E3 PreliminaryMechanismPEM unclearMechanistic
Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts.
Missailidis, Daniel, Sanislav, Oana, Allan, Claire Y et al.·International journal of molecular sciences·2021
This study looked at how cells from ME/CFS patients use energy differently than healthy cells. Researchers found that ME/CFS cells are overproducing enzymes that break down fats, amino acids, and other nutrients to fuel their mitochondria (the cell's power plants), while their glycolysis (the main way cells normally produce energy) stays normal. This suggests ME/CFS cells may be forced to use alternative, less efficient pathways to generate the energy they need.
Energy Metabolism