ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

3261–3280 of 6,209 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Causal attributions for somatic sensations in patients with chronic fatigue syndrome and their partners.

Butler, J A, Chalder, T, Wessely, S·Psychological medicine·2001

This study looked at how people with ME/CFS explain their symptoms—whether they believe physical causes are responsible versus other factors. Researchers found that patients with ME/CFS tend to blame physical causes for their symptoms more often than healthy controls do. Interestingly, family members living with ME/CFS patients also blamed physical causes for the patients' symptoms, but not for their own symptoms. The researchers suggest that how partners view the illness might affect how well patients recover.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpretation of symptoms in chronic fatigue syndrome.

Dendy, C, Cooper, M, Sharpe, M·Behaviour research and therapy·2001

This study looked at how people with ME/CFS interpret their physical symptoms—whether they tend to see them as signs of physical illness versus emotional stress. Researchers gave patients with ME/CFS, depression, multiple sclerosis, and healthy people a questionnaire about how they understand their symptoms. They found that people with ME/CFS were more likely to attribute their symptoms to physical causes and less likely to see them as related to emotional feelings, even compared to MS patients.

E2 ModerateCohortPEM unclearCross-Sectional

Hemodynamic instability in chronic fatigue syndrome: indices and diagnostic significance.

Naschitz, J E, Sabo, E, Naschitz, S et al.·Seminars in arthritis and rheumatism·2001

This study tested how the body's blood pressure and heart rate respond when patients stand up from lying down (a tilt test). Researchers found that people with ME/CFS have much more unstable cardiovascular responses compared to healthy people and those with other conditions. A mathematical score called the hemodynamic instability score (HIS) could correctly identify ME/CFS patients 97% of the time, suggesting this test might help doctors diagnose the condition.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Urinary free cortisol in chronic fatigue syndrome.

Cleare, A J, Blair, D, Chambers, S et al.·The American journal of psychiatry·2001

This study measured a stress hormone called cortisol in the urine of people with ME/CFS and compared it to healthy controls. The researchers found that people with ME/CFS had lower cortisol levels than expected. This difference was consistent across the patient group and wasn't explained by depression, medications, sleep problems, or disability levels.

Endocrine Disruption

E2 ModerateCohortPEM not requiredObservational

A twin study of chronic fatigue.

Buchwald, D, Herrell, R, Ashton, S et al.·Psychosomatic medicine·2001

This study looked at whether chronic fatigue runs in families by comparing identical twins to fraternal twins. Researchers found that identical twins were more likely to both have chronic fatigue than fraternal twins, suggesting that genes play a role in who develops the condition. The findings suggest that genetics may account for about half of the reason some people develop chronic fatigue syndrome.

E2 ModerateCohortPEM not requiredCase-Control

Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT.

Lewis, D H, Mayberg, H S, Fischer, M E et al.·Radiology·2001

Researchers used brain imaging scans to look for differences in blood flow to the brain in people with ME/CFS compared to their identical twins who don't have the disease. They found that the brain scans of people with ME/CFS looked very similar to those of their healthy twins, suggesting that ME/CFS may not cause detectable changes in how blood flows through the brain at rest.

E2 ModerateCohortPEM unclearCross-Sectional

Multiple chemical sensitivity and chronic fatigue syndrome in British Gulf War veterans.

Reid, S, Hotopf, M, Hull, L et al.·American journal of epidemiology·2001

This study looked at how often ME/CFS and multiple chemical sensitivity (MCS—a condition where people react badly to everyday chemicals) occurred in British military personnel who served in the Gulf War. Researchers compared three groups: those deployed to the Gulf, those sent to Bosnia, and those who served during the Gulf War period but weren't deployed. They found that both conditions were more common in Gulf veterans, and MCS was strongly linked to pesticide exposure.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredCross-Sectional

Sexual abuse, physical abuse, chronic fatigue, and chronic fatigue syndrome: a community-based study.

Taylor, R R, Jason, L A·The Journal of nervous and mental disease·2001

This study looked at whether childhood abuse (sexual or physical) was more common in adults with ME/CFS compared to healthy people. Researchers surveyed a random sample from the community and found that while abuse history was linked to other types of chronic fatigue conditions, it was actually less common in people diagnosed with ME/CFS specifically. This finding contradicts earlier suggestions that most ME/CFS patients have experienced childhood abuse.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Discriminating between chronic fatigue syndrome and depression: a cognitive analysis.

Moss-Morris, R, Petrie, K J·Psychological medicine·2001

This study compared how people with ME/CFS think and feel about their illness compared to people with depression and healthy people. The researchers found that people with ME/CFS and people with depression have different thought patterns: people with depression tend to blame themselves and doubt their worth, while people with ME/CFS focus on their physical symptoms, see themselves as sick, and tend to rest more to manage their condition. These different thinking patterns stayed consistent over 6 months and were linked to how much disability and fatigue people experienced.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue.

Jason, L A, Taylor, R R, Carrico, A W·Chronobiology international·2001

This study looked at when people developed ME/CFS and chronic fatigue symptoms to see if there was a pattern linked to seasons or viral infections. Researchers asked 31 people with CFS and 44 with similar fatigue symptoms what month their illness started. They found that more people than expected reported symptom onset in January, suggesting that seasonal factors—possibly increased viral infections in winter—might play a role in triggering these conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Paul, L M, Wood, L, Maclaren, W·Gait & posture·2001

This study looked at whether people with ME/CFS have problems with walking and balance, and whether light exercise makes these problems worse. Researchers compared 11 ME/CFS patients with 11 healthy people and found that while ME/CFS patients did show different walking patterns, their balance was similar to healthy controls, and the exercise test did not worsen either group's balance or gait.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome.

De Becker, P, McGregor, N, De Meirleir, K·Journal of internal medicine·2001

This study looked at 2,073 patients with chronic fatigue to understand how well two common diagnostic criteria (Fukuda and Holmes) identify ME/CFS. The researchers found that the Holmes criteria selected patients with more severe symptoms, while the Fukuda criteria included a broader group with milder cases. Adding or removing certain symptoms from the current diagnostic criteria could help doctors better identify who truly has ME/CFS.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Thoroughly modern worries: the relationship of worries about modernity to reported symptoms, health and medical care utilization.

Petrie, K J, Sivertsen, B, Hysing, M et al.·Journal of psychosomatic research·2001

This study looked at whether worries about modern health threats (like pollution, food safety, and radiation) are linked to symptom reporting and chronic fatigue syndrome (CFS). Researchers surveyed over 8,000 people and found that those with higher worries about modernity reported more physical symptoms, food intolerances, and CFS diagnoses. The study suggests that health anxiety about modern threats may influence how people interpret body signals and perceive their health.

E2 ModerateCohortPEM not requiredCase-Control

A family history study of chronic fatigue syndrome.

Walsh, C M, Zainal, N Z, Middleton, S J et al.·Psychiatric genetics·2001

This study examined whether ME/CFS runs in families by comparing relatives of people with ME/CFS to relatives of people with other medical conditions. Researchers found that relatives of ME/CFS patients were significantly more likely to also have ME/CFS, suggesting that family history and possibly genetics play a role in developing the condition.

E2 ModerateBehavioralPEM not requiredObservational

The use of a symptom "self-report" inventory to evaluate the acceptability and efficacy of a walking program for patients suffering with chronic fatigue syndrome.

Coutts, R, Weatherby, R, Davie, A·Journal of psychosomatic research·2001

This study tested whether a walking program could help people with ME/CFS feel better. Twenty patients with ME/CFS walked for 12 weeks at a pace matched to their fitness level. The researchers found that patients reported improvements in psychological stress and some other symptoms, and importantly, the walking did not make their ME/CFS symptoms worse.

Interventions

E2 ModerateCohortPEM not requiredObservational

The biochemical study of intermaxillary fixation (IMF) stress in oral surgery inpatients.

Sakaino, H·The Kurume medical journal·2001

This study looked at how oral surgery patients respond to intermaxillary fixation (IMF), a procedure that temporarily wires the jaw shut. Researchers measured stress hormones in urine and found that IMF causes significant stress, leading to irritability and sleep problems. When patients were given an anti-anxiety medication, their stress hormone levels were reduced.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome.

Manuel y Keenoy, B, Moorkens, G, Vertommen, J et al.·Life sciences·2001

This study looked at whether oxidative stress—a type of cellular damage—might contribute to ME/CFS. Researchers compared 33 people with ME/CFS to 28 people with similar symptoms who didn't meet ME/CFS criteria. They found that people with ME/CFS had higher levels of fat damage in their blood particles and lower levels of a protective protein called transferrin, suggesting their bodies may be more vulnerable to oxidative damage.

E2 ModerateCohortPEM not requiredCross-Sectional

Physiological responses to incremental exercise in patients with chronic fatigue syndrome.

Inbar, O, Dlin, R, Rotstein, A et al.·Medicine and science in sports and exercise·2001

Researchers compared how the bodies of 15 people with ME/CFS responded to a gradually increasing exercise test on a treadmill, compared to 15 healthy people. People with ME/CFS showed lower heart rates and weaker cardiovascular responses during exercise, even when they appeared to be pushing themselves as hard as they could. This suggests their bodies may have trouble with either heart function or muscle oxygen use during physical exertion.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Patients' perceptions of medical care in chronic fatigue syndrome.

Deale, A, Wessely, S·Social science & medicine (1982)·2001

This study asked 68 ME/CFS patients about their experiences with medical care. Two-thirds of patients were unhappy with the care they received. Patients felt most satisfied when doctors listened, showed genuine interest, and communicated clearly—not necessarily when doctors could cure the illness. Patients were most frustrated when doctors were dismissive, confused about ME/CFS, or gave conflicting advice.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal assessment of neuropsychological functioning, psychiatric status, functional disability and employment status in chronic fatigue syndrome.

Tiersky, L A, DeLuca, J, Hill, N et al.·Applied neuropsychology·2001

Researchers tracked 35 people with ME/CFS over about 3.5 years to see how they changed over time. They found that attention, mood, fatigue, and disability improved somewhat during this period. However, most people remained significantly disabled and unemployed at the end of the study, suggesting that while some aspects may get better, ME/CFS typically leaves people unable to work long-term.

Cognitive Impairment

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Causal attributions for somatic sensations in patients with chronic fatigue syndrome and their partners.

Interpretation of symptoms in chronic fatigue syndrome.

Hemodynamic instability in chronic fatigue syndrome: indices and diagnostic significance.

Urinary free cortisol in chronic fatigue syndrome.

A twin study of chronic fatigue.

Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT.

Multiple chemical sensitivity and chronic fatigue syndrome in British Gulf War veterans.

Sexual abuse, physical abuse, chronic fatigue, and chronic fatigue syndrome: a community-based study.

Discriminating between chronic fatigue syndrome and depression: a cognitive analysis.

A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue.

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome.

Thoroughly modern worries: the relationship of worries about modernity to reported symptoms, health and medical care utilization.

A family history study of chronic fatigue syndrome.

The use of a symptom "self-report" inventory to evaluate the acceptability and efficacy of a walking program for patients suffering with chronic fatigue syndrome.

The biochemical study of intermaxillary fixation (IMF) stress in oral surgery inpatients.

Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome.

Physiological responses to incremental exercise in patients with chronic fatigue syndrome.

Patients' perceptions of medical care in chronic fatigue syndrome.

Longitudinal assessment of neuropsychological functioning, psychiatric status, functional disability and employment status in chronic fatigue syndrome.

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