ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

1461–1480 of 2,785 studies

E2 ModerateCohortPEM not requiredCross-Sectional

No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women.

He, Xiaotong, Walker, Thomas D J, Maranga, Innocent O et al.·PloS one·2012

This study tested whether a virus called XMRV could be found in cervical samples from 224 Kenyan women, some with HIV and some without. Using sensitive lab techniques, the researchers found no trace of XMRV in any of the samples. This supports the idea that XMRV, once linked to ME/CFS, is likely a lab contamination rather than a real human infection.

E2 ModerateCohortPEM not requiredObservational

[Effects of tuina on the mechanical properties of skeletal muscles of four limbs in patients with chronic fatigue syndrome].

Liu, Kun-Peng, Fang, Min, Jiang, Shu-Yun·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2012

This study tested whether tuina (a traditional Chinese massage therapy) could help ME/CFS patients regain muscle strength and reduce fatigue. Sixty people participated—30 with ME/CFS and 30 healthy controls. After 10 sessions of tuina therapy, ME/CFS patients showed improvements in muscle strength measurements and reported feeling less fatigued, though their muscles remained weaker than those of healthy people.

E2 ModerateCohortPEM not requiredCase-Control

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.

Hanevik, Kurt, Kristoffersen, Einar K, Sørnes, Steinar et al.·BMC infectious diseases·2012

This study looked at immune system changes in people who developed chronic fatigue and gut problems after a Giardia infection. Researchers found that people with post-infectious chronic fatigue had lower levels of natural killer (NK) cells, which are important for fighting infections. The more severe someone's fatigue and stomach symptoms were, the lower their NK cells tended to be.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile.

Cockshell, Susan J, Mathias, Jane L·Journal of clinical and experimental neuropsychology·2012

This study tested whether people with ME/CFS perform poorly on thinking tests because they aren't trying hard enough, or because of the illness itself. Researchers gave 54 people with ME/CFS and 54 healthy people a special test designed to measure effort and intention during testing. The results showed that most people in both groups were trying their best, and very few showed signs of not putting in effort—suggesting that low effort is not the reason people with ME/CFS struggle with cognitive tasks.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care.

Wiborg, Jan F, Knoop, Hans, Wensing, Michel et al.·Behaviour research and therapy·2012

This study looked at how well cognitive behavior therapy (CBT) for ME/CFS works when delivered by different therapists in regular mental health clinics rather than specialized centers. Researchers found that the individual therapist made a big difference in patient outcomes—accounting for 21% of the improvement variation. The therapist's beliefs about using treatment manuals and the specific clinic where treatment happened both influenced how well patients did.

E2 ModerateDiagnosticPEM unclearMethods-Paper

Data mining: comparing the empiric CFS to the Canadian ME/CFS case definition.

Jason, Leonard A, Skendrovic, Beth, Furst, Jacob et al.·Journal of clinical psychology·2012

This study compared two different sets of diagnostic criteria used to identify ME/CFS patients. Researchers used a computer-based analysis technique to test which questions from patient surveys were most helpful in accurately diagnosing the illness. They found that the Canadian criteria correctly identified 87% of ME/CFS patients, while the older empiric criteria identified about 79%, suggesting the Canadian approach may be more effective for diagnosis.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Contrasting case definitions for chronic fatigue syndrome, Myalgic Encephalomyelitis/chronic fatigue syndrome and myalgic encephalomyelitis.

Jason, Leonard A, Brown, Abigail, Clyne, Erin et al.·Evaluation & the health professions·2012

This study looked at patients diagnosed with chronic fatigue syndrome (CFS) using an older definition and compared how many of them would also meet two newer, stricter definitions: ME/CFS and ME. Researchers found that patients meeting the newer, stricter definitions had more severe symptoms and greater disability than those who only met the older CFS definition. This suggests that the newer definitions may help doctors identify the most severely affected patients.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Katz, Ben Z, Stewart, Julian M, Shiraishi, Yukiko et al.·Clinical pediatrics·2012

This study looked at whether teenagers with ME/CFS have trouble standing up for long periods (a condition called orthostatic intolerance). Researchers tested 36 teens with ME/CFS and 43 recovered teens, all about 6 months after having infectious mononucleosis. Surprisingly, they found that similar numbers of both groups had difficulty with standing tolerance, suggesting this may not be a key difference between those who recover and those who develop ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.

Maes, Michael, Mihaylova, Ivana, Kubera, Marta et al.·Metabolic brain disease·2012

This study examined immune system markers in people with ME/CFS, depression, and healthy controls. Researchers found that people with ME/CFS had higher levels of specific immune antibodies (IgM) attacking certain body molecules compared to people with depression. These antibodies were especially high against fatty acid anchors and oxidatively damaged proteins, suggesting ME/CFS may involve distinct immune processes that differ from depression.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls.

White, Andrea T, Light, Alan R, Hughen, Ronald W et al.·Psychosomatic medicine·2012

This study compared how the bodies of ME/CFS patients, multiple sclerosis (MS) patients, and healthy people respond to moderate exercise by measuring changes in specific genes in blood cells. ME/CFS patients experienced much larger increases in fatigue and pain after exercise, and showed distinctive patterns of gene activity related to pain sensing and stress hormones that were different from MS patients and healthy controls.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies.

Ravindran, Murugan, Adewuyi, Oluwatoyin, Zheng, Yin et al.·Global journal of health science·2012

Many people with ME/CFS experience shortness of breath, but this study found that their lungs work normally—the problem isn't with how well air moves in and out. Instead, people with ME/CFS seem to be overly sensitive to physical sensations like rapid heartbeat, chest pain, and dizziness during exertion, which makes them feel breathless. This suggests the shortness of breath in ME/CFS comes from how the nervous system processes these sensations rather than from damaged lungs.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.

Loew, Stephen J, Watson, Kenneth·Perceptual and motor skills·2012

This study looked at whether a specific gene called APOB might be linked to Meares-Irlen syndrome, a condition that affects how the eyes process visual information and can make reading difficult. The researchers found that certain variations of this gene were more common in people with Meares-Irlen syndrome than in people without it. This is interesting because the same gene has been connected to problems with fat and cholesterol metabolism, which have also been found in ME/CFS and other conditions.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredCross-Sectional

Factor analysis of the Beck Depression Inventory-II with patients with chronic fatigue syndrome.

Brown, Molly, Kaplan, Carly, Jason, Leonard·Journal of health psychology·2012

This study looked at how well a depression screening tool (the Beck Depression Inventory-II) works for people with ME/CFS. The researchers found that the tool picks up on physical and emotional symptoms separately, and that people with ME/CFS tend to score high on the physical symptom questions because many overlap with ME/CFS symptoms like fatigue. A simpler version of the tool designed for primary care settings worked better for this group.

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging.

Hollingsworth, K G, Hodgson, T, Macgowan, G A et al.·Journal of internal medicine·2012

This study used advanced heart imaging (MRI) to look at how the hearts of people with ME/CFS work compared to healthy people. Researchers found that ME/CFS patients had smaller hearts with less blood volume, weaker pumping strength, and abnormal twisting and relaxation patterns. These heart changes may help explain why ME/CFS patients experience such severe fatigue and exercise intolerance.

E2 ModerateCohortPEM not requiredObservational

Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue.

Broderick, Gordon, Katz, Ben Z, Fernandes, Henrique et al.·Journal of translational medicine·2012

This study followed 301 teenagers who had infectious mononucleosis caused by the Epstein-Barr virus (EBV) for two years. Some developed ME/CFS after their infection while others recovered completely. Researchers measured multiple immune molecules called cytokines in the blood to see if they could identify a pattern that distinguishes people with post-infectious ME/CFS from those who fully recovered.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

Telephone-based guided self-help for adolescents with chronic fatigue syndrome: A non-randomised cohort study.

Lloyd, Samantha, Chalder, Trudie, Sallis, Hannah M et al.·Behaviour research and therapy·2012

This study tested whether teenagers with chronic fatigue syndrome could benefit from a short telephone-based self-help program based on cognitive-behavioural therapy principles. Sixty-three adolescents received six sessions over three months, with follow-up support. Six months after treatment, participants reported significantly less fatigue and attended school more often, suggesting this simple intervention may help some young people with CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Patterns of food avoidance in chronic fatigue syndrome: is there a case for dietary recommendations?

Trabal, J, Leyes, P, Fernández-Solá, J et al.·Nutricion hospitalaria·2012

This study looked at what foods people with severe ME/CFS avoid eating and why. Researchers found that many patients restrict dairy and gluten, but digestive symptoms didn't actually improve when they avoided these foods. The study suggests that some dietary restrictions may be based on advice rather than actual food problems, and recommends that dietary changes should only be made when there's a proven allergy or intolerance.

E2 ModerateCohortPEM not requiredCross-Sectional

Lipid and protein oxidation in female patients with chronic fatigue syndrome.

Tomic, Slavica, Brkic, Snezana, Maric, Daniela et al.·Archives of medical science : AMS·2012

This study looked for signs of oxidative stress—damage caused by harmful molecules in the body—in women with ME/CFS compared to healthy women. Researchers found that women with ME/CFS had higher levels of markers showing damage to fats and proteins in their blood, along with an unhealthy cholesterol pattern. These findings suggest that oxidative stress may be occurring in ME/CFS and could potentially increase heart disease risk over time.

E2 ModerateCohortPEM unclearCross-Sectional

Fibromyalgia and chronic fatigue syndrome in children.

Itoh, Yasuhiko, Shigemori, Tomoko, Igarashi, Tohru et al.·Pediatrics international : official journal of the Japan Pediatric Society·2012

This study looked at two conditions that cause long-term pain and exhaustion in children: fibromyalgia and chronic fatigue syndrome. Researchers tested blood samples from children with each condition to see if they had similar immune system patterns. They found that while these conditions share some symptoms, they appear to have different immune system signatures, suggesting they may be separate diseases—though some children can have both.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome.

Burbelo, Peter D, Bayat, Ahmad, Wagner, Jason et al.·American journal of translational research·2012

This study tested whether a virus called HHV-6 might be causing chronic fatigue syndrome (ME/CFS). Researchers compared antibodies (immune system markers) against HHV-6 in people with ME/CFS and healthy controls. They found that both groups had similar levels of HHV-6 antibodies, suggesting this virus is unlikely to be a major cause of ME/CFS.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women.

[Effects of tuina on the mechanical properties of skeletal muscles of four limbs in patients with chronic fatigue syndrome].

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.

Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile.

Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care.

Data mining: comparing the empiric CFS to the Canadian ME/CFS case definition.

Contrasting case definitions for chronic fatigue syndrome, Myalgic Encephalomyelitis/chronic fatigue syndrome and myalgic encephalomyelitis.

Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.

Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls.

Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies.

A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.

Factor analysis of the Beck Depression Inventory-II with patients with chronic fatigue syndrome.

Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging.

Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue.

Telephone-based guided self-help for adolescents with chronic fatigue syndrome: A non-randomised cohort study.

Patterns of food avoidance in chronic fatigue syndrome: is there a case for dietary recommendations?

Lipid and protein oxidation in female patients with chronic fatigue syndrome.

Fibromyalgia and chronic fatigue syndrome in children.

No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research