E3 PreliminaryMechanismPEM not requiredObservational
Acute psychosocial stress-mediated changes in the expression and methylation of perforin in chronic fatigue syndrome.
Falkenberg, Virginia R, Whistler, Toni, Murray, Janna R et al.·Genetics & epigenetics·2013
This study looked at how a stressful situation affects a type of immune cell protein called perforin in people with ME/CFS versus healthy people. Researchers gave both groups a stress test and measured changes in perforin levels and a chemical modification (methylation) that controls whether genes are turned on or off. They found that while both groups increased perforin during stress, people with ME/CFS had a lower peak response and differently regulated perforin levels afterward.
Immune System