ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6021–6040 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue immune dysfunction syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

ME/CFS causes extreme tiredness that lasts longer than six months and may be linked to a viral infection that doesn't go away normally. Researchers found that people with ME/CFS have problems with immune cells, especially natural killer (NK) cells, which normally help fight off viruses and control the immune system. When NK cell function improved in some patients, their ME/CFS symptoms got better, suggesting that fixing these immune cells might be key to recovery.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Rheumatic fever and disorders of the musculoskeletal system.

Coovadia, H M·Current opinion in rheumatology·1992

This editorial reviews recent findings about rheumatic fever and other muscle and bone disorders, including a brief mention of chronic fatigue syndrome in children. The authors discuss new understanding of how certain infections cause these conditions and how doctors can better diagnose and treat them.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Kitani, T, Kuratsune, H, Yamaguchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

In 1992, Japanese researchers created new diagnostic guidelines to help doctors identify ME/CFS in their patients. These guidelines were based on earlier American standards but included some modifications, such as defining less severe cases and recognizing a form that develops after infections.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome: the present concept and historical perspective].

Kitani, T·Nihon rinsho. Japanese journal of clinical medicine·1992

This is an editorial article that reviews what ME/CFS (chronic fatigue syndrome) is and how our understanding of it has changed over time. The author examines the current definition of ME/CFS and discusses its history, helping readers understand how medical perspectives on this illness have evolved.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E et al.·Revista clinica espanola·1992

This review summarizes what scientists know about human herpesvirus type 6 (HHV-6), a common virus that most people carry their whole lives. The virus can cause rash illnesses in children and mono-like symptoms in adults, and some research suggests it might play a role in chronic fatigue syndrome and other long-term illnesses.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Psychological aspects of chronic fatigue syndrome.

Murray, J B·Perceptual and motor skills·1992

This review examined how psychological factors relate to chronic fatigue syndrome (ME/CFS). The author looked at existing research to understand the mental and emotional aspects of living with this illness. This work helps clarify that ME/CFS involves psychological dimensions that are important to understand and address in patient care.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Kanayama, Y·Nihon rinsho. Japanese journal of clinical medicine·1992

This review article describes the main symptoms and characteristics of ME/CFS, including persistent fatigue lasting more than 6 months, low-grade fevers, swollen lymph nodes, muscle and joint pain, and mood-related symptoms. Since no specific blood test or scan can definitively diagnose ME/CFS, doctors must rule out other known causes of fatigue before making the diagnosis. The underlying cause remains unknown, though researchers suspect it may involve an infection combined with psychological factors.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

Chronic fatigue syndrome: studies on skeletal muscle.

Grau, J M, Casademont, J, Pedrol, E et al.·Clinical neuropathology·1992

This study looked at muscle tissue samples from 20 ME/CFS patients to understand why muscles feel so tired and weak. The researchers found that most patients had either normal muscle tissue or only minor changes, and they did not find the patterns of inflammation typically seen in viral muscle diseases. The study also tested whether L-carnitine supplements could help patients improve over three months, but found no clinical benefit.

Immune System

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].

Kato, Y, Kamijima, S, Kashiwagi, A et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study describes two women with ME/CFS who had unusual medical findings. One woman had very high levels of antibodies to HHV-6, a virus that may reactivate in ME/CFS patients. The second woman's ME/CFS symptoms improved when she had high blood pressure and a hormone imbalance, but her symptoms returned after surgery to remove an adrenal gland. These cases suggest that viruses and hormones might play a role in ME/CFS, though more research is needed to understand how.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome.

James, D G, Brook, M G, Bannister, B A·Postgraduate medical journal·1992

This 1992 review article discusses chronic fatigue syndrome (ME/CFS), a condition causing severe tiredness that doesn't improve with rest. The authors examine what was known about the illness at that time, including how it affects patients and possible causes. This early medical overview helped establish ME/CFS as a recognized health condition worthy of serious medical attention.

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: considerations relevant to children and adolescents.

Dale, J K, Straus, S E·Advances in pediatric infectious diseases·1992

This paper reviews how ME/CFS (chronic fatigue syndrome) presents differently in children and teenagers compared to adults. The authors discuss important clinical considerations for recognizing and understanding the condition in younger patients. The review highlights that children and adolescents with ME/CFS face unique challenges in diagnosis and management.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Viral infection and its causative role for chronic fatigue syndrome].

Okano, M·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines whether viral infections, particularly Epstein-Barr virus (EBV), cause ME/CFS. The author notes that ME/CFS shares symptoms with chronic EBV infection—including fatigue, swollen lymph nodes, and fever—but the connection remains unclear. The review also discusses a more severe condition called severe chronic active EBV infection and highlights that the true cause and best treatment for ME/CFS are still unknown.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Bauermeister, C D, Wagner, C, Brede, H D·Medizinische Monatsschrift fur Pharmazeuten·1992

This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Berneman, Z N, Ablashi, D V, Li, G et al.·Proceedings of the National Academy of Sciences of the United States of America·1992

Researchers isolated a virus called HHV-7 from a patient with ME/CFS and studied how it infects cells. They found that HHV-7 is related to another herpesvirus (HHV-6) but is genetically different enough to be classified as its own distinct virus. However, the study found no clear link between HHV-7 and ME/CFS in the general population.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

McCluskey, D R, Riley, M S·Comprehensive therapy·1992

ME/CFS likely involves multiple different problems happening in the body at the same time, rather than one single cause. Most patients get sick after a viral infection, but scientists haven't found clear evidence the virus stays in the body long-term. People with ME/CFS have real physical limitations in how much exercise they can do, and they may perceive their own effort and tiredness differently than healthy people do.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

Ur, E, White, P D, Grossman, A·European archives of psychiatry and clinical neuroscience·1992

This paper proposes that certain immune signals in the brain called cytokines (particularly IL-1 and IL-6) may become overactive in ME/CFS and depression, triggering a chain reaction in the body's stress system that produces fatigue and other symptoms. The authors suggest that viral infections might trigger this cytokine activation. While this is a theoretical proposal rather than a study with patient data, it offered an important new way of thinking about what causes chronic fatigue and depression.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Severe chronic fatigue syndrome in chidhood: A discussion of psychopathological mechanisms.

Garralda, M Elena·European child & adolescent psychiatry·1992

This study describes two children with severe ME/CFS and explores how psychological factors might contribute to maintaining the illness. The researchers found that viral infections, depression, personality traits, and family relationships may all play a role in how the condition develops and persists in children. Both children improved with appropriate treatment, suggesting that addressing these various factors together can help with recovery.

E3 PreliminaryCohortPEM not requiredCase-Control

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Welch, L S, Sokas, R·Toxicology and industrial health·1992

When workers were exposed to problems in a building (sick-building syndrome), some developed multiple chemical sensitivity (MCS)—a condition where people react to low levels of chemicals. This study looked at 20 people affected by the outbreak and found that most had existing health conditions like allergies or asthma that got worse. Importantly, having ME/CFS did not predict who would develop MCS, and many people had ongoing problems beyond just MCS after leaving the building.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredObservational

Chronic Fatigue Syndrome: Do herbs or homeopathy help?

Leyton, E, Pross, H·Canadian family physician Medecin de famille canadien·1992

This study tested whether herbal and homeopathic treatments could help six ME/CFS patients feel better. Researchers tracked symptoms and measured blood markers before and after treatment. The treatments did not produce any measurable improvements in symptoms or immune function.

Interventions

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Evidence browser

[Chronic fatigue immune dysfunction syndrome].

Rheumatic fever and disorders of the musculoskeletal system.

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

[Chronic fatigue syndrome: the present concept and historical perspective].

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Psychological aspects of chronic fatigue syndrome.

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Chronic fatigue syndrome: studies on skeletal muscle.

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].

The chronic fatigue syndrome.

The chronic fatigue syndrome: considerations relevant to children and adolescents.

[Viral infection and its causative role for chronic fatigue syndrome].

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Chronic fatigue syndrome.

Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

Severe chronic fatigue syndrome in chidhood: A discussion of psychopathological mechanisms.

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Chronic Fatigue Syndrome: Do herbs or homeopathy help?

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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