ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2420 studies

2301–2320 of 2,420 studies

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1991

This review examines three related conditions—fibromyalgia, chronic fatigue syndrome, and myofascial pain—that often occur together and cause pain, tiredness, and sleep problems. Researchers are discovering that these conditions may share common biological causes involving how the body senses pain, hormone imbalances, and problems with muscle function. Unfortunately, the new treatments being tested at that time were not particularly effective.

Pain and SensitizationSleepDiagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Chronic fatigue syndrome; psychiatric aspects].

Hawton, K E, Hengeveld, M W·Nederlands tijdschrift voor geneeskunde·1991

This 1991 review article examines the psychiatric aspects of chronic fatigue syndrome (ME/CFS), exploring how mental health factors relate to the condition. The authors discuss the connection between psychiatric symptoms and fatigue, helping to clarify whether psychological issues cause ME/CFS or occur alongside it. This work contributed to early medical understanding of how ME/CFS affects both the body and mind.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Psychiatric perspectives: an overview.

Woods, T O, Goldberg, D P·British medical bulletin·1991

This review examines how psychological and social factors may play a role in ME/CFS. The authors suggest that while a viral illness may trigger the condition in people with certain personality traits, over time the disorder becomes maintained by how people and doctors respond to the illness rather than the original virus itself. They discuss how doctor-patient interactions and how people cope with their illness may contribute to keeping ME/CFS going.

E3 PreliminaryCommentaryPEM not requiredEditorial

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

Armon, C, Kurland, L T·Reviews of infectious diseases·1991

This article examines how ME/CFS is diagnosed and points out problems with the current definition used by doctors. The authors identified several issues: the definition doesn't clearly address what happens when patients do too much activity, it doesn't specify how much rest is needed, and it may miss cases in poorer communities. They suggest a new flowchart that could help identify different types of ME/CFS and potentially help some patients avoid developing the condition.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome.

Lloyd, A R, Gandevia, S C, Hales, J P·Brain : a journal of neurology·1991

Researchers tested whether ME/CFS patients have weak muscles or lack motivation during exercise compared to healthy people. They measured muscle strength and effort in both groups while performing repetitive arm exercises for 45 minutes. Both groups showed similar muscle performance and reported similar levels of effort, suggesting that muscle weakness or poor motivation are not the primary causes of fatigue in ME/CFS.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Clinical indications and diagnostic techniques of human herpesvirus-6 (HHV-6) infection.

Krueger, G R, Ablashi, D V, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines how doctors can diagnose human herpesvirus-6 (HHV-6) infection and its connection to various illnesses, including a condition called postinfectious chronic fatigue syndrome. HHV-6 is a common virus that most people catch in childhood and then carry dormant in their bodies for life. The authors explain which tests doctors should use to accurately identify active HHV-6 infection and discuss why proper diagnosis matters for treatment.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Definition and measurement of fatigue.

Barofsky, I, Legro, M W·Reviews of infectious diseases·1991

This paper examines how fatigue is defined and measured in ME/CFS, highlighting that these definitions have not been well-developed in medical research. The authors reviewed different tools available to measure fatigue—ranging from simple single-item questions to more complex multi-part assessments—and discussed how fatigue in ME/CFS differs from fatigue studied in healthy people in laboratory settings. They emphasize the need to study fatigue as it actually occurs in patients with ME/CFS and to use consistent measurement methods across research.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-6 (HHV-6) (short review).

Ablashi, D V, Salahuddin, S Z, Josephs, S F et al.·In vivo (Athens, Greece)·1991

This review examines Human Herpesvirus-6 (HHV-6), a common virus that most people carry. The virus can reactivate in people with certain illnesses, including ME/CFS. The study found that people with ME/CFS sometimes have higher levels of antibodies to HHV-6, suggesting the virus may be active in their bodies.

Immune System

E3 PreliminaryCommentaryPEM unclearEditorial

Pain syndromes, disability, and chronic disease in childhood.

Malleson, P N·Current opinion in rheumatology·1991

This editorial discusses how chronic pain and long-term illnesses affect children, and suggests that conditions like fibromyalgia and chronic fatigue syndrome (ME/CFS) may be related to each other. The author notes that doctors need better training to understand these complex conditions and that psychological factors may play a role in how these illnesses develop and affect children's lives.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

Analysis of clinical, epidemiologic, and laboratory data on chronic fatigue syndrome.

Redmond, C K·Reviews of infectious diseases·1991

This paper reviews how ME/CFS research has been studied and analyzed over time. The authors found that many ME/CFS studies don't use the best statistical methods available. They recommend that future ME/CFS research should include expert statisticians who can use more advanced analytical techniques to better understand patterns in patient data and find clues about what causes this illness.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Evaluation and management of patients with chronic fatigue.

Matthews, D A, Manu, P, Lane, T J·The American journal of the medical sciences·1991

This review article examines how doctors diagnose and treat patients who experience chronic fatigue in everyday medical practice. The authors note that chronic fatigue has many possible causes, including medical illnesses, psychiatric conditions like depression and anxiety, lifestyle factors, and medications. They emphasize that building trust with patients and using a combination of psychiatric evaluation, functional assessment, and both medication and behavioral therapy approaches are important for effective care.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates.

Ablashi, D V, Balachandran, N, Josephs, S F et al.·Virology·1991

Researchers studied different versions of human herpesvirus-6 (HHV-6), a virus found in people with various conditions including chronic fatigue syndrome. They found that HHV-6 comes in at least two distinct types—similar to how there are two types of cold sores—and these types behave differently in the lab, infecting different cell types and reacting differently to immune system antibodies.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Lewis, S F, Haller, R G·Reviews of infectious diseases·1991

This review article explains how scientists measure exercise capacity and fatigue in the body. It describes three key concepts: aerobic fitness (how efficiently your heart and muscles use oxygen), muscle strength (your muscles' ability to produce force), and fatigue (the loss of strength that happens during activity). The authors discuss how these measurements might help us better understand what happens in ME/CFS when patients experience excessive fatigue.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Depression and chronic fatigue in the patient with chronic pain.

Covington, E C·Primary care·1991

This study explores how chronic pain, fatigue, and depression often occur together in patients. The authors suggest that these three conditions share common causes and may influence each other. Treatment works best when doctors address each problem separately using a combination of physical rehabilitation, education, medications, and counseling.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredMechanistic

Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome.

Demitrack, M A, Dale, J K, Straus, S E et al.·The Journal of clinical endocrinology and metabolism·1991

This study examined whether ME/CFS patients have a problem with their body's stress hormone system, specifically the network that controls cortisol production. Researchers found that ME/CFS patients had lower cortisol levels than healthy people, but their bodies were responding unusually to stimulation—suggesting the problem lies in the brain's control center rather than the adrenal glands themselves.

Endocrine Disruption

E3 PreliminaryMechanismPEM unclear

Immunodysregulation and chronic fatigue syndrome.

Kundu, S K, Ahronheim, G A, Menezes, J·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This study examined whether ME/CFS involves problems with the immune system that aren't working properly. The researchers looked at immune system dysfunction in patients with chronic fatigue syndrome to understand if an imbalance in immune responses might explain the illness. This early research helped establish that immune abnormalities could be involved in ME/CFS.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Molecular approaches to epidemiologic evaluation of viruses as risk factors for patients who have chronic fatigue syndrome.

Miller, G·Reviews of infectious diseases·1991

This paper proposes that studying how viral infections like flu, hepatitis, and mono can trigger long-term fatigue might help us understand ME/CFS. The researchers suggest examining not just whether someone had a virus, but how much virus was present, which type of virus it was, where it spread in the body, and whether the virus was active or dormant. They also recommend looking carefully at how individual patients' immune systems respond to specific parts of viruses.

Immune System

E3 PreliminaryCommentaryPEM not requiredEditorial

Assessment of depression in patients with chronic fatigue syndrome.

Thase, M E·Reviews of infectious diseases·1991

This paper examines how depression and ME/CFS are connected and how to tell them apart. The authors warn that depression is sometimes mistakenly diagnosed as ME/CFS, while in other cases ME/CFS itself may cause depression-like symptoms. They recommend that doctors use multiple assessment tools and be careful to distinguish between these conditions rather than assuming one is the cause of the other.

E3 PreliminaryReviewPEM unclearReview-Narrative

Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).

Ablashi, D V, Zompetta, C, Lease, C et al.·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This review article examines whether human herpesvirus 6 (HHV6), a common virus that infects most people in childhood, might be connected to ME/CFS. The authors gathered available evidence about HHV6 and its potential role in causing or contributing to chronic fatigue syndrome symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurasthenia and chronic fatigue syndrome: the role of culture in the making of a diagnosis.

Abbey, S E, Garfinkel, P E·The American journal of psychiatry·1991

This article compares chronic fatigue syndrome (CFS) to an older diagnosis called neurasthenia that was common in the 1800s. The authors suggest that both conditions became popular during times of major social and economic change, and both were seen as medical rather than mental health problems. They argue that CFS may eventually be viewed the same way neurasthenia is today—as primarily a psychiatric or stress-related condition rather than a distinct medical illness.

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Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

[Chronic fatigue syndrome; psychiatric aspects].

Psychiatric perspectives: an overview.

Chronic fatigue syndrome: issues in the diagnosis and estimation of incidence.

Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome.

Clinical indications and diagnostic techniques of human herpesvirus-6 (HHV-6) infection.

Definition and measurement of fatigue.

Human herpesvirus-6 (HHV-6) (short review).

Pain syndromes, disability, and chronic disease in childhood.

Analysis of clinical, epidemiologic, and laboratory data on chronic fatigue syndrome.

Evaluation and management of patients with chronic fatigue.

Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates.

Physiologic measurement of exercise and fatigue with special reference to chronic fatigue syndrome.

Depression and chronic fatigue in the patient with chronic pain.

Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome.

Immunodysregulation and chronic fatigue syndrome.

Molecular approaches to epidemiologic evaluation of viruses as risk factors for patients who have chronic fatigue syndrome.

Assessment of depression in patients with chronic fatigue syndrome.

Human herpesvirus 6 (HHV6) and chronic fatigue syndrome (CFS).

Neurasthenia and chronic fatigue syndrome: the role of culture in the making of a diagnosis.

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