ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

161–180 of 220 studies

E3 PreliminaryGuidelinePEM requiredGuideline

Guidance on Home-Based Care for People with Severe ME/CFS: A Transdisciplinary Expert Statement.

Hermisson, Joachim, Schreiner, Claudia, Weichselbaumer, Stefanie et al.·Wiener medizinische Wochenschrift (1946)·2026

This is a clinical guidance document developed by experts across nursing, physical therapy, medicine, and public health to help healthcare professionals and family caregivers provide home-based care for people with severe ME/CFS. The guide describes practical adjustments to everyday care tasks—such as nutrition, personal hygiene, communication, and emotional support—designed to respect the exertion thresholds associated with post-exertional malaise (PEM), the hallmark symptom of ME/CFS. The recommendations are based on strategies reported as helpful by patients and family caregivers, though the strength of evidence for each measure has not been formally graded in this summary.

Severe MEInterventionsPost-Exertional Malaise

E3 PreliminaryGuidelinePEM requiredGuideline

[Transdisciplinary Expert Statement: care guide for people severely affected by ME/CFS in home-based care].

Hermisson, Joachim, Schreiner, Claudia, Weichselbaumer, Stefanie et al.·Wiener medizinische Wochenschrift (1946)·2026

This guide describes practical home-care approaches for people severely affected by ME/CFS, developed by combining advice from patients and family caregivers with input from nursing, physiotherapy, and medical professionals. The guide addresses how to adjust daily care activities—such as nutrition, hygiene, and communication—to avoid overexertion and post-exertional malaise (PEM). However, because this is a compiled expert consensus rather than a systematic trial, the strength of evidence for each recommendation remains unclear.

Severe MEInterventionsPost-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

A Continuous Oral Regimen of High-Dose Cromolyn Sodium Is Effective for Some Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Patients With Mast Cell Activation Syndrome.

Christoforou, Maritsa E, van Campen, Linda C, Visser, Frans C et al.·Cureus·2026

This study looked at five ME/CFS patients who also had mast cell activation syndrome (a condition where immune cells release too many chemicals). These patients took a medication called cromolyn sodium in higher doses than usual—up to 2400 mg per day instead of the standard 800 mg—by sipping it continuously throughout the day rather than taking four separate doses. All five patients reported improvements in their symptoms.

Evidence Atlas

Evidence browser

Guidance on Home-Based Care for People with Severe ME/CFS: A Transdisciplinary Expert Statement.

[Transdisciplinary Expert Statement: care guide for people severely affected by ME/CFS in home-based care].

A Continuous Oral Regimen of High-Dose Cromolyn Sodium Is Effective for Some Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Patients With Mast Cell Activation Syndrome.

Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports.

The novel application of the Lightning Process to treat Long COVID in primary care - Case report.

Patient perspectives of recovery from myalgic encephalomyelitis/chronic fatigue syndrome: An interpretive description study.

Combining Topic Modeling, Sentiment Analysis, and Corpus Linguistics to Analyze Unstructured Web-Based Patient Experience Data: Case Study of Modafinil Experiences.

Corona With Lyme: A Long COVID Case Study.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: How to Help Yourself.

‘The Lightning Process’ and chronic fatigue syndrome/myalgic encephalomyelitis.

An Exercise Prescription as a Novel Management Strategy for Treatment of Long COVID.

Can l-carnitine reduce post-COVID-19 fatigue?

Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study.

Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis.

Approaching recovery from myalgic encephalomyelitis and chronic fatigue syndrome: Challenges to consider in research and practice.

Paroxysmal Kinesigenic Dyskinesia Symptoms Markedly Reduced with Parenteral Vitamins and Minerals: A Case Report.

Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate: An open-label, proof-of-principle pilot trial.

Same, Same But Different? Cognitive Behavioural Treatment Approaches for Paediatric CFS/ME and Depression.

A Novel Approach to Treating CFS and Co-morbid Health Anxiety: A Case Study.

FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research