ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2401–2420 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: predictors of functional status in a national nursing sample.

Wagner-Raphael, Lynne I, Jason, Leonard A, Ferrari, Joseph R·Journal of occupational health psychology·1999

This study looked at nurses with severe tiredness to understand how fatigue affects their daily lives and well-being. Researchers found that as fatigue got worse, people had more trouble with physical activities, work tasks, social interactions, and overall quality of life. Nurses who had ME/CFS experienced greater difficulties than those with fatigue from other causes.

E2 ModerateCohortPEM not requiredObservational

Human herpesviruses in chronic fatigue syndrome.

Wallace, H L, Natelson, B, Gause, W et al.·Clinical and diagnostic laboratory immunology·1999

Researchers tested whether common viruses (HHV6, HHV7, Epstein-Barr virus, and cytomegalovirus) are more active or present in people with ME/CFS compared to healthy people. They examined blood samples from ME/CFS patients and matched healthy controls, looking for both the viruses themselves and antibodies (immune markers) against these viruses. They found no significant differences between the two groups, suggesting these particular viruses may not be a primary driver of ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychiatric adjustment in adolescents with a history of chronic fatigue syndrome.

Garralda, E, Rangel, L, Levin, M et al.·Journal of the American Academy of Child and Adolescent Psychiatry·1999

This study looked at mental health in teenagers who had ME/CFS, comparing them to healthy peers. Researchers found that teenagers with a history of ME/CFS were more likely to experience anxiety and depression, had more emotional symptoms, and felt worse about themselves—especially regarding how they fit in socially. Interestingly, those who had recovered from ME/CFS actually showed more anxiety disorders than those still experiencing active illness.

E2 ModerateCohortPEM unclearLongitudinal

Prognostic factors for persons with idiopathic chronic fatigue.

Hartz, A J, Kuhn, E M, Bentler, S E et al.·Archives of family medicine·1999

This study followed 199 people with chronic fatigue for 2 years to understand which factors predicted who would improve. Researchers found that people who had clearer thinking, fewer additional symptoms, better sleep patterns, and were married tended to show the most improvement in fatigue. Interestingly, when patients improved in other symptoms like depression, muscle pain, or sleep problems, their fatigue also tended to improve together.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Korszun, A, Sackett-Lundeen, L, Papadopoulos, E et al.·The Journal of rheumatology·1999

This study looked at melatonin—a hormone that helps control sleep and daily rhythms—in women with fibromyalgia and chronic fatigue syndrome. Researchers collected blood samples every 10 minutes over 24 hours and found that women with fibromyalgia had higher melatonin levels at night compared to healthy controls, but women with chronic fatigue syndrome did not. The authors concluded there is no evidence that taking melatonin supplements would help these patients.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Michiels, V, de Gucht, V, Cluydts, R et al.·Journal of clinical and experimental neuropsychology·1999

This study tested thinking and memory skills in 29 people with ME/CFS and compared them to 22 healthy people of similar age and education. The results showed that people with ME/CFS had slower thinking speed and difficulty processing information efficiently, but their ability to shift attention or focus on specific visual tasks was not notably impaired. Interestingly, memory problems appeared to stem from difficulty storing new information initially, rather than trouble recalling it later.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

[Patients with fatigue in family practice: prevalence and treatment].

Kenter, E G, Okkes, I M·Nederlands tijdschrift voor geneeskunde·1999

This study looked at how often people visit their doctor complaining of fatigue and what doctors do about it. Researchers tracked visits from general practitioners across the Netherlands over 10 years, involving over 93,000 patient visits. They found that about 92 out of every 1,000 patients saw their doctor each year because of fatigue, but only about 4% had fatigue lasting 6 months or longer.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue and chemical sensitivities in Gulf Registry Veterans.

Kipen, H M, Hallman, W, Kang, H et al.·Archives of environmental health·1999

This study looked at symptoms reported by Gulf War veterans to see how many experienced chronic fatigue and chemical sensitivities. Researchers found that about 16% of veterans met the standard criteria for ME/CFS, about 13% had multiple chemical sensitivities, and a small percentage had both conditions. The findings suggest these conditions were common among Gulf War veterans, though the study was based only on questionnaire responses rather than medical exams.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

The 1microg short Synacthen test in chronic fatigue syndrome.

Hudson, M, Cleare, A J·Clinical endocrinology·1999

This study tested whether people with ME/CFS have lower levels of cortisol (a stress hormone) or weaker adrenal gland responses compared to healthy people. Researchers gave small doses of a hormone called Synacthen to 20 ME/CFS patients and 20 healthy controls, then measured cortisol levels over an hour. They found no significant differences between the two groups, suggesting that reduced adrenal reserve may not explain ME/CFS symptoms.

Endocrine Disruption

E2 ModerateBehavioralPEM unclearCross-Sectional

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Christodoulou, C, Deluca, J, Johnson, S K et al.·Journal of psychosomatic research·1999

This study looked at personality traits in people with ME/CFS compared to healthy people and those with multiple sclerosis (MS). The researchers used a personality framework that measures how people respond to harm, seek rewards, and persist with goals. Both ME/CFS and MS patients showed similar patterns: they were more cautious about potential harm and less focused on social rewards than healthy controls.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of Euroqol EQ-5D and SF-36 in patients with chronic fatigue syndrome.

Myers, C, Wilks, D·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·1999

This study compared two common questionnaires that measure quality of life and health status in people with ME/CFS. Researchers gave both questionnaires to 85 patients and found that the results from the two tests were very similar to each other. The study found that people with ME/CFS reported high levels of physical disability and moderate emotional or psychological problems.

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome in private practice psychiatry: family history of physical and mental health.

Endicott, N A·Journal of psychosomatic research·1999

This study looked at 45 psychiatric patients with ME/CFS and compared their family medical histories to two similar groups of psychiatric patients without ME/CFS. Researchers found that ME/CFS patients' parents tended to die younger and had more cancer, autoimmune disorders, and ME/CFS-like illnesses compared to the families of control patients. There were no significant differences in mental health conditions between the families.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological states and neuropsychological performances in chronic Lyme disease.

Elkins, L E, Pollina, D A, Scheffer, S R et al.·Applied neuropsychology·1999

This study looked at mood and thinking abilities in 30 people with post-Lyme syndrome (a condition that can develop after Lyme disease). Researchers found that these patients had lower levels of positive feelings (like happiness or hopefulness) compared to the general population, but their actual thinking and memory skills tested normally. The study suggests that reduced positive mood, rather than depression or other psychiatric conditions, may be the most important psychological marker of this illness.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Autonomic function in patients with chronic fatigue syndrome.

Soetekouw, P M, Lenders, J W, Bleijenberg, G et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1999

Researchers tested whether ME/CFS patients have problems with the part of the nervous system that automatically controls heart rate and blood pressure. They compared 37 ME/CFS patients to 38 healthy people using several tests (like standing up quickly, holding their breath, and doing mental math). The study found only minor differences, suggesting that major autonomic problems may not be the primary issue in ME/CFS, though some specific responses to stress were reduced.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.

Evengård, B, Briese, T, Lindh, G et al.·Journal of neurovirology·1999

Researchers tested whether a virus called Borna disease virus (BDV) might be causing ME/CFS in Swedish patients. They examined blood samples from 169 patients and 62 healthy controls using two different detection methods—one looking for antibodies (immune system markers) and another looking for viral genetic material. They found no evidence of BDV in any of the patient samples, suggesting this particular virus is not responsible for ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

TNF-alpha and chronic fatigue syndrome.

Moss, R B, Mercandetti, A, Vojdani, A·Journal of clinical immunology·1999

This study looked at whether a molecule called TNF-alpha, which helps control inflammation in the body, is elevated in people with ME/CFS. Researchers compared blood levels of TNF-alpha in patients with ME/CFS to healthy people without the condition. They found that people with ME/CFS had significantly higher levels of TNF-alpha, suggesting that inflammation may play a role in the disease.

Immune System

E2 ModerateBehavioralPEM unclearCross-Sectional

Psychiatric diagnoses in Gulf War veterans with fatiguing illness.

Lange, G, Tiersky, L, DeLuca, J et al.·Psychiatry research·1999

Researchers studied Gulf War veterans with severe fatigue to see whether psychiatric disorders could explain their illness. About half of the veterans with Gulf War Illness had similar rates of psychiatric diagnoses as healthy veterans, while the other half had more psychiatric problems. The study found that psychiatric conditions alone cannot account for the fatiguing illness these veterans experience.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Sterzl, Ivan, Procházková, Jarmila, Hrdá, Pavlína et al.·Neuro endocrinology letters·1999

This study tested whether allergies to metals like mercury (found in old dental fillings) and nickel might trigger fatigue and autoimmune problems in people with ME/CFS. Researchers compared three groups of tired patients with healthy controls and found that people with fatigue were more sensitive to these metals. When some patients had their mercury-containing fillings removed and replaced, their fatigue improved significantly.

Immune System

E2 ModerateBehavioralPEM not requiredCase-Control

Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis.

Theorell, T, Blomkvist, V, Lindh, G et al.·Psychosomatic medicine·1999

This study looked at whether stressful life events and infections in the months before ME/CFS develops might play a role in triggering the illness. Researchers interviewed 46 people with ME/CFS and 46 matched control subjects without the illness, asking them to recall what happened and how they felt month-by-month for a year. They found that people who developed ME/CFS experienced more infections and stressful events—especially in the 3 months right before onset—and their fatigue, pain, and fever symptoms stayed very high even after diagnosis, unlike the control group who recovered.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Associations between perfectionism, mood, and fatigue in chronic fatigue syndrome: a pilot study.

Blenkiron, P, Edwards, R, Lynch, S·The Journal of nervous and mental disease·1999

This study looked at whether people with ME/CFS who tend to be perfectionists experience different levels of fatigue, anxiety, or depression compared to healthy people. Researchers found that people with ME/CFS actually had lower perfectionism scores than healthy controls, and were less likely to set high standards for others. Interestingly, this lower expectation of others was linked to less physical fatigue.

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Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: predictors of functional status in a national nursing sample.

Human herpesviruses in chronic fatigue syndrome.

Psychiatric adjustment in adolescents with a history of chronic fatigue syndrome.

Prognostic factors for persons with idiopathic chronic fatigue.

Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

[Patients with fatigue in family practice: prevalence and treatment].

Prevalence of chronic fatigue and chemical sensitivities in Gulf Registry Veterans.

The 1microg short Synacthen test in chronic fatigue syndrome.

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Comparison of Euroqol EQ-5D and SF-36 in patients with chronic fatigue syndrome.

Chronic fatigue syndrome in private practice psychiatry: family history of physical and mental health.

Psychological states and neuropsychological performances in chronic Lyme disease.

Autonomic function in patients with chronic fatigue syndrome.

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.

TNF-alpha and chronic fatigue syndrome.

Psychiatric diagnoses in Gulf War veterans with fatiguing illness.

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis.

Associations between perfectionism, mood, and fatigue in chronic fatigue syndrome: a pilot study.

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