ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1301–1320 of 2,795 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep characteristics, exercise capacity and physical activity in patients with chronic fatigue syndrome.

Aerenhouts, Dirk, Ickmans, Kelly, Clarys, Peter et al.·Disability and rehabilitation·2015

This study looked at how sleep problems and low activity levels are connected in people with ME/CFS. Researchers measured fitness capacity, sleep patterns, and daily activity in 42 women with ME/CFS and compared them to 24 healthy inactive women. People with ME/CFS slept more, spent more time in bed, had difficulty falling asleep and staying asleep, and were less physically active than the control group.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Characteristics of women with endometriosis from the USA and Puerto Rico.

Fourquet, Jessica, Sinaii, Ninet, Stratton, Pamela et al.·Journal of endometriosis and pelvic pain disorders·2015

This study compared women with endometriosis in the USA and Puerto Rico to see if their symptoms and health conditions differed. Researchers found that while both groups experienced similar types of pain and fertility problems, women in the USA reported more severe pain and more often had other chronic conditions like chronic fatigue syndrome and fibromyalgia. Women in Puerto Rico more frequently reported miscarriages.

E2 ModerateCohortPEM unclearCross-Sectional

Measuring substantial reductions in activity.

Schafer, Charles, Evans, Meredyth, Jason, Leonard A et al.·Journal of prevention & intervention in the community·2015

ME/CFS diagnosis requires showing a significant drop in daily activities, but doctors have struggled to measure this fairly. This study looked at different ways to measure activity levels—including work, quality of life surveys, and activity trackers—to find which method works best. The researchers found that tracking current work activities was the most useful way to show the substantial reduction in functioning that ME/CFS patients experience.

E2 ModerateCohortPEM not requiredCase-Control

Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?

Boles, Richard G, Zaki, Essam A, Kerr, Jonathan R et al.·Mitochondrion·2015

This study found that two specific variations in mitochondrial DNA (the energy-producing structures in our cells) appear more frequently in people with ME/CFS and several other conditions that cause fatigue, pain, or dysfunction. The researchers looked at people with a particular genetic background and found that having one or both of these DNA variations was linked to increased risk of developing these conditions. This suggests these genetic variations may be a shared risk factor across multiple illnesses.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Functional level of patients with chronic fatigue syndrome reporting use of alternative vs. traditional treatments.

Wise, Shelby, Jantke, Rachel, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2015

This study looked at 97 ME/CFS patients to compare how well they were functioning based on the treatments they used. Patients were divided into three groups: those using only complementary/alternative medicine (CAM), those using only traditional medicine, and those using both. The study found that patients using CAM alone had better social functioning and fewer psychiatric diagnoses compared to the other groups.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

[The prevalence of low back pain in hospital staff and its relationship with chronic fatigue syndrome and occupational factors].

Terzi, Rabia, Altın, Firuzan·Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology·2015

This study looked at hospital workers to see how many experienced lower back pain and whether it was connected to chronic fatigue syndrome (ME/CFS). About 60% of the 365 hospital staff surveyed had back pain in the previous year, and those with back pain were significantly more likely to also have ME/CFS. Working irregular shifts and spending many years in the job appeared to increase the risk of developing ME/CFS.

E2 ModerateCohortPEM not requiredCase-Control

Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome.

Rajeevan, Mangalathu S, Dimulescu, Irina, Murray, Janna et al.·Human immunology·2015

Researchers compared the genes of 50 people with ME/CFS to 121 healthy people to look for differences in genes related to immune system and inflammation. They found 32 genetic differences associated with ME/CFS, particularly in genes controlling how the body's natural defense system works. These findings suggest that problems with immune activation may play a role in ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredObservational

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.

Vangeel, Elise, Van Den Eede, Filip, Hompes, Titia et al.·Psychosomatic medicine·2015

This study looked at a chemical marker called DNA methylation on a gene (NR3C1) that controls how the body responds to stress. Researchers found that people with ME/CFS had lower levels of this methylation compared to healthy people, which may explain why their bodies don't handle stress hormones properly. Interestingly, childhood trauma did not appear to create additional changes in this marker among ME/CFS patients.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredLongitudinal

The impact of significant other expressed emotion on patient outcomes in chronic fatigue syndrome.

Band, Rebecca, Barrowclough, Christine, Wearden, Alison·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2014

This study looked at how the emotional responses of family members or partners affect ME/CFS patients' health outcomes. Researchers found that when significant others were overly critical or overly involved, patients tended to have worse fatigue, more disability, and more depression 6 months later. The emotional support you receive from those close to you appears to matter for how your ME/CFS progresses.

E2 ModerateCohortPEM not requiredLongitudinal

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: a population-based matched-cohort study.

Chung, Shiu-Dong, Lin, Ching-Chun, Liu, Shih-Ping et al.·Neurourology and urodynamics·2014

This study found that people with obstructive sleep apnea (OSA)—a condition where breathing stops repeatedly during sleep—are nearly 4 times more likely to develop bladder pain syndrome/interstitial cystitis (BPS/IC) compared to people without OSA. Researchers followed over 32,000 people in Taiwan for 3 years and tracked who developed BPS/IC. The findings suggest that sleep problems and bladder pain may be connected, and doctors should ask patients with sleep apnea about urinary symptoms.

Sleep

E2 ModeratePEM unclearRegistry-Resource

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012.

Bakken, Inger Johanne, Tveito, Kari, Gunnes, Nina et al.·BMC medicine·2014

This study tracked how often ME/CFS is diagnosed in Norway between 2008 and 2012. Researchers found that about 26 people per 100,000 develop ME/CFS each year, and women are diagnosed about three times more often than men. Interestingly, the disease peaks twice: once in teenagers and again in people in their 30s, which suggests that different life stages or age-related factors may influence who gets ME/CFS.

E2 ModeratePEM not requiredRegistry-Resource

Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.

Belcaro, G, Cornelli, U, Luzzi, R et al.·Panminerva medica·2014

This small study tested whether a supplement made from French oak wood extract (Robuvit®) could help people with chronic fatigue syndrome (CFS) when combined with a structured management plan. About half of the 91 participants received the supplement for 6 months while the other half followed the management plan alone. The supplement group showed greater improvements in fatigue symptoms and mood compared to the management-only group, and no side effects were reported.

Interventions

E2 ModerateBehavioralPEM not requiredObservational

Implementing evidence-based practice for patients with chronic fatigue syndrome.

Wiborg, Jan F, Wensing, Michel, Tummers, Marcia et al.·Clinical psychology & psychotherapy·2014

This study looked at whether community mental health centres could successfully offer cognitive behaviour therapy (CBT) to ME/CFS patients using a training manual and support. Three centres treated over 40 patients each, with good results—most patients improved in fatigue and physical functioning. The research found that while the manual was helpful, therapists still needed direct support from experts when starting out.

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome and personality: a case-control study using the Alternative Five Factor Model.

Sáez-Francàs, Naia, Valero, Sergi, Calvo, Natalia et al.·Psychiatry research·2014

This study looked at personality traits in people with ME/CFS compared to healthy people without the condition. Researchers found that people with ME/CFS tend to have lower levels of activity and drive, and higher levels of anxiety and worry. These personality differences were the strongest markers that could distinguish ME/CFS patients from people without the condition.

E2 ModerateMechanismPEM unclearMechanistic

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Yasuhito Nakatomi, Kei Mizuno, Akira Ishii et al.·Brain, Behavior, and Immunity·2014·n=9

Japanese researchers used PET imaging with a neuroinflammation tracer (PK11195) in 9 ME/CFS patients and healthy controls. They found significantly elevated neuroinflammation signals across multiple brain regions in ME/CFS patients, particularly in the cingulate cortex, thalamus, and brainstem — areas regulating fatigue and cognition.

Neuroinflammation

E2 ModerateCohortPEM not requiredObservational

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Lebedeva, A V, Shchukin, I A, Soldatov, M A et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2014

This study looked at 35 people with multiple sclerosis (MS) who experienced severe fatigue and mood problems. Researchers gave them a supplement called idebenon for 6 months and found it reduced their fatigue, tiredness, and depression. While this is interesting, it's important to note this study focused on MS patients, not ME/CFS patients, though both conditions involve fatigue.

E2 ModerateCohortPEM unclearCross-Sectional

Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis.

Brenu, Ekua Weba, Huth, Teilah K, Hardcastle, Sharni L et al.·International immunology·2014

This study compared immune system cells in 30 people with ME/CFS and 25 healthy controls to identify which immune cells are abnormal in ME/CFS. Researchers found several key differences: patients with ME/CFS had unusual numbers and activity levels of immune cells called B cells, regulatory T cells, and neutrophils. These findings suggest that ME/CFS involves problems with how the immune system regulates itself, similar to autoimmune diseases.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Tsai, S-Y, Yang, T-Y, Chen, H-J et al.·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014

This study found that people who had shingles (herpes zoster) had a higher risk of developing ME/CFS compared to people who didn't have shingles. Researchers followed thousands of people over several years and found that those with a history of shingles were about 29% more likely to develop chronic fatigue syndrome, suggesting that viral infections like shingles may trigger ME/CFS in some people.

E2 ModerateCohortPEM unclearCross-Sectional

Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome.

Maes, Michael, Leunis, Jean-Claude, Geffard, Michel et al.·Neuro endocrinology letters·2014

This study found that many people with ME/CFS experience stomach and digestive problems, and this appears to be linked to bacteria from the gut leaking into the bloodstream. Researchers identified two groups of ME/CFS patients: those with significant abdominal discomfort and those without. The group with digestive symptoms showed higher levels of immune responses to gut bacteria, suggesting their intestinal barrier may be more permeable.

Immune System

E2 ModerateCohortPEM unclearLongitudinal

Prevalence, health care utilization, and costs of fibromyalgia, irritable bowel, and chronic fatigue syndromes in the military health system, 2006-2010.

Jeffery, Diana D, Bulathsinhala, Lakmini, Kroc, Michelle et al.·Military medicine·2014

This study looked at how many military service members had fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome between 2006 and 2010. Fibromyalgia diagnoses increased significantly during this period, while chronic fatigue syndrome diagnoses stayed about the same. The cost of treating fibromyalgia cases rose dramatically, especially after new fibromyalgia medications became available.

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Sleep characteristics, exercise capacity and physical activity in patients with chronic fatigue syndrome.

Characteristics of women with endometriosis from the USA and Puerto Rico.

Measuring substantial reductions in activity.

Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?

Functional level of patients with chronic fatigue syndrome reporting use of alternative vs. traditional treatments.

[The prevalence of low back pain in hospital staff and its relationship with chronic fatigue syndrome and occupational factors].

Pathway-focused genetic evaluation of immune and inflammation related genes with chronic fatigue syndrome.

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.

The impact of significant other expressed emotion on patient outcomes in chronic fatigue syndrome.

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: a population-based matched-cohort study.

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012.

Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.

Implementing evidence-based practice for patients with chronic fatigue syndrome.

Chronic fatigue syndrome and personality: a case-control study using the Alternative Five Factor Model.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis.

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome.

Prevalence, health care utilization, and costs of fibromyalgia, irritable bowel, and chronic fatigue syndromes in the military health system, 2006-2010.

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