ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2423 studies

1221–1240 of 2,423 studies

E3 PreliminaryMechanismPEM unclearMechanistic

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

Barrioluengo, Verónica, Wang, Yi, Le Grice, Stuart F J et al.·The FEBS journal·2012

This study examined how accurately a virus called XMRV copies its genetic material when it infects human cells. Researchers compared XMRV's copying accuracy to two other viruses (HIV and another mouse virus) by measuring how often mistakes happen during the copying process. The study found that XMRV makes copies with reasonable accuracy, though with a different pattern of errors than HIV.

E3 PreliminaryReviewPEM unclearReview-Narrative

Central sensitization as a component of post-deployment syndrome.

Lewis, Jeffrey D, Wassermann, Eric M, Chao, Wendy et al.·NeuroRehabilitation·2012

This study suggests that post-deployment syndrome—a condition affecting military veterans with chronic pain, fatigue, and memory problems—may develop through a process called central sensitization. Central sensitization means the nervous system becomes overly sensitive and amplifies pain signals. The researchers propose this happens because of changes in how the brain and spinal cord process information, and that stress and genes may increase the risk.

Pain and Sensitization

E3 PreliminaryMechanismPEM unclearCross-Sectional

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

Mendoza, Ramon, Silverman, Robert H, Klein, Eric A et al.·PloS one·2012

Researchers tested blood and fluid samples from prostate cancer patients to see if they contained XMRV, a virus that was once thought to cause chronic fatigue syndrome. They found no evidence of the virus in any of the samples, including in nine patients who had previously tested positive for XMRV. This study supports the growing scientific consensus that XMRV does not actually infect humans.

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

Ma, Xiaochu, Zhou, Shiying, Wei, Meili et al.·Virus genes·2012

This study investigated whether XMRV, a virus previously thought to be associated with chronic fatigue syndrome, could actually infect human cells. Researchers found that XMRV is a laboratory-made virus created accidentally during experiments with mouse tissues, not a naturally occurring pathogen. Testing showed that XMRV cannot infect human immune cells, suggesting it is unlikely to cause disease in people.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Minimum data elements for research reports on CFS.

Jason, Leonard A, Unger, Elizabeth R, Dimitrakoff, Jordan D et al.·Brain, behavior, and immunity·2012

Researchers noticed that different ME/CFS studies were collecting and reporting information in very different ways, making it hard to compare results across laboratories. This paper outlines the essential information that all ME/CFS research studies should include—like how patients were selected, what their characteristics are, and how they were tested—so that future studies can be compared fairly and findings can be better understood.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Suma, S, Veerendra Kumar, B·Indian journal of dental research : official publication of Indian Society for Dental Research·2012

This paper discusses jaw and joint problems (temporomandibular disorders) that commonly occur alongside conditions like ME/CFS and fibromyalgia. It explains that these jaw problems are often overlooked because they stem from increased pain sensitivity related to stress and psychological factors, rather than just physical damage. The authors argue that dentists need to recognize these connections and adjust their treatment approach for patients with these overlapping conditions.

Pain and Sensitization

E3 PreliminaryMechanismPEM unclear

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

Lee, Deanna, Das Gupta, Jaydip, Gaughan, Christina et al.·PloS one·2012

Scientists investigated whether a virus called XMRV could cause chronic fatigue syndrome or prostate cancer. Even though an earlier study claimed to find this virus in some patients, many follow-up studies couldn't confirm it. This research tested blood and tissue samples from 39 prostate cancer patients using multiple methods and found no sign of XMRV infection, suggesting the virus doesn't naturally infect humans—it likely came from contamination in laboratory experiments.

E3 PreliminaryMechanismPEM not requiredObservational

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.

Ocon, Anthony J, Messer, Zachary R, Medow, Marvin S et al.·Clinical science (London, England : 1979)·2012

This study tested whether standing at increasing angles on a tilt table—a procedure that stresses the body's ability to maintain blood flow while upright—makes 'brain fog' worse in people with ME/CFS who also have POTS (a condition causing rapid heartbeat when standing). Researchers found that when people with CFS/POTS stood at steeper angles while doing concentration and memory tests, their performance got worse compared to healthy people, suggesting that orthostatic stress (the challenge of staying upright) does interfere with thinking and memory.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryCommentaryPEM unclearEditorial

Fatigue and disrupted sleep-wake patterns in patients with cancer: a shared mechanism.

Wu, Horng-Shiuann, Davis, Jean E, Natavio, Teofanes·Clinical journal of oncology nursing·2012

Cancer patients often experience severe tiredness and sleep problems at the same time, suggesting they may share a common cause. This paper proposes that stress hormones—particularly those controlled by a system called the HPA axis—may be disrupted in ways that trigger both fatigue and poor sleep. Because ME/CFS patients have similar symptoms and similar HPA axis problems, studying cancer-related fatigue might help us understand ME/CFS better.

Sleep

E3 PreliminaryCohortPEM not requiredCase-Control

Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.

Lerner, A Martin, Ariza, Maria E, Williams, Marshall et al.·PloS one·2012

This study looked at a small group of ME/CFS patients to see if they had a specific pattern of antibodies (immune proteins) related to Epstein-Barr virus (EBV), a common virus that causes mono. The researchers found that most of these patients had high levels of antibodies against EBV proteins, and when they treated these patients with an antiviral medication for over a year, the patients improved. This suggests that EBV might be involved in ME/CFS for some patients, and a blood test might help identify them.

Immune System

E3 PreliminaryCohortPEM unclearObservational

Lack of the detection of XMRV or polytropic MLV-related sequences in blood cells from HIV-1-infected patients in Spain.

Luczkowiak, Joanna, Martínez-Prats, Lorena, Sierra, Olalla et al.·Journal of acquired immune deficiency syndromes (1999)·2012

Researchers tested blood samples from 40 HIV-infected patients in Spain to see if they carried XMRV or related viruses, which had been proposed as possible causes of ME/CFS. They found no evidence of these viruses in any patient. Some positive results turned out to be contamination from mouse DNA in the laboratory, suggesting that earlier positive findings in other studies may have been false positives caused by contamination rather than real infections.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Biomarkers of stress and fatigue].

Tanaka, Yoshihide·Nihon rinsho. Japanese journal of clinical medicine·2012

This paper reviews different ways to measure stress and fatigue in the body. Instead of just asking patients how stressed they feel, researchers are looking for physical markers—like stress hormones in saliva or hair—that show whether someone is experiencing chronic stress. The authors explain how chronic stress affects the nervous system, hormones, and immune system, and discuss which biological markers might be useful for understanding chronic fatigue syndrome.

BiomarkersImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive enzymes in the neonatal pig.

Lackeyram, D, Mine, Y, Widowski, T et al.·Journal of animal science·2012

Researchers gave young pigs either hydrogen peroxide (a substance that causes oxidative stress, similar to cellular damage) or saline over 10 days to study how oxidative stress might affect ME/CFS. Pigs given hydrogen peroxide showed reduced antioxidant levels, less physical activity, and decreased ability to digest certain carbohydrates in their intestines. This suggests that oxidative stress may interfere with how the gut breaks down food, which could contribute to fatigue and other ME/CFS symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

The tale of xenotropic murine leukemia virus-related virus.

Groom, Harriet C T, Bishop, Kate N·The Journal of general virology·2012

In 2009, scientists announced they found a virus called XMRV in many ME/CFS patients, raising hopes for a breakthrough. However, when other researchers tried to repeat these findings, they couldn't find the virus in patient samples. By 2011, it became clear that the original samples were contaminated, meaning the virus had accidentally been introduced during testing rather than being present in patients naturally. This review explains how this scientific discovery turned out to be a false alarm.

E3 PreliminaryMechanismPEM not requiredMechanistic

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.

Côté, Marceline, Zheng, Yi-Min, Liu, Shan-Lu·PloS one·2012

This study examined how XMRV, a virus once suspected to be linked to ME/CFS, enters human cells. Researchers found that XMRV enters cells differently than many other viruses—it doesn't require acidic conditions inside the cell. They also discovered that a small tail-like structure on the virus's outer coating controls whether the virus can fuse with and infect cells.

E3 PreliminaryCohortPEM not required

Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence.

Naess, Halvor, Nyland, Morten, Hausken, Trygve et al.·BMC gastroenterology·2012

After a water contamination outbreak in Norway caused a bacterial infection (giardiasis), some patients developed long-lasting severe fatigue similar to ME/CFS. This study looked at 58 patients who met the official diagnostic criteria for CFS following this infection. Most patients reported their condition was getting worse over time, and all of them had to take extended time off work or school due to their fatigue and reduced ability to function.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions.

Staud, Roland·Expert review of neurotherapeutics·2012

People with chronic pain often have trouble turning off pain signals in their brain and spinal cord, even when they should. This review explains that many chronic pain conditions—including ME/CFS—share a common problem: their bodies amplify pain signals instead of suppressing them. Tests can measure how well someone's natural pain-blocking system works, and these tests might help predict who will develop chronic pain.

Pain and Sensitization

E3 PreliminaryMechanismPEM not required

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

Fagermoen, Even, Sulheim, Dag, Winger, Anette et al.·BMC research notes·2012

This small study tested whether a blood pressure medication called clonidine could be safe and helpful for teenagers with ME/CFS. Five teenagers took a low dose of clonidine for two weeks, and researchers measured drug levels in their blood, how their hearts and blood pressure responded to position changes, and any side effects. The medication appeared safe with no serious problems, and it seemed to help improve their body's blood pressure responses.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Validation of the three-factor model of the PSQI in a large sample of chronic fatigue syndrome (CFS) patients.

Mariman, An, Vogelaers, Dirk, Hanoulle, Ignace et al.·Journal of psychosomatic research·2012

This study tested whether a sleep questionnaire commonly used in research works properly for people with ME/CFS. Researchers asked 413 patients with ME/CFS to fill out the Pittsburgh Sleep Quality Index (PSQI), which measures sleep problems. They found that the questionnaire best divides sleep issues into three separate categories: sleep efficiency (how much time you actually sleep), perceived sleep quality (how good your sleep feels), and daily disturbances (how tiredness affects daytime functioning).

Sleep

E3 PreliminaryMechanismPEM unclearMechanistic

Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.

Cao, Yin, Hu, Yuan, Liu, Ping et al.·Journal of ethnopharmacology·2012

Researchers tested a traditional Chinese herbal formula called Kai Xin San (KXS) on mice that had been made fatigued through forced exercise. Mice treated with KXS showed improvements in physical recovery markers, better immune cell activity, and reduced signs of exhaustion compared to untreated fatigued mice. The results suggest this herbal combination may help reduce fatigue by affecting the body's energy metabolism and immune system.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

Central sensitization as a component of post-deployment syndrome.

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).

Minimum data elements for research reports on CFS.

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.

Fatigue and disrupted sleep-wake patterns in patients with cancer: a shared mechanism.

Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.

Lack of the detection of XMRV or polytropic MLV-related sequences in blood cells from HIV-1-infected patients in Spain.

[Biomarkers of stress and fatigue].

The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive enzymes in the neonatal pig.

The tale of xenotropic murine leukemia virus-related virus.

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.

Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence.

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions.

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

Validation of the three-factor model of the PSQI in a large sample of chronic fatigue syndrome (CFS) patients.

Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research