ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1161–1180 of 2,422 studies

'The letting go, the building up, [and] the gradual process of rebuilding': identity change and post-traumatic growth in myalgic encephalomyelitis/chronic fatigue syndrome.

Arroll, Megan A, Howard, Alex·Psychology & health·2013

This study talked to 10 people with ME/CFS about how the illness changed who they are as a person. Participants described losing abilities they once had, feeling isolated from others, and worrying about their future. Interestingly, some people reported finding unexpected personal growth through this experience—developing a stronger sense of their 'true self' after accepting their new limitations.

E3 PreliminaryCohortPEM not requiredObservational

The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome.

Akarsu, Selim, Tekin, Levent, Ay, Hakan et al.·Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2013

This small study looked at whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could help people with ME/CFS. Sixteen patients received 15 treatment sessions over three weeks, and researchers measured fatigue and quality of life before and after. All three fatigue measures showed improvement after treatment, and the therapy was well tolerated.

E3 PreliminaryMechanismPEM unclearMechanistic

A metagenomic approach to investigate the microbial causes of myalgic encephalomyelitis/chronic fatigue syndrome: moving beyond XMRV.

Miller, Ruth R, Gardy, Jennifer L, Tang, Patrick et al.·Fatigue : biomedicine, health & behavior·2013

This study used advanced genetic sequencing techniques to search for microorganisms (bacteria, viruses, and fungi) that might cause ME/CFS. Rather than looking for one specific virus, the researchers cast a wider net to detect any microbes present in patient samples. This approach moved beyond previous unsuccessful searches for a single virus, offering a more comprehensive way to understand whether infections play a role in ME/CFS.

Gut Microbiome

E3 PreliminaryReviewPEM unclearReview-Narrative

Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.

Morris, Gerwyn, Anderson, George, Berk, Michael et al.·Molecular neurobiology·2013

This review examines how a natural substance called Coenzyme Q10 (CoQ10) helps cells produce energy and protect themselves from damage. The authors found that low levels of CoQ10 may contribute to ME/CFS and similar conditions that cause fatigue and exhaustion. Studies suggest that taking CoQ10 supplements might help reduce fatigue and improve exercise tolerance in people with ME/CFS, similar to benefits seen in patients with Parkinson's disease and fibromyalgia.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome.

Kishi, Akifumi, Togo, Fumiharu, Cook, Dane B et al.·Physiological reports·2013

This study looked at how sleep changes after exercise in healthy people versus those with ME/CFS. Researchers found that while exercise helped healthy people sleep more deeply and continuously, people with ME/CFS showed different sleep patterns—specifically more disruptions when moving from REM sleep (dream sleep) back to wakefulness. Importantly, these REM sleep disruptions in ME/CFS patients were linked to increased fatigue, pain, and sleepiness the next day.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome.

Maes, Michael·Modern trends in pharmacopsychiatry·2013

This study suggests that ME/CFS involves several overlapping biological problems: inflammation, oxidative stress (cellular damage), and activation of certain immune pathways. The researchers found that ME (characterized by post-exertional malaise) is more severe than CFS, and both conditions have higher levels of inflammatory markers than regular chronic fatigue. Understanding these biological mechanisms may help develop new targeted treatments.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study.

Costantini, Antonio, Pala, Maria Immacolata·Journal of alternative and complementary medicine (New York, N.Y.)·2013

This small study tested whether high-dose vitamin B1 (thiamine) could help fatigue in people with inflammatory bowel disease. Twelve patients took large amounts of thiamine for 20 days, and ten of them reported their fatigue almost completely went away. The researchers suggest that fatigue in these patients may come from cells not absorbing thiamine properly, rather than from actual vitamin deficiency in the blood.

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?

Meeus, Mira, Nijs, Jo, Hermans, Linda et al.·Expert opinion on therapeutic targets·2013

This study explores how damage to the energy-producing parts of cells (mitochondria) might explain why ME/CFS and fibromyalgia patients experience persistent pain and fatigue. When the body experiences oxidative stress, it produces harmful molecules that can damage mitochondria and reduce the energy (ATP) available to muscles and the brain. The researchers suggest that boosting antioxidants and repairing mitochondria could be promising treatments worth testing.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.

Medow, Marvin S, Aggarwal, Arun, Baugham, Ila et al.·Journal of applied physiology (Bethesda, Md. : 1985)·2013

When skin is heated, blood vessels normally dilate to increase blood flow. This study found that people with ME/CFS have lower baseline blood flow in their skin compared to healthy people. When researchers used drugs to reduce harmful molecules called reactive oxygen species (particularly hydrogen peroxide), blood flow improved and the initial blood vessel response to heat increased in ME/CFS patients but not in healthy controls.

Pain and SensitizationAutonomic Nervous System

E3 PreliminaryMechanismPEM unclearMechanistic

Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis.

Proal, Amy D, Albert, Paul J, Marshall, Trevor G et al.·Immunologic research·2013

This study suggests that ME/CFS may be caused by multiple germs (bacteria, viruses, and fungi) working together in the body, rather than a single pathogen. The researchers proposed that these microbes interfere with how our genes are expressed, and developed an immunostimulatory treatment that showed promise in improving both how patients feel and measurable health markers.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Re-writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

Castori, Marco, Morlino, Silvia, Celletti, Claudia et al.·American journal of medical genetics. Part A·2013

This review examines joint hypermobility syndrome and a related condition called Ehlers-Danlos syndrome hypermobility type, which cause chronic pain, loose joints, and other symptoms like fatigue and headaches. The authors describe how these conditions develop over time and suggest that they may share similar underlying mechanisms with other chronic illnesses like ME/CFS and fibromyalgia. The goal is to help doctors better recognize and treat these conditions.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredObservational

Looking for idiopathic intracranial hypertension in patients with chronic fatigue syndrome.

Higgins, Nicholas, Pickard, John, Lever, Andrew·Journal of observational pain medicine·2013

This study looked at whether some ME/CFS patients with severe headaches might actually have a separate condition called idiopathic intracranial hypertension (IIH)—increased fluid pressure around the brain. Researchers tested 20 ME/CFS patients with prominent headaches and found that 8 of them had elevated pressure levels, suggesting they had undiagnosed IIH. This raises the possibility that some people diagnosed with ME/CFS might benefit from testing and treatment for this other condition.

E3 PreliminaryMechanismPEM unclearMechanistic

Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis.

Broderick, Gordon, Ben-Hamo, Rotem, Vashishtha, Saurabh et al.·Brain, behavior, and immunity·2013

This study looked at how the immune systems of Gulf War veterans respond to exercise compared to healthy people and those with ME/CFS. Researchers drew blood before, during peak exercise, and 4 hours after exercise, then analyzed gene activity and immune markers. They found that Gulf War Illness involves an exaggerated immune and stress response to exercise, while ME/CFS showed the opposite pattern with a dampened immune response.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Distinguishing between depression and chronic fatigue syndrome].

Asberg, Marie, Nygren, Ake, Nager, Anna·Lakartidningen·2013

This study examines how depression and ME/CFS are different conditions, even though they can look similar on the surface. The researchers discuss why it's important for doctors to tell these conditions apart, since they require different treatment approaches. Understanding these differences helps ensure patients get the right care for their specific condition.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Norepinephrine and epinephrine responses to physiological and pharmacological stimulation in chronic fatigue syndrome.

Strahler, Jana, Fischer, Susanne, Nater, Urs M et al.·Biological psychology·2013

This study looked at how the body's stress hormones (norepinephrine and epinephrine) respond in ME/CFS patients compared to healthy people. Researchers tested 21 ME/CFS patients and 20 controls using exercise and a hormone-stimulation test, measuring stress hormones before and after. ME/CFS patients showed weaker hormone responses to exercise, particularly lower baseline levels and blunted epinephrine release, which could help explain why physical activity feels so exhausting.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies - novel tool for diagnostics and patient follow-up.

Osnes, Liv T, Nakken, Britt, Bodolay, Edit et al.·Autoimmunity reviews·2013

This article reviews how scientists measure specific immune system molecules called cytokines and immune cells to help diagnose and monitor autoimmune diseases and immune deficiencies. By measuring both inflammatory and anti-inflammatory markers together, doctors can better understand what's happening in a patient's immune system and track whether treatments are working.

BiomarkersImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome.

Nakamura, Toru, Schwander, Stephan, Donnelly, Robert et al.·Clinical and vaccine immunology : CVI·2013

Researchers tested whether exercise and sleep loss could trigger increased inflammatory markers in the blood of ME/CFS patients, since many people report that physical activity and poor sleep make their symptoms worse. They found that neither exercise nor sleep deprivation caused the expected increases in inflammatory proteins in people with ME/CFS compared to healthy controls. This suggests that immune activation from these stressors may not be the main reason symptoms worsen with exertion or sleep loss.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Irritable bowel syndrome and migraine: bystanders or partners?

Chang, Full-Young, Lu, Ching-Liang·Journal of neurogastroenterology and motility·2013

This editorial examines two common chronic pain conditions—irritable bowel syndrome (IBS) and migraine—and explores whether they might be related. Both conditions are more common in women, significantly reduce quality of life, and often occur together in the same patients. The authors suggest these disorders may share underlying causes related to how the nervous system processes pain, rather than being completely separate diseases.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Clinical Practice: Chronic fatigue syndrome.

Werker, Charlotte L, Nijhof, Sanne L, van de Putte, Elise M·European journal of pediatrics·2013

This review explains how doctors diagnose ME/CFS in teenagers and describes what we know works to treat it. ME/CFS is a serious illness causing extreme fatigue that doesn't get better with rest, along with other symptoms like trouble thinking clearly, sore throat, and muscle pain. The good news is that a type of talking therapy called cognitive behavioural therapy helps about two-thirds of teenagers with ME/CFS feel better and stay better for years.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study.

Higgins, Nicholas, Pickard, John, Lever, Andrew·JRSM short reports·2013

This study looked at whether some people with ME/CFS might actually have a condition called idiopathic intracranial hypertension (IIH), which involves increased pressure around the brain and spinal cord. The researchers performed lumbar punctures (spinal taps) on ME/CFS patients with headaches and measured the fluid pressure around their spinal cord. They found that some patients improved after the procedure, suggesting a possible link between the two conditions.

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'The letting go, the building up, [and] the gradual process of rebuilding': identity change and post-traumatic growth in myalgic encephalomyelitis/chronic fatigue syndrome.

The efficacy of hyperbaric oxygen therapy in the management of chronic fatigue syndrome.

A metagenomic approach to investigate the microbial causes of myalgic encephalomyelitis/chronic fatigue syndrome: moving beyond XMRV.

Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.

The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome.

Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome.

Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study.

The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?

Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.

Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis.

Re-writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

Looking for idiopathic intracranial hypertension in patients with chronic fatigue syndrome.

Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis.

[Distinguishing between depression and chronic fatigue syndrome].

Norepinephrine and epinephrine responses to physiological and pharmacological stimulation in chronic fatigue syndrome.

Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies - novel tool for diagnostics and patient follow-up.

Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome.

Irritable bowel syndrome and migraine: bystanders or partners?

Clinical Practice: Chronic fatigue syndrome.

Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study.

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