ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

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Evidence of mitochondrial dysfunction and impaired redox signalling in a subgroup of patients with myalgic encephalomyelitis/chronic fatigue syndrome

Cara Tomas, Jessica Newton, Stuart Watson·The EPMA Journal·2017·n=25

This UK study analyzed mitochondrial function in immune cells from ME/CFS patients using the Seahorse assay. They found reduced ATP production capacity, impaired electron transport chain function, and altered redox signaling in a subgroup of ME/CFS patients compared to healthy controls.

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Evidence of mitochondrial dysfunction and impaired redox signalling in a subgroup of patients with myalgic encephalomyelitis/chronic fatigue syndrome

Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome.

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism.

Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome.

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.

Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms.

Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?

Irritable bowel syndrome may be associated with maternal inheritance and mitochondrial DNA control region sequence variants.

HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?

Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology.

The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission.

Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity.

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome.

Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.

Physiological cost of walking in those with chronic fatigue syndrome (CFS): a case-control study.

Chronic fatigue syndrome and mitochondrial dysfunction.

Transcription profile analysis of vastus lateralis muscle from patients with chronic fatigue syndrome.

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