ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

637 studies

241–260 of 637 studies

E0 ConsensusReviewPEM unclearReview-Narrative

Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Yamano, Emi, Watanabe, Yasuyoshi, Kataoka, Yosky·International journal of molecular sciences·2021

ME/CFS is a serious condition that causes extreme exhaustion and is difficult to diagnose because we don't have reliable tests for it. This review examined research on how the chemicals in patients' bodies differ from healthy people, looking for patterns that could help doctors identify ME/CFS with a simple blood test. Scientists reviewed studies that measured these body chemicals and tested them in animal models to understand what goes wrong in ME/CFS.

Biomarkers

E0 ConsensusReviewPEM requiredReview-Narrative

A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome.

Noor, Nazir, Urits, Ivan, Degueure, Arielle et al.·Anesthesiology and pain medicine·2021

This review summarizes what researchers currently understand about ME/CFS, a complex illness causing severe fatigue and other symptoms. The condition may involve problems with the immune system, stress response, or nervous system, and can be triggered by infections like Epstein-Barr virus, though not always. Diagnosis requires six months of fatigue plus four symptoms like memory problems, sore throat, or post-exertion malaise, and doctors must rule out other conditions first. Treatment options include therapy, medication, and newer approaches like electrical stimulation, though more research is needed to find the best approaches.

SleepImmune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM unclearEditorial

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Ariza, Maria Eugenia·Biomolecules·2021

This review examines whether certain viruses, particularly Epstein-Barr virus (EBV), may play a role in ME/CFS. Earlier research on this topic produced mixed results, leading some scientists to think viruses weren't involved. However, newer research methods have found that specific proteins made by EBV could contribute to immune system and nervous system problems in some ME/CFS patients.

BiomarkersImmune System

E0 ConsensusReviewPEM not requiredSystematic-Review

The Safety of Baduanjin Exercise: A Systematic Review.

Fang, Jianqi, Zhang, Liying, Wu, Fangzhen et al.·Evidence-based complementary and alternative medicine : eCAM·2021

Baduanjin is a gentle exercise therapy from traditional Chinese medicine that is becoming more popular around the world. This review looked at 47 studies involving 3,877 people to find out what side effects people experienced when doing Baduanjin. Most studies didn't carefully track side effects, but those that did reported issues like muscle aches, heart palpitations, dizziness, knee pain, and fatigue—though it's unclear if Baduanjin actually caused these problems.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

Cognitive-behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies.

Nakao, Mutsuhiro, Shirotsuki, Kentaro, Sugaya, Nagisa·BioPsychoSocial medicine·2021

This review examined whether cognitive-behavioral therapy (CBT)—a type of talk therapy that helps people challenge unhelpful thoughts and avoidant behaviors—can help manage stress and mental health problems. The researchers looked at hundreds of studies published between 1987 and 2021 and found that CBT appeared helpful for various conditions including chronic fatigue syndrome, depression, and anxiety, at least in the short term. They also noted that CBT can now be delivered online or through smartphone apps, though more research is needed to understand how well these benefits last over time.

E0 ConsensusReviewPEM unclearSystematic-Review

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology.

Wong, Timothy L, Weitzer, Danielle J·Medicina (Kaunas, Lithuania)·2021

Researchers reviewed 21 studies about Long COVID (symptoms lasting months after COVID-19 infection) and compared them to ME/CFS symptoms. They found that Long COVID patients reported 25 out of 29 known ME/CFS symptoms, suggesting these two conditions share many similarities. The study highlights the need for better monitoring and treatment of patients with Long COVID, and calls for more standardized research methods to understand both conditions better.

Long COVID Overlap

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review of nutraceutical interventions for mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome.

Maksoud, Rebekah, Balinas, Cassandra, Holden, Sean et al.·Journal of translational medicine·2021

This review looked at whether special supplements that target the energy-producing parts of cells (mitochondria) might help ME/CFS patients feel less fatigued. The researchers searched for published studies testing these supplements in ME/CFS patients and found 9 studies. About two-thirds of these studies showed some improvement in fatigue, but the overall evidence isn't strong enough yet to say these supplements definitely work.

Energy Metabolism

E0 ConsensusGuidelinePEM requiredGuideline

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management.

Bateman, Lucinda, Bested, Alison C, Bonilla, Hector F et al.·Mayo Clinic proceedings·2021

This article brings together 21 expert doctors who specialize in ME/CFS to share the best ways to diagnose and treat this complex illness. The experts explain that most people with ME/CFS don't get properly diagnosed, and many receive treatments that can actually make them worse. They provide clear, practical guidance that general doctors can use to help ME/CFS patients feel better and improve their quality of life.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearMeta-Analysis

The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression data.

Malato, João, Sotzny, Franziska, Bauer, Sandra et al.·Heliyon·2021

This study looked at whether people with ME/CFS have lower levels of a protein called ACE2, which the COVID-19 virus uses to enter cells. The researchers analyzed existing genetic data from ME/CFS patients and found that ACE2 levels were indeed reduced in ME/CFS patients compared to healthy people. The authors suggest this may put ME/CFS patients at higher risk for severe COVID-19 and recommend they be prioritized for vaccination.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Maksoud, Rebekah, Eaton-Fitch, Natalie, Matula, Michael et al.·Healthcare (Basel, Switzerland)·2021

Many ME/CFS patients report that their sleep feels unrefreshing and disturbed, even when they sleep for long hours. This review looked at 20 studies that used objective sleep monitoring equipment (like devices that measure brain waves and breathing during sleep) to understand what's actually happening with sleep in ME/CFS patients. The researchers found that the results across different studies were inconsistent, meaning there's no clear pattern yet about what makes ME/CFS sleep different from healthy sleep.

Sleep

E0 ConsensusReviewPEM unclearReview-Narrative

The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review.

O'Neal, Adam J, Hanson, Maureen R·Frontiers in medicine·2021

This review examined whether enteroviruses—common viruses that cause colds, stomach infections, and other illnesses—might be responsible for ME/CFS. While some studies found these viruses more often in ME/CFS patients than in healthy people, the evidence has been mixed and hard to interpret. The authors argue that past research methods weren't good enough to definitively answer the question, and they call for better studies using modern technology to investigate this possibility further.

E0 ConsensusReviewPEM unclearReview-Narrative

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

König, Rahel S, Albrich, Werner C, Kahlert, Christian R et al.·Frontiers in immunology·2021

This review examines whether changes in gut bacteria might contribute to ME/CFS. The authors suggest that lifetime antibiotic use could alter the balance of gut microbes, which might then affect the gut barrier, brain function, and energy production in cells. They propose several potential treatment approaches like probiotics and dietary changes, but emphasize that much more research is needed to understand if gut bacteria actually cause ME/CFS or simply change as a result of the disease.

Cognitive Impairment

E0 ConsensusReviewPEM unclearMeta-Analysis

Efficacy of Qigong Exercise for Treatment of Fatigue: A Systematic Review and Meta-Analysis.

Wang, Rui, Huang, Xueyan, Wu, Yeqi et al.·Frontiers in medicine·2021

Researchers reviewed 16 studies testing whether Qigong exercise (a traditional Chinese practice combining movement, breathing, and meditation) helps reduce fatigue in patients with various illnesses, including chronic fatigue syndrome. They found that people who did Qigong showed meaningful improvements in their fatigue levels compared to control groups, though the effect was modest. However, Qigong did not clearly improve overall quality of life in the studies reviewed.

E0 ConsensusReviewPEM not requiredReview-Narrative

Cognitive symptoms after COVID-19.

Altuna, M, Sánchez-Saudinós, Mª B, Lleó, A·Neurology perspectives·2021

COVID-19 can cause cognitive problems—such as difficulty thinking, concentrating, or remembering—that sometimes last for months after infection. These cognitive symptoms can happen even in people with mild COVID cases, which is unusual compared to other viral illnesses. This review found that cognitive problems after COVID share similarities with symptoms seen in ME/CFS and can significantly affect daily life and quality of life.

Cognitive Impairment

E0 ConsensusGuidelinePEM unclearGuideline

Approach to Fatigue: Best Practice.

Dukes, Jason C, Chakan, Matthew, Mills, Aaron et al.·The Medical clinics of North America·2021

Fatigue can come from many different causes, so doctors need to carefully listen to patients' histories and perform physical exams rather than just ordering lots of tests. Fatigue may be caused by an underlying medical condition that can be treated, or it may be a primary condition on its own (now called system exertion intolerance disease). Currently, there are no FDA-approved medications specifically for primary fatigue, so treatment focuses on personalized exercise programs and cognitive behavioral therapy.

Diagnostics

E0 ConsensusReviewPEM requiredReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?

Murga Gandasegui, Iñigo, Aranburu Laka, Larraitz, Gargiulo, Pascual-Ángel et al.·Medicina (Kaunas, Lithuania)·2021

This review examines whether ME/CFS is primarily a neurological disorder by looking at brain imaging studies and tests of the autonomic nervous system (the part that controls automatic body functions like heart rate). The authors found that while brain imaging shows various changes in ME/CFS patients, these changes aren't specific enough to diagnose the condition on their own. However, specialized tests measuring heart rate variability and immune responses show promise as potential biomarkers that could help identify and monitor ME/CFS.

BiomarkersPost-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

Recovery from chronic fatigue syndrome: a systematic review-heterogeneity of definition limits study comparison.

Moore, Yasmin, Serafimova, Teona, Anderson, Nina et al.·Archives of disease in childhood·2021

This study looked at how often children with ME/CFS recover and what 'recovery' actually means. Researchers found that different studies define recovery in very different ways—some focus on returning to school, others on fatigue levels, and others on physical activity. Because of these differences, recovery rates ranged wildly from 4.5% to 83%, making it hard to compare studies fairly.

Diagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome.

Ruiz-Pablos, Manuel, Paiva, Bruno, Montero-Mateo, Rosario et al.·Frontiers in immunology·2021

This review examines whether Epstein-Barr virus (EBV), a common virus that causes mononucleosis, might play a role in causing ME/CFS in some patients. The researchers found that certain people may have genetic traits that make them more vulnerable to EBV, and in these individuals, the virus might hide from the immune system in a way that leads to ME/CFS symptoms. They suggest that antiviral treatments targeting EBV could potentially help some ME/CFS patients.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Perfectionism, depression and anxiety in chronic fatigue syndrome: A systematic review.

Wright, Amelia, Fisher, Peter L, Baker, Nita et al.·Journal of psychosomatic research·2021

This review looked at seven studies examining whether perfectionism (setting very high standards and worrying about mistakes) is connected to depression in people with ME/CFS. Researchers found strong links between perfectionism and depression, particularly worrying excessively about making mistakes. However, there's much less research on whether perfectionism is linked to anxiety in ME/CFS patients.

E0 ConsensusReviewPEM not requiredMeta-Analysis

Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis.

Lim, Eun-Jin, Son, Chang-Gue·Journal of clinical medicine·2021

This study looked at how common ME/CFS is in Korea and Japan by reviewing eight existing studies. Researchers found that about 0.76-0.77% of people in these countries have ME/CFS—meaning roughly 1 in 130 people. Women were affected about twice as often as men in Korea, though this difference was smaller in Japan.

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Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

The Safety of Baduanjin Exercise: A Systematic Review.

Cognitive-behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies.

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology.

A systematic review of nutraceutical interventions for mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management.

The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in myalgic encephalomyelitis/chronic fatigue syndrome: A meta-analysis of public DNA methylation and gene expression data.

Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review.

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).

Efficacy of Qigong Exercise for Treatment of Fatigue: A Systematic Review and Meta-Analysis.

Cognitive symptoms after COVID-19.

Approach to Fatigue: Best Practice.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?

Recovery from chronic fatigue syndrome: a systematic review-heterogeneity of definition limits study comparison.

Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome.

Perfectionism, depression and anxiety in chronic fatigue syndrome: A systematic review.

Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis.

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