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generalPEM-relevant

ME/CFS (general)

260 studies in the atlas

Studies that reference ME/CFS without fitting a specific physiological or interventional topic on this atlas. Primarily diagnostic, epidemiological, or cross-cutting work. Curated manually into more specific topics over time.

Research Momentum

260 publications over 38 years. Recent trend: decreasing (11/year over the last 3 years).

Top Studies

60 of 260, sorted by review status and evidence level

E0PEM ✓

Assessment of symptoms in myalgic encephalomyelitis/chronic fatigue syndrome: a comparative study of existing scales.

2025 · Moderate
Lu, Jing et al.·Frontiers in neurology·Review-NarrativeEditor reviewed
E0PEM ✓

The Draft Report by the Institute for Quality and Efficiency in Healthcare Does Not Provide Any Evidence That Graded Exercise Therapy and Cognitive Behavioral Therapy Are Safe and Effective Treatments for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2023 · Weak
Vink, Mark et al.·Diseases (Basel, Switzerland)·EditorialEditor reviewed
E0PEM ?

The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome.

2022 · Moderate
Thomas, Natalie et al.·Frontiers in neuroendocrinology·Review-NarrativeEditor reviewed
E0PEM ✓

The Updated NICE Guidance Exposed the Serious Flaws in CBT and Graded Exercise Therapy Trials for ME/CFS.

2022 · Moderate
Vink, Mark et al.·Healthcare (Basel, Switzerland)·EditorialEditor reviewed
E0PEM ✗

The Safety of Baduanjin Exercise: A Systematic Review.

2021 · Preliminary
Fang, Jianqi et al.·Evidence-based complementary and alternative medicine : eCAM·Systematic-ReviewEditor reviewed
E0PEM ✓

Graded exercise therapy does not restore the ability to work in ME/CFS - Rethinking of a Cochrane review.

2020 · Moderate
Vink, Mark et al.·Work (Reading, Mass.)·CommentaryEditor reviewed
E0PEM ?

Peak Oxygen Uptake in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Meta-Analysis.

2019 · Higher
Franklin, John Derek et al.·International journal of sports medicine·Meta-AnalysisEditor reviewed
E0PEM ✓

Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review.

2018 · Moderate
Vink, Mark et al.·Health psychology open·Systematic-ReviewEditor reviewed
E0PEM ✓

Effect of Acute Exercise on Fatigue in People with ME/CFS/SEID: A Meta-analysis.

2016 · Preliminary
Loy, Bryan D et al.·Medicine and science in sports and exercise·Meta-AnalysisEditor reviewed
E0PEM ✗

In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome.

2012 · Moderate
Nijs, Jo et al.·European journal of clinical investigation·Review-NarrativeEditor reviewed
E0PEM ✗

Tired of being inactive: a systematic literature review of physical activity, physiological exercise capacity and muscle strength in patients with chronic fatigue syndrome.

2011 · Moderate
Nijs, Jo et al.·Disability and rehabilitation·Systematic-ReviewEditor reviewed
E0PEM ✓

Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: a systematic review.

2007 · Moderate
Meeus, Mira et al.·European journal of pain (London, England)·Systematic-ReviewEditor reviewed
E0PEM ✗

The chronic fatigue syndrome--an update.

2007 · Moderate
Wyller, Vegard Bruun·Acta neurologica Scandinavica. Supplementum·Review-NarrativeEditor reviewed
E0PEM ?

Chronic musculoskeletal pain in chronic fatigue syndrome: recent developments and therapeutic implications.

2006 · Moderate
Nijs, Jo et al.·Manual therapy·Review-NarrativeEditor reviewed
E0PEM ?

A status report on chronic fatigue syndrome.

2002 · Preliminary
Natelson, Benjamin H et al.·Environmental health perspectives·EditorialEditor reviewed
E0PEM ?

Chronic fatigue syndrome: From etiology and mechanism to diagnosis and treatment.

2026 · Moderate
Xu, Qing et al.·Journal of psychiatric research·Systematic-ReviewEditor reviewed
E0PEM ?

[Herbal treatment options for post-viral symptoms and long COVID].

2026 · Preliminary
Krassnig, Katharina et al.·Wiener medizinische Wochenschrift (1946)·Review-NarrativeEditor reviewed
E0PEM ✓

The pivotal role of central sensitization in long COVID, fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome.

2025 · Moderate
Goldenberg, Don L·Expert review of neurotherapeutics·EditorialEditor reviewed
E0PEM ?

Adrenergic dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia: A systematic review and meta-analysis.

2025 · Moderate
Hendrix, Jolien et al.·European journal of clinical investigation·Meta-AnalysisEditor reviewed
E0PEM ?

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview.

2024 · Preliminary
Mantle, David et al.·International journal of molecular sciences·Review-NarrativeEditor reviewed
E0PEM ✗

The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review.

2024 · Preliminary
Peebles, Karen C et al.·Autonomic neuroscience : basic & clinical·Systematic-ReviewEditor reviewed
E0PEM ?

Long COVID in pediatrics-epidemiology, diagnosis, and management.

2024 · Moderate
Toepfner, Nicole et al.·European journal of pediatrics·Review-NarrativeEditor reviewed
E0PEM ?

Physical Activity and Fatigue Symptoms: Neurotypical Adults and People with Chronic Multisymptom Illnesses.

2024 · Preliminary
Boruch, Alex et al.·Current topics in behavioral neurosciences·Review-NarrativeEditor reviewed
E0PEM ?

Postacute Sequelae of SARS-CoV-2 in Children.

2024 · Preliminary
Rao, Suchitra et al.·Pediatrics·Review-NarrativeEditor reviewed
E0PEM ✓

A scoping review of 'Pacing' for management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): lessons learned for the long COVID pandemic.

2023 · Preliminary
Sanal-Hayes, Nilihan E M et al.·Journal of translational medicine·Systematic-ReviewEditor reviewed
E0PEM ✓

Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not?

2023 · Moderate
Joseph, Phillip et al.·Chest·Review-NarrativeEditor reviewed
E0PEM ✓

Long-Term COVID 19 Sequelae in Adolescents: the Overlap with Orthostatic Intolerance and ME/CFS.

2022 · Preliminary
Morrow, Amanda K et al.·Current pediatrics reports·EditorialEditor reviewed
E0PEM ?

Clinical overlap between fibromyalgia and myalgic encephalomyelitis. A systematic review and meta-analysis.

2022 · Moderate
Ramírez-Morales, Ricardo et al.·Autoimmunity reviews·Meta-AnalysisEditor reviewed
E0PEM ✓

Is It Useful to Question the Recovery Behaviour of Patients with ME/CFS or Long COVID?

2022 · Moderate
Vink, Mark et al.·Healthcare (Basel, Switzerland)·Systematic-ReviewEditor reviewed
E0PEM ✓

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management.

2021 · Higher
Bateman, Lucinda et al.·Mayo Clinic proceedings·GuidelineEditor reviewed
E0PEM ✗

Post COVID-19 Syndrome in Patients with Asymptomatic/Mild Form.

2021 · Preliminary
Malkova, Annа et al.·Pathogens (Basel, Switzerland)·Review-NarrativeEditor reviewed
E0PEM ?

Elevated Perceived Exertion in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Meta-analysis.

2020 · Higher
Barhorst, Ellen E et al.·Medicine and science in sports and exercise·Meta-AnalysisEditor reviewed
E0PEM ✗

Fear of movement and avoidance behaviour toward physical activity in chronic-fatigue syndrome and fibromyalgia: state of the art and implications for clinical practice.

2013 · Moderate
Nijs, Jo et al.·Clinical rheumatology·Systematic-ReviewEditor reviewed
E0PEM ?

Exercise and the Athlete With Infectious Mononucleosis.

2017 · Moderate
Shephard, Roy J·Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·Review-NarrativeEditor reviewed
E1PEM ✗

A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study.

2021 · Preliminary
Kan, Juntao et al.·Frontiers in nutrition·RCTEditor reviewed
E1PEM ✓

Telephone-administered versus live group cognitive behavioral stress management for adults with CFS.

2017 · Moderate
Hall, Daniel L et al.·Journal of psychosomatic research·ObservationalEditor reviewed
E1PEM ✓

Fatigue Exacerbation by Interval or Continuous Exercise in Chronic Fatigue Syndrome.

2016 · Moderate
Sandler, Carolina X et al.·Medicine and science in sports and exercise·RCTEditor reviewed
E1PEM ✗

Provision of social support to individuals with chronic fatigue syndrome.

2010 · Moderate
Jason, Leonard A et al.·Journal of clinical psychology·RCTEditor reviewed
E1PEM ✗

Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.

2008 · Moderate
Malaguarnera, Michele et al.·Archives of gerontology and geriatrics·RCTEditor reviewed
E2PEM ✓

Heterogeneity in Measures of Illness among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Explained by Clinical Practice: A Study in Seven U.S. Specialty Clinics.

2024 · Moderate
Unger, Elizabeth R et al.·Journal of clinical medicine·Cross-SectionalEditor reviewed
E2PEM ✓

Cognitive assessment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a cognitive substudy of the multi-site clinical assessment of ME/CFS (MCAM).

2024 · Moderate
Lange, Gudrun et al.·Frontiers in neuroscience·LongitudinalEditor reviewed
E2PEM ✓

Consequences of sarcolemma fatigue on maximal muscle strength production in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

2023 · Moderate
Retornaz, Frédérique et al.·Clinical biomechanics (Bristol, Avon)·Case-ControlEditor reviewed
E2PEM ?

Severe and Very Severe Myalgic Encephalopathy/Chronic Fatigue Syndrome ME/CFS in Norway: Symptom Burden and Access to Care.

2023 · Moderate
Sommerfelt, Kristian et al.·Journal of clinical medicine·Cross-SectionalEditor reviewed
E2PEM ?

A unique circular RNA expression pattern in the peripheral blood of myalgic encephalomyelitis/chronic fatigue syndrome patients.

2023 · Preliminary
Cheng, Yuning et al.·Gene·LongitudinalEditor reviewed
E2PEM ✓

Factors Influencing the Prognosis of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2022 · Moderate
Ghali, Alaa et al.·Diagnostics (Basel, Switzerland)·ObservationalEditor reviewed
E2PEM ?

Cardiopulmonary, metabolic, and perceptual responses during exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Multi-site Clinical Assessment of ME/CFS (MCAM) sub-study.

2022 · Moderate
Cook, Dane B et al.·PloS one·Cross-SectionalEditor reviewed
E2PEM ✓

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2021 · Moderate
Freitag, Helma et al.·Journal of clinical medicine·Cross-SectionalEditor reviewed
E2PEM ?

Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2021 · Preliminary
Van Oosterwijck, Jessica et al.·Journal of clinical medicine·Case-ControlEditor reviewed
E2PEM ?

Anticipation of and response to exercise in adolescents with CFS: An experimental study.

2021 · Moderate
Loades, M E et al.·Journal of psychosomatic research·Cross-SectionalEditor reviewed
E2PEM ✓

Validation of the Severity of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Other Measures than History: Activity Bracelet, Cardiopulmonary Exercise Testing and a Validated Activity Questionnaire: SF-36.

2020 · Moderate
van Campen, C Linda M C et al.·Healthcare (Basel, Switzerland)·Cross-SectionalEditor reviewed
E2PEM ?

Maximal handgrip strength can predict maximal physical performance in patients with chronic fatigue.

2020 · Moderate
Jammes, Yves et al.·Clinical biomechanics (Bristol, Avon)·Cross-SectionalEditor reviewed
E2PEM ?

Physical activity measures in patients with myalgic encephalomyelitis/chronic fatigue syndrome: correlations between peak oxygen consumption, the physical functioning scale of the SF-36 questionnaire, and the number of steps from an activity meter.

2020 · Moderate
van Campen, C M C et al.·Journal of translational medicine·Cross-SectionalEditor reviewed
E2PEM ?

Preliminary ICF core set for patients with myalgic encephalomyelitis/chronic fatigue syndrome in rehabilitation medicine.

2020 · Preliminary
Bileviciute-Ljungar, Indre et al.·Journal of rehabilitation medicine·ObservationalEditor reviewed
E2PEM ?

Cognitive Function Declines Following Orthostatic Stress in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

2020 · Moderate
van Campen, C Linda M C et al.·Frontiers in neuroscience·ObservationalEditor reviewed
E2PEM ✗

Patterns of daytime physical activity in patients with chronic fatigue syndrome.

2020 · Moderate
King, E et al.·Journal of psychosomatic research·Cross-SectionalEditor reviewed
E2PEM ?

Guided graded Exercise Self-help for chronic fatigue syndrome: patient experiences and perceptions.

2020 · Moderate
Cheshire, Anna et al.·Disability and rehabilitation·ObservationalEditor reviewed
E2PEM ?

Cardiac Dimensions and Function Are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2020 · Moderate
Iversen, Per Ole et al.·Healthcare (Basel, Switzerland)·Cross-SectionalEditor reviewed
E2PEM ✓

Chronic fatigue syndrome in the emergency department.

2019 · Preliminary
Timbol, Christian R et al.·Open access emergency medicine : OAEM·Cross-SectionalEditor reviewed
E2PEM ?

Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2019 · Preliminary
Nelson, Maximillian J et al.·Journal of translational medicine·Cross-SectionalEditor reviewed
E2PEM ✗

Onset Patterns and Course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

2019 · Moderate
Chu, Lily et al.·Frontiers in pediatrics·Cross-SectionalEditor reviewed

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