ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1161–1180 of 2,423 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome in the UK armed forces.

Le Blackadder-Coward, J C Q, Perry, S·Journal of the Royal Naval Medical Service·2013

This study examined how ME/CFS (also called CFS) affects people serving in the UK military, and how the condition should be recognized and managed in this specific setting. ME/CFS can significantly impact a service member's career and ability to work in challenging military environments. The article discusses how doctors can better identify and treat this condition in military personnel.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

Diagnosing Chronic Fatigue Syndrome in South Asians: Lessons from a Secondary Analysis of a UK Qualitative Study.

De Silva, R Erandie Ediriweera, Bayliss, Kerin, Riste, Lisa et al.·Journal of family medicine and primary care·2013

This study looked at why ME/CFS is rarely diagnosed in South Asia, even though people there experience its symptoms. By interviewing South Asian patients, doctors, and community leaders in the UK, researchers found that cultural beliefs, language barriers, and doctors' lack of knowledge about ME/CFS make it harder for people to get a proper diagnosis. The study suggests that raising awareness about ME/CFS in South Asia could help more people get diagnosed and treated.

Diagnostics

E3 PreliminaryBehavioralPEM not requiredCase-Control

A case of chronic fatigue syndrome improved by traditional Korean medicine.

Son, Chang-Gue·Integrative medicine research·2013

This report describes one woman with ME/CFS who experienced significant improvement in her fatigue after receiving traditional Korean medicine treatments, including herbal medicine, acupuncture, and moxibustion over three months. Her fatigue severity scores were cut roughly in half during treatment. While this single case suggests these treatments may help some people, it does not prove they work for everyone with ME/CFS.

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions.

Morris, Gerwyn, Maes, Michael·Neuro endocrinology letters·2013

Over the past 50+ years, doctors have created many different definitions and diagnostic criteria for ME/CFS, but these criteria were often based on expert opinion rather than scientific evidence. This paper examines why so many different definitions exist and argues that future diagnostic criteria should be built on objective test results (like blood work and brain imaging) rather than just symptoms alone, to better distinguish between ME and CFS as two related but separate conditions.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

A metagenomic approach to investigate the microbial causes of myalgic encephalomyelitis/chronic fatigue syndrome: moving beyond XMRV.

Miller, Ruth R, Gardy, Jennifer L, Tang, Patrick et al.·Fatigue : biomedicine, health & behavior·2013

This study used advanced genetic sequencing techniques to search for microorganisms (bacteria, viruses, and fungi) that might cause ME/CFS. Rather than looking for one specific virus, the researchers cast a wider net to detect any microbes present in patient samples. This approach moved beyond previous unsuccessful searches for a single virus, offering a more comprehensive way to understand whether infections play a role in ME/CFS.

Gut Microbiome

E3 PreliminaryBehavioralPEM unclear

'The letting go, the building up, [and] the gradual process of rebuilding': identity change and post-traumatic growth in myalgic encephalomyelitis/chronic fatigue syndrome.

Arroll, Megan A, Howard, Alex·Psychology & health·2013

This study talked to 10 people with ME/CFS about how the illness changed who they are as a person. Participants described losing abilities they once had, feeling isolated from others, and worrying about their future. Interestingly, some people reported finding unexpected personal growth through this experience—developing a stronger sense of their 'true self' after accepting their new limitations.

E3 PreliminaryBehavioralPEM not requiredMechanistic

Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation.

Shreevathsa, M, Ravishankar, B, Dwivedi, Rambabu·Ayu·2013

Researchers tested an Ayurvedic herbal mixture called Mamsyadi Kwatha to see if it could help with depression and fatigue-like symptoms in mice. The mixture contains three plant ingredients and showed some ability to reduce signs of depression and fatigue in animal tests, suggesting it might have antidepressant properties.

E3 PreliminaryMechanismPEM not requiredMechanistic

Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.

Medow, Marvin S, Aggarwal, Arun, Baugham, Ila et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2013

When skin is heated, blood vessels normally dilate to increase blood flow. This study found that people with ME/CFS have lower baseline blood flow in their skin compared to healthy people. When researchers used drugs to reduce harmful molecules called reactive oxygen species (particularly hydrogen peroxide), blood flow improved and the initial blood vessel response to heat increased in ME/CFS patients but not in healthy controls.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryCommentaryPEM unclearEditorial

New developments in the diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome.

Pontari, Michel, Giusto, Laura·Current opinion in urology·2013

This article discusses how chronic prostatitis and chronic pelvic pain syndrome in men can present differently—some men have pain localized to the pelvic area, while others experience widespread body symptoms similar to other chronic conditions. The authors review new treatment options including physical therapy, acupuncture, psychological support, and medications, and note that these conditions often occur alongside other chronic pain disorders like fibromyalgia and chronic fatigue syndrome.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.

Tokizane, Kyohei, Konishi, Hiroyuki, Yasui, Masaya et al.·Molecular and cellular endocrinology·2013

When the body experiences prolonged stress, it can affect how the pituitary gland (a small gland in the brain that controls many hormones) works. In this rat study, researchers found that stress caused increased production of a protein called VGF in certain pituitary cells. Interestingly, this increase happened because stress reduced levels of dopamine, a chemical messenger that normally keeps VGF levels low.

Endocrine Disruption

E3 PreliminaryCohortPEM not requiredCross-Sectional

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Sivaranjani, N, Rao, S Venkata, Rajeev, G·Journal of clinical and diagnostic research : JCDR·2013

This study looked at whether skin damage from harmful molecules called reactive oxygen species plays a role in atopic dermatitis (eczema). Researchers compared 25 people with atopic dermatitis to 25 healthy people and measured levels of damaging molecules and protective antioxidants in their bodies. They found that people with eczema had more damage and lower levels of natural protective substances, suggesting that antioxidants might help treat the condition.

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?

Meeus, Mira, Nijs, Jo, Hermans, Linda et al.·Expert opinion on therapeutic targets·2013

This study explores how damage to the energy-producing parts of cells (mitochondria) might explain why ME/CFS and fibromyalgia patients experience persistent pain and fatigue. When the body experiences oxidative stress, it produces harmful molecules that can damage mitochondria and reduce the energy (ATP) available to muscles and the brain. The researchers suggest that boosting antioxidants and repairing mitochondria could be promising treatments worth testing.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.

Morris, Gerwyn, Anderson, George, Berk, Michael et al.·Molecular neurobiology·2013

This review examines how a natural substance called Coenzyme Q10 (CoQ10) helps cells produce energy and protect themselves from damage. The authors found that low levels of CoQ10 may contribute to ME/CFS and similar conditions that cause fatigue and exhaustion. Studies suggest that taking CoQ10 supplements might help reduce fatigue and improve exercise tolerance in people with ME/CFS, similar to benefits seen in patients with Parkinson's disease and fibromyalgia.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredObservational

The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome.

Akarsu, Selim, Tekin, Levent, Ay, Hakan et al.·Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2013

This small study looked at whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could help people with ME/CFS. Sixteen patients received 15 treatment sessions over three weeks, and researchers measured fatigue and quality of life before and after. All three fatigue measures showed improvement after treatment, and the therapy was well tolerated.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Distinguishing between depression and chronic fatigue syndrome].

Asberg, Marie, Nygren, Ake, Nager, Anna·Lakartidningen·2013

This study examines how depression and ME/CFS are different conditions, even though they can look similar on the surface. The researchers discuss why it's important for doctors to tell these conditions apart, since they require different treatment approaches. Understanding these differences helps ensure patients get the right care for their specific condition.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome.

Maes, Michael·Modern trends in pharmacopsychiatry·2013

This study suggests that ME/CFS involves several overlapping biological problems: inflammation, oxidative stress (cellular damage), and activation of certain immune pathways. The researchers found that ME (characterized by post-exertional malaise) is more severe than CFS, and both conditions have higher levels of inflammatory markers than regular chronic fatigue. Understanding these biological mechanisms may help develop new targeted treatments.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Jason, Leonard A, Brown, Molly, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2013

This study reviewed research on the Energy Envelope approach, a self-management strategy that helps ME/CFS patients track and limit their daily activities to stay within their available energy level. Rather than pushing through exhaustion, patients learn to pace themselves carefully to avoid crashes. Research shows this approach can reduce symptom flare-ups and improve quality of life for people with ME/CFS.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Somatic symptoms in consultation-liaison psychiatry.

Grover, Sandeep, Kate, Natasha·International review of psychiatry (Abingdon, England)·2013

This review discusses how doctors who specialize in both medical and mental health (called consultation-liaison psychiatrists) can help patients with ME/CFS and similar conditions where physical symptoms don't have a clear medical explanation. The review explains that these patients often experience depression and anxiety alongside their physical symptoms, and they use healthcare services frequently. Treatment options include talking therapies, cognitive behavior therapy, and antidepressants, which work with varying degrees of success.

E3 PreliminaryBehavioralPEM unclear

[Moxibustion at Yongquan (KI 1) for sleep disorders of chronic fatigue syndrome].

Chen, Xiao-Qin, Gang, Zhi-Xiu, Xu, Zhi-Peng·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2013

This study explored whether moxibustion—a traditional Chinese medicine technique involving burning herbs near the skin—might help improve sleep problems in people with ME/CFS. The treatment focused on a specific acupuncture point on the sole of the foot called Yongquan (KI 1). While the study suggests this approach may have helped some patients sleep better, the research quality is limited and more rigorous testing is needed.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fatigue syndromes--an overview of terminology, definitions and classificatory concepts].

Dörr, Johanna, Nater, Urs·Psychotherapie, Psychosomatik, medizinische Psychologie·2013

This article reviews how doctors classify and differentiate between different fatigue conditions, including ME/CFS, burnout, and an older condition called neurasthenia. The authors found that while these conditions share some symptoms, they have important differences—but there currently isn't enough research to clearly separate them. Depression often occurs alongside ME/CFS and burnout, making diagnosis more complicated.

Diagnostics

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Evidence browser

Chronic fatigue syndrome in the UK armed forces.

Diagnosing Chronic Fatigue Syndrome in South Asians: Lessons from a Secondary Analysis of a UK Qualitative Study.

A case of chronic fatigue syndrome improved by traditional Korean medicine.

Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions.

A metagenomic approach to investigate the microbial causes of myalgic encephalomyelitis/chronic fatigue syndrome: moving beyond XMRV.

'The letting go, the building up, [and] the gradual process of rebuilding': identity change and post-traumatic growth in myalgic encephalomyelitis/chronic fatigue syndrome.

Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation.

Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.

New developments in the diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome.

Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.

Role of reactive oxygen species and antioxidants in atopic dermatitis.

The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?

Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.

The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome.

[Distinguishing between depression and chronic fatigue syndrome].

Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome.

Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Somatic symptoms in consultation-liaison psychiatry.

[Moxibustion at Yongquan (KI 1) for sleep disorders of chronic fatigue syndrome].

[Fatigue syndromes--an overview of terminology, definitions and classificatory concepts].

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

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