connection, it does not provide definitive answers about whether an infection causes the illness.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Analysis of neuropsychological functioning in patients with chronic fatigue syndrome.

Grafman, J, Schwartz, V, Dale, J K et al.·Journal of neurology, neurosurgery, and psychiatry·1993

This study tested memory and thinking skills in 20 people with ME/CFS who reported memory problems. The researchers found that patients did have mild difficulty with memory tasks that required deep thinking and organization of information, but performed normally on other types of memory tests. Importantly, the severity of fatigue and other physical findings did not predict how well people performed on memory tests.

Cognitive Impairment

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Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

[The chronic fatigue syndrome].

Women's health issues: a review of the current literature in the social work journals, 1985-1992.

[Chronic fatigue syndrome--a defined unity?].

From the Centers for Disease Control and Prevention. Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

[Chronic fatigue syndrome: a critical review].

Central basis of muscle fatigue in chronic fatigue syndrome.

Clinical presentation of chronic fatigue syndrome.

Chronic fatigue syndrome: signs and symptoms.

Hypothesis: the nasal fatigue reflex.

[The chronic fatigue syndrome].

Ways of coping with chronic fatigue syndrome: development of an illness management questionnaire.

Is juvenile diabetes a viral disease?

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Low NK syndrome and its relationship to chronic fatigue syndrome.

[The "anti-Ki" syndrome: major clinical features].

Pharmacological approaches to the therapy of chronic fatigue syndrome.

Is chronic fatigue syndrome an infectious disease?

Analysis of neuropsychological functioning in patients with chronic fatigue syndrome.

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