ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

801–820 of 6,187 studies

Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome.

Dougall, Dominic, Johnson, Anthony, Goldsmith, Kimberley et al.·Journal of psychosomatic research·2014

This study looked at side effects and health changes that happened to people with ME/CFS who tried four different treatments in the PACE trial. Researchers found that side effects were common across all treatment types, but people doing graded exercise therapy (GET) and adaptive pacing therapy (APT) were more likely to experience a noticeable worsening of their physical abilities. The study suggests that the high rate of side effects may reflect how ME/CFS affects the body rather than being caused by the treatments themselves.

E1 ReplicatedTrialPEM unclearRCT

Pilot study investigating the utility of a specialized online symptom management program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome as compared to an online meditation program.

Arroll, Megan A, Attree, Elizabeth A, Marshall, Clare L et al.·Psychology research and behavior management·2014

This pilot study tested whether an online program designed to help people manage ME/CFS symptoms could be helpful for patients. Researchers compared this specialized program to an online meditation program and tracked changes in fatigue, symptoms, and how much control people felt they had over their condition over 8 weeks. The specialized program showed some benefits, particularly in helping people feel more in control and improving sleep difficulties, though overall ME/CFS symptoms didn't change significantly.

Sleep

E1 ReplicatedTrialPEM not requiredLongitudinal

Agomelatine but not melatonin improves fatigue perception: a longitudinal proof-of-concept study.

Pardini, M, Cordano, C, Benassi, F et al.·European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2014

This study tested whether a medication called agomelatine could reduce fatigue in people with ME/CFS. The researchers compared agomelatine to melatonin (a common sleep supplement) over 24 weeks in 62 patients. Agomelatine improved fatigue and quality of life, while melatonin alone did not—and when patients switched from melatonin to agomelatine, their fatigue improved.

Evidence Atlas

Evidence browser

Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome.

Pilot study investigating the utility of a specialized online symptom management program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome as compared to an online meditation program.

Agomelatine but not melatonin improves fatigue perception: a longitudinal proof-of-concept study.

Isometric yoga improves the fatigue and pain of patients with chronic fatigue syndrome who are resistant to conventional therapy: a randomized, controlled trial.

Chronic fatigue self-management in primary care: a randomized trial.

Mediators of the effects on fatigue of pragmatic rehabilitation for chronic fatigue syndrome.

Cost-effectiveness of supported self-management for CFS/ME patients in primary care.

Differences in physical functioning between relatively active and passive patients with Chronic Fatigue Syndrome.

Does acetaminophen activate endogenous pain inhibition in chronic fatigue syndrome/fibromyalgia and rheumatoid arthritis? A double-blind randomized controlled cross-over trial.

Does neuropsychological test performance predict outcome of cognitive behavior therapy for Chronic Fatigue Syndrome and what is the role of underperformance?

Moderators of the treatment response to guided self-instruction for chronic fatigue syndrome.

Effects of qigong exercise on fatigue, anxiety, and depressive symptoms of patients with chronic fatigue syndrome-like illness: a randomized controlled trial.

Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome.

[Impacts on chronic fatigue syndrome of qi deficiency syndrome and T cell subgroups in patients treated with acupuncture at selective time].

[The use of melatonin in the treatment of chronic fatigue syndrome and circadian rhythm disorders in Parkinson's disease].

Mindfulness therapy for somatization disorder and functional somatic syndromes: randomized trial with one-year follow-up.

Mindfulness therapy for somatization disorder and functional somatic syndromes: analysis of economic consequences alongside a randomized trial.

Effects of sleep restriction and exercise deprivation on somatic symptoms and mood in healthy adults.

Recovery from chronic fatigue syndrome after treatments given in the PACE trial.

The feasibility and acceptability of conducting a trial of specialist medical care and the Lightning Process in children with chronic fatigue syndrome: feasibility randomized controlled trial (SMILE study).

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research