ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6041–6060 of 6,188 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

Kanayama, Y·Nihon rinsho. Japanese journal of clinical medicine·1992

This review article describes the main symptoms and characteristics of ME/CFS, including persistent fatigue lasting more than 6 months, low-grade fevers, swollen lymph nodes, muscle and joint pain, and mood-related symptoms. Since no specific blood test or scan can definitively diagnose ME/CFS, doctors must rule out other known causes of fatigue before making the diagnosis. The underlying cause remains unknown, though researchers suspect it may involve an infection combined with psychological factors.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

The chronic fatigue syndrome: considerations relevant to children and adolescents.

Dale, J K, Straus, S E·Advances in pediatric infectious diseases·1992

This paper reviews how ME/CFS (chronic fatigue syndrome) presents differently in children and teenagers compared to adults. The authors discuss important clinical considerations for recognizing and understanding the condition in younger patients. The review highlights that children and adolescents with ME/CFS face unique challenges in diagnosis and management.

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunologically mediated fatigue: a murine model.

Chao, C C, DeLaHunt, M, Hu, S et al.·Clinical immunology and immunopathology·1992

Researchers infected mice with agents that trigger immune system activation and found that the mice became fatigued—they ran much less on their exercise wheels and took longer to groom themselves after swimming. The infected mice also showed elevated levels of a immune signaling molecule called TGF-beta, which is also found at high levels in ME/CFS patients. This study suggests that an overly active immune response may be directly responsible for the fatigue experienced in ME/CFS.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples.

Ho-Yen, D O, Joss, A W, Balfour, A H et al.·Journal of clinical pathology·1992

This study tested a laboratory technique called PCR to detect a parasite called Toxoplasma gondii in blood samples. Researchers found that PCR was fast, accurate, and sensitive enough to detect even very small amounts of the parasite. The test helped doctors decide whether patients needed treatment, especially those with weakened immune systems.

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E et al.·Revista clinica espanola·1992

This review summarizes what scientists know about human herpesvirus type 6 (HHV-6), a common virus that most people carry their whole lives. The virus can cause rash illnesses in children and mono-like symptoms in adults, and some research suggests it might play a role in chronic fatigue syndrome and other long-term illnesses.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Winters, E G, Quinet, R J·The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1992

ME/CFS is a complex illness characterized by severe, debilitating fatigue that often starts suddenly with flu-like symptoms. While researchers have investigated viruses and immune system changes in ME/CFS patients, no single cause has been definitively identified. Currently, there is no specific cure, though cognitive behavioral therapy and certain medications may help some patients manage their condition.

Immune System

E3 PreliminaryCohortPEM not requiredObservational

Chronic fatigue syndrome: studies on skeletal muscle.

Grau, J M, Casademont, J, Pedrol, E et al.·Clinical neuropathology·1992

This study looked at muscle tissue samples from 20 ME/CFS patients to understand why muscles feel so tired and weak. The researchers found that most patients had either normal muscle tissue or only minor changes, and they did not find the patterns of inflammation typically seen in viral muscle diseases. The study also tested whether L-carnitine supplements could help patients improve over three months, but found no clinical benefit.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Berneman, Z N, Ablashi, D V, Li, G et al.·Proceedings of the National Academy of Sciences of the United States of America·1992

Researchers isolated a virus called HHV-7 from a patient with ME/CFS and studied how it infects cells. They found that HHV-7 is related to another herpesvirus (HHV-6) but is genetically different enough to be classified as its own distinct virus. However, the study found no clear link between HHV-7 and ME/CFS in the general population.

Immune System

E3 PreliminaryBehavioralPEM not required

Chronic fatigue syndrome and women: can therapy help?

Burke, S G·Social work·1992

This article discusses how therapy can help people with ME/CFS, a condition that affects more women than men, typically between ages 25 and 55. The author shares a real case story of a woman with ME/CFS and describes how a mental health professional worked with her to address both the physical symptoms of the illness and emotional challenges like depression that often come with it. The article emphasizes that effective treatment needs to consider the patient's medical condition, emotions, relationships, and life circumstances all together.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue immune dysfunction syndrome].

Uchida, A·Nihon rinsho. Japanese journal of clinical medicine·1992

ME/CFS causes extreme tiredness that lasts longer than six months and may be linked to a viral infection that doesn't go away normally. Researchers found that people with ME/CFS have problems with immune cells, especially natural killer (NK) cells, which normally help fight off viruses and control the immune system. When NK cell function improved in some patients, their ME/CFS symptoms got better, suggesting that fixing these immune cells might be key to recovery.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Definition of the chronic fatigue syndrome and its issues].

Hashimoto, N·Nihon rinsho. Japanese journal of clinical medicine·1992

This article reviews how ME/CFS was officially defined by the CDC in 1988 and identifies problems with that definition. The author points out that while the definition tries to rule out other conditions, it has trouble distinguishing ME/CFS from similar conditions like fibromyalgia and depression, and it's difficult to measure in real-world clinical practice.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Ware, N C, Kleinman, A·Psychosomatic medicine·1992

This study examines how culture and social life shape the experience of ME/CFS and related illnesses. The researchers found that symptoms don't just come from the body—they are also influenced by what happens in patients' relationships, work, and daily lives. When patients' life circumstances improve, their symptoms often improve too, showing that body and society are deeply connected.

E3 PreliminaryCohortPEM not requiredCase-Control

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Welch, L S, Sokas, R·Toxicology and industrial health·1992

When workers were exposed to problems in a building (sick-building syndrome), some developed multiple chemical sensitivity (MCS)—a condition where people react to low levels of chemicals. This study looked at 20 people affected by the outbreak and found that most had existing health conditions like allergies or asthma that got worse. Importantly, having ME/CFS did not predict who would develop MCS, and many people had ongoing problems beyond just MCS after leaving the building.

Pain and Sensitization

E3 PreliminaryCommentaryPEM not requiredEditorial

Rheumatic fever and disorders of the musculoskeletal system.

Coovadia, H M·Current opinion in rheumatology·1992

This editorial reviews recent findings about rheumatic fever and other muscle and bone disorders, including a brief mention of chronic fatigue syndrome in children. The authors discuss new understanding of how certain infections cause these conditions and how doctors can better diagnose and treat them.

E3 PreliminaryMechanismPEM not requiredObservational

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

Goodnick, P J, Sandoval, R, Brickman, A et al.·Biological psychiatry·1992

This study tested whether bupropion, an antidepressant medication, could help ME/CFS patients who didn't benefit from or couldn't tolerate fluoxetine (another antidepressant). Nine patients took 300 mg of bupropion daily for 8 weeks and showed significant improvement in depression symptoms. The researchers also found that bupropion appeared to affect certain brain chemicals and immune markers in ways that correlated with symptom improvement.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

McCluskey, D R, Riley, M S·Comprehensive therapy·1992

ME/CFS likely involves multiple different problems happening in the body at the same time, rather than one single cause. Most patients get sick after a viral infection, but scientists haven't found clear evidence the virus stays in the body long-term. People with ME/CFS have real physical limitations in how much exercise they can do, and they may perceive their own effort and tiredness differently than healthy people do.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

Ur, E, White, P D, Grossman, A·European archives of psychiatry and clinical neuroscience·1992

This paper proposes that certain immune signals in the brain called cytokines (particularly IL-1 and IL-6) may become overactive in ME/CFS and depression, triggering a chain reaction in the body's stress system that produces fatigue and other symptoms. The authors suggest that viral infections might trigger this cytokine activation. While this is a theoretical proposal rather than a study with patient data, it offered an important new way of thinking about what causes chronic fatigue and depression.

Immune System

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Evidence browser

[Chronic fatigue syndrome--symptoms, signs, laboratory tests, and prognosis].

The chronic fatigue syndrome: considerations relevant to children and adolescents.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Immunologically mediated fatigue: a murine model.

Use of the polymerase chain reaction to detect Toxoplasma gondii in human blood samples.

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].

Chronic fatigue syndrome.

Chronic fatigue syndrome: studies on skeletal muscle.

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Chronic fatigue syndrome and women: can therapy help?

[Chronic fatigue immune dysfunction syndrome].

[Definition of the chronic fatigue syndrome and its issues].

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Rheumatic fever and disorders of the musculoskeletal system.

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

Chronic fatigue syndrome.

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Hypothesis: cytokines may be activated to cause depressive illness and chronic fatigue syndrome.

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Biomarkers

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