ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

121–140 of 184 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.

Lee, Jin-Seok, Jeon, Yoo-Jin, Park, Samuel-Young et al.·Biomolecules·2020

Researchers tested three different mouse models to find the best one for studying ME/CFS. They found that removing the adrenal glands (small organs that produce stress hormones) in mice created fatigue and pain symptoms most similar to ME/CFS, while other common models mainly produced depression-like behaviors. The adrenal-removed mice also showed specific brain changes involving inflammation and stress hormone pathways.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Ryabkova, Varvara A, Churilov, Leonid P, Shoenfeld, Yehuda·International journal of molecular sciences·2019

This review explores three interconnected biological processes that may cause fibromyalgia and chronic fatigue syndrome (ME/CFS): the immune system attacking the body's own tissues, inflammation in the nervous system, and damage to small nerve fibers. The authors propose that these three mechanisms work together and may explain why patients experience widespread pain, extreme fatigue, and other symptoms like brain fog and sleep problems. They also examine whether similar mechanisms might explain some adverse reactions to HPV vaccination.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Morris, Gerwyn, Maes, Michael, Berk, Michael et al.·Metabolic brain disease·2019

This study proposes a theory for how ME/CFS might develop, starting with an infection that triggers lasting problems in the body's immune system and stress response. The authors suggest that in genetically vulnerable people, this leads to a chain of events: increased inflammation, intestinal problems that allow bacteria-related substances to enter the bloodstream, nervous system dysfunction, and eventually a state where the immune system becomes exhausted and less able to fight back. This model tries to explain why ME/CFS patients have the specific symptoms and lab abnormalities doctors observe.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Williams PhD, Marshall V, Cox, Brandon, Lafuse PhD, William P et al.·Clinical therapeutics·2019

This study explores whether a protein from the Epstein-Barr virus (EBV) may trigger brain inflammation in ME/CFS patients. Researchers found that this viral protein can change how brain cells function and alter important chemical pathways involved in energy, mood, and pain processing. The findings suggest that in some ME/CFS patients, this viral protein might contribute to fatigue, pain, and thinking difficulties.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Gherardi, Romain K, Crépeaux, Guillemette, Authier, François-Jérome·Autoimmunity reviews·2019

This review examines whether ME/CFS could be triggered by aluminum-containing substances in certain vaccines. The authors present evidence that aluminum particles may persist in immune cells and travel to the brain, potentially causing the cognitive problems, muscle pain, and fatigue seen in ME/CFS. They argue this condition represents a broader category of vaccine-related adverse effects called ASIA.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome.

Yasui, Masaya, Menjyo, Yuki, Tokizane, Kyohei et al.·Journal of neuroinflammation·2019

This study used rats exposed to chronic stress to understand why ME/CFS patients experience widespread pain without obvious tissue damage. Researchers found that stress caused sensory nerve fibers (proprioceptors) that detect body position to become overactive, which then triggered immune cells in the spinal cord called microglia to activate and cause pain. When they immobilized the ankle to reduce proprioceptor signaling, both the immune activation and pain behavior decreased.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroinflammation disorders exacerbated by environmental stressors.

O'Callaghan, James P, Miller, Diane B·Metabolism: clinical and experimental·2019

This review examines how inflammation in the brain and nervous system may be involved in ME/CFS and similar conditions. The authors suggest that various environmental stressors—like infections or other physical demands—can trigger or worsen this brain inflammation, leading to symptoms like fatigue, muscle pain, and brain fog. They propose that stress affects a key hormone system in the body (the HPA axis), which may play a role in how long these symptoms persist.

Neuroinflammation

E3 PreliminaryReviewPEM requiredReview-Narrative

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

VanElzakker, Michael B, Brumfield, Sydney A, Lara Mejia, Paula S·Frontiers in neurology·2018

This review examines different methods scientists use to look for signs of brain inflammation in ME/CFS, including specialized brain scans and blood tests. The authors found that while these techniques show promise, many studies have used inconsistent methods that make it hard to compare results across different research teams. They argue that scientists need better techniques and more careful standardization if we want to find reliable biological markers that could help diagnose ME/CFS.

NeuroinflammationBiomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi, Kuratsune, Hirohiko·Brain and nerve = Shinkei kenkyu no shinpo·2018

This review summarizes research on ME/CFS conducted in Japan since the disease was first identified there in 1990. Scientists have been searching for objective biological markers to help diagnose ME/CFS and understand what causes it. Recent brain imaging studies found evidence of immune cell activation in the brains of ME/CFS patients, which may be linked to the severity of their symptoms.

NeuroinflammationBiomarkers

E3 PreliminaryReviewPEM not requiredReview-Narrative

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Noda, Mami, Ifuku, Masataka, Hossain, Md Shamim et al.·Frontiers in psychiatry·2018

This review examines how brain inflammation might cause ME/CFS symptoms. When the body fights off a viral infection, special immune cells in the brain called microglia and astrocytes can become overactive and trigger a chain of events that reduces serotonin levels—a chemical important for mood and energy. Understanding this pathway could help researchers develop new treatments for ME/CFS.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Stress, inflammation and natural treatments.

Theoharides, T C, Kavalioti, M·Journal of biological regulators and homeostatic agents·2018

This study explores how stress and inflammation work together to cause several conditions including ME/CFS, fibromyalgia, and others. The researchers found that immune cells called mast cells and brain cells called microglia may communicate in ways that trigger inflammation during stress. They suggest that a natural supplement combining luteolin and Ashwagandha might help reduce this inflammation and benefit patients with these conditions.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study examined the brains of people with ME/CFS using three types of imaging technology (PET scans, MRI, and MEG) to look for physical differences compared to healthy people. Researchers found that people with ME/CFS have reduced blood flow and energy use in certain brain areas, decreased levels of important chemical messengers, and inflammation in the brain that appears connected to symptom severity. These findings suggest ME/CFS involves real, measurable brain changes rather than being purely psychological.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases.

Theoharides, Theoharis C, Tsilioni, Irene·Current topics in medicinal chemistry·2018

This review examines how certain molecules in the brain called cytokines and neuropeptides may trigger inflammation in specific brain areas (the hypothalamus and amygdala) in people with ME/CFS. The authors propose that a natural compound called tetramethoxyluteolin (a modified form of a plant-derived substance called luteolin) might help reduce this inflammation and improve symptoms. The study suggests this compound could be delivered directly into the nasal passages to reach the brain more effectively.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

Hatziagelaki, Erifili, Adamaki, Maria, Tsilioni, Irene et al.·The Journal of pharmacology and experimental therapeutics·2018

This study proposes that ME/CFS may be caused by inflammation in a small brain region called the hypothalamus, triggered by problems with how cells produce energy. The researchers suggest that when mitochondria (the energy factories in cells) malfunction, they may release harmful substances that activate immune cells in the brain, creating a chain reaction that leads to ME/CFS symptoms. If this theory is correct, it could open new doors for treating the condition by targeting this brain inflammation.

Neuroinflammation

E3 PreliminaryReviewPEM unclearReview-Narrative

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

Yamamura, Takashi, Ono, Hirohiko, Sato, Wakiro·Brain and nerve = Shinkei kenkyu no shinpo·2018

This study found that people with ME/CFS have unusual patterns of immune system chemicals (cytokines) in their blood and spinal fluid, and some patients have antibodies that attack their own bodies. When researchers treated some ME/CFS patients with a medication that removes certain immune cells called B cells, patients improved. This suggests that ME/CFS may be caused by the immune system mistakenly attacking the body.

NeuroinflammationImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?

Morris, Gerwyn, Berk, Michael, Puri, Basant K·Molecular neurobiology·2018

This review compared brain imaging findings across three conditions—multiple sclerosis, depression, and ME/CFS—looking for similarities that might suggest a common underlying cause. The researchers found that all three conditions show similar patterns of brain abnormalities, including problems with blood flow to the brain and changes in brain structure. They suggest that inflammation and immune cell dysfunction in the brain may explain why patients with these different diagnoses have comparable brain imaging problems.

Neuroinflammation

E3 PreliminaryMechanismPEM unclearObservational

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Nakatomi, Yasuhito, Kuratsune, Hirohiko, Watanabe, Yasuyoshi·Brain and nerve = Shinkei kenkyu no shinpo·2018

Researchers used a special imaging scan called PET to look at the brains of people with ME/CFS and found signs of inflammation (immune system activation) throughout several brain regions. This inflammation was connected to how severe patients' symptoms were, including problems with thinking and memory, as well as widespread pain. This discovery suggests that ME/CFS involves measurable changes in the brain that could eventually lead to better ways to diagnose and treat the condition.

NeuroinflammationBiomarkers

E3 PreliminaryReviewPEM unclearReview-Narrative

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Glassford, Julian A G·Frontiers in physiology·2017

This article reviews research suggesting that ME/CFS may result from problems in how the nervous system and immune system interact. The author discusses how physical strain on the spine and nerves, combined with prolonged infections and immune activation, may trigger a chain reaction of inflammation in the brain and throughout the body. This inflammation can affect energy production, hormone balance, and how the body processes pain.

Neuroinflammation

E3 PreliminaryMechanismPEM not requiredMechanistic

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

Crépeaux, Guillemette, Eidi, Housam, David, Marie-Odile et al.·Toxicology·2017

This study gave mice different amounts of aluminum hydroxide (a substance used in vaccines) injected into muscle and then checked their brains 6 months later. Surprisingly, the mice that received the lowest dose showed cognitive and movement changes, increased immune cell activity in the brain, and accumulated more aluminum in their brains—while the mice given higher doses did not. This unusual pattern suggests that aluminum's harmful effects may not simply follow the traditional "more dose = more harm" rule.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM not requiredCase-Control

CNS findings in chronic fatigue syndrome and a neuropathological case report.

Ferrero, Kimberly, Silver, Mitchell, Cocchetto, Alan et al.·Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2017

This study examines brain tissue from one person who had ME/CFS and died, looking for physical changes that might explain the illness. Researchers found several abnormalities in the brain including areas of damaged nerve fibers, tangles similar to those seen in Alzheimer's disease, and deposits of a protein called amyloid. These findings suggest that ME/CFS may involve damage to the brain's structure and deserve further investigation.

Neuroinflammation

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An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system.

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome.

Neuroinflammation disorders exacerbated by environmental stressors.

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

[History of Researches on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Glial Activation and Expression of the Serotonin Transporter in Chronic Fatigue Syndrome.

Stress, inflammation and natural treatments.

[Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?

[Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome].

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity.

CNS findings in chronic fatigue syndrome and a neuropathological case report.

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