ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4261–4280 of 6,209 studies

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Lubell, Jeffrey·Journal of translational medicine·2022

This editorial letter explores whether problems with blood vessel function and damage might explain some of the key symptoms of ME/CFS, including pain, inflammation, and post-exertional malaise (the exhaustion that follows physical activity). The author proposes that if blood vessels aren't working properly, they may not deliver enough oxygen and nutrients to tissues, which could trigger the symptoms many ME/CFS patients experience.

Post-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCase-Control

Stellate ganglion block reduces symptoms of Long COVID: A case series.

Liu, Luke D, Duricka, Deborah L·Journal of neuroimmunology·2022

This small study looked at a procedure called a stellate ganglion block, which uses local anesthetic to temporarily quiet the nerve signals in the neck that control your 'fight or flight' response. Two Long COVID patients received this procedure, and their symptoms—including fatigue, brain fog, and dizziness upon standing—improved. The authors suggest that an imbalance in the autonomic nervous system (the system that controls automatic body functions) may be contributing to Long COVID symptoms.

Neuroinflammation

E3 PreliminaryCohortPEM unclearCase-Control

Orthostatic intolerance as a potential contributor to prolonged fatigue and inconsistent performance in elite swimmers.

Petracek, Lindsay S, Eastin, Ella F, Rowe, Ian R et al.·BMC sports science, medicine & rehabilitation·2022

This study looked at five elite swimmers who experienced severe fatigue and couldn't perform at their usual level. The researchers tested whether orthostatic intolerance—a condition where the body struggles to maintain proper blood pressure when standing—might explain their symptoms. When the swimmers were tested with standing or tilt table tests, they all felt fatigued and other symptoms appeared. After receiving treatment with extra salt and fluids, all five swimmers felt significantly better and returned to normal performance.

Autonomic Nervous System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Breast implant illness: scientific evidence of its existence.

Cohen Tervaert, J W, Mohazab, N, Redmond, D et al.·Expert review of clinical immunology·2022

This review examined whether silicone breast implants cause a condition called breast implant illness (BII), which includes symptoms like chronic fatigue, joint pain, muscle pain, and brain fog. The authors concluded that there is a causal link between silicone implants and these systemic symptoms in some women, and that removing the implants typically resolves the symptoms.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Mechanism of acupuncture and moxibustion in treatment of chronic fatigue syndrome from perspective of intestinal flora].

Li, Chao-Ran, Sun, Zhong-Ren, Wang, Yu-Lin et al.·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2022

This study explores how gut bacteria may contribute to chronic fatigue syndrome and suggests that acupuncture and moxibustion (traditional Chinese medicine techniques) might help by restoring healthy gut bacteria. The researchers believe that an imbalance in gut bacteria can trigger inflammation and metabolism problems in ME/CFS patients, and that these traditional treatments could reduce fatigue by improving gut health and communication between the gut and brain.

Gut MicrobiomeImmune System

E3 PreliminaryMechanismPEM unclearMechanistic

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients.

Eaton-Fitch, Natalie, Du Preez, Stanley, Cabanas, Hélène et al.·Journal of translational medicine·2022

This study found that immune cells called natural killer cells in ME/CFS patients have a broken calcium channel (TRPM3) that prevents them from working properly. When researchers treated these cells overnight with a drug called naltrexone, the calcium channel started working better and the immune cells functioned more like those from healthy people. This suggests that ME/CFS may involve faulty ion channels and that naltrexone could potentially help restore immune cell function.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Long COVID Citizen Scientists: Developing a Needs-Based Research Agenda by Persons Affected by Long COVID.

Ziegler, Sarah, Raineri, Alessia, Nittas, Vasileios et al.·The patient·2022

This study asked people with Long COVID what research questions matter most to them. Researchers created a group of 28 people with Long COVID and ME/CFS, plus a larger working group of over 240 people, who together identified 68 research questions and ranked which ones were most important. The top five priorities were: finding better treatments and rehabilitation, ensuring continuous care between doctors, improving access to healthcare, training healthcare providers to understand Long COVID, and studying Long COVID in children and teens.

E3 PreliminaryMechanismPEM unclearMechanistic

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.

Sasso, Etianne Martini, Muraki, Katsuhiko, Eaton-Fitch, Natalie et al.·Molecular medicine (Cambridge, Mass.)·2022

This study examined a specific ion channel called TRPM3 in immune cells from patients with ME/CFS and long COVID, comparing them to healthy people. Researchers found that both ME/CFS and long COVID patients had similar problems with how this ion channel functions. The findings suggest that broken ion channels might be part of why these conditions cause long-lasting fatigue and other symptoms.

Immune System

E3 PreliminaryMechanismPEM unclearMechanistic

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro.

Flaskamp, Lavinia, Roubal, Constanze, Uddin, Steven et al.·Cells·2022

This study examined blood samples from people with long COVID and those who developed ME/CFS after COVID-19, comparing them to healthy controls. Researchers tested whether certain proteins in these blood samples could harm the cells that line blood vessels. They found that the blood of ME/CFS patients contained more of these harmful proteins, and the blood samples from both patient groups affected blood vessel cells in different ways that could contribute to the fatigue and other symptoms these patients experience.

E3 PreliminaryMechanismPEM not requiredMechanistic

Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome.

Miao, Xiaoyao, Li, Shuo, Xiao, Bingkun et al.·Biomedical chromatography : BMC·2022

Researchers tested whether a traditional Chinese medicine formula called Danggui Buxue Tang (DBT) could help rats with chronic fatigue syndrome caused by stress and food restriction. After 4 weeks of treatment, rats given DBT showed better energy levels, reduced fatigue markers in their blood, and improved physical performance compared to untreated rats with CFS.

E3 PreliminaryReviewPEM unclearReview-Narrative

COVID-19 in the perioperative setting: A review of the literature and the clinical landscape.

O'Glasser, Avital Y, Schenning, Katie J·Perioperative care and operating room management·2022

This article reviews what doctors know about surgical risks for people who have had COVID-19. It discusses how hospitals have had to balance treating COVID-19 patients while also catching up on surgeries that were delayed during the pandemic. The authors highlight that COVID-19 survivors face higher risks during surgery and anesthesia, and they call for careful planning to keep these patients safe.

E3 PreliminaryCohortPEM not requiredCase-Control

[Fatigue Doesn't Always have to be caused by SARS-CoV-2: Case Report].

Howanietz, Helmuth, Graf, Ulrike, Kainz, Theresa·Padiatrie und Padologie·2022

This case report describes a 17-year-old girl who experienced severe fatigue caused by Epstein-Barr virus (EBV) infection, commonly known as infectious mononucleosis. The authors highlight that fatigue in young people can come from many different causes, not just COVID-19, and that it's important to identify the correct cause. Notably, about 13.5% of people who have EBV infection go on to develop ME/CFS, making proper diagnosis essential.

Diagnostics

E3 PreliminaryMechanismPEM not requiredMechanistic

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells.

Bahramian, Elham, Furr, Mercede, Wu, Jerry T et al.·Frontiers in immunology·2022

This study examined how two closely related viruses called HHV-6A and HHV-6B infect different types of nerve cells in the brain. Researchers found that both viruses can infect certain brain cells that use glutamate and dopamine (chemical messengers), but neither virus infected a third type of brain cell that uses GABA. Importantly, HHV-6A appeared to cause more damage to infected cells than HHV-6B, suggesting it may be more harmful to nerve tissue.

Neuroinflammation

E3 PreliminaryBehavioralPEM unclear

‘The Lightning Process’ and chronic fatigue syndrome/myalgic encephalomyelitis.

Vallings, Rosamund·Journal of primary health care·2022

This study examines 'The Lightning Process,' a coaching program that some people claim can help with ME/CFS. The author, a doctor experienced in ME/CFS care, analyzed what is known about this approach and its effects on patients with this illness. The study raises concerns about whether the program is safe and effective for people with ME/CFS.

Interventions

E3 PreliminaryReviewPEM unclearReview-Narrative

The contested meaning of "long COVID" - Patients, doctors, and the politics of subjective evidence.

Roth, Phillip H, Gadebusch-Bondio, Mariacarla·Social science & medicine (1982)·2022

This study examines how patients created and spread the term "long COVID" by sharing their personal experiences online, which eventually led doctors and health officials to recognize it as a real condition. The researchers compare this process to how ME/CFS patients have struggled for recognition over decades, showing that social media and patient voices can shape how medicine understands and responds to complex illnesses.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Stress, asthenia and cognitive disorders].

Vasenina, E E, Gankina, O A, Levin, O S·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022

This article examines how extreme tiredness (asthenia) relates to ME/CFS and other conditions affecting mood and thinking. The authors explain that severe fatigue can start as the body's warning signal that energy is running out, but it can develop into a serious, disabling disease on its own. They discuss how fatigue often occurs together with depression, anxiety, and problems with memory or concentration, which can make it harder for doctors to figure out what's really causing a patient's symptoms.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

At the Root of 3 "Long" Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome.

James, Lisa M, Georgopoulos, Apostolos P·Neuroscience insights·2022

This review explores why some people develop long-lasting illnesses after exposure to viruses or bacteria, while others recover normally. The researchers propose that certain infections may persist in the body longer in people with specific immune system markers (HLA types), potentially causing ongoing damage to the brain and other organs. They suggest this mechanism might explain symptoms seen in ME/CFS, long-COVID, and Gulf War Illness.

NeuroinflammationImmune System

E3 PreliminaryCohortPEM not required

Could Modafinil Be an Option in the Treatment of Sexual Dysfunctions Due to Antidepressant Use in Women? Two Case Reports.

Yilbaş, Barış·Turk psikiyatri dergisi = Turkish journal of psychiatry·2022

Some antidepressant medications can cause sexual side effects like loss of desire and difficulty with arousal. This report describes two women whose sexual problems improved when modafinil (a medication used for sleep disorders and fatigue) was added to their antidepressant treatment. One woman saw significant improvement at 100 mg daily, while the other needed 200 mg daily to see meaningful improvement.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

COVID-19 and chronic fatigue syndrome: An endocrine perspective.

Bansal, Rashika, Gubbi, Sriram, Koch, Christian A·Journal of clinical & translational endocrinology·2022

Some people who recover from COVID-19 experience long-lasting exhaustion and other debilitating symptoms similar to ME/CFS. This review examines how COVID-19 might affect the body's hormone systems, particularly the glands that control stress response and energy levels. The authors suggest doctors should check patients' hormone levels as part of their care plan.

Endocrine DisruptionLong COVID Overlap

E3 PreliminaryMechanismPEM unclearMechanistic

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.

Nishi, Kensuke, Yoshimoto, Shohei, Nishi, Soichiro et al.·International journal of molecular sciences·2022

This study looked at a Japanese treatment called Epipharyngeal Abrasive Therapy (EAT) that targets chronic inflammation in the epipharynx (the area behind your nasal cavity). The researchers found that patients who received EAT had significantly lower levels of IL-6, a key inflammatory molecule linked to ME/CFS symptoms, compared to those who didn't receive the treatment. This suggests that reducing inflammation in this specific area might help improve systemic symptoms in ME/CFS and similar conditions.

Immune System

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Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Stellate ganglion block reduces symptoms of Long COVID: A case series.

Orthostatic intolerance as a potential contributor to prolonged fatigue and inconsistent performance in elite swimmers.

Breast implant illness: scientific evidence of its existence.

[Mechanism of acupuncture and moxibustion in treatment of chronic fatigue syndrome from perspective of intestinal flora].

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients.

Long COVID Citizen Scientists: Developing a Needs-Based Research Agenda by Persons Affected by Long COVID.

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.

Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro.

Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome.

COVID-19 in the perioperative setting: A review of the literature and the clinical landscape.

[Fatigue Doesn't Always have to be caused by SARS-CoV-2: Case Report].

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells.

‘The Lightning Process’ and chronic fatigue syndrome/myalgic encephalomyelitis.

The contested meaning of "long COVID" - Patients, doctors, and the politics of subjective evidence.

[Stress, asthenia and cognitive disorders].

At the Root of 3 "Long" Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome.

Could Modafinil Be an Option in the Treatment of Sexual Dysfunctions Due to Antidepressant Use in Women? Two Case Reports.

COVID-19 and chronic fatigue syndrome: An endocrine perspective.

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.

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