ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

1221–1240 of 2,422 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Loss of stress response as a consequence of viral infection: implications for disease and therapy.

Hooper, Philip L, Hightower, Lawrence E, Hooper, Paul L·Cell stress & chaperones·2012

This paper suggests that viral infections may damage the body's ability to handle stress at the cellular level, making tissues more vulnerable to injury. Rather than looking for one specific virus causing ME/CFS, the authors propose that ME/CFS might result from a general, nonspecific cellular damage response that occurs after many types of viral infections. Understanding this mechanism could open new treatment possibilities for conditions that have not responded well to existing therapies.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.

Ocon, Anthony J, Messer, Zachary R, Medow, Marvin S et al.·Clinical science (London, England : 1979)·2012

This study tested whether standing at increasing angles on a tilt table—a procedure that stresses the body's ability to maintain blood flow while upright—makes 'brain fog' worse in people with ME/CFS who also have POTS (a condition causing rapid heartbeat when standing). Researchers found that when people with CFS/POTS stood at steeper angles while doing concentration and memory tests, their performance got worse compared to healthy people, suggesting that orthostatic stress (the challenge of staying upright) does interfere with thinking and memory.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryCohortPEM unclearObservational

Lack of the detection of XMRV or polytropic MLV-related sequences in blood cells from HIV-1-infected patients in Spain.

Luczkowiak, Joanna, Martínez-Prats, Lorena, Sierra, Olalla et al.·Journal of acquired immune deficiency syndromes (1999)·2012

Researchers tested blood samples from 40 HIV-infected patients in Spain to see if they carried XMRV or related viruses, which had been proposed as possible causes of ME/CFS. They found no evidence of these viruses in any patient. Some positive results turned out to be contamination from mouse DNA in the laboratory, suggesting that earlier positive findings in other studies may have been false positives caused by contamination rather than real infections.

E3 PreliminaryMechanismPEM not requiredMechanistic

Identification of XMRV infection-associated microRNAs in four cell types in culture.

Mohan, Ketha V K, Devadas, Krishnakumar, Sainath Rao, Shilpakala et al.·PloS one·2012

This study looked at how a virus called XMRV affects the behavior of microRNAs—tiny molecules that control how genes are expressed—in different types of human cells grown in the laboratory. Researchers infected four different cell types with XMRV and measured changes in microRNA patterns at different time points. They found that certain microRNAs changed in response to the virus infection.

Immune System

E3 PreliminaryMechanismPEM unclear

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

Lee, Deanna, Das Gupta, Jaydip, Gaughan, Christina et al.·PloS one·2012

Scientists investigated whether a virus called XMRV could cause chronic fatigue syndrome or prostate cancer. Even though an earlier study claimed to find this virus in some patients, many follow-up studies couldn't confirm it. This research tested blood and tissue samples from 39 prostate cancer patients using multiple methods and found no sign of XMRV infection, suggesting the virus doesn't naturally infect humans—it likely came from contamination in laboratory experiments.

E3 PreliminaryReviewPEM unclearReview-Narrative

Central sensitization as a component of post-deployment syndrome.

Lewis, Jeffrey D, Wassermann, Eric M, Chao, Wendy et al.·NeuroRehabilitation·2012

This study suggests that post-deployment syndrome—a condition affecting military veterans with chronic pain, fatigue, and memory problems—may develop through a process called central sensitization. Central sensitization means the nervous system becomes overly sensitive and amplifies pain signals. The researchers propose this happens because of changes in how the brain and spinal cord process information, and that stress and genes may increase the risk.

Pain and Sensitization

E3 PreliminaryDiagnosticPEM not requiredCross-Sectional

Validation of the three-factor model of the PSQI in a large sample of chronic fatigue syndrome (CFS) patients.

Mariman, An, Vogelaers, Dirk, Hanoulle, Ignace et al.·Journal of psychosomatic research·2012

This study tested whether a sleep questionnaire commonly used in research works properly for people with ME/CFS. Researchers asked 413 patients with ME/CFS to fill out the Pittsburgh Sleep Quality Index (PSQI), which measures sleep problems. They found that the questionnaire best divides sleep issues into three separate categories: sleep efficiency (how much time you actually sleep), perceived sleep quality (how good your sleep feels), and daily disturbances (how tiredness affects daytime functioning).

Sleep

E3 PreliminaryMechanismPEM unclearMechanistic

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

Barrioluengo, Verónica, Wang, Yi, Le Grice, Stuart F J et al.·The FEBS journal·2012

This study examined how accurately a virus called XMRV copies its genetic material when it infects human cells. Researchers compared XMRV's copying accuracy to two other viruses (HIV and another mouse virus) by measuring how often mistakes happen during the copying process. The study found that XMRV makes copies with reasonable accuracy, though with a different pattern of errors than HIV.

E3 PreliminaryMechanismPEM not requiredMechanistic

Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species.

Sakuma, Toshie, Tonne, Jason M, Malcolm, Jessica A et al.·PloS one·2012

Researchers studied a virus called XMRV that can jump between animal species to understand how viruses adapt when they infect new hosts. They infected a type of mouse with XMRV and watched what happened over a year, including whether the virus could be passed to offspring. The mice stayed healthy and the virus didn't spread much to the next generation, suggesting that while the virus can infect new species, it doesn't easily take hold or spread.

E3 PreliminaryReviewPEM unclearReview-Narrative

The relationship between muscle pain and fatigue.

Mastaglia, Frank L·Neuromuscular disorders : NMD·2012

When muscles work hard, pain and fatigue often happen together and can make it harder to exercise. This review examines how pain and tiredness are connected in people with muscle disorders, and explores whether brain stimulation techniques might help reduce both symptoms. Researchers used special magnetic brain stimulation tools to study how the brain controls muscles during exhausting activity.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.

Lerner, A Martin, Ariza, Maria E, Williams, Marshall et al.·PloS one·2012

This study looked at a small group of ME/CFS patients to see if they had a specific pattern of antibodies (immune proteins) related to Epstein-Barr virus (EBV), a common virus that causes mono. The researchers found that most of these patients had high levels of antibodies against EBV proteins, and when they treated these patients with an antiviral medication for over a year, the patients improved. This suggests that EBV might be involved in ME/CFS for some patients, and a blood test might help identify them.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Minimum data elements for research reports on CFS.

Jason, Leonard A, Unger, Elizabeth R, Dimitrakoff, Jordan D et al.·Brain, behavior, and immunity·2012

Researchers noticed that different ME/CFS studies were collecting and reporting information in very different ways, making it hard to compare results across laboratories. This paper outlines the essential information that all ME/CFS research studies should include—like how patients were selected, what their characteristics are, and how they were tested—so that future studies can be compared fairly and findings can be better understood.

Diagnostics

E3 PreliminaryMechanismPEM unclearCase-Control

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Brenu, Ekua W, Ashton, Kevin J, van Driel, Mieke et al.·Journal of affective disorders·2012

Researchers studied tiny molecules called microRNAs in immune cells from people with ME/CFS and healthy controls. They found that people with ME/CFS have lower levels of certain microRNAs in their immune cells, which may explain why their immune systems don't work as well. These microRNA changes could be useful biomarkers—like a fingerprint—to help diagnose or understand ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not required

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

Fagermoen, Even, Sulheim, Dag, Winger, Anette et al.·BMC research notes·2012

This small study tested whether a blood pressure medication called clonidine could be safe and helpful for teenagers with ME/CFS. Five teenagers took a low dose of clonidine for two weeks, and researchers measured drug levels in their blood, how their hearts and blood pressure responded to position changes, and any side effects. The medication appeared safe with no serious problems, and it seemed to help improve their body's blood pressure responses.

Autonomic Nervous System

E3 PreliminaryMechanismPEM unclearCross-Sectional

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

Mendoza, Ramon, Silverman, Robert H, Klein, Eric A et al.·PloS one·2012

Researchers tested blood and fluid samples from prostate cancer patients to see if they contained XMRV, a virus that was once thought to cause chronic fatigue syndrome. They found no evidence of the virus in any of the samples, including in nine patients who had previously tested positive for XMRV. This study supports the growing scientific consensus that XMRV does not actually infect humans.

E3 PreliminaryReviewPEM unclearReview-Narrative

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Suma, S, Veerendra Kumar, B·Indian journal of dental research : official publication of Indian Society for Dental Research·2012

This paper discusses jaw and joint problems (temporomandibular disorders) that commonly occur alongside conditions like ME/CFS and fibromyalgia. It explains that these jaw problems are often overlooked because they stem from increased pain sensitivity related to stress and psychological factors, rather than just physical damage. The authors argue that dentists need to recognize these connections and adjust their treatment approach for patients with these overlapping conditions.

Pain and Sensitization

E3 PreliminaryCommentaryPEM unclearEditorial

Fatigue and disrupted sleep-wake patterns in patients with cancer: a shared mechanism.

Wu, Horng-Shiuann, Davis, Jean E, Natavio, Teofanes·Clinical journal of oncology nursing·2012

Cancer patients often experience severe tiredness and sleep problems at the same time, suggesting they may share a common cause. This paper proposes that stress hormones—particularly those controlled by a system called the HPA axis—may be disrupted in ways that trigger both fatigue and poor sleep. Because ME/CFS patients have similar symptoms and similar HPA axis problems, studying cancer-related fatigue might help us understand ME/CFS better.

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.

Côté, Marceline, Zheng, Yi-Min, Liu, Shan-Lu·PloS one·2012

This study examined how XMRV, a virus once suspected to be linked to ME/CFS, enters human cells. Researchers found that XMRV enters cells differently than many other viruses—it doesn't require acidic conditions inside the cell. They also discovered that a small tail-like structure on the virus's outer coating controls whether the virus can fuse with and infect cells.

E3 PreliminaryCohortPEM not required

Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence.

Naess, Halvor, Nyland, Morten, Hausken, Trygve et al.·BMC gastroenterology·2012

After a water contamination outbreak in Norway caused a bacterial infection (giardiasis), some patients developed long-lasting severe fatigue similar to ME/CFS. This study looked at 58 patients who met the official diagnostic criteria for CFS following this infection. Most patients reported their condition was getting worse over time, and all of them had to take extended time off work or school due to their fatigue and reduced ability to function.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Live sequence charts to model medical information.

Aslakson, Eric, Szekely, Smadar, Vernon, Suzanne D et al.·Theoretical biology & medical modelling·2012

Researchers developed a new way to organize and understand patient medical records by translating written descriptions of illness into visual diagrams. They tested this approach using an actual patient interview with someone who was later diagnosed with ME/CFS. This method could help doctors and researchers better track how diseases develop over time and identify important patterns in patient histories.

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Evidence browser

Loss of stress response as a consequence of viral infection: implications for disease and therapy.

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.

Lack of the detection of XMRV or polytropic MLV-related sequences in blood cells from HIV-1-infected patients in Spain.

Identification of XMRV infection-associated microRNAs in four cell types in culture.

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

Central sensitization as a component of post-deployment syndrome.

Validation of the three-factor model of the PSQI in a large sample of chronic fatigue syndrome (CFS) patients.

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species.

The relationship between muscle pain and fatigue.

Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset.

Minimum data elements for research reports on CFS.

Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Fatigue and disrupted sleep-wake patterns in patients with cancer: a shared mechanism.

Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.

Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence.

Live sequence charts to model medical information.

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