ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

6061–6080 of 6,211 studies

E3 PreliminaryBehavioralPEM not required

Chronic fatigue syndrome and women: can therapy help?

Burke, S G·Social work·1992

This article discusses how therapy can help people with ME/CFS, a condition that affects more women than men, typically between ages 25 and 55. The author shares a real case story of a woman with ME/CFS and describes how a mental health professional worked with her to address both the physical symptoms of the illness and emotional challenges like depression that often come with it. The article emphasizes that effective treatment needs to consider the patient's medical condition, emotions, relationships, and life circumstances all together.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Ware, N C, Kleinman, A·Psychosomatic medicine·1992

This study examines how culture and social life shape the experience of ME/CFS and related illnesses. The researchers found that symptoms don't just come from the body—they are also influenced by what happens in patients' relationships, work, and daily lives. When patients' life circumstances improve, their symptoms often improve too, showing that body and society are deeply connected.

E3 PreliminaryCohortPEM not requiredCase-Control

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

Welch, L S, Sokas, R·Toxicology and industrial health·1992

When workers were exposed to problems in a building (sick-building syndrome), some developed multiple chemical sensitivity (MCS)—a condition where people react to low levels of chemicals. This study looked at 20 people affected by the outbreak and found that most had existing health conditions like allergies or asthma that got worse. Importantly, having ME/CFS did not predict who would develop MCS, and many people had ongoing problems beyond just MCS after leaving the building.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Bauermeister, C D, Wagner, C, Brede, H D·Medizinische Monatsschrift fur Pharmazeuten·1992

This 1992 study investigated whether a common virus called human herpesvirus 6 (HHV-6) might be connected to ME/CFS. Researchers examined the relationship between this virus and chronic fatigue syndrome symptoms. While early research suggested a possible link, this study represents early work in understanding whether HHV-6 plays a role in the disease.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome. A review from the general practice perspective.

Holmwood, C, Shannon, C·Australian family physician·1992

This 1992 editorial confirms that ME/CFS is a real condition that significantly impacts people's quality of life, though the exact cause was not yet known. The authors suggest that treatment should focus on supportive counseling, explanation of the condition, psychiatric support when needed, and gradually increasing activity levels to help people return to normal functioning.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Klonoff, D C·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1992

ME/CFS is a complex illness characterized by persistent fatigue and other symptoms, but doctors currently have no blood test or scan to diagnose it—they rely instead on what patients report. Research has identified that several factors may increase risk of developing ME/CFS, including viral infections, mental health conditions, and allergies, and studies show problems across multiple body systems including immune, nervous, hormone, and muscle function. While there is no cure yet, treatments like exercise, counseling, and medications can help manage some symptoms.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

Chronic fatigue syndrome: studies on skeletal muscle.

Grau, J M, Casademont, J, Pedrol, E et al.·Clinical neuropathology·1992

This study looked at muscle tissue samples from 20 ME/CFS patients to understand why muscles feel so tired and weak. The researchers found that most patients had either normal muscle tissue or only minor changes, and they did not find the patterns of inflammation typically seen in viral muscle diseases. The study also tested whether L-carnitine supplements could help patients improve over three months, but found no clinical benefit.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome in school children].

Kawa, K·Nihon rinsho. Japanese journal of clinical medicine·1992

This review examines chronic fatigue syndrome (ME/CFS) in school-age children, a population that is often overlooked since most known cases occur in adults over 30. The authors emphasize that ME/CFS causes long-lasting, disabling fatigue lasting at least 6 months that cannot be explained by other medical conditions. They stress the importance of understanding how the brain, hormonal system, and immune system interact in ME/CFS, and note that doctors must carefully distinguish ME/CFS from school absence due to other reasons or psychological disorders.

E3 PreliminaryMechanismPEM not requiredMechanistic

Immunologically mediated fatigue: a murine model.

Chao, C C, DeLaHunt, M, Hu, S et al.·Clinical immunology and immunopathology·1992

Researchers infected mice with agents that trigger immune system activation and found that the mice became fatigued—they ran much less on their exercise wheels and took longer to groom themselves after swimming. The infected mice also showed elevated levels of a immune signaling molecule called TGF-beta, which is also found at high levels in ME/CFS patients. This study suggests that an overly active immune response may be directly responsible for the fatigue experienced in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Winters, E G, Quinet, R J·The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1992

ME/CFS is a complex illness characterized by severe, debilitating fatigue that often starts suddenly with flu-like symptoms. While researchers have investigated viruses and immune system changes in ME/CFS patients, no single cause has been definitively identified. Currently, there is no specific cure, though cognitive behavioral therapy and certain medications may help some patients manage their condition.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].

Takahashi, H, Imai, K, Katanuma, A et al.·Arerugi = [Allergy]·1992

This case study describes a 29-year-old woman with ME/CFS who had severe fatigue, fever, swollen lymph nodes, and muscle pain that didn't improve with standard treatments. When doctors gave her intravenous magnesium sulphate once a week for about 6 weeks, her extreme tiredness improved and she was able to do more daily activities, eventually leaving the hospital.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Berneman, Z N, Ablashi, D V, Li, G et al.·Proceedings of the National Academy of Sciences of the United States of America·1992

Researchers isolated a virus called HHV-7 from a patient with ME/CFS and studied how it infects cells. They found that HHV-7 is related to another herpesvirus (HHV-6) but is genetically different enough to be classified as its own distinct virus. However, the study found no clear link between HHV-7 and ME/CFS in the general population.

Immune System

E3 PreliminaryBehavioralPEM not requiredCase-Control

Psychosocial management of chronic fatigue syndrome in adolescence.

Rikard-Bell, C J, Waters, B G·The Australian and New Zealand journal of psychiatry·1992

This study looked at how to help teenagers with ME/CFS using rehabilitation approaches that focus on practical recovery rather than debating what causes the illness. The authors present two case studies of adolescents with different outcomes and suggest that avoiding arguments about whether ME/CFS is 'all in the mind' or biological helps doctors provide better, more consistent care.

E3 PreliminaryMechanismPEM not requiredObservational

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

Demitrack, M A, Gold, P W, Dale, J K et al.·Biological psychiatry·1992

This study measured chemical messengers in the blood and spinal fluid of people with ME/CFS and compared them to healthy individuals. Researchers found that people with ME/CFS had lower levels of one chemical (MHPG, related to stress response) and higher levels of another (5-HIAA, related to mood regulation). These differences suggest ME/CFS may have biological markers that distinguish it from purely psychiatric conditions.

Endocrine Disruption

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Kitani, T, Kuratsune, H, Yamaguchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

In 1992, Japanese researchers created new diagnostic guidelines to help doctors identify ME/CFS in their patients. These guidelines were based on earlier American standards but included some modifications, such as defining less severe cases and recognizing a form that develops after infections.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Search for retrovirus in the chronic fatigue syndrome.

Gow, J W, Simpson, K, Schliephake, A et al.·Journal of clinical pathology·1992

Researchers tested blood and muscle tissue from 30 ME/CFS patients to see if a virus called a retrovirus might be causing the illness. They used sensitive laboratory techniques to look for viral genetic material. They found no evidence that retroviruses were present in any of the patients tested, suggesting that this particular type of virus is not responsible for ME/CFS.

E3 PreliminaryCohortPEM unclearObservational

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Hashimoto, N, Kuraishi, Y, Yokose, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study identified 51 patients with ME/CFS diagnosed using official CDC criteria between 1991 and 1992. Most patients were women in their 20s–30s who had been seen by many doctors before receiving a correct diagnosis. Standard blood tests did not reveal abnormal findings, though some immune markers were mildly abnormal. About 57% of patients showed general improvement, and doctors used various medications to manage severe symptoms.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Downey, D C·Medical hypotheses·1992

This study examined 19 patients with severe fatigue who showed unusual reactions to copper-containing bracelets or necklaces. The researchers found that 8 of these patients had deficiencies in enzymes related to heme (a component of blood), and suggested that problems with copper metabolism and heme processing might explain fatigue in conditions like ME/CFS, multiple sclerosis, and other disorders.

Biomarkers

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

Goodnick, P J, Sandoval, R, Brickman, A et al.·Biological psychiatry·1992

This study tested whether bupropion, an antidepressant medication, could help ME/CFS patients who didn't benefit from or couldn't tolerate fluoxetine (another antidepressant). Nine patients took 300 mg of bupropion daily for 8 weeks and showed significant improvement in depression symptoms. The researchers also found that bupropion appeared to affect certain brain chemicals and immune markers in ways that correlated with symptom improvement.

Interventions

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Evidence browser

Chronic fatigue syndrome and women: can therapy help?

Culture and somatic experience: the social course of illness in neurasthenia and chronic fatigue syndrome.

Development of multiple chemical sensitivity after an outbreak of sick-building syndrome.

[What is the relation of human herpesvirus 6 to chronic fatigue syndrome?].

Chronic fatigue syndrome. A review from the general practice perspective.

Chronic fatigue syndrome.

Chronic fatigue syndrome: studies on skeletal muscle.

[Chronic fatigue syndrome in school children].

Immunologically mediated fatigue: a murine model.

Chronic fatigue syndrome.

[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].

Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.

Psychosocial management of chronic fatigue syndrome in adolescence.

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings.

[Diagnostic criteria for chronic fatigue syndrome by the CFS Study Group in Japan].

Search for retrovirus in the chronic fatigue syndrome.

[Chronic fatigue syndrome--51 cases in the Jikei University School of Medicine].

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Bupropion treatment of fluoxetine-resistant chronic fatigue syndrome.

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