ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1721–1740 of 2,807 studies

E2 ModerateCohortPEM not requiredLongitudinal

The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

Beever, Richard·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study tested whether far-infrared sauna sessions (3 times per week for 3 months) could improve quality of life in people with type II diabetes. Researchers found that participants reported improvements in physical health, general health, stress, and fatigue. The study suggests that saunas might help people with diabetes feel better, and interestingly, more people seemed willing to try saunas compared to other lifestyle changes.

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.

Groom, Harriet C T, Boucherit, Virginie C, Makinson, Kerry et al.·Retrovirology·2010

This study looked for a virus called XMRV in 170 ME/CFS patients and 395 healthy controls to see if the virus was linked to the disease. Researchers used two methods: direct detection of viral material and blood tests looking for immune responses. They found no evidence that XMRV was associated with ME/CFS, contradicting an earlier study that had reported finding the virus in most CFS patients.

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired sleep in chronic fatigue syndrome: how is it best measured?

Creti, Laura, Libman, Eva, Baltzan, Marcel et al.·Journal of health psychology·2010

This study compared three different ways of measuring sleep in people with ME/CFS: overnight hospital testing (polysomnography), wrist-worn activity monitors (actigraphy), and patients reporting on their own sleep. Researchers found that while objective measurements matched what patients reported about total sleep time, the objective tests didn't capture daytime symptoms like non-refreshing sleep, fatigue, or sleepiness that patients actually experience.

E2 ModerateCohortPEM not requiredCase-Control

Nitric oxide concentrations are normal and unrelated to activity level in chronic fatigue syndrome: a case-control study.

Meeus, Mira, VAN Eupen, Inge, Hondequin, Jasmien et al.·In vivo (Athens, Greece)·2010

This study examined whether a chemical messenger in the blood called nitric oxide (NO) is related to how active people are in ME/CFS. Researchers measured activity levels and blood NO in 30 ME/CFS patients and 29 healthy but inactive people over one week. While ME/CFS patients were indeed much less active than controls, the amount of NO in their blood was normal and had no connection to their activity levels.

Biomarkers

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal MRI shows no cerebral abnormality in chronic fatigue syndrome.

Perrin, R, Embleton, K, Pentreath, V W et al.·The British journal of radiology·2010

This study used MRI brain scans to look for physical abnormalities in people with ME/CFS compared to healthy people. Eighteen patients with ME/CFS and nine healthy volunteers were scanned twice, one year apart. The researchers found no significant differences between the two groups in brain size, fluid levels, blood flow, or white matter lesions, and these measurements remained stable over the year.

Biomarkers

E2 ModerateCohortPEM unclearObservational

Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia.

Weaver, Shelley A, Janal, Malvin N, Aktan, Nadine et al.·Journal of women's health (2002)·2010

Researchers gave patients with ME/CFS a tryptophan infusion (a building block for serotonin, a brain chemical) to see how their bodies would respond. They found that women with ME/CFS alone had a stronger response in a hormone called prolactin compared to healthy women, but women with ME/CFS plus fibromyalgia did not show this difference. Men in all groups showed similar responses, suggesting ME/CFS may work differently in women than in men.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.

Mohammed, Reem Hamdy Abdellatif, ElMakhzangy, Hesham Ibrahim, Gamal, Amira et al.·Clinical rheumatology·2010

This study looked at 306 people in Egypt with chronic hepatitis C virus (HCV) infection to see how often they experienced joint pain, fatigue, dry eyes, and other autoimmune-related symptoms. Researchers found that about 16% of people with HCV had these types of rheumatologic symptoms, with fatigue and dry eyes being most common. The study suggests that HCV infection can trigger these kinds of whole-body symptoms through autoimmune mechanisms.

E2 ModerateCohortPEM not requiredCase-Control

Impaired cardiovascular response to standing in chronic fatigue syndrome.

Hollingsworth, Kieren G, Jones, David E J, Taylor, Roy et al.·European journal of clinical investigation·2010

This study found that people with ME/CFS have abnormal heart function when standing up, and their heart and muscle cells struggle to produce energy efficiently. Researchers used specialized scans to measure energy metabolism in the heart and muscles, and found that about one-third of ME/CFS patients showed significant heart energy problems. When standing, ME/CFS patients had stronger heart contractions and more symptoms compared to healthy controls, suggesting their bodies are working much harder to maintain blood flow.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Robinson, M, Gray, S R, Watson, M S et al.·Scandinavian journal of medicine & science in sports·2010

This study looked at specific markers of inflammation and oxidative stress (cellular damage) in people with ME/CFS compared to healthy individuals, both at rest and after exercise. Researchers found that a marker called F2-isoprostanes—which indicates oxidative stress—was consistently higher in ME/CFS patients. However, they did not find differences in inflammation markers like IL-6 between the two groups.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Cameron, Barbara, Flamand, Louis, Juwana, Hedy et al.·Journal of medical virology·2010

Researchers tested blood samples from ME/CFS patients and healthy controls to see whether three common herpesviruses (EBV, CMV, and HHV-6) were actively reactivating or causing ongoing infection. They found no evidence that these viruses were actively infected or reactivating in ME/CFS patients compared to controls who recovered normally from infection.

Immune System

E2 ModerateBehavioralPEM not requiredCase-Control

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

Martin, Maryanne, Alexeeva, Iana·British journal of health psychology·2010

This study looked at whether people with ME/CFS have a tendency to automatically focus their attention on illness-related information, and whether they interpret ambiguous words in an illness-focused way. The researchers found that people with ME/CFS did not show these automatic biases. However, they did find that people with ME/CFS experienced greater mood swings when they spent time thinking repetitively about their condition (rumination) compared to when they were distracted.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Satterfield, Brent C, Garcia, Rebecca A, Gurrieri, Fiorella et al.·Molecular autism·2010

This study tested whether a virus called XMRV is present in children with autism, particularly those born to mothers with ME/CFS. Researchers used blood tests and antibody checks on over 400 participants and found no evidence that XMRV is linked to autism. This helps clarify that despite earlier media suggestions, this particular virus does not appear to contribute to autism development.

E2 ModerateCohortPEM not requiredCross-Sectional

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

Scully, Paul, McKernan, Declan P, Keohane, John et al.·The American journal of gastroenterology·2010

This study looked at inflammation markers in the blood of women with irritable bowel syndrome (IBS), particularly those who also had fibromyalgia, premenstrual symptoms, or chronic fatigue syndrome. Researchers found that women with IBS plus these extra conditions had higher levels of four inflammation-related substances (IL-1β, IL-6, IL-8, and TNFα) compared to healthy women, while those with IBS alone had elevated levels of two of these markers.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study.

Suárez, Andrea, Guillamó, Elisabet, Roig, Teresa et al.·Journal of women's health (2002)·2010

This study looked at a chemical called nitric oxide in the blood of people with ME/CFS and healthy controls before and after exercise. Researchers found that people with ME/CFS had much higher levels of this chemical in their blood after exercise compared to healthy people. The findings suggest that measuring nitric oxide response to exercise might help doctors diagnose ME/CFS in the future.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

[Multiple chemical sensitivity: epidemiological, clinical and prognostic differences between occupational and non-occupational cases].

Nogué Xarau, Santiago, Alarcón Romay, María, Martínez Martínez, José-Miguel et al.·Medicina clinica·2010

This study looked at 165 people with multiple chemical sensitivity (MCS)—a condition where people react badly to everyday chemicals—to see if it made a difference whether their condition started from workplace exposure or other sources. People whose MCS began at work had fewer related conditions like chronic fatigue and fibromyalgia, and were less likely to become permanently disabled, compared to those whose MCS developed from non-work exposures.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality features and personality disorders in chronic fatigue syndrome: a population-based study.

Nater, Urs M, Jones, James F, Lin, Jin-Mann S et al.·Psychotherapy and psychosomatics·2010

This study looked at whether certain personality traits are more common in people with ME/CFS. Researchers compared 113 people with ME/CFS to people without it and found that those with ME/CFS had higher rates of certain personality patterns (like being more anxious or withdrawn) and personality disorders. However, these personality differences were not unique to ME/CFS—they also appeared in other chronically ill groups.

E2 ModerateCohortPEM unclearCross-Sectional

No evidence for XMRV association in pediatric idiopathic diseases in France.

Jeziorski, Eric, Foulongne, Vincent, Ludwig, Catherine et al.·Retrovirology·2010

Researchers tested whether a virus called XMRV might be causing various childhood illnesses and respiratory diseases. They checked samples from 151 children and adults with different conditions, but found no evidence that XMRV was present in any of them. This suggests that XMRV is likely not responsible for these particular diseases.

E2 ModerateCohortPEM unclearCase-Control

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.

Meeus, Mira, Nijs, Jo, Huybrechts, Sven et al.·Clinical rheumatology·2010

This study tested whether people with ME/CFS feel pain more intensely than healthy people, even in areas where they don't typically experience pain. Researchers measured how much pressure patients and healthy volunteers could tolerate before feeling pain. They found that ME/CFS patients with chronic pain had significantly lower pain thresholds everywhere on their body, suggesting their nervous system may be in a heightened state of sensitivity.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue and chronic fatigue syndrome-like complaints in the general population.

van't Leven, Marjolein, Zielhuis, Gerhard A, van der Meer, Jos W et al.·European journal of public health·2010

This study surveyed over 9,000 Dutch adults to understand how common fatigue is in the general population and what factors might be associated with it. Researchers found that about 1% of adults experience fatigue meeting CFS-like criteria, and 30% experience longer-lasting fatigue. People with CFS-like fatigue were more likely to be female, less physically active, obese, and taking painkillers regularly.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Latent class analysis of functional somatic symptoms in a population-based sample of twins.

Kato, Kenji, Sullivan, Patrick F, Pedersen, Nancy L·Journal of psychosomatic research·2010

This study looked at how people with chronic fatigue and multiple physical symptoms cluster into different groups. Researchers studied over 28,000 twins and found five distinct groups: those with no symptoms, those mainly tired, those with stomach problems, those with pain, and those with many symptoms across all areas. The study suggests that while genes play a small role, environmental factors (like stress, infections, or lifestyle) are much more important in determining who develops these symptoms.

Pain and Sensitization

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The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.

Impaired sleep in chronic fatigue syndrome: how is it best measured?

Nitric oxide concentrations are normal and unrelated to activity level in chronic fatigue syndrome: a case-control study.

Longitudinal MRI shows no cerebral abnormality in chronic fatigue syndrome.

Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia.

Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.

Impaired cardiovascular response to standing in chronic fatigue syndrome.

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

Nitric oxide metabolite production during exercise in chronic fatigue syndrome: a case-control study.

[Multiple chemical sensitivity: epidemiological, clinical and prognostic differences between occupational and non-occupational cases].

Personality features and personality disorders in chronic fatigue syndrome: a population-based study.

No evidence for XMRV association in pediatric idiopathic diseases in France.

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.

Fatigue and chronic fatigue syndrome-like complaints in the general population.

Latent class analysis of functional somatic symptoms in a population-based sample of twins.

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