ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2422 studies

901–920 of 2,422 studies

E3 PreliminaryBehavioralPEM unclearCross-Sectional

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Taylor, Anna K, Loades, Maria, Brigden, Amberly Lc et al.·Clinical child psychology and psychiatry·2017

This study talked with nine young people (aged 13-17) who have ME/CFS and depression to understand how these two conditions connect. Most young people felt that ME/CFS caused their depression because the illness stopped them doing activities they loved and changed their daily lives. Many also noticed that feeling sad made their ME/CFS symptoms worse, creating a difficult cycle. The researchers found that different combinations of treatments—like talking therapy, medicine, and careful activity planning—worked best for different people.

E3 PreliminaryMechanismPEM unclearObservational

Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.

Petrides, George, Zalewski, Pawel, McCulloch, David et al.·Fatigue : biomedicine, health & behavior·2017

This study looked at how the nervous system controls the heart in people with ME/CFS, focusing on a specific part called the sympathetic nervous system. Researchers used specialized imaging to examine nerve connections in the heart and compared them to problems with autonomic function (the automatic nervous system that controls heart rate and blood pressure). The findings suggest that differences in heart nerve connections may be related to why some ME/CFS patients experience autonomic symptoms like dizziness and heart rate changes.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

A sociological stance on fatigue and tiredness: Social inequalities, norms and representations.

Loriol, Marc·Neurophysiologie clinique = Clinical neurophysiology·2017

This study examines fatigue from a social perspective, looking at how people's work and living conditions, social environment, and cultural beliefs affect their experience of exhaustion. Rather than treating fatigue only as a medical problem, the authors explore how different groups in society experience and understand tiredness differently, and how societal expectations about work and productivity shape whether someone feels appropriately tired or dangerously exhausted.

E3 PreliminaryReviewPEM unclearReview-Narrative

Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings.

Gerwyn, Morris, Maes, Michael·Current rheumatology reports·2017

This review examines why ME/CFS patients experience muscle fatigue and pain. Researchers found that several biological problems may contribute to these symptoms: damaged cellular energy factories (mitochondria), harmful stress molecules building up in the body, and reduced production of protective proteins. These problems together may explain why ME/CFS patients get tired quickly and struggle with exercise.

Post-Exertional Malaise

E3 PreliminaryBehavioralPEM not requiredCross-Sectional

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

Picariello, Federica, Ali, Sheila, Foubister, Caroline et al.·British journal of health psychology·2017

This study looked at what 13 ME/CFS patients thought about cognitive behavioural therapy (CBT), a talking therapy that helps people change unhelpful thinking patterns and behaviors. Most patients were satisfied with CBT and felt better, though not completely recovered. The study found that the personal support from a therapist and accepting that ME/CFS involves both physical and mental factors were important for success.

Interventions

E3 PreliminaryDiagnosticPEM unclearCross-Sectional

Important factors to consider when treating children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): perspectives of health professionals from specialist services.

Parslow, Roxanne M, Shaw, Alison, Haywood, Kirstie L et al.·BMC pediatrics·2017

This study asked specialist doctors and nurses who treat children with ME/CFS what they believe are the most important things to measure when checking how well a child is doing. The experts identified four key areas: symptoms (like fatigue and pain), physical ability to do things, participation in school and social activities, and emotional wellbeing. The goal is to create a better way to measure treatment success that matches what children and families actually care about.

E3 PreliminaryCohortPEM unclearCase-Control

A thermal dysregulation problem after breast cancer surgery; what could be?

Rüstemova, Diana, Genc, Aysun, Bora, Gül et al.·Medicine·2017

A 41-year-old woman developed a persistent feeling of being cold after breast cancer surgery and was diagnosed with ME/CFS after other conditions were ruled out. She improved significantly with aerobic exercise done for at least 30 minutes, three or more days per week. This case suggests that abnormal temperature regulation—feeling unusually cold or hot—may be a symptom of ME/CFS that doctors should watch for.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

American journal of epidemiology·2017

This study describes how researchers set up a large project to better understand and diagnose ME/CFS across multiple medical centers. The researchers created a system to carefully collect information about ME/CFS patients over time, combining both new patient data and information from medical records. This kind of organized approach helps scientists learn more about the condition and how to recognize it accurately.

E3 PreliminaryReviewPEM not requiredReview-Narrative

The interface between chronic fatigue syndrome and depression: A psychobiological and neurophysiological conundrum.

Larkin, Derek, Martin, Colin R·Neurophysiologie clinique = Clinical neurophysiology·2017

Many people with ME/CFS experience depression alongside their physical symptoms, but it's unclear whether depression causes the fatigue, results from it, or whether they share common underlying biological causes. This paper reviews what we know about the connection between ME/CFS and depression, examining possible explanations from brain function, immune system activity, and psychological factors. Understanding this relationship better could help doctors develop more effective treatments that address both the fatigue and mood symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Frontline Temporomandibular Joint/Orofacial Pain Therapy for Every Dental Practice.

Germain, Lisa, Malcmacher, Louis·Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2017

This article explains how dentists can help patients with temporomandibular joint (jaw joint) and orofacial pain using straightforward, conservative treatment approaches. The authors note that jaw pain often occurs alongside other pain conditions, including chronic fatigue syndrome (ME/CFS), and suggest that dentists with proper training can be a first line of care for these patients.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Emotional conflict processing in adolescent chronic fatigue syndrome: A pilot study using functional magnetic resonance imaging.

Wortinger, Laura Anne, Endestad, Tor, Melinder, Annika Maria D et al.·Journal of clinical and experimental neuropsychology·2017

This study looked at how the brains of teenagers with ME/CFS process emotions and handle conflicting information. Researchers used brain imaging to watch what happened when young people with ME/CFS and healthy teenagers tried to identify emotions in faces while being distracted by conflicting words. Teenagers with ME/CFS showed weaker brain responses in areas that handle emotions and decision-making, and their brain activity was linked to how severe their fatigue was.

Cognitive Impairment

E3 PreliminaryMechanismPEM not requiredMechanistic

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Wang, Xiang-Yi, Liu, Chang-Zheng, Lei, Bo·Zhen ci yan jiu = Acupuncture research·2017

Researchers tested whether acupuncture could help rats with chronic fatigue syndrome by measuring changes in immune system markers. Acupuncture was applied to three specific points for two weeks, and the treated rats showed improved tiredness and swimming performance compared to untreated rats. The study suggests acupuncture may work by rebalancing immune system signals that become disrupted in ME/CFS.

Immune System

E3 PreliminaryCohortPEM unclearObservational

Life according to ME: Caught in the ebb-tide.

Lian, Olaug S, Rapport, Frances·Health (London, England : 1997)·2016

This study asked 10 people with ME in Norway to share stories and photos about places where their illness felt better or worse. The researchers found that people with ME carefully balance activity and rest, and they seek out peaceful places (usually home) to recover while avoiding places that drain their energy. The study shows how the physical and emotional qualities of different environments directly affect how people experience and manage their ME.

E3 PreliminaryMechanismPEM requiredMechanistic

Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome.

Fluge, Øystein, Mella, Olav, Bruland, Ove et al.·JCI insight·2016

This study found that people with ME/CFS have abnormal patterns of amino acids (building blocks of protein) in their blood, suggesting their bodies struggle to produce energy efficiently through normal metabolic pathways. The research identified a specific problem with an enzyme called pyruvate dehydrogenase that helps convert fuel into cellular energy, and showed that cells from ME/CFS patients produce excess lactate (a byproduct of incomplete energy metabolism) when stressed. These findings help explain why ME/CFS patients experience exhaustion after exertion and poor recovery.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.

Morris, Gerwyn, Berk, Michael, Galecki, Piotr et al.·Molecular neurobiology·2016

This review examines why people with ME/CFS and similar immune-based illnesses experience severe, disabling fatigue. The authors identify multiple biological pathways that may contribute to this fatigue, including excessive inflammation, problems with how cells produce energy, and chemical imbalances in the brain and muscles. The fatigue appears to result from a complex interaction between the immune system, energy production, and brain function rather than a single cause.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue.

Aoki, Ryo, Kobayashi, Nobuyuki, Suzuki, Go et al.·Biochemical and biophysical research communications·2016

This study looked at whether two common viruses (HHV-6 and HHV-7) in saliva could help doctors tell the difference between normal tiredness and the severe, long-lasting fatigue seen in conditions like ME/CFS. The researchers found that these viruses increased in saliva when people were physically stressed or tired from work, then quickly decreased with rest. Importantly, these viruses did NOT increase in people with ME/CFS, sleep apnea, or depression, suggesting they might be useful markers for normal fatigue but not pathological fatigue.

Biomarkers

E3 PreliminaryCohortPEM unclearCase-Control

Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.

Sukocheva, Olga A, Manavis, Jim, Kok, Tuck-Weng et al.·BMC infectious diseases·2016

This case report describes a young woman who developed severe, long-lasting illness after a Q fever infection and died 10 years later. After her death, researchers examined her tissues and found pieces of the bacteria (Coxiella burnetii) and its DNA still present in multiple organs, including her brain, heart, lungs, and spleen. This suggests that Q fever bacteria can persist in the body in a dormant or inactive form, potentially triggering ongoing illness.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME).

Petty, Robert D, McCarthy, Neil E, Le Dieu, Rifca et al.·PloS one·2016

This study examined tiny molecules called microRNAs in immune cells from ME/CFS patients and healthy people. Researchers found that four specific microRNAs were abnormally high in patients' blood, particularly in natural killer (NK) immune cells. When they tested these microRNAs in the lab, they found they affected how NK cells work, suggesting this might contribute to ME/CFS symptoms.

BiomarkersImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

Reversal of Refractory Ulcerative Colitis and Severe Chronic Fatigue Syndrome Symptoms Arising from Immune Disturbance in an HLA-DR/DQ Genetically Susceptible Individual with Multiple Biotoxin Exposures.

Gunn, Shelly R, Gunn, G Gibson, Mueller, Francis W·The American journal of case reports·2016

This case report describes one 25-year-old man who had both severe inflammatory bowel disease and chronic fatigue syndrome that improved dramatically after identifying and removing mold exposure from his home, receiving a hormone replacement therapy (VIP), and doing stress-reduction exercises. The patient's genetic makeup made him more susceptible to problems when exposed to toxic mold, and treating the underlying immune disturbance resolved his symptoms without medication.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease.

Williams, Marshall V, Cox, Brandon, Ariza, Maria Eugenia·Pathogens (Basel, Switzerland)·2016

This review examines how herpesvirus proteins called dUTPases may trigger harmful immune responses in ME/CFS and other diseases. Most adults carry dormant herpesviruses (like Epstein-Barr virus) that can reactivate throughout life. The researchers suggest that proteins released during reactivation may overstimulate the immune system, potentially worsening ME/CFS symptoms and inflammation.

Immune System

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'It's personal to me': A qualitative study of depression in young people with CFS/ME.

Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.

A sociological stance on fatigue and tiredness: Social inequalities, norms and representations.

Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings.

'It feels sometimes like my house has burnt down, but I can see the sky': A qualitative study exploring patients' views of cognitive behavioural therapy for chronic fatigue syndrome.

Important factors to consider when treating children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): perspectives of health professionals from specialist services.

A thermal dysregulation problem after breast cancer surgery; what could be?

RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY".

The interface between chronic fatigue syndrome and depression: A psychobiological and neurophysiological conundrum.

Frontline Temporomandibular Joint/Orofacial Pain Therapy for Every Dental Practice.

Emotional conflict processing in adolescent chronic fatigue syndrome: A pilot study using functional magnetic resonance imaging.

[Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome].

Life according to ME: Caught in the ebb-tide.

Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome.

The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.

Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue.

Coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report.

MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME).

Reversal of Refractory Ulcerative Colitis and Severe Chronic Fatigue Syndrome Symptoms Arising from Immune Disturbance in an HLA-DR/DQ Genetically Susceptible Individual with Multiple Biotoxin Exposures.

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease.

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