ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1261–1280 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report.

Coplan, Jeremy, Singh, Deepan, Gopinath, Srinath et al.·The Journal of neuropsychiatry and clinical neurosciences·2015

Researchers found that people with anxiety disorders often experience multiple related physical and mental health conditions together—including joint looseness, chronic pain, immune problems, and mood disorders. They studied 76 patients and discovered that over 80% had panic attacks, fibromyalgia, and depression at the same time. This suggests these conditions may be connected as part of a larger syndrome rather than separate illnesses.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

[Mapping of function in chronic fatigue syndrome].

Nyland, Harald, Næss, Halvor, Nyland, Morten·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2015

This study examined how different body functions are affected in people with ME/CFS by mapping their characteristics across a group of patients. The research looked at various functional areas to better understand the pattern of symptoms and impairments experienced by those with the condition. This type of mapping helps clinicians and researchers see which functions are most commonly affected and how they relate to each other.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.

Kempke, Stefan, Luyten, Patrick, De Coninck, Sarah et al.·Psychoneuroendocrinology·2015

This study looked at whether traumatic experiences in childhood are connected to how the body's stress system (the HPA axis) works in people with ME/CFS. Researchers measured stress hormone levels in 40 women with ME/CFS and tested how their bodies responded to stress. They found that emotional neglect in childhood was linked to a blunted (reduced) stress response, suggesting that some ME/CFS patients may have a stress system that doesn't react normally to challenges.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana.

Bauer, Amy E, Olivas, Sonora, Cooper, Maria et al.·BMC veterinary research·2015

Researchers tested milk samples from 316 dairy farms in Indiana to see how common a bacterium called Coxiella burnetii is in cattle herds. This bacterium causes Q fever, which can lead to chronic fatigue in people. They found that over 61% of Indiana dairy herds had evidence of this bacterium in their milk, suggesting it is widespread among cattle.

E2 ModerateDiagnosticPEM unclearMethods-Paper

Issues in Estimating Rates of Pediatric Chronic Fatigue Syndrome and Myalgic Encephalomyelitis in a Community-based Sample.

Jason, Leonard A, Katz, Ben Z, Mears, Cynthia et al.·Avicenna journal of neuropsychophysiology·2015

This study looked at how common ME/CFS is in children living in regular communities, not just in doctor's offices. Researchers used a two-step approach: first they screened children for ME/CFS-like symptoms, then they did detailed medical and mental health evaluations to confirm diagnoses. The study also compared children with ME/CFS to healthy children without the condition.

Diagnostics

E2 ModerateCohortPEM requiredCross-Sectional

Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease.

Jason, Leonard A, Sunnquist, Madison, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2015

Researchers compared different ways of diagnosing ME/CFS by testing 796 patients using a new diagnostic system called SEID (Systemic Exertion Intolerance Disease). They found that the new SEID criteria identified about 88% of patients, which is similar to an older diagnostic system but captures a larger group than some other definitions. The study suggests that different diagnostic criteria can identify different sizes and severity levels of patient populations.

Cognitive ImpairmentPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Altered resting-state functional connectivity in women with chronic fatigue syndrome.

Kim, Byung-Hoon, Namkoong, Kee, Kim, Jae-Jin et al.·Psychiatry research·2015

This study used brain scans to examine how different regions of the brain communicate with each other in women with ME/CFS compared to healthy women. Researchers found that certain brain areas involved in attention and emotion showed increased communication in ME/CFS patients, and this increased activity was linked to symptom severity. Interestingly, the overall efficiency of brain network communication was reduced in people with ME/CFS, suggesting the brain may be working harder to accomplish its tasks.

E2 ModerateCohortPEM not requiredCross-Sectional

The association between daytime napping and cognitive functioning in chronic fatigue syndrome.

Gotts, Zoe M, Ellis, Jason G, Deary, Vincent et al.·PloS one·2015

This study looked at how sleep patterns, especially daytime napping, affect fatigue, sleepiness, and thinking ability in people with ME/CFS. Researchers asked 118 patients to keep a sleep diary for two weeks and complete daily assessments of their symptoms. They found that afternoon napping was linked to worse cognitive problems and increased daytime sleepiness, suggesting that when and how much patients nap may influence how well they can think and function.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic multisymptom illness among female Veterans deployed to Iraq and Afghanistan.

Mohanty, April F, Muthukutty, Anusha, Carter, Marjorie E et al.·Medical care·2015

This study looked at how common chronic multisymptom illnesses—including chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome—are among female veterans who deployed to Iraq and Afghanistan. Researchers found that these conditions were more than twice as common in this group compared to other female veterans. The study suggests that deployment experiences may play a role in developing these illnesses.

E2 ModerateCohortPEM unclearCross-Sectional

Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.

Khaiboullina, Svetlana F, DeMeirleir, Kenny L, Rawat, Shanti et al.·Cytokine·2015

This study looked at chemical messengers in the blood called cytokines to understand Gulf War illness (GWI) and ME/CFS better. Researchers found that certain cytokines could identify ME/CFS patients very well, but were less reliable for GWI patients. The findings suggest that while GWI and ME/CFS share many similar symptoms, they may have different underlying immune system problems.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Specific and number of comorbidities are associated with increased levels of temporomandibular pain intensity and duration.

Dahan, Haissam, Shir, Yoram, Velly, Ana et al.·The journal of headache and pain·2015

This study examined how jaw pain (temporomandibular disorder) relates to other chronic pain conditions, particularly in people with ME/CFS. Researchers found that people with jaw pain who also had migraine or ME/CFS experienced more severe and longer-lasting jaw pain. Having multiple pain conditions at the same time was linked to worse jaw pain symptoms.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Lau, Chi-ieong, Lin, Che-Chen, Chen, Wei-Hung et al.·Journal of psychosomatic research·2015

This study found that people with migraine headaches are 1.5 times more likely to develop ME/CFS than people without migraine. The risk was even higher in older adults (age 65+), who were more than twice as likely to develop ME/CFS if they had migraines. The more frequently someone had migraines, the higher their risk of developing ME/CFS appeared to be.

E2 ModerateCohortPEM unclearCross-Sectional

Measuring substantial reductions in activity.

Schafer, Charles, Evans, Meredyth, Jason, Leonard A et al.·Journal of prevention & intervention in the community·2015

ME/CFS diagnosis requires showing a significant drop in daily activities, but doctors have struggled to measure this fairly. This study looked at different ways to measure activity levels—including work, quality of life surveys, and activity trackers—to find which method works best. The researchers found that tracking current work activities was the most useful way to show the substantial reduction in functioning that ME/CFS patients experience.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The Preinterventional Psychiatric History as a Major Predictor for a Reduced Quality of Life After Treatment of Unruptured Intracranial Aneurysms.

Fontana, Johann, Wenz, Ralf, Groden, Christoph et al.·World neurosurgery·2015

This study looked at patients who had surgery for unruptured brain aneurysms (weak blood vessel spots in the brain that hadn't bled yet) and compared them to patients who had surgery for brain tumors. The researchers found that patients with a history of psychiatric conditions before surgery reported worse quality of life and more chronic fatigue symptoms after surgery, but when they removed those patients from the analysis, the differences went away. This suggests that pre-existing mental health conditions, not the aneurysm or surgery itself, may explain poor outcomes.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Perceived fatigue is highly prevalent and debilitating in patients with mitochondrial disease.

Gorman, Gráinne S, Elson, Joanna L, Newman, Jane et al.·Neuromuscular disorders : NMD·2015

This study found that fatigue is very common and severely disabling in people with mitochondrial disease. About 62% of patients reported excessive fatigue, and 32% experienced severe fatigue that significantly limited their daily activities—levels comparable to fatigue in ME/CFS patients. The researchers surveyed 132 patients and compared their fatigue levels to healthy people and ME/CFS patients to understand how widespread and serious this problem is.

E2 ModerateCohortPEM unclearCross-Sectional

Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.

Regland, Björn, Forsmark, Sara, Halaouate, Lena et al.·PloS one·2015

This study looked at 38 ME/CFS patients who were receiving vitamin B12 injections and oral folic acid to see how well this treatment worked for them. Patients who improved the most received more frequent injections at higher doses, took more folic acid, and were less likely to use strong pain medications like opioids. The researchers found that this treatment combination showed real benefits for some patients, particularly when carefully matched to individual needs.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Painful temporomandibular disorders are common in patients with postural orthostatic tachycardia syndrome and impact significantly upon quality of life.

Durham, Justin, McDonald, Claire, Hutchinson, Luke et al.·Journal of oral & facial pain and headache·2015

This study found that people with PoTS (a condition causing rapid heart rate when standing) often also have painful jaw disorders (TMD). Nearly half of the patients studied screened positive for TMD, and those with TMD reported that it significantly worsened their quality of life. The researchers suggest that doctors should routinely check for jaw pain in PoTS patients.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle.

Miwa, Kunihisa·Heart and vessels·2015

This study looked at heart function in 40 ME/CFS patients compared to 40 healthy people. Researchers found that ME/CFS patients frequently had smaller hearts and difficulty standing up without dizziness or other symptoms (orthostatic intolerance). The smaller heart size appeared to pump less blood with each beat, which may explain why patients struggle with upright posture and fatigue.

Autonomic Nervous System

E2 ModerateCohortPEM requiredCross-Sectional

Factor Analysis of the DePaul Symptom Questionnaire: Identifying Core Domains.

Jason, Leonard A, Sunnquist, Madison, Brown, Abigail et al.·Journal of neurology and neurobiology·2015

Researchers analyzed symptom patterns in people with ME/CFS from three countries to better understand what makes this illness unique. Using statistical analysis, they found that ME/CFS symptoms naturally organize into four main groups: exhaustion that gets worse after activity, brain fog and memory problems, sleep issues, and a combination of hormone, nervous system, and immune problems. This organized way of thinking about symptoms could help doctors recognize and study the disease more effectively.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredCross-Sectional

Examining the Institute of Medicine's Recommendations Regarding Chronic Fatigue Syndrome: Clinical Versus Research Criteria.

Jason, Leonard A, McManimen, Stephanie, Sunnquist, Madison et al.·Journal of neurology and psychology·2015

This study compared two different sets of diagnostic criteria for ME/CFS: one proposed by the Institute of Medicine for clinical use, and another (the Canadian criteria) recommended for research. Using patient data from the US, UK, and Norway, researchers found that patients meeting the research criteria were significantly more severely affected across multiple symptoms and daily functioning areas. This suggests the two criteria sets identify somewhat different groups of patients.

Post-Exertional Malaise

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A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report.

[Mapping of function in chronic fatigue syndrome].

Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.

Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana.

Issues in Estimating Rates of Pediatric Chronic Fatigue Syndrome and Myalgic Encephalomyelitis in a Community-based Sample.

Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease.

Altered resting-state functional connectivity in women with chronic fatigue syndrome.

The association between daytime napping and cognitive functioning in chronic fatigue syndrome.

Chronic multisymptom illness among female Veterans deployed to Iraq and Afghanistan.

Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.

Specific and number of comorbidities are associated with increased levels of temporomandibular pain intensity and duration.

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Measuring substantial reductions in activity.

The Preinterventional Psychiatric History as a Major Predictor for a Reduced Quality of Life After Treatment of Unruptured Intracranial Aneurysms.

Perceived fatigue is highly prevalent and debilitating in patients with mitochondrial disease.

Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.

Painful temporomandibular disorders are common in patients with postural orthostatic tachycardia syndrome and impact significantly upon quality of life.

Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle.

Factor Analysis of the DePaul Symptom Questionnaire: Identifying Core Domains.

Examining the Institute of Medicine's Recommendations Regarding Chronic Fatigue Syndrome: Clinical Versus Research Criteria.

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