ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

1201–1205 of 1,205 studies

E3 PreliminaryCohortPEM not requiredCross-Sectional

Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Jones, J F, Williams, M, Schooley, R T et al.·Archives of internal medicine·1988

This 1988 study tested whether people with ME/CFS had unusual antibody patterns against Epstein-Barr virus (EBV), a common virus that causes mononucleosis. Researchers measured antibodies against viral enzymes that are only produced when EBV is actively replicating. A small group of ME/CFS patients with very high EBV antibody levels did show these unusual enzyme antibodies, similar to patterns seen in people with nasopharyngeal cancer.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human B-lymphotropic virus (human herpesvirus-6).

Ablashi, D V, Josephs, S F, Buchbinder, A et al.·Journal of virological methods·1988

This study describes a virus called human herpesvirus-6 (HHV-6) that was newly discovered in 1986. Researchers found that this virus can infect many different types of cells in the body and detected antibodies to it in about 26% of healthy people. Interestingly, they found higher levels of HHV-6 antibodies in people with certain cancers, autoimmune diseases, HIV/AIDS, and chronic fatigue syndrome, suggesting the virus may play a role in these conditions.

Immune System

E3 PreliminaryPEM unclear

[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].

Berends, G M, Peeters, M F, Lepoutre, J M et al.·Nederlands tijdschrift voor geneeskunde·1988

This 1988 case study examined whether Epstein-Barr virus (EBV)—a common virus that causes infections like mononucleosis—might be connected to ME/CFS. The researchers looked at individual patient cases to explore possible links between EBV infection and the development of chronic fatigue syndrome symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndromes: relationship to chronic viral infections.

Komaroff, A L·Journal of virological methods·1988

This review examines whether ME/CFS (a condition causing severe, long-lasting tiredness) is connected to chronic viral infections, particularly herpes-type viruses. The authors found that ME/CFS often starts suddenly like the flu and is associated with symptoms like fever, sore throat, and muscle pain. While blood tests sometimes show signs of viral infection, particularly Epstein-Barr virus and human herpesvirus-6, the study could not prove that these viruses actually cause ME/CFS.

Immune System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome.

Caligiuri, M, Murray, C, Buchwald, D et al.·Journal of immunology (Baltimore, Md. : 1950)·1987

This study examined immune cells called natural killer cells in people with ME/CFS and compared them to healthy controls. Researchers found that ME/CFS patients had fewer of a specific type of natural killer cell and that these cells were less effective at fighting virus-infected cells, even after being stimulated to work harder. This suggests a potential immune system dysfunction in ME/CFS.

Immune System

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Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome.

Human B-lymphotropic virus (human herpesvirus-6).

[Chronic fatigue syndrome; is there a connection with the Epstein-Barr virus?].

Chronic fatigue syndromes: relationship to chronic viral infections.

Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome.

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