ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6001–6020 of 6,188 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Low NK syndrome and its relationship to chronic fatigue syndrome.

Aoki, T, Miyakoshi, H, Usuda, Y et al.·Clinical immunology and immunopathology·1993

This study examined whether people with chronic fatigue syndrome (ME/CFS) have lower numbers or reduced function of natural killer (NK) cells, which are part of the immune system that helps fight infections and abnormal cells. The researchers found that some ME/CFS patients showed low NK cell levels or activity, suggesting the immune system may not be working normally in this condition. This finding could help explain why people with ME/CFS experience persistent exhaustion and infections.

Immune System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Ways of coping with chronic fatigue syndrome: development of an illness management questionnaire.

Ray, C, Weir, W, Stewart, D et al.·Social science & medicine (1982)·1993

Researchers created a questionnaire to understand how people with ME/CFS cope with their illness and manage day-to-day life. They found that patients use four main coping strategies: trying to stay active, adjusting to the illness, focusing on symptoms, and seeking information. These coping approaches were linked to how well patients functioned and their levels of anxiety and depression.

E3 PreliminaryCohortPEM unclearCase-Control

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Bojić, I, Mijusković, P, Lilić, D et al.·Vojnosanitetski pregled·1993

This 1993 study examined whether Epstein-Barr virus (EBV)—a common virus that causes mononucleosis—might be connected to chronic fatigue syndrome (ME/CFS). Researchers compared a group of people with ME/CFS to a control group to see if EBV infection patterns differed between them. The study aimed to explore whether EBV could play a role in developing or maintaining ME/CFS symptoms.

E3 PreliminaryMechanismPEM not requiredCase-Control

Exercise performance and fatiguability in patients with chronic fatigue syndrome.

Gibson, H, Carroll, N, Clague, J E et al.·Journal of neurology, neurosurgery, and psychiatry·1993

This study compared how muscles work in people with ME/CFS and healthy controls during and after exercise. Researchers found that the muscles themselves functioned normally, but people with ME/CFS reported feeling much more tired and exhausted during exercise relative to their heart rate compared to controls. This suggests that the fatigue comes from how the brain perceives effort rather than from actual muscle damage or weakness.

E3 PreliminaryCommentaryPEM not requiredEditorial

Somatization, illness attribution and the sociocultural psychiatry of chronic fatigue syndrome.

Abbey, S E·Ciba Foundation symposium·1993

This paper explores how psychological factors, personal beliefs about illness, and social influences may play a role in ME/CFS. The author examines how things like perfectionism, how people cope with stress, and the way doctors and media talk about ME/CFS can affect whether someone develops the condition or how severe their symptoms become.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Pharmacological approaches to the therapy of chronic fatigue syndrome.

McCluskey, D R·Ciba Foundation symposium·1993

This study examined various medications used to treat ME/CFS and found that none completely resolved symptoms. The researchers suggest that ME/CFS may be caused by a sleep regulation problem in the brain, which leads to not only extreme tiredness but also pain sensitivity, temperature control issues, and mood problems. They propose that medications affecting brain chemicals, especially serotonin, might help and should be tested in larger clinical trials.

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Central basis of muscle fatigue in chronic fatigue syndrome.

Kent-Braun, J A, Sharma, K R, Weiner, M W et al.·Neurology·1993

Researchers tested whether muscle fatigue in ME/CFS patients was caused by problems within the muscle itself or in the brain's ability to control muscles. They found that the muscles worked normally and used energy normally during exercise, but the patients' brains were unable to fully activate their muscles during hard, sustained work. This suggests the primary problem may be in how the nervous system controls muscles rather than in the muscles themselves.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Is juvenile diabetes a viral disease?

Fohlman, J, Friman, G·Annals of medicine·1993

This review examines whether viruses—particularly enteroviruses like Coxsackie and ECHO viruses—might trigger type 1 diabetes in children. The authors suggest that a person can catch one of these viruses, and even though the initial infection may go unnoticed, the virus can persist in the body and potentially trigger the immune system to attack the insulin-producing cells in the pancreas. Interestingly, the authors mention that similar persistent viral infections might also play a role in chronic fatigue syndrome.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Jason, L A·The journal of primary prevention·1993

This 1993 paper explores how the mind, nervous system, and immune system are connected in ME/CFS, and how community support might help with recovery. The authors use a real patient's story to show how understanding these connections and building supportive relationships could be helpful for people struggling with this illness.

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome. A fresh look at an old problem.

McSherry, J·Canadian family physician Medecin de famille canadien·1993

This editorial discusses chronic fatigue syndrome (ME/CFS) as a real medical condition affecting about 3 in 100,000 people. Most patients experience symptoms for approximately 2.5 years before recovering to normal health. Since there is no single definitive test, doctors diagnose ME/CFS by ruling out other diseases, and currently no one treatment works for everyone.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Ware, N C·Ciba Foundation symposium·1993

This study interviewed 50 people with chronic fatigue to understand how their daily lives, families, and work environments shaped their experience of illness. The researchers found that people often traced their illness to stressful life events and busy lifestyles, and that having ME/CFS sometimes led them to make positive changes by slowing down. The study also explains why ME/CFS patients often feel dismissed—society tends to separate 'mind' from 'body,' making psychological factors seem less real than physical ones.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue in historical perspective.

Shorter, E·Ciba Foundation symposium·1993

This historical review examines how chronic fatigue as an illness has been understood and named over the past 150 years. The author traces how doctors have called similar conditions by different names—from 'neurasthenia' in the 1800s to 'myalgic encephalomyelitis,' 'chronic Epstein-Barr virus infection,' and 'fibromyalgia'—and explains how these separate medical concepts have recently begun to converge into what we now call chronic fatigue syndrome. The study shows that chronic fatigue became increasingly common in Europe and North America by the early 1900s, though it was rarely documented before the mid-1800s.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Hypothesis: the nasal fatigue reflex.

Chester, A C·Integrative physiological and behavioral science : the official journal of the Pavlovian Society·1993

This paper proposes a new theory: that extreme fatigue in ME/CFS and related conditions might be the body's protective reflex triggered by nasal or sinus problems. The idea is that in our evolutionary past, when a good sense of smell was crucial for survival, fatigue would have kept sick animals resting safely at home while their nose healed. The author suggests this ancient reflex may still be active in humans today.

E3 PreliminaryCohortPEM not requiredObservational

Chronic fatigue syndrome: studies on skeletal muscle.

Grau, J M, Casademont, J, Pedrol, E et al.·Clinical neuropathology·1992

This study looked at muscle tissue samples from 20 ME/CFS patients to understand why muscles feel so tired and weak. The researchers found that most patients had either normal muscle tissue or only minor changes, and they did not find the patterns of inflammation typically seen in viral muscle diseases. The study also tested whether L-carnitine supplements could help patients improve over three months, but found no clinical benefit.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E et al.·Revista clinica espanola·1992

This review summarizes what scientists know about human herpesvirus type 6 (HHV-6), a common virus that most people carry their whole lives. The virus can cause rash illnesses in children and mono-like symptoms in adults, and some research suggests it might play a role in chronic fatigue syndrome and other long-term illnesses.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Rheumatic fever and disorders of the musculoskeletal system.

Coovadia, H M·Current opinion in rheumatology·1992

This editorial reviews recent findings about rheumatic fever and other muscle and bone disorders, including a brief mention of chronic fatigue syndrome in children. The authors discuss new understanding of how certain infections cause these conditions and how doctors can better diagnose and treat them.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue immune dysfunction syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

ME/CFS causes extreme tiredness that lasts longer than six months and may be linked to a viral infection that doesn't go away normally. Researchers found that people with ME/CFS have problems with immune cells, especially natural killer (NK) cells, which normally help fight off viruses and control the immune system. When NK cell function improved in some patients, their ME/CFS symptoms got better, suggesting that fixing these immune cells might be key to recovery.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Winters, E G, Quinet, R J·The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1992

ME/CFS is a complex illness characterized by severe, debilitating fatigue that often starts suddenly with flu-like symptoms. While researchers have investigated viruses and immune system changes in ME/CFS patients, no single cause has been definitively identified. Currently, there is no specific cure, though cognitive behavioral therapy and certain medications may help some patients manage their condition.

Immune System

E3 PreliminaryPEM not required

Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome.

Drago, F, Romagnoli, M, Loi, A et al.·Archives of dermatology·1992

This case study describes a single patient with ME/CFS who developed an unusual, long-lasting skin rash called erythema multiforme that didn't respond to standard steroid treatment. Researchers found evidence of Epstein-Barr virus (EBV)—the virus that causes infectious mononucleosis—in the skin lesions and other body tissues. The rash improved when the patient was treated with an antiviral medication (acyclovir), but returned when the medication was stopped.

Immune System

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Low NK syndrome and its relationship to chronic fatigue syndrome.

Ways of coping with chronic fatigue syndrome: development of an illness management questionnaire.

[The chronic fatigue syndrome associated with Epstein-Barr virus infection].

Exercise performance and fatiguability in patients with chronic fatigue syndrome.

Somatization, illness attribution and the sociocultural psychiatry of chronic fatigue syndrome.

Pharmacological approaches to the therapy of chronic fatigue syndrome.

Central basis of muscle fatigue in chronic fatigue syndrome.

Is juvenile diabetes a viral disease?

Chronic Fatigue Syndrome: New hope from psychoneuroimmunology and community psychology.

Chronic fatigue syndrome. A fresh look at an old problem.

Society, mind and body in chronic fatigue syndrome: an anthropological view.

Chronic fatigue in historical perspective.

Hypothesis: the nasal fatigue reflex.

Chronic fatigue syndrome: studies on skeletal muscle.

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Rheumatic fever and disorders of the musculoskeletal system.

[Chronic fatigue immune dysfunction syndrome].

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Chronic fatigue syndrome.

Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome.

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