ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

721–738 of 738 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Fry, A M, Martin, M·Journal of psychosomatic research·1996

This 1996 study examined whether the extreme tiredness experienced by people with ME/CFS comes from problems in the muscles or the brain's motor control. After reviewing existing research on muscle function and brain activity, the researchers concluded that the fatigue is not caused by physical muscle damage or weakness. Instead, they suggest that the brain may be processing fatigue signals in an unusual way, influenced by how people think about and interpret their symptoms.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression.

Samii, A, Wassermann, E M, Ikoma, K et al.·Neurology·1996

This study measured how the brain's motor cortex responds to exercise using magnetic stimulation in people with ME/CFS, depressed patients, and healthy controls. After exercise, healthy people showed a much stronger increase in brain activity (218%), while ME/CFS patients showed a weaker increase (126%), suggesting their brains may not respond as vigorously to physical exertion as they should.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a review of the literature].

Hamre, H J·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1995

ME/CFS is a real medical condition that causes extreme tiredness, low-grade fevers, sore throats, and pain in joints and muscles, often starting after a flu-like illness. Exercise makes symptoms significantly worse. While doctors don't yet have a single blood test to diagnose it, research shows patients may have problems with brain blood flow, immune system issues, and mitochondrial (cellular energy) abnormalities.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredObservational

Human adjuvant disease revisited: a review of eleven post-augmentation mammoplasty patients.

Fenske, T K, Davis, P, Aaron, S L·Clinical and experimental rheumatology·1994

This study examined 11 women who developed widespread pain, fatigue, and joint symptoms after receiving silicone breast implants. The researchers found that 6 patients met criteria for fibromyalgia and 5 had chronic fatigue syndrome symptoms, but none had evidence of a traditional autoimmune disease. The authors suggest these cases should be classified as CFS or fibromyalgia rather than a unique implant-related disease.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Nixon, P G·Biofeedback and self-regulation·1994

This study focuses on a condition called 'effort syndrome,' which causes people to feel exhausted during physical activity. The researchers found that patients with effort syndrome breathe too heavily (hyperventilate), which changes the chemistry of their blood and makes their muscles tire much earlier than normal. By measuring breathing patterns during exercise, doctors can identify how much work each patient can do before their body runs out of chemical buffers.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

Lloyd, A, Gandevia, S, Brockman, A et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers asked whether a specific immune response causes the fatigue that ME/CFS patients experience after exercise. They had patients and healthy people do a 30-minute hand-grip exercise and checked their blood for immune chemicals (cytokines) before, during, and after exercise. Surprisingly, they found no changes in these immune chemicals in either group, and patients actually reported feeling less fatigued after the exercise—the opposite of what happens in real life.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a defined unity?].

Rasmussen, A K, Andersen, V, Nielsen, H et al.·Ugeskrift for laeger·1994

This 1994 review examined what scientists knew about ME/CFS at that time, looking at whether a persistent virus or immune system problem caused the condition. The authors found that existing research did not consistently support either explanation, and that different studies often contradicted each other. They concluded that more careful research was needed to understand what actually causes ME/CFS and how to tell it apart from other illnesses.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Lanham, R J·Clinical laboratory science : journal of the American Society for Medical Technology·1994

This review examined what we know about ME/CFS, a condition characterized by extreme tiredness, pain, and thinking difficulties that come and go in cycles. While researchers don't yet know what causes ME/CFS, studies show that people with this condition often have unusual immune system test results. Currently, there is no single blood test or marker that can definitively diagnose ME/CFS, so doctors treat symptoms based on what each patient experiences.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearCross-Sectional

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Peterson, P K, Sirr, S A, Grammith, F C et al.·Clinical and diagnostic laboratory immunology·1994

Researchers tested whether light exercise (30 minutes of slow walking) would trigger abnormal immune and brain blood flow responses in ME/CFS patients compared to healthy people. They found that ME/CFS patients had higher levels of a specific immune protein (TGF-beta) both at rest and after exercise, and also showed changes in brain blood flow. These changes appeared larger in ME/CFS patients than in healthy controls, though the difference wasn't statistically significant.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredObservational

Acylcarnitine deficiency in chronic fatigue syndrome.

Kuratsune, H, Yamaguti, K, Takahashi, M et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study found that people with ME/CFS have lower levels of acylcarnitine, a substance that helps muscles produce energy, in their blood. Because acylcarnitine plays an important role in how muscles use energy, this deficiency might explain why ME/CFS patients experience fatigue, muscle pain, and weakness. Importantly, acylcarnitine levels tended to improve as patients recovered, suggesting it could be useful for tracking disease severity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearEditorial

The grey area of effort syndrome and hyperventilation: from Thomas Lewis to today.

Nixon, P G·Journal of the Royal College of Physicians of London·1993

This article reviews the historical concept of 'effort syndrome'—a condition where the body loses its ability to handle physical exertion due to chemical imbalances, particularly in how the body buffers acids produced during exercise. The author argues that this old diagnosis remains relevant today and should be considered when evaluating chronic fatigue and other unexplained illnesses, especially when emotional stress and overbreathing (hyperventilation) are present.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryBehavioralPEM unclearConference-Abstract

Muscle histopathology and physiology in chronic fatigue syndrome.

Edwards, R H, Gibson, H, Clague, J E et al.·Ciba Foundation symposium·1993

Researchers examined muscle tissue from 108 ME/CFS patients and 22 healthy people using microscopes to look for structural damage, and tested muscle strength before and after exercise. They found no consistent muscle damage that explained fatigue symptoms, and muscle strength worked normally even after exercise. The study suggests ME/CFS is not caused by a primary muscle disease.

Post-Exertional Malaise

E3 PreliminaryReviewPEM requiredReview-Narrative

Clinical presentation of chronic fatigue syndrome.

Komaroff, A L·Ciba Foundation symposium·1993

ME/CFS is a long-lasting illness that causes severe tiredness lasting at least six months, along with other symptoms like fever, sore throat, joint pain, and worsening after physical activity. While some symptoms can look like mental health conditions, ME/CFS has physical features—like sudden onset following a flu-like illness and post-exertional exhaustion—that suggest it involves real biological problems. This condition significantly impacts people's ability to work, study, and care for themselves.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

McCluskey, D R, Riley, M S·Comprehensive therapy·1992

ME/CFS likely involves multiple different problems happening in the body at the same time, rather than one single cause. Most patients get sick after a viral infection, but scientists haven't found clear evidence the virus stays in the body long-term. People with ME/CFS have real physical limitations in how much exercise they can do, and they may perceive their own effort and tiredness differently than healthy people do.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearObservational

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

Wong, R, Lopaschuk, G, Zhu, G et al.·Chest·1992

This study used a special imaging technique (31P NMR spectroscopy) to examine how muscles use energy during exercise in people with ME/CFS compared to healthy volunteers. Patients with ME/CFS became exhausted much faster during exercise (about 8 minutes versus 11 minutes) and had lower levels of ATP, the main energy molecule muscles use. The patterns of energy use looked similar between groups, but happened much more quickly in the ME/CFS group.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Kuratsune, H, Yamaguti, K, Hattori, H et al.·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 59 patients with ME/CFS to identify common symptoms and laboratory abnormalities. The main findings were that patients experienced prolonged fatigue after exercise, headaches, sleep problems, and mild fevers. Researchers found that ME/CFS patients had low levels of a substance called acylcarnitine in their muscles, which may help explain why their bodies struggle to produce energy and why they experience muscle pain and worsening symptoms after activity.

BiomarkersPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Lewis, S F, Haller, R G·Reviews of infectious diseases·1991

This review article explains how scientists measure exercise capacity and fatigue in the body. It describes three key concepts: aerobic fitness (how efficiently your heart and muscles use oxygen), muscle strength (your muscles' ability to produce force), and fatigue (the loss of strength that happens during activity). The authors discuss how these measurements might help us better understand what happens in ME/CFS when patients experience excessive fatigue.

Post-Exertional Malaise

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

Armon, C, Kurland, L T·Reviews of infectious diseases·1991

This article examines how ME/CFS is diagnosed and points out problems with the current definition used by doctors. The authors identified several issues: the definition doesn't clearly address what happens when patients do too much activity, it doesn't specify how much rest is needed, and it may miss cases in poorer communities. They suggest a new flowchart that could help identify different types of ME/CFS and potentially help some patients avoid developing the condition.

Post-Exertional Malaise

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Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression.

[Chronic fatigue syndrome--a review of the literature].

Human adjuvant disease revisited: a review of eleven post-augmentation mammoplasty patients.

Effort syndrome: hyperventilation and reduction of anaerobic threshold.

Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.

[Chronic fatigue syndrome--a defined unity?].

Chronic fatigue syndrome: a diagnostic challenge for the laboratory.

Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.

Acylcarnitine deficiency in chronic fatigue syndrome.

The grey area of effort syndrome and hyperventilation: from Thomas Lewis to today.

Muscle histopathology and physiology in chronic fatigue syndrome.

Clinical presentation of chronic fatigue syndrome.

Chronic fatigue syndrome.

Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.

[Symptoms, signs and laboratory findings in patients with chronic fatigue syndrome].

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

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