ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2808 studies

2601–2620 of 2,808 studies

E2 ModerateCohortPEM not requiredLongitudinal

Changing epidemiology of Ross River virus disease in South Australia.

Selden, S M, Cameron, A S·The Medical journal of Australia·1996

This study followed people in South Australia who had Ross River virus (RRV) infections to see how long symptoms lasted. Researchers found that more than half of patients still had joint pain and tiredness 15 months after infection, with similar patterns continuing for 30 months. The symptoms were very disabling for many people and resembled chronic fatigue syndrome.

E2 ModerateCohortPEM not requiredCross-Sectional

Serum carnitine and disabling fatigue in multiple sclerosis.

Fukazawa, T, Sasaki, H, Kikuchi, S et al.·Psychiatry and clinical neurosciences·1996

This study tested whether a substance called carnitine, which helps muscles use fat for energy, might be low in people with multiple sclerosis (MS) and could explain their severe fatigue. Researchers compared carnitine levels in 25 MS patients and healthy people of similar age and sex, but found no differences between groups or between MS patients with and without severe fatigue.

Energy Metabolism

E2 ModerateCohortPEM not requiredObservational

A comparison of the characteristics of chronic fatigue syndrome in primary and tertiary care.

Euba, R, Chalder, T, Deale, A et al.·The British journal of psychiatry : the journal of mental science·1996

This study compared ME/CFS patients seen in general doctor's offices with those referred to a specialist clinic. Patients at the specialist clinic had more severe fatigue and physical symptoms, and were more functionally disabled, but were often wealthier and more likely to believe their illness had a physical cause. Interestingly, nearly half of those referred to the specialist clinic didn't actually meet the official criteria for ME/CFS.

E2 ModerateCohortPEM not requiredObservational

No findings of enteroviruses in Swedish patients with chronic fatigue syndrome.

Lindh, G, Samuelson, A, Hedlund, K O et al.·Scandinavian journal of infectious diseases·1996

Researchers tested 34 Swedish patients with ME/CFS to see if a virus called enterovirus might be causing their illness. They looked for the virus in stool samples, blood, spinal fluid, and muscle tissue using several different detection methods. The study found no evidence of enterovirus infection in any of the patients tested.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

Conti, F, Magrini, L, Priori, R et al.·Allergy·1996

This study measured a protein called eosinophil cationic protein (ECP) in the blood of ME/CFS patients to see if their immune cells called eosinophils were overly active. Researchers found that ME/CFS patients had significantly higher ECP levels than healthy controls, and most ME/CFS patients also tested positive for allergies. However, ME/CFS patients with allergies did not have higher ECP levels than those without allergies, suggesting the connection may be more complex than initially expected.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Preliminary determination of a molecular basis of chronic fatigue syndrome.

McGregor, N R, Dunstan, R H, Zerbes, M et al.·Biochemical and molecular medicine·1996

Researchers tested the urine of 20 ME/CFS patients and 45 healthy controls to look for chemical differences. They found that ME/CFS patients had different levels of several substances in their urine, particularly one called CFSUM1 and beta-alanine, which were higher in patients with more severe symptoms. These findings suggest ME/CFS may have measurable biological markers that could help identify the condition.

BiomarkersEnergy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

Assessing somatization disorder in the chronic fatigue syndrome.

Johnson, S K, DeLuca, J, Natelson, B H·Psychosomatic medicine·1996

This study compared how often doctors diagnosed somatization disorder (a condition where emotional distress causes physical symptoms) in ME/CFS patients versus people with multiple sclerosis, depression, or no illness. The researchers found that whether symptoms were labeled as 'psychiatric' or 'physical' dramatically changed the diagnosis rate, suggesting that labeling is somewhat arbitrary in ME/CFS. Very few patients in any group actually met strict diagnostic criteria for somatization disorder.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Descriptive epidemiology of chronic fatigue syndrome based on a nationwide survey in Japan.

Minowa, M, Jiamo, M·Journal of epidemiology·1996

Researchers surveyed hospitals across Japan in 1992 to understand how many people have ME/CFS and how it spreads. They found that about 0.85 cases per 100,000 people were diagnosed that year, with slightly more women affected than men. The number of cases appeared to be growing from 1992 to 1993, and a small percentage of cases started after an infection.

E2 ModerateCohortPEM not requiredCase-Control

An examination of the working case definition of chronic fatigue syndrome.

Komaroff, A L, Fagioli, L R, Geiger, A M et al.·The American journal of medicine·1996

Researchers studied 281 patients with severe, long-lasting fatigue to see how well the official definition of ME/CFS worked. They compared these patients to healthy people and people with similar conditions like multiple sclerosis and depression. The study found that certain symptoms—like muscle pain, post-exertion exhaustion, headaches, and flu-like symptoms—were very common in ME/CFS patients but rare in the other groups.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Clinical and neurocognitive features of the post Lyme syndrome.

Bujak, D I, Weinstein, A, Dornbush, R L·The Journal of rheumatology·1996

This study looked at people who had Lyme disease and continued to have fatigue, joint pain, and memory problems even after antibiotic treatment. Researchers compared 23 of these patients to 23 people who recovered fully from Lyme disease. The group with ongoing symptoms performed worse on memory and concentration tests, reported more sleep and mood problems, and showed signs of greater emotional distress.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Cell-mediated immune function and the outcome of chronic fatigue syndrome.

Wilson, A, Hickie, I, Lloyd, A et al.·International journal of immunopharmacology·1995

Researchers followed 103 ME/CFS patients for an average of 3.2 years to see if their immune system function predicted how well they would recover. Most patients improved over time, but about one-third remained unable to work. The study found that immune cell measurements taken at the start did not seem to predict who would get better or worse.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Silicone breast implant--associated musculoskeletal manifestations.

Cuellar, M L, Gluck, O, Molina, J F et al.·Clinical rheumatology·1995

This study looked at 300 women with silicone breast implants who came to a rheumatology clinic with muscle and joint pain. The researchers found that over 80% of these women had signs of connective tissue disease, and more than half met criteria for fibromyalgia or chronic fatigue syndrome. When some women had their implants removed, over 70% reported improvement in their overall symptoms.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Parvovirus B19 infection--persistence and genetic variation.

Kerr, J R, Curran, M D, Moore, J E et al.·Scandinavian journal of infectious diseases·1995

Researchers followed 53 people who had acute parvovirus B19 infection (a virus that causes rash and joint pain) for several years. They found that 7 people, all women, still had the virus detectable in their blood years later. Of these 7, one person developed chronic fatigue syndrome along with persistent joint pain, suggesting that B19 infection might sometimes persist in the body and potentially trigger long-term symptoms.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Does high 'action-proneness' make people more vulnerable to chronic fatigue syndrome? A controlled psychometric study.

Van Houdenhove, B, Onghena, P, Neerinckx, E et al.·Journal of psychosomatic research·1995

This study asked whether people who are naturally very active and driven before getting sick might be more likely to develop ME/CFS. Researchers compared 35 ME/CFS patients with three other groups (pain patients, patients with other chronic conditions, and people with anxiety) and found that ME/CFS patients reported being significantly more active and action-oriented before their illness began. This suggests that having a naturally 'busy' or hyperactive lifestyle before becoming ill might play a role in developing ME/CFS.

E2 ModerateCohortPEM unclearCross-Sectional

Reducing heterogeneity in chronic fatigue syndrome: a comparison with depression and multiple sclerosis.

Natelson, B H, Johnson, S K, DeLuca, J et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

This study examined whether ME/CFS becomes simpler to understand when researchers focus on patients who did not have mental health conditions before getting sick. The researchers found that when they excluded patients with prior psychiatric problems, ME/CFS patients resembled those with mild multiple sclerosis more than those with depression, suggesting the illness may have a physical cause like an infection or immune system problem.

E2 ModerateBehavioralPEM unclearLongitudinal

Outcome and prognosis of patients with chronic fatigue vs chronic fatigue syndrome.

Bombardier, C H, Buchwald, D·Archives of internal medicine·1995

This study followed 445 patients with chronic fatigue or chronic fatigue syndrome (CFS) for about 1.5 years to see how they recovered. While 64% of patients improved overall, only 2% felt completely better. Patients diagnosed with CFS had more severe symptoms and lower functioning than those with simple chronic fatigue, and depression made recovery less likely.

E2 ModerateBehavioralPEM not requiredObservational

A clinical study of chronic fatigue syndrome.

Shanks, M F, Ho-Yen, D O·The British journal of psychiatry : the journal of mental science·1995

This study looked at 64 ME/CFS patients to understand whether psychiatric conditions (like depression or anxiety) are part of ME/CFS itself or develop separately. Researchers found that patients without pre-existing psychiatric disorders had milder illness overall, suggesting that ME/CFS can occur on its own. Most patients improved with counseling and by staying within their energy limits.

E2 ModerateCohortPEM unclearCross-Sectional

High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders.

Klein, R, Berg, P A·European journal of medical research·1995

Researchers found that patients with ME/CFS and fibromyalgia syndrome (FMS) often have similar antibodies in their blood—proteins the immune system produces that may attack the body's own tissues. About 62% of ME/CFS patients and 73% of FMS patients had antibodies against serotonin, a chemical important for mood and pain regulation. Interestingly, these antibodies were also found in family members of affected patients, suggesting a genetic component may play a role.

Immune System

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue and the chronic fatigue syndrome: prevalence in a Pacific Northwest health care system.

Buchwald, D, Umali, P, Umali, J et al.·Annals of internal medicine·1995

This study surveyed over 3,000 people in a Seattle health plan to find out how common ME/CFS and chronic fatigue are in the community. Researchers found that about 19% of people reported chronic fatigue, but only a tiny fraction actually met the strict diagnostic criteria for ME/CFS. Those with ME/CFS or chronic fatigue had worse physical health, more difficulty with daily activities, and more emotional stress compared to healthy people without fatigue.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

The practice of infectious diseases in the 1990s: the Canadian experience.

Schlech, W F·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

This study surveyed Canadian infectious disease doctors in 1990 to see what kinds of infections they were treating. The researchers found that bacterial infections were more common in hospitalized patients, while viral infections were more common in office visits. Interestingly, the survey included mentions of chronic fatigue syndrome alongside other infectious diseases, suggesting doctors were considering it in their practice at that time.

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Changing epidemiology of Ross River virus disease in South Australia.

Serum carnitine and disabling fatigue in multiple sclerosis.

A comparison of the characteristics of chronic fatigue syndrome in primary and tertiary care.

No findings of enteroviruses in Swedish patients with chronic fatigue syndrome.

Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

Preliminary determination of a molecular basis of chronic fatigue syndrome.

Assessing somatization disorder in the chronic fatigue syndrome.

Descriptive epidemiology of chronic fatigue syndrome based on a nationwide survey in Japan.

An examination of the working case definition of chronic fatigue syndrome.

Clinical and neurocognitive features of the post Lyme syndrome.

Cell-mediated immune function and the outcome of chronic fatigue syndrome.

Silicone breast implant--associated musculoskeletal manifestations.

Parvovirus B19 infection--persistence and genetic variation.

Does high 'action-proneness' make people more vulnerable to chronic fatigue syndrome? A controlled psychometric study.

Reducing heterogeneity in chronic fatigue syndrome: a comparison with depression and multiple sclerosis.

Outcome and prognosis of patients with chronic fatigue vs chronic fatigue syndrome.

A clinical study of chronic fatigue syndrome.

High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders.

Chronic fatigue and the chronic fatigue syndrome: prevalence in a Pacific Northwest health care system.

The practice of infectious diseases in the 1990s: the Canadian experience.

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