ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

141–160 of 206 studies

How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS.

Nacul, Luis, O'Boyle, Shennae, Palla, Luigi et al.·Frontiers in neurology·2020

This study proposes a framework for understanding how ME/CFS develops and changes over time, similar to other long-term illnesses. The authors suggest that ME/CFS progresses through stages—starting with genetic and environmental risk factors, moving through an early phase with high energy use and immune system problems, and potentially progressing to a later phase with low energy production and multiple system involvement. They emphasize that ME/CFS is not the same in every person or at every stage of illness, and that some people may improve if their body can restore better balance.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM not required

The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function.

Tomas, Cara, Elson, Joanna L, Strassheim, Victoria et al.·PloS one·2020

This study looked at how well the energy-producing parts of cells (mitochondria) work in people with ME/CFS compared to healthy people. Researchers found that both people with moderate and severe ME/CFS had problems with how their cells produce energy, but severely affected patients had additional problems with how their cells break down glucose for energy. This suggests that severe ME/CFS involves more widespread energy problems than moderate ME/CFS.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearMechanistic

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Schreiner, Philipp, Harrer, Thomas, Scheibenbogen, Carmen et al.·ImmunoHorizons·2020

This study explores how a virus called HHV-6 might trigger ME/CFS by examining what happens inside cells when the virus reactivates. The researchers found that when HHV-6 wakes up, it causes cells to switch into a protective mode that fights other viruses but seriously damages the cell's power plants (mitochondria) and energy-making abilities. Importantly, blood serum from ME/CFS patients showed similar patterns, suggesting HHV-6 reactivation may play a role in the disease.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Sugars and Sweeteners: Structure, Properties and In Silico Modeling.

Janežič, Dušanka, Jäntschi, Lorentz, Bolboacă, Sorana D·Current medicinal chemistry·2020

This study reviews how different types of sugars and sweeteners affect health, including their possible links to chronic fatigue syndrome (ME/CFS). The researchers explain that each sugar and sweetener is processed differently by the body based on its chemical structure, and they used computer models to help understand and predict how these substances might affect health.

Energy Metabolism

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Spinach and quinoa - prospective food sources of biologically active substances].

Sidorova, Yu S, Petrov, N A, Shipelin, V A et al.·Voprosy pitaniia·2020

This review examined whether common foods like spinach and quinoa contain natural compounds that might help with chronic fatigue and other health problems. Researchers found that both foods contain substances called phytoecdysteroids and other active compounds that have been shown in animal studies to reduce fatigue, improve memory, and support overall health. The authors suggest these foods could be useful additions to supplements and specialized diets.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

Thakur, Vandana, Jamwal, Sumit, Kumar, Mandeep et al.·Neurotoxicity research·2020

Researchers studied a substance called hemin in mice to see if it could help with fatigue-like symptoms. Mice that were stressed for 21 days showed signs of exhaustion, weakness, and anxiety. When treated with hemin, these mice improved—they became more active, stronger, and less anxious. The improvements seemed to work through a specific pathway in the body related to an enzyme called HO-1.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Understanding neuromuscular disorders in chronic fatigue syndrome.

Jammes, Yves, Retornaz, Frédérique·F1000Research·2019

This study examined how muscles work differently in people with ME/CFS. Researchers found that both the brain's ability to signal muscles and the muscles' ability to respond are impaired in ME/CFS patients. The muscles also appear to have trouble managing harmful molecules called free radicals, especially after exercise, and they may not be producing enough protective proteins that normally shield cells from damage.

Energy MetabolismPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging.

Sztretye, Mónika, Dienes, Beatrix, Gönczi, Mónika et al.·Oxidative medicine and cellular longevity·2019

This review examines astaxanthin, a powerful natural antioxidant found in marine organisms, and how it might help protect cells from damage caused by oxidative stress—an imbalance that occurs in ME/CFS and many other diseases. The authors explain how astaxanthin may work by targeting and protecting mitochondria, the energy-producing structures in our cells. They suggest this compound could potentially help prevent or slow disease progression and aging-related health problems.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.

Ohba, Takuya, Domoto, Shinichi, Tanaka, Miyu et al.·Biological & pharmaceutical bulletin·2019

Researchers created a mouse model of ME/CFS by repeatedly forcing mice to swim, which produced fatigue-like behaviors similar to the human condition. They found that this stress reduced the activity of an important energy-producing enzyme called PDH in muscle cells. When they treated the mice with a drug that reactivates PDH, the fatigue-like symptoms improved, suggesting this enzyme may be a target for future ME/CFS treatments.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCase-Control

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Fijen, Lauré, Weijmer, Marcel·BMJ case reports·2019

This case report describes an elderly man with ME/CFS who developed serious kidney damage after taking high doses of vitamin C supplements. He also had a pancreatic condition that affected his ability to digest fats properly. The combination of these two factors caused harmful crystal buildup in his kidneys, leading to acute kidney failure that required dialysis treatment.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredObservational

Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types.

Tomas, Cara, Brown, Audrey E, Newton, Julia L et al.·PeerJ·2019

This study looked at whether the powerhouses of cells (mitochondria) work differently in ME/CFS patients compared to healthy people. Researchers tested muscle cells and immune cells from the blood using a special technique to measure how well different parts of the mitochondrial energy-production system functioned. Surprisingly, they found no significant differences between ME/CFS patients and healthy controls, suggesting that if mitochondria aren't working properly in ME/CFS, the problem may occur before it reaches the mitochondria itself.

Energy Metabolism

E3 PreliminaryCohortPEM unclear

Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI.

Sahbai, S, Kauv, P, Abrivard, M et al.·European journal of nuclear medicine and molecular imaging·2019

This study examined a single ME/CFS patient's brain using advanced imaging technology (PET/MRI) that can show both brain activity and blood flow simultaneously. The researchers found that certain areas in the back of the patient's brain showed significantly lower metabolic activity (meaning cells were using less energy), but blood flow to those same areas appeared normal. This unusual pattern suggests that ME/CFS may involve a specific type of brain dysfunction that current standard brain scans might miss.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearCross-Sectional

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

Perez, Melanie, Jaundoo, Rajeev, Hilton, Kelly et al.·Frontiers in pediatrics·2019

Researchers analyzed the DNA of 383 ME/CFS patients to look for genetic variations that might make someone more susceptible to developing the illness. They found thousands of genetic differences that were more common in ME/CFS patients compared to the general population, and these differences clustered in three main areas: immune system function, hormone regulation, and metabolism. While this suggests genetics may play a role in ME/CFS vulnerability, it doesn't explain the entire cause of the disease.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS.

Kashi, Alex A, Davis, Ronald W, Phair, Robert D·Diagnostics (Basel, Switzerland)·2019

This study proposes a new theory about what might cause ME/CFS based on how the body processes an amino acid called tryptophan. The researchers suggest that if two proteins involved in tryptophan processing don't work properly together, the body could get stuck in a harmful state that causes ME/CFS symptoms. According to their mathematical model, if we could find a way to reset tryptophan levels back to normal, patients might recover.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

Rusin, Andrej, Seymour, Colin, Mothersill, Carmel·International journal of radiation biology·2018

This study looked at whether ME/CFS and radiation sickness might share similar problems in how cells produce energy. Researchers found evidence that both conditions may involve damage to mitochondria (the "power plants" of cells) and disrupted energy production. They suggest specific biological pathways worth studying to better understand ME/CFS and possibly develop new treatments.

Energy Metabolism

E3 PreliminaryMechanismPEM not requiredMechanistic

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Dong, Jia-Zi, Wei, Yun-Tao, Xu, Huan-Yu et al.·Zhen ci yan jiu = Acupuncture research·2018

This study tested whether acupuncture at a specific point (ST 36) could improve muscle weakness in rats with a chronic fatigue condition. Researchers found that the treatment increased muscle strength and improved how the rats' muscles produce energy by activating protective cellular pathways. The results suggest acupuncture may help muscle cells work more efficiently and reduce damage from fatigue.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity.

Proal, Amy, Marshall, Trevor·Frontiers in pediatrics·2018

This review explores the idea that ME/CFS may be caused by persistent infections (like Epstein-Barr virus) that disrupt the body's microbial communities and normal cell functions. These infections can interfere with how cells work, how genes are expressed, and how the immune system responds, potentially leading to the chronic symptoms patients experience. The authors suggest that treating ME/CFS might involve helping the immune system fight these persistent infections.

Energy MetabolismImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Dehydroepiandrosterone Research: Past, Current, and Future.

Klinge, Carolyn M, Clark, Barbara J, Prough, Russell A·Vitamins and hormones·2018

This is a historical review of dehydroepiandrosterone (DHEA), a hormone that naturally decreases with age. Scientists have studied whether DHEA might help with various health conditions including chronic fatigue syndrome, but the evidence in humans is limited. While some benefits have been found in postmenopausal women and certain autoimmune disorders, most human studies show only weak connections between DHEA levels and disease outcomes.

Energy MetabolismImmune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

Wang, Xue, Qu, Yidi, Zhang, Yongfeng et al.·Oxidative medicine and cellular longevity·2018

This study tested whether a medicinal mushroom called Sarcodon imbricatus could reduce fatigue in mice with chronic fatigue syndrome. The mushroom extract improved the mice's exercise ability, reduced tiredness, and boosted the body's natural antioxidant defenses—systems that protect cells from damage.

Energy Metabolism

E3 PreliminaryReviewPEM unclearReview-Narrative

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

Lacourt, Tamara E, Vichaya, Elisabeth G, Chiu, Gabriel S et al.·Frontiers in behavioral neuroscience·2018

This study explores why people with ME/CFS experience persistent fatigue by examining how inflammation in the body may damage cells' ability to produce energy. The researchers propose that chronic inflammation forces cells to switch to a less efficient energy-production method, while at the same time the body may be spending energy at rates it cannot sustain, creating an energy crisis. Sleep problems and disrupted body rhythms may also play a role in this imbalance.

Energy MetabolismPost-Exertional Malaise

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How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS.

The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function.

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Sugars and Sweeteners: Structure, Properties and In Silico Modeling.

[Spinach and quinoa - prospective food sources of biologically active substances].

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

Understanding neuromuscular disorders in chronic fatigue syndrome.

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.

Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency.

Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types.

Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI.

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study.

The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS.

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

[Electroacupuncture of "Zusanli" (ST 36) Raises Muscular Force by Adjusting AMPK/PGC-1 α Signaling in Rats with Chronic Fatigue Syndrome].

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity.

Dehydroepiandrosterone Research: Past, Current, and Future.

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative Stress.

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.

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