ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3181–3200 of 6,209 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Functional status, neuropsychological functioning, and mood in chronic fatigue syndrome (CFS): relationship to psychiatric disorder.

Tiersky, Lana A, Matheis, Robert J, Deluca, John et al.·The Journal of nervous and mental disease·2003

This study looked at how depression and anxiety affect people with ME/CFS. Researchers compared four groups: people with ME/CFS alone, people with ME/CFS plus mental health symptoms that started after CFS, people with ME/CFS plus mental health symptoms that started before CFS, and healthy controls. The main finding was that while mental health problems don't make the physical fatigue and weakness worse, they do make people feel more emotionally distressed—especially if those mental health issues came before the CFS diagnosis.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects.

Douche-Aourik, Fatima, Berlier, Willy, Féasson, Léonard et al.·Journal of medical virology·2003

Researchers tested muscle tissue samples from patients with fibromyalgia/ME/CFS and inflammatory muscle diseases to see if they contained enterovirus (a type of virus). They found viral genetic material in some patient samples but not in healthy people, though they did not find evidence of active viral proteins. This suggests that if a virus is present, it may be dormant or not fully active in muscle tissue.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Unexplained fatigue syndromes in a multinational primary care sample: specificity of definition and prevalence and distinctiveness from depression and generalized anxiety.

Skapinakis, Petros, Lewis, Glyn, Mavreas, Venetsanos·The American journal of psychiatry·2003

This study looked at how different definitions of unexplained fatigue affect how many people are diagnosed and whether they also have depression or anxiety. Researchers interviewed over 5,400 primary care patients from 14 countries and found that when they required more physical symptoms in addition to fatigue, fewer people were diagnosed, but those diagnosed were more likely to also have depression or anxiety.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychiatric adjustment in chronic fatigue syndrome of childhood and in juvenile idiopathic arthritis.

Rangel, L, Garralda, M E, Hall, A et al.·Psychological medicine·2003

This study compared psychiatric and emotional problems in children with ME/CFS versus children with juvenile arthritis, another serious chronic illness. Children with ME/CFS had significantly more depression, anxiety, and personality difficulties than the arthritis group, even though both groups faced similar challenges from living with chronic illness. This suggests that ME/CFS may involve specific factors that increase psychiatric risk beyond what chronic illness alone would explain.

E2 ModerateBehavioralPEM not requiredCase-Control

Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case-control study.

Hatcher, Simon, House, Allan·Psychological medicine·2003

This study compared 64 people with ME/CFS to 64 similar people without the condition to see if stressful life events played a role in developing the illness. Researchers found that ME/CFS patients were much more likely to have experienced severe stress or difficult situations in the few months before getting sick. Particularly interesting was that about 30% of ME/CFS patients had faced an unsolvable dilemma (a 'no-win' situation) before illness onset, while none of the healthy controls had experienced this.

E2 ModerateCohortPEM not requiredCross-Sectional

Perceived exertion in fatiguing illness: civilians with chronic fatigue syndrome.

Cook, Dane B, Nagelkirk, Paul R, Peckerman, Arnold et al.·Medicine and science in sports and exercise·2003

This study looked at how hard exercise feels to people with ME/CFS compared to healthy people. Researchers had both groups exercise on a treadmill and rate their effort. While people with ME/CFS said exercise felt harder at moderate intensities, when researchers compared effort levels to each person's maximum oxygen capacity, there was no real difference—suggesting the difference in how hard it felt might be explained by their lower fitness level rather than a problem with how their body perceives effort.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Enterovirus related metabolic myopathy: a postviral fatigue syndrome.

Lane, R J M, Soteriou, B A, Zhang, H et al.·Journal of neurology, neurosurgery, and psychiatry·2003

Researchers tested muscle samples from ME/CFS patients to see if they contained enterovirus (a type of virus). They found that about 21% of ME/CFS patients had enterovirus in their muscles, while none of the healthy control subjects did. Patients with enterovirus in their muscles were more likely to show abnormal lactate (a byproduct of muscle work) buildup during exercise, suggesting their muscles weren't using energy efficiently.

Energy MetabolismPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

A measure of heart rate variability is sensitive to orthostatic challenge in women with chronic fatigue syndrome.

Yamamoto, Yoshiharu, LaManca, John J, Natelson, Benjamin H·Experimental biology and medicine (Maywood, N.J.)·2003

This study tested whether a simple heart rhythm measurement during a tilt test could help diagnose ME/CFS. Researchers compared heart rate patterns in 24 women with ME/CFS and 22 healthy women while they lay down and then tilted upright for 10 minutes. They found that women with ME/CFS showed a distinctive abnormal change in their heart rhythm pattern during tilting that could identify about 9 out of 10 ME/CFS patients correctly.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells.

Amel Kashipaz, M R, Swinden, D, Todd, I et al.·Clinical and experimental immunology·2003

Researchers tested whether immune system cells from ME/CFS and fibromyalgia patients produce abnormal levels of inflammatory chemicals called cytokines. Using advanced microscopy techniques to examine individual immune cells, they found that cytokine production was normal in patients compared to healthy controls. This suggests that abnormal cytokine production may not be the main cause of these conditions.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.

Tiev, Kiet Phong, Demettre, Edith, Ercolano, Philippe et al.·Clinical and diagnostic laboratory immunology·2003

This study looked at a protein called RNase L in the immune cells of ME/CFS patients and healthy people. Researchers found that ME/CFS patients had a different pattern of RNase L forms compared to healthy volunteers, and this pattern could potentially be used as a simple blood test to help diagnose ME/CFS. The test showed promise in distinguishing ME/CFS patients from healthy people in this small group.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired postural cerebral hemodynamics in young patients with chronic fatigue with and without orthostatic intolerance.

Tanaka, Hidetaka, Matsushima, Reiko, Tamai, Hiroshi et al.·The Journal of pediatrics·2002

This study measured how blood flow to the brain changes when young people with ME/CFS stand up, compared to healthy controls. Researchers found that many ME/CFS patients—especially those who feel dizzy or have a racing heart when standing—did not get the normal quick boost of oxygen to their brain that healthy people do. This suggests that problems with brain blood flow during position changes may be connected to ME/CFS symptoms.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue in chronic migraine patients.

Peres, M F P, Zukerman, E, Young, W B et al.·Cephalalgia : an international journal of headache·2002

This study looked at fatigue in 63 patients with chronic migraine headaches. The researchers found that most of these patients experienced significant fatigue, and many met the diagnostic criteria for chronic fatigue syndrome (CFS). The study suggests that fatigue and migraines may be connected conditions that should be recognized and treated together.

E2 ModerateCohortPEM not requiredCross-Sectional

Self-reported symptoms and medical conditions among 11,868 Gulf War-era veterans: the Seabee Health Study.

Gray, Gregory C, Reed, Robert J, Kaiser, Kevin S et al.·American journal of epidemiology·2002

This study surveyed nearly 12,000 Navy Seabees who served around the time of the 1991 Gulf War to understand their health problems. Compared to Seabees who didn't deploy to the Gulf, those who did reported significantly more health issues, including chronic fatigue syndrome, PTSD, chemical sensitivity, and irritable bowel syndrome. Women, reserve members, and certain military units had higher rates of these combined symptoms.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients.

Skowera, A, Stewart, E, Davis, E T et al.·Clinical and experimental immunology·2002

This study looked for a specific type of immune protein called antinuclear autoantibodies (ANAs) in people with ME/CFS and Gulf War veterans with multiple symptoms. Researchers compared blood samples from ME/CFS patients, symptomatic Gulf War veterans, and healthy controls. They found no significant differences in ANA levels between any of the groups, and none of the patients had the specific nuclear envelope ANA type that had been suggested as a possible ME/CFS marker.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Servaes, Petra, Prins, Judith, Verhagen, Stans et al.·Journal of psychosomatic research·2002

This study compared 57 women with ME/CFS to 57 women who had breast cancer and were experiencing severe fatigue after treatment. Researchers measured fatigue, physical activity, mood, sleep, and concentration using questionnaires, tests, and activity monitors worn for 12 days. While both groups experienced significant fatigue, ME/CFS patients generally had more severe symptoms overall, though some breast cancer survivors reported similar problems with sleep and concentration.

SleepCognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Van Houdenhove, Boudewijn, Neerinckx, Eddy, Onghena, Patrick et al.·Psychotherapy and psychosomatics·2002

This study looked at the everyday frustrations and worries that ME/CFS and fibromyalgia patients experience compared to people with other chronic illnesses like multiple sclerosis and rheumatoid arthritis. Researchers found that ME/CFS and fibromyalgia patients reported more frequent daily hassles and felt more emotionally distressed by them. The main worries for ME/CFS and fibromyalgia patients centered on feeling bad about themselves, feeling uncertain, and not being recognized or understood by others.

E2 ModerateCohortPEM not requiredCross-Sectional

Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome.

Snell, Christopher R, Vanness, J Mark, Strayer, David R et al.·In vivo (Athens, Greece)·2002

This study looked at whether exercise test results could predict high levels of RNase L, an enzyme that may be involved in ME/CFS. Researchers asked 73 patients to exercise until they were exhausted, and found that those with elevated RNase L had lower exercise capacity than those with normal levels. The findings suggest that simple exercise tests might help doctors identify which ME/CFS patients have this particular biological abnormality.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of allergen-specific IgE among patients with chronic fatigue syndrome.

Kowal, Krzysztof, Schacterele, Richard S, Schur, Peter H et al.·Allergy and asthma proceedings·2002

This study tested 50 ME/CFS patients for allergies by measuring specific immune proteins called allergen-specific IgE in their blood. Contrary to earlier patient surveys suggesting very high allergy rates, only 36% of ME/CFS patients had detectable allergic antibodies to common allergens like dust mites, pollen, and foods. This rate was similar to what researchers find in the general healthy population, suggesting that allergies may not be uniquely associated with ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

A tender sinus does not always mean rhinosinusitis.

Naranch, K, Park, Y-J, Repka-Ramirez, M S et al.·Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2002

This study measured how sensitive people's sinuses and skin are to pressure pain across different groups: healthy people, those with sinus infections or allergies, and people with ME/CFS. The researchers found that people with ME/CFS had much more sensitive sinuses and skin overall compared to healthy people, suggesting that ME/CFS causes widespread pain sensitivity rather than actual sinus infection.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue.

Farquhar, William B, Hunt, Brian E, Taylor, J Andrew et al.·American journal of physiology. Heart and circulatory physiology·2002

This study looked at whether people with ME/CFS have lower blood volume (the amount of fluid circulating in their bodies) and whether this might explain their exercise problems. Researchers compared 17 ME/CFS patients with 17 healthy controls, measuring blood volume and fitness capacity. They found that ME/CFS patients had significantly reduced exercise capacity and a trend toward lower blood volume, and these two measurements were strongly related to each other.

Post-Exertional Malaise

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Functional status, neuropsychological functioning, and mood in chronic fatigue syndrome (CFS): relationship to psychiatric disorder.

Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects.

Unexplained fatigue syndromes in a multinational primary care sample: specificity of definition and prevalence and distinctiveness from depression and generalized anxiety.

Psychiatric adjustment in chronic fatigue syndrome of childhood and in juvenile idiopathic arthritis.

Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case-control study.

Perceived exertion in fatiguing illness: civilians with chronic fatigue syndrome.

Enterovirus related metabolic myopathy: a postviral fatigue syndrome.

A measure of heart rate variability is sensitive to orthostatic challenge in women with chronic fatigue syndrome.

Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells.

RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.

Impaired postural cerebral hemodynamics in young patients with chronic fatigue with and without orthostatic intolerance.

Fatigue in chronic migraine patients.

Self-reported symptoms and medical conditions among 11,868 Gulf War-era veterans: the Seabee Health Study.

Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients.

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome.

Prevalence of allergen-specific IgE among patients with chronic fatigue syndrome.

A tender sinus does not always mean rhinosinusitis.

Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue.

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