ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

101–120 of 6,209 studies

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID.

Silva-Passadouro, Bárbara, Tamasauskas, Arnas, Khoja, Omar et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2024

This study reviewed research on brain wave patterns in three related conditions: fibromyalgia, ME/CFS, and Long COVID. Researchers found that ME/CFS and fibromyalgia show different patterns of brain activity when measured using EEG, a test that records electrical activity in the brain. The study suggests these conditions may involve different changes in how the brain functions, which could eventually help doctors identify and treat each condition more specifically.

E0 ConsensusReviewPEM not requiredSystematic-Review

The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review.

Peebles, Karen C, Jacobs, Charl, Makaroff, Logan et al.·Autonomic neuroscience : basic & clinical·2024

This review looked at 10 studies examining whether exercise helps people with POTS (a condition causing dizziness and fast heart rate when standing) who also have joint hypermobility, chronic fatigue, or fibromyalgia. The research found that 3 months of gradually increasing exercise—starting lying down and progressing to standing—reduced POTS symptoms and improved quality of life. However, very few studies have specifically tested exercise in people with the combination of POTS and joint hypermobility problems.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

Autoimmunity's enigmatic role: exploring the connection with myalgic encephalomyelitis/chronic fatigue syndrome.

Batham, Jacob, Dwyer, Jessica, Eaton-Fitch, Natalie et al.·BMC immunology·2024

Researchers reviewed 10 studies to understand whether ME/CFS is caused by autoimmunity—a condition where the immune system attacks the body's own cells. While some signs of autoimmune activity were found in ME/CFS patients, the evidence is mixed and not strong enough to confirm that autoimmunity is the main cause. The authors conclude that ME/CFS is more complex than a straightforward autoimmune disease.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Ear abnormalities in chronic fatigue syndrome (CFS), fibromyalgia (FM), Coronavirus-19 infectious disease (COVID) and long-COVID syndrome (PCS), sick-building syndrome (SBS), post-orthostatic tachycardia syndrome (PoTS), and autoimmune/inflammatory syndrome induced by adjuvants (ASIA): A systematic review.

Skare, Thelma L, de Carvalho, Jozélio Freire, de Medeiros, Italo Roberto Torres et al.·Autoimmunity reviews·2024

This review examined hearing and balance problems (including hearing loss, tinnitus, dizziness, and vertigo) reported across multiple conditions including ME/CFS, fibromyalgia, and long COVID. Researchers searched medical literature from 1990 to 2024 and found that while hearing problems are common, balance problems are less frequently reported. The study suggests these symptoms may stem from immune system dysfunction affecting the inner ear.

Immune System

E0 ConsensusReviewPEM unclearEvidence-Map

Healthcare system barriers impacting the care of Canadians with myalgic encephalomyelitis: A scoping review.

Hussein, Said, Eiriksson, Lauren, MacQuarrie, Maureen et al.·Journal of evaluation in clinical practice·2024

This study looked at all available Canadian research to understand why people with ME/CFS struggle to get good healthcare. The researchers found that the main problems are: doctors often don't believe ME is real, healthcare providers aren't trained to recognize it, there's a lack of good information about the disease, and sexism plays a role. The study suggests that improving doctor education and creating better care systems could help ME patients get the support they need.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis.

Nakane, Shunya, Koike, Haruki, Hayashi, Tomohiro et al.·International journal of molecular sciences·2024

This review describes autoimmune autonomic ganglionopathy (AAG), a rare condition where the immune system attacks nerve cells that control automatic body functions like heart rate and blood pressure. The authors explain how doctors can diagnose AAG and how it differs from other similar conditions, including ME/CFS and long COVID, which can have overlapping symptoms.

Autonomic Nervous SystemDiagnostics

E0 ConsensusReviewPEM not requiredSystematic-Review

Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.

Gindri, Izabelle de Mello, Ferrari, Gustavo, Pinto, Luiz Paulo S et al.·American journal of physiology. Endocrinology and metabolism·2024

This review examined whether taking NAD+ or NADH supplements (molecules that help cells produce energy) are safe and helpful for people with different health conditions, including chronic fatigue syndrome. Researchers looked at 10 clinical trials involving 489 people and found that these supplements were generally well-tolerated, with some people reporting improvements in fatigue, quality of life, and sleep. The most common side effects were mild and included muscle pain, headaches, and sleep disturbances, but nothing serious.

Sleep

E0 ConsensusReviewPEM unclearReview-Narrative

Long COVID in pediatrics-epidemiology, diagnosis, and management.

Toepfner, Nicole, Brinkmann, Folke, Augustin, Silvia et al.·European journal of pediatrics·2024

This review looked at what we know about Long COVID in children and teenagers after COVID-19 infection. Most young people recover within a few months, but some experience long-lasting symptoms like fatigue, difficulty with exercise, and anxiety that can last over a year and affect daily life. The review found that a small number of these children meet the criteria for ME/CFS, but currently there are no blood tests or scans to confirm Long COVID, making it difficult to diagnose.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Translating insights into therapies for Long Covid.

Antar, Annukka A R, Cox, Andrea L·Science translational medicine·2024

Long Covid causes a variety of symptoms—like exhaustion, weakness, and brain fog—that last long after a COVID-19 infection ends. This review examines what scientists currently understand about what might cause Long Covid and looks at early laboratory studies and clinical trials testing potential treatments. The authors emphasize that more large-scale research is needed to understand why different people experience different symptoms and to develop effective therapies.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM unclearMeta-Analysis

Is the effect of cognitive behaviour therapy for chronic fatigue syndrome (ME/CFS) moderated by the presence of comorbid depressive symptoms? A meta-analysis of three treatment delivery formats.

Kuut, T A, Buffart, L M, Braamse, A M J et al.·Journal of psychosomatic research·2024

This study looked at whether cognitive behaviour therapy (CBT) works differently for ME/CFS patients depending on whether they also have depression. The researchers combined data from six clinical trials with over 1,000 patients and found that for internet-based CBT, patients with depression improved less than those without depression. However, for face-to-face CBT (whether one-on-one or in groups), depression didn't seem to affect how much patients improved.

E0 ConsensusReviewPEM not requiredReview-Narrative

Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions.

Hazrati, Ebrahim, Eftekhar, Seyed Parsa, Mosaed, Reza et al.·Molecular pain·2024

This review examined how a specific pathway in the body that breaks down the amino acid tryptophan might contribute to chronic pain, including in ME/CFS patients. The review looked at research across various pain conditions and depression, finding that certain chemicals produced along this pathway can either protect or damage nerve cells. The authors suggest that targeting this pathway could lead to new, non-opioid treatments for chronic pain.

NeuroinflammationEnergy Metabolism

E0 ConsensusReviewPEM not requiredSystematic-Review

Functional Somatic Syndromes Are Associated With Varied Postoperative Outcomes and Increased Opioid Use After Spine Surgery: A Systematic Review.

Masood, Raisa, LeRoy, Taryn E, Moverman, Michael A et al.·Global spine journal·2024

This review looked at seven studies involving over 40,000 patients to understand how people with fibromyalgia and other chronic pain conditions fare after spine surgery. The main finding was that patients with fibromyalgia were more likely to use opioid painkillers for longer periods after surgery and reported less improvement in their symptoms compared to those without fibromyalgia. Very little research exists on how other conditions like ME/CFS affect spine surgery outcomes.

E0 ConsensusReviewPEM not requiredSystematic-Review

L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review.

Wang, Wenbo, Pan, Da, Liu, Qi et al.·Nutrients·2024

Researchers reviewed 60 studies about whether L-carnitine, a natural supplement, might help with nervous system and mental health problems. They found it showed promise for some conditions like stroke and Alzheimer's disease, but had limited effectiveness for others including chronic fatigue syndrome, depression, and ALS. This review summarizes what we currently know about L-carnitine's potential benefits and limitations across different neurological conditions.

E0 ConsensusReviewPEM unclearSystematic-Review

Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials.

Park, Jae-Woong, Park, Byung-Jin, Lee, Jin-Seok et al.·Journal of translational medicine·2024

This study looked at 60 previous clinical trials involving over 7,000 ME/CFS patients to understand how severe their fatigue really is. Researchers converted all the different fatigue measurements used in these trials into a common scale (0-100) so they could compare results. They found that ME/CFS patients experience very high fatigue levels (around 78 out of 100), affecting their thinking, physical abilities, and mood in different ways.

Diagnostics

E0 ConsensusGuidelinePEM unclear

NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence.

Barry, Peter Walter, Kelley, Kate, Tan, Toni et al.·Journal of neurology, neurosurgery, and psychiatry·2024

In 2021, NICE (the UK's health guideline organization) published official recommendations for diagnosing and treating ME/CFS based on careful review of available research. When critics raised concerns about how the evidence was interpreted, the guideline authors explained that these criticisms were based on misunderstandings of how the guideline process works. This paper defends the guideline as a balanced and thoughtful approach to managing this serious condition.

Diagnostics

E0 ConsensusReviewPEM requiredSystematic-Review

Qigong and Tai Chi for ME/CFS: A Systematic Review of Randomized Controlled Trials.

Markwart, Michaela, Felsenstein, Donna, Mehta, Darshan H et al.·Global advances in integrative medicine and health·2024

This review looked at studies testing whether Qigong (a gentle Chinese exercise practice) might help people with ME/CFS. Researchers found 5 good-quality studies with a total of 481 people. The results suggest Qigong may help reduce symptom severity and improve both physical and emotional well-being, though more research is needed to be sure. Currently, there are no similar high-quality studies on Tai Chi for ME/CFS.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

[Multimodal Treatment Strategies for Homebound Patients with Severe ME/CFS: A Scoping Review].

Mayer-Huber, Sandra, Kircher, Alissa, Eberhartinger, Maria et al.·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2024

This review looked at 14 published studies about ways to treat people with severe ME/CFS who are homebound or bedbound. The researchers found that the most helpful approaches were either home visits from healthcare providers or telemedicine (video/phone appointments). The studies highlighted that treatment works best when it's flexible, tailored to each person's daily needs, and includes family members in the care plan.

E0 ConsensusReviewPEM requiredReview-Narrative

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives.

Stallmach, Andreas, Quickert, Stefanie, Puta, Christian et al.·Frontiers in immunology·2024

This review examines whether changes in gut bacteria might play a role in ME/CFS, particularly in cases that develop after infections like COVID-19. The authors found that many ME/CFS patients do show differences in their gut bacteria compared to healthy people, and these changes might trigger immune and inflammatory problems. However, the review concludes that current research hasn't proven that gut bacteria changes actually cause ME/CFS—only that they often occur together.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Identifying microRNAs Possibly Implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Review.

Tsamou, Maria, Kremers, Fabiënne A C, Samaritakis, Keano A et al.·International journal of molecular sciences·2024

This review examined tiny molecules called microRNAs that may play a role in ME/CFS and fibromyalgia. Researchers looked at existing studies to identify which microRNAs appear to be abnormal in these conditions and what role they might play in causing symptoms. They found that certain microRNAs may be involved in immune system problems, energy production difficulties, and increased pain sensitivity—processes that could help explain why people with these diseases experience fatigue, pain, and other symptoms.

BiomarkersImmune System

E0 ConsensusReviewPEM not requiredGuideline

Celiac Disease-Related Conditions: Who to Test?

Zingone, Fabiana, Bai, Julio C, Cellier, Christophe et al.·Gastroenterology·2024

This review looked at which patients should be tested for celiac disease, a condition where the immune system reacts to gluten in food. The authors found that celiac disease is often missed and recommend testing in people with certain autoimmune diseases, digestive problems, thyroid disease, and other specific conditions—including chronic fatigue syndrome. They suggest blood tests first, with biopsies during endoscopy if needed to confirm the diagnosis.

Diagnostics

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Evidence browser

A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID.

The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review.

Autoimmunity's enigmatic role: exploring the connection with myalgic encephalomyelitis/chronic fatigue syndrome.

Healthcare system barriers impacting the care of Canadians with myalgic encephalomyelitis: A scoping review.

Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis.

Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.

Long COVID in pediatrics-epidemiology, diagnosis, and management.

Translating insights into therapies for Long Covid.

Is the effect of cognitive behaviour therapy for chronic fatigue syndrome (ME/CFS) moderated by the presence of comorbid depressive symptoms? A meta-analysis of three treatment delivery formats.

Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions.

Functional Somatic Syndromes Are Associated With Varied Postoperative Outcomes and Increased Opioid Use After Spine Surgery: A Systematic Review.

L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review.

Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials.

NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence.

Qigong and Tai Chi for ME/CFS: A Systematic Review of Randomized Controlled Trials.

[Multimodal Treatment Strategies for Homebound Patients with Severe ME/CFS: A Scoping Review].

The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives.

Identifying microRNAs Possibly Implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Review.

Celiac Disease-Related Conditions: Who to Test?

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