ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

661–680 of 1,186 studies

E3 PreliminaryMechanismPEM unclearObservational

A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life, and Immunologic Variables in Long COVID.

Abbasi, Asghar, Gattoni, Chiara, Iacovino, Michelina et al.·Journal of clinical medicine·2024

This study tested whether supervised aerobic exercise training could help people with long COVID. Fourteen participants completed 20 sessions of exercise training over 10 weeks. After training, people reported feeling less fatigued, less anxious and depressed, and had better heart and lung fitness—without experiencing harmful immune system changes.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Clinical Remission After Therapeutic Apheresis in a Patient Suffering from Long Term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case Report.

Burgard, Harald·International medical case reports journal·2024

This case report describes one woman with ME/CFS for over 15 years who underwent a blood-cleaning treatment called double-filtration apheresis eight times over two years. After treatment, she experienced significant improvement in her fatigue, thinking problems, and other symptoms, with benefits that lasted over time. While this is promising, it is based on just one patient's experience and needs much larger studies to confirm whether this treatment works for others with ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome.

Iu, David S, Maya, Jessica, Vu, Luyen T et al.·Proceedings of the National Academy of Sciences of the United States of America·2024

This study found that certain immune cells called CD8+ T cells in people with ME/CFS show signs of exhaustion—they appear worn out and unable to function properly. Researchers used advanced techniques to examine the genes active in these cells and discovered that the cells have shifted into a state similar to what happens when the immune system fights a long-lasting infection. This exhaustion might explain some of the immune system problems seen in ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Kavyani, Bahar, Ahn, Seong Beom, Missailidis, Daniel et al.·Molecular neurobiology·2024

This study found that ME/CFS patients have imbalances in a particular chemical pathway in their body (the kynurenine pathway) that appears connected to inflammation and symptom severity. The researchers discovered that higher levels of one early chemical in this pathway correlated with worse symptoms, while lower levels of later chemicals in the pathway might affect how cells produce energy. Interestingly, they also found that five of the most significantly changed proteins in ME/CFS patients are involved in gut health, suggesting the gut microbiome may play an important role in the disease.

Energy MetabolismBiomarkersImmune SystemGut Microbiome

E3 PreliminaryCohortPEM unclearCase-Control

Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity.

Jahanbani, Fereshteh, Sing, Justin Cyril, Maynard, Rajan Douglas et al.·Frontiers in immunology·2024

This study tracked one very severely ill ME/CFS patient over time, measuring immune system markers and detailed health information. Researchers found that the patient's immune system was shifted toward a Th2-type response (typically seen in allergies), with unusually high levels of certain immune chemicals. The study also introduced new smartphone apps to help patients and doctors track symptoms and treatment responses in real time.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies.

Annesley, Sarah J, Missailidis, Daniel, Heng, Benjamin et al.·Trends in molecular medicine·2024

This article reviews recent research on ME/CFS and long COVID, two illnesses that share similar symptoms and may have overlapping causes. ME/CFS typically develops after a viral infection and can last for many years, while long COVID is a newer condition affecting some people recovering from COVID-19. By studying ME/CFS, which has been around longer, researchers hope to better understand what might happen to long COVID patients over time and develop better treatments and tests for both conditions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases.

Sokolovska, Liba, Cistjakovs, Maksims, Matroze, Asnate et al.·Microorganisms·2024

This review examines how Human Herpesvirus 6 (HHV-6), a virus that most people carry, might trigger autoimmune diseases where the immune system mistakenly attacks the body's own cells. The virus can hide in the body for years and reactivate later, and it appears to interfere with immune system function. Researchers found evidence linking HHV-6 to several autoimmune conditions, including multiple sclerosis and thyroid disease.

Immune System

E3 PreliminaryMechanismPEM requiredMechanistic

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.

Vu, Luyen Tien, Ahmed, Faraz, Zhu, Hongya et al.·Cell reports. Medicine·2024

Researchers used advanced technology to examine immune cells from ME/CFS patients and healthy controls, both at rest and after exercise. They found that ME/CFS patients have problems with a type of immune cell called monocytes that appear abnormal and may be moving into tissues inappropriately. After exercise, patients showed additional problems with platelets (cells involved in blood clotting), suggesting the disease involves multiple layers of immune system dysfunction.

Post-Exertional MalaiseImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Jensen, Michael Anthony, Dafoe, Miranda Lee, Wilhelmy, Julie et al.·Biochemistry·2024

Researchers found that some ME/CFS patients may have special antibodies in their blood that can break down myelin, the protective coating around nerves. This breakdown could explain nerve pain and muscle weakness in ME/CFS. The study also showed that a drug already approved for multiple sclerosis might be able to stop this harmful antibody activity.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target.

Sasso, Etianne Martini, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Frontiers in immunology·2024

Researchers observed that a type of immune cell in people with post-COVID-19 condition has altered activity in an ion channel called TRPM3, similar to what has been reported in ME/CFS patients. In a small laboratory study, when cells from post-COVID-19 patients were treated with naltrexone (a medication used in some ME/CFS research), the TRPM3 channel activity appeared to be restored in test-tube conditions. However, these are very early findings from laboratory experiments with only 9 patients per group, and it remains unclear whether this observation would translate to clinical benefit in people.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing.

Zheng, Daisi, Li, Xiaolong, Wang, Peicheng et al.·Frontiers in immunology·2024

Researchers discovered that ME/CFS and lupus (SLE) may share similar immune problems, particularly involving immune cells called monocytes that become overactive and produce excess inflammation. By studying genes and immune cells from both diseases, they identified five key inflammatory proteins that appear important in fatigue, and they predict that certain existing drugs—particularly N-acetyl-L-cysteine and camptothecin—might help reduce this inflammation.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution.

Reich, Jana, Serdar, Dilan, Weißmann, Ann-Christin et al.·Journal of virology·2024

This study focuses on improving laboratory techniques for studying HHV-6A, a common virus that stays dormant in the body for life. Researchers tested different methods to grow this virus in the lab more efficiently, discovering that certain immune-suppressing drugs and low-oxygen conditions help the virus replicate better. While this doesn't directly treat ME/CFS patients, understanding how HHV-6A behaves in the lab is an important step toward developing better treatments.

Immune System

E3 PreliminaryCohortPEM requiredCross-Sectional

Immune exhaustion in ME/CFS and long COVID.

Eaton-Fitch, Natalie, Rudd, Penny, Er, Teagan et al.·JCI insight·2024

This study looked at immune system genes in blood samples from people with ME/CFS and long COVID to understand why their immune systems aren't working properly. Researchers found that people with ME/CFS had reduced immune signaling and infection-fighting genes, suggesting immune suppression, while long COVID patients showed different patterns of immune dysregulation. These findings suggest that both conditions involve problems with how the immune system activates and responds, which may help explain why people with these illnesses struggle with persistent symptoms.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.

Lockwood, Mark B, Sung, Choa, Alvernaz, Suzanne A et al.·Biological research for nursing·2024

Kidney transplant patients often feel very tired and sick even after their new kidney works well. Scientists think the bacteria living in our digestive system might explain why this happens. Transplant medications can change these helpful bacteria, which may affect how our immune system, hormones, and brain work together. This article explores how fixing the gut bacteria might help transplant patients feel better.

Immune SystemGut Microbiome

E3 PreliminaryMechanismPEM not requiredMechanistic

An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.

Bondar, Galyna, Mahapatra, Abhinandan Das, Bao, Tra-Mi et al.·Journal of clinical medicine·2024

This study examined how genes in immune cells respond to exercise in people with heart failure and healthy volunteers. Researchers took blood samples before, during, and after exercise on a stationary bike and looked for changes in gene activity. They found that certain genes responded differently to exercise depending on how fit someone was, suggesting that gene patterns might help doctors understand exercise capacity and predict outcomes.

Immune System

E3 PreliminaryCommentaryPEM not required

Editorial: CD24 in the regulation of cellular development and disease.

Christian, Sherri L, Cambridge, Geraldine·Frontiers in immunology·2024

This is an editorial piece that discusses CD24, a protein found on cell surfaces that helps control how our immune cells develop and function. The authors review research on how CD24 is involved in various diseases and health conditions. While not a research study itself, this editorial helps explain why scientists think CD24 might be important for understanding different illnesses.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

[Therapeutic effect and mechanism of Jingfang Granules on chronic fatigue syndrome based on intestinal flora and metabolomics].

Wang, Kun, Wei, Fang-Jiao, Cui, De-Yu et al.·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2024

Researchers tested a traditional Chinese herbal treatment called Jingfang Granules on mice with fatigue symptoms similar to ME/CFS. The treatment improved the mice's physical endurance, reduced markers of exhaustion and inflammation in the blood and tissues, and appeared to work by restoring healthy gut bacteria and adjusting how the body processes certain amino acids.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing.

Sun, Yujing, Zhang, Zhenhua, Qiao, Qincheng et al.·Journal of translational medicine·2024

Researchers used advanced cell analysis to examine immune cells from the blood of 4 ME/CFS patients and 4 healthy people. They found that ME/CFS patients have an unusual mix of immune cells, with too many T cells but too few natural killer cells and other immune cells that normally fight infections. Some of their immune cells also show signs of overactivity while others seem weakened, and the researchers identified a potential blood test marker that could help diagnose ME/CFS.

BiomarkersImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Widespread Myalgia and Chronic Fatigue: Phagocytes from Macrophagic Myofasciitis Patients Exposed to Aluminum Oxyhydroxide-Adjuvanted Vaccine Exhibit Specific Inflammatory, Autophagic, and Mitochondrial Responses.

Masson, Jean-Daniel, Badran, Ghidaa, Gherardi, Romain K et al.·Toxics·2024

Researchers studied immune cells from patients with macrophagic myofasciitis (MMF), a condition where aluminum from vaccine adjuvants accumulates in muscle tissue and is associated with widespread pain and severe fatigue similar to ME/CFS. When these cells were exposed to aluminum adjuvants in the laboratory, they showed altered inflammatory responses and changes in how they produce energy, compared to cells from healthy controls. These are preliminary findings in cells grown in a dish and do not yet establish whether this mechanism occurs in ME/CFS patients.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome.

Huitsing, Kaylin, Tritsch, Tara, Arias, Francisco Javier Carrera et al.·Molecular medicine (Cambridge, Mass.)·2024

This study explores why people with ME/CFS often experience dry eyes, sore throats, and stuffy noses. Researchers investigated whether problems with mucin proteins—substances that create protective layers in your mouth, nose, and eyes—might contribute to ME/CFS symptoms. Using computer analysis and genetic data, they hypothesized that weakened mucus membranes could lead to chronic inflammation in these areas, potentially worsening the condition.

Immune System

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A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life, and Immunologic Variables in Long COVID.

Clinical Remission After Therapeutic Apheresis in a Patient Suffering from Long Term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case Report.

Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome.

Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity.

Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies.

From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases.

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.

Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Investigation into the restoration of TRPM3 ion channel activity in post-COVID-19 condition: a potential pharmacotherapeutic target.

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing.

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution.

Immune exhaustion in ME/CFS and long COVID.

The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.

An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.

Editorial: CD24 in the regulation of cellular development and disease.

[Therapeutic effect and mechanism of Jingfang Granules on chronic fatigue syndrome based on intestinal flora and metabolomics].

Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing.

Widespread Myalgia and Chronic Fatigue: Phagocytes from Macrophagic Myofasciitis Patients Exposed to Aluminum Oxyhydroxide-Adjuvanted Vaccine Exhibit Specific Inflammatory, Autophagic, and Mitochondrial Responses.

The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome.

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