ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

1221–1240 of 2,420 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Live sequence charts to model medical information.

Aslakson, Eric, Szekely, Smadar, Vernon, Suzanne D et al.·Theoretical biology & medical modelling·2012

Researchers developed a new way to organize and understand patient medical records by translating written descriptions of illness into visual diagrams. They tested this approach using an actual patient interview with someone who was later diagnosed with ME/CFS. This method could help doctors and researchers better track how diseases develop over time and identify important patterns in patient histories.

E3 PreliminaryMechanismPEM not requiredMechanistic

Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences.

Singh, P K, Chopra, K, Kuhad, A et al.·Neurogastroenterology and motility·2012

This study tested whether a beneficial bacteria called Lactobacillus acidophilus could help reduce fatigue symptoms in rats. Researchers created extreme fatigue in rats through repeated exhausting swimming, then gave some rats either the bacteria alone or the bacteria packaged in special beads designed to survive digestion. The bacteria treatment reduced fatigue-like behavior and improved markers of inflammation and immune system stress.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive enzymes in the neonatal pig.

Lackeyram, D, Mine, Y, Widowski, T et al.·Journal of animal science·2012

Researchers gave young pigs either hydrogen peroxide (a substance that causes oxidative stress, similar to cellular damage) or saline over 10 days to study how oxidative stress might affect ME/CFS. Pigs given hydrogen peroxide showed reduced antioxidant levels, less physical activity, and decreased ability to digest certain carbohydrates in their intestines. This suggests that oxidative stress may interfere with how the gut breaks down food, which could contribute to fatigue and other ME/CFS symptoms.

E3 PreliminaryReviewPEM unclearReview-Narrative

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Suma, S, Veerendra Kumar, B·Indian journal of dental research : official publication of Indian Society for Dental Research·2012

This paper discusses jaw and joint problems (temporomandibular disorders) that commonly occur alongside conditions like ME/CFS and fibromyalgia. It explains that these jaw problems are often overlooked because they stem from increased pain sensitivity related to stress and psychological factors, rather than just physical damage. The authors argue that dentists need to recognize these connections and adjust their treatment approach for patients with these overlapping conditions.

Pain and Sensitization

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Multiple sources of contamination in samples from patients reported to have XMRV infection.

Kearney, Mary F, Spindler, Jonathan, Wiegand, Ann et al.·PloS one·2012

Researchers tested blood samples from ME/CFS patients that were previously reported to contain a virus called XMRV. Using careful testing methods, they found that the virus-like sequences in patient blood samples were actually contamination from mouse DNA used in lab experiments, not the XMRV virus itself. When they did find actual XMRV virus, it appeared in healthy control samples and came from cross-contamination in the lab rather than from patient infections.

E3 PreliminaryMechanismPEM not requiredMechanistic

Identification of XMRV infection-associated microRNAs in four cell types in culture.

Mohan, Ketha V K, Devadas, Krishnakumar, Sainath Rao, Shilpakala et al.·PloS one·2012

This study looked at how a virus called XMRV affects the behavior of microRNAs—tiny molecules that control how genes are expressed—in different types of human cells grown in the laboratory. Researchers infected four different cell types with XMRV and measured changes in microRNA patterns at different time points. They found that certain microRNAs changed in response to the virus infection.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species.

Sakuma, Toshie, Tonne, Jason M, Malcolm, Jessica A et al.·PloS one·2012

Researchers studied a virus called XMRV that can jump between animal species to understand how viruses adapt when they infect new hosts. They infected a type of mouse with XMRV and watched what happened over a year, including whether the virus could be passed to offspring. The mice stayed healthy and the virus didn't spread much to the next generation, suggesting that while the virus can infect new species, it doesn't easily take hold or spread.

E3 PreliminaryMechanismPEM unclearMechanistic

Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.

Cao, Yin, Hu, Yuan, Liu, Ping et al.·Journal of ethnopharmacology·2012

Researchers tested a traditional Chinese herbal formula called Kai Xin San (KXS) on mice that had been made fatigued through forced exercise. Mice treated with KXS showed improvements in physical recovery markers, better immune cell activity, and reduced signs of exhaustion compared to untreated fatigued mice. The results suggest this herbal combination may help reduce fatigue by affecting the body's energy metabolism and immune system.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.

Ocon, Anthony J, Messer, Zachary R, Medow, Marvin S et al.·Clinical science (London, England : 1979)·2012

This study tested whether standing at increasing angles on a tilt table—a procedure that stresses the body's ability to maintain blood flow while upright—makes 'brain fog' worse in people with ME/CFS who also have POTS (a condition causing rapid heartbeat when standing). Researchers found that when people with CFS/POTS stood at steeper angles while doing concentration and memory tests, their performance got worse compared to healthy people, suggesting that orthostatic stress (the challenge of staying upright) does interfere with thinking and memory.

Autonomic Nervous SystemCognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Lack of evidence for a role of xenotropic murine leukemia virus-related virus in the pathogenesis of prostate cancer and/or chronic fatigue syndrome.

Hong, Ping, Li, Jinming·Virus research·2012

A virus called XMRV was once thought to possibly cause ME/CFS and prostate cancer, but this review found no solid evidence supporting that connection. The authors looked at multiple studies and concluded that most positive findings were likely due to contamination in lab samples, not actual infection. This virus does not appear to play a role in causing ME/CFS.

E3 PreliminaryMechanismPEM unclear

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

Lee, Deanna, Das Gupta, Jaydip, Gaughan, Christina et al.·PloS one·2012

Scientists investigated whether a virus called XMRV could cause chronic fatigue syndrome or prostate cancer. Even though an earlier study claimed to find this virus in some patients, many follow-up studies couldn't confirm it. This research tested blood and tissue samples from 39 prostate cancer patients using multiple methods and found no sign of XMRV infection, suggesting the virus doesn't naturally infect humans—it likely came from contamination in laboratory experiments.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Minimum data elements for research reports on CFS.

Jason, Leonard A, Unger, Elizabeth R, Dimitrakoff, Jordan D et al.·Brain, behavior, and immunity·2012

Researchers noticed that different ME/CFS studies were collecting and reporting information in very different ways, making it hard to compare results across laboratories. This paper outlines the essential information that all ME/CFS research studies should include—like how patients were selected, what their characteristics are, and how they were tested—so that future studies can be compared fairly and findings can be better understood.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.

Light, Kathleen C, White, Andrea T, Tadler, Scott et al.·Pain research and treatment·2012

This study looked at genes and how they are expressed (turned on or off) in people with fibromyalgia and chronic fatigue syndrome. Researchers focused on three main biological systems: the stress response system, the hormone system that controls stress, and the serotonin system (which affects mood and pain). They found that certain genes, particularly those controlling stress hormones and pain sensing, may play a role in why some people develop or maintain these conditions.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

The role of antipsychotics in the management of fibromyalgia.

Calandre, Elena P, Rico-Villademoros, Fernando·CNS drugs·2012

This review examines whether antipsychotic medications—drugs typically used to treat psychiatric conditions—might also help people with fibromyalgia manage pain, sleep problems, fatigue, and mood disturbances. The authors found that some antipsychotics, particularly quetiapine, have shown promise in small studies and case reports, though most research is preliminary and more rigorous testing is needed.

Pain and SensitizationSleep

E3 PreliminaryReviewPEM not requiredReview-Narrative

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions.

Staud, Roland·Expert review of neurotherapeutics·2012

People with chronic pain often have trouble turning off pain signals in their brain and spinal cord, even when they should. This review explains that many chronic pain conditions—including ME/CFS—share a common problem: their bodies amplify pain signals instead of suppressing them. Tests can measure how well someone's natural pain-blocking system works, and these tests might help predict who will develop chronic pain.

Pain and Sensitization

E3 PreliminaryMechanismPEM unclearCross-Sectional

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

Mendoza, Ramon, Silverman, Robert H, Klein, Eric A et al.·PloS one·2012

Researchers tested blood and fluid samples from prostate cancer patients to see if they contained XMRV, a virus that was once thought to cause chronic fatigue syndrome. They found no evidence of the virus in any of the samples, including in nine patients who had previously tested positive for XMRV. This study supports the growing scientific consensus that XMRV does not actually infect humans.

E3 PreliminaryCohortPEM unclearObservational

Lack of the detection of XMRV or polytropic MLV-related sequences in blood cells from HIV-1-infected patients in Spain.

Luczkowiak, Joanna, Martínez-Prats, Lorena, Sierra, Olalla et al.·Journal of acquired immune deficiency syndromes (1999)·2012

Researchers tested blood samples from 40 HIV-infected patients in Spain to see if they carried XMRV or related viruses, which had been proposed as possible causes of ME/CFS. They found no evidence of these viruses in any patient. Some positive results turned out to be contamination from mouse DNA in the laboratory, suggesting that earlier positive findings in other studies may have been false positives caused by contamination rather than real infections.

E3 PreliminaryReviewPEM unclearReview-Narrative

The relationship between muscle pain and fatigue.

Mastaglia, Frank L·Neuromuscular disorders : NMD·2012

When muscles work hard, pain and fatigue often happen together and can make it harder to exercise. This review examines how pain and tiredness are connected in people with muscle disorders, and explores whether brain stimulation techniques might help reduce both symptoms. Researchers used special magnetic brain stimulation tools to study how the brain controls muscles during exhausting activity.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

A role for corticosteroid-binding globulin variants in stress-related disorders.

Marathe, Chinmay S, Torpy, David J·Expert review of endocrinology & metabolism·2012

This review examines how genetic variations in a protein called corticosteroid-binding globulin (CBG) may influence whether someone develops ME/CFS, fibromyalgia, or chronic pain. CBG helps transport cortisol (the body's stress hormone) in the blood, and when this protein doesn't work properly, it may affect how the body responds to stress. The researchers looked at evidence from genetic studies and animal models suggesting that inherited differences in the CBG gene could increase someone's risk of developing these stress-related conditions.

Endocrine Disruption

E3 PreliminaryMechanismPEM not required

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

Fagermoen, Even, Sulheim, Dag, Winger, Anette et al.·BMC research notes·2012

This small study tested whether a blood pressure medication called clonidine could be safe and helpful for teenagers with ME/CFS. Five teenagers took a low dose of clonidine for two weeks, and researchers measured drug levels in their blood, how their hearts and blood pressure responded to position changes, and any side effects. The medication appeared safe with no serious problems, and it seemed to help improve their body's blood pressure responses.

Autonomic Nervous System

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Evidence Atlas

Evidence browser

Live sequence charts to model medical information.

Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences.

The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive enzymes in the neonatal pig.

Temporomandibular disorders and functional somatic syndromes: deliberations for the dentist.

Multiple sources of contamination in samples from patients reported to have XMRV infection.

Identification of XMRV infection-associated microRNAs in four cell types in culture.

Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species.

Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.

Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.

Lack of evidence for a role of xenotropic murine leukemia virus-related virus in the pathogenesis of prostate cancer and/or chronic fatigue syndrome.

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.

Minimum data elements for research reports on CFS.

Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.

The role of antipsychotics in the management of fibromyalgia.

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions.

No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

Lack of the detection of XMRV or polytropic MLV-related sequences in blood cells from HIV-1-infected patients in Spain.

The relationship between muscle pain and fatigue.

A role for corticosteroid-binding globulin variants in stress-related disorders.

Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial.

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