ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

4421–4440 of 6,163 studies

E3 PreliminaryCohortPEM unclearCase-Control

Successful Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome with Chronic Febricula Using the Traditional Japanese Medicine Shosaikoto.

Numata, Takehiro, Miura, Kazuki, Akaishi, Tetsuya et al.·Internal medicine (Tokyo, Japan)·2020

A 14-year-old girl with ME/CFS who had experienced severe tiredness, low-grade fevers, and school absence for 20 months was treated with shosaikoto, a traditional Japanese herbal medicine. Within several weeks, her symptoms improved dramatically and she was able to return to school. This case suggests that shosaikoto may help some ME/CFS patients, particularly those with persistent low fevers.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking.

Parslow, Roxanne M, Anderson, Nina, Byrne, Danielle et al.·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2020

Researchers asked young people with ME/CFS and their parents what aspects of their health and daily life matter most to them. Using a card-ranking game, 21 young people (ages 12-17) and their parents identified and discussed the outcomes that would be most important to improve. The study found that symptoms, tiredness, 'payback' (crashing after activity), and hobbies were ranked as most important by both groups, though young people prioritized school more and parents worried more about mood.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Kerr, Jonathan·Biomolecules·2020

This study looked at specific genes called EGR genes that turn on in response to stress and infection. Researchers found that these genes were abnormally active in blood samples from some ME/CFS patients, and this activity matched up with signs of Epstein-Barr virus (EBV) reactivation. This suggests that in some people with ME/CFS, a dormant virus may be waking up and triggering an ongoing immune response.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity.

Nipate, Sonali S, Tiwari, Anand H·Journal of Ayurveda and integrative medicine·2020

This study tested whether an extract from Spilanthes oleracea (a plant used in traditional medicine) could help relieve fatigue symptoms in mice subjected to chronic stress. The researchers found that the plant extract reduced markers of cellular damage and improved physical performance in stressed mice, suggesting it may work by reducing harmful molecules called oxidative stress in the body.

E3 PreliminaryMechanismPEM unclearCross-Sectional

Altered Structural Brain Networks Related to Adrenergic/Muscarinic Receptor Autoantibodies in Chronic Fatigue Syndrome.

Fujii, Hiroyuki, Sato, Wakiro, Kimura, Yukio et al.·Journal of neuroimaging : official journal of the American Society of Neuroimaging·2020

This study looked at whether certain antibodies in the blood (proteins that attack the body's own receptors) are connected to changes in brain structure in ME/CFS patients. Researchers scanned the brains of 89 ME/CFS patients and measured levels of four specific autoantibodies, then looked for patterns. They found that two of these autoantibodies showed a relationship with how brain networks are organized in specific areas, suggesting these antibodies might be useful markers for identifying ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclear

A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors.

Wirth, Klaus, Scheibenbogen, Carmen·Autoimmunity reviews·2020

Researchers found that some ME/CFS patients have antibodies (immune proteins) that attack receptors that normally help blood vessels relax and improve blood flow. When these receptors don't work properly, blood vessels may constrict and reduce oxygen delivery to muscles and the brain. This could explain why ME/CFS patients experience fatigue, pain, and cognitive problems.

Autonomic Nervous System

E3 PreliminaryReviewPEM unclearReview-Narrative

Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grabowska, Anna D, Lacerda, Eliana M, Nacul, Luís et al.·Frontiers in pediatrics·2020

This study reviews how genetic research teams check the quality of their data when looking for genes connected to ME/CFS. The researchers examined the methods different studies use to make sure their genetic findings are reliable and trustworthy. Understanding these quality control checks helps ensure that genetic discoveries about ME/CFS are real and not due to errors in the data.

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

Thakur, Vandana, Jamwal, Sumit, Kumar, Mandeep et al.·Neurotoxicity research·2020

Researchers studied a substance called hemin in mice to see if it could help with fatigue-like symptoms. Mice that were stressed for 21 days showed signs of exhaustion, weakness, and anxiety. When treated with hemin, these mice improved—they became more active, stronger, and less anxious. The improvements seemed to work through a specific pathway in the body related to an enzyme called HO-1.

Energy Metabolism

E3 PreliminaryMechanismPEM unclearMechanistic

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients.

Ovejero, Tamara, Sadones, Océane, Sánchez-Fito, Teresa et al.·International journal of molecular sciences·2020

Researchers discovered that fibromyalgia patients have unusual activity of genetic sequences called transposable elements (pieces of DNA that can move and copy themselves) in their immune cells. This overactivity was linked to higher levels of interferon proteins, which trigger inflammation and flu-like symptoms. This finding may help explain why fibromyalgia patients often feel sick even when they don't have an actual infection.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) in Familial Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Sung, Alexander P, Tang, Jennifer J-J, Guglielmo, Michael J et al.·Fatigue : biomedicine, health & behavior·2020

This study looked at immune cells called NK cells in families where multiple members have ME/CFS. The researchers found that ME/CFS patients and their healthy family members both had fewer of a specific type of NK cell and weaker immune responses compared to unrelated healthy people. This suggests that a genetic weakness in immune cell function might run in families and could increase the risk of developing ME/CFS.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia.

Polli, Andrea, Ghosh, Manosij, Bakusic, Jelena et al.·Arthritis & rheumatology (Hoboken, N.J.)·2020

This study found that people with ME/CFS and fibromyalgia have unusual patterns in how their genes are regulated, specifically involving a molecule called BDNF that affects pain and nerve function. Researchers measured genetic markers and protein levels in blood samples and found that changes in how BDNF genes are 'switched on and off' may explain why patients experience severe fatigue, pain, and widespread body aches.

Pain and Sensitization

E3 PreliminaryMechanismPEM unclearMechanistic

IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS.

Hartwig, Jelka, Sotzny, Franziska, Bauer, Sandra et al.·Brain, behavior, & immunity - health·2020

This study examined a specific immune problem in some ME/CFS patients: abnormal antibodies that interfere with a receptor protein called β2 adrenergic receptor, which helps regulate immune response and stress recovery. Researchers found that immune cells (antibodies) from healthy people could activate this receptor and boost immune regulation, but antibodies from ME/CFS patients with elevated levels of these specific autoantibodies could not. This dysfunction in the immune system may help explain why ME/CFS patients experience persistent fatigue and immune dysregulation.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Network Pharmacology to Uncover the Biological Basis of Spleen Qi Deficiency Syndrome and Herbal Treatment.

Wang, Xin, Wu, Min, Lai, Xinxing et al.·Oxidative medicine and cellular longevity·2020

This study used computer analysis and lab experiments to understand how traditional Chinese medicine views a condition called "spleen qi deficiency," which is linked to various diseases including chronic fatigue. Researchers found that this condition may involve problems with the immune system and how the body handles stress at the cellular level. They also identified which herbs traditionally used for this condition work by boosting immune cell activity.

Immune System

E3 PreliminaryCohortPEM unclearCase-Control

Severe ME in Children.

Speight, Nigel·Healthcare (Basel, Switzerland)·2020

This study looks at severe ME/CFS in children who are so sick they can barely leave their homes or beds. The doctor who wrote it shares real patient stories to show how the illness presents and how to manage it properly. The study highlights an important problem: many doctors don't recognize or diagnose ME/CFS, and there's very little information available about the most severely affected patients.

Severe ME

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Impact of Long-Term Cryopreservation on Blood Immune Cell Markers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Biomarker Discovery.

Gómez-Mora, Elisabet, Carrillo, Jorge, Urrea, Víctor et al.·Frontiers in immunology·2020

This study looked at how freezing blood samples affects the ability to detect immune cell changes in ME/CFS patients. Researchers compared fresh blood samples with frozen ones from ME/CFS patients and healthy people, testing various immune markers. They found that some immune markers stay reliable after freezing, but others—particularly certain natural killer cell markers—change significantly, which could make them unreliable for future research.

Immune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome.

Jammes, Yves, Adjriou, Nabil, Kipson, Nathalie et al.·Journal of translational medicine·2020

This study examined muscle function and stress markers in 72 ME/CFS patients during rest, exercise, and recovery. Researchers found that about half the patients showed significant changes in how their muscles respond to electrical signals, combined with higher levels of oxidative stress (cellular damage from chemical imbalance). The other half showed normal muscle responses and lower stress markers. This suggests ME/CFS may include at least two different biological subtypes.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCross-Sectional

Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing.

van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C·Healthcare (Basel, Switzerland)·2020

This study looked at blood flow to the brain in 19 people with severe ME/CFS who have difficulty standing up (orthostatic intolerance). When patients tilted their heads up at a mild 20-degree angle for 15 minutes, blood flow to their brains dropped by an average of 27%. All 19 patients showed this abnormal reduction in brain blood flow, suggesting this shorter, gentler test could help diagnose the condition even in the most severely ill patients who cannot tolerate longer or more intense tests.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Extracting medication information from unstructured public health data: a demonstration on data from population-based and tertiary-based samples.

Chen, Robert, Ho, Joyce C, Lin, Jin-Mann S·BMC medical research methodology·2020

Researchers developed a computer program to automatically read through medical records and extract information about what medications ME/CFS patients are taking and why they're taking them. Instead of having someone manually review thousands of medication entries (which is slow and error-prone), their automated system condensed over 1,200 different medication names into 89 standard categories and organized reasons for use into 65 categories. This tool could help future research studies more quickly analyze medication patterns in ME/CFS patients.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Clinical History Segment Extraction from Chronic Fatigue Syndrome Assessments to Model Disease Trajectories.

Priou, Sonia, Viani, Natalia, Vernugopan, Veshalee et al.·Studies in health technology and informatics·2020

Researchers developed a computer method to automatically read and extract important information from patient medical records about ME/CFS. Since doctors write many patient notes in free text rather than structured data, this tool helps pull out symptom descriptions and track how the illness changes over time for individual patients. This approach could help researchers understand common patterns in how ME/CFS affects different people.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Brain Responses in CFS and TMD to Autonomic Challenges: An Exploratory fMRI Study.

Vuong, Q C, Allison, J R, Finkelmeyer, A et al.·JDR clinical and translational research·2020

This study looked at how the brains of people with ME/CFS respond during a specific breathing test (the Valsalva maneuver) that activates the autonomic nervous system—the part of your nervous system that controls automatic body functions like heart rate and breathing. Researchers compared brain scans of people with ME/CFS who also had jaw pain (temporomandibular disorder) to those with ME/CFS alone and healthy controls. They found that people with both conditions showed stronger brain activity in areas related to pain and fatigue, suggesting that problems with autonomic nervous system control may contribute to both conditions.

Autonomic Nervous System

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Successful Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome with Chronic Febricula Using the Traditional Japanese Medicine Shosaikoto.

Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking.

Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity.

Altered Structural Brain Networks Related to Adrenergic/Muscarinic Receptor Autoantibodies in Chronic Fatigue Syndrome.

A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors.

Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients.

Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) in Familial Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia.

IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS.

Network Pharmacology to Uncover the Biological Basis of Spleen Qi Deficiency Syndrome and Herbal Treatment.

Severe ME in Children.

Impact of Long-Term Cryopreservation on Blood Immune Cell Markers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Biomarker Discovery.

Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome.

Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing.

Extracting medication information from unstructured public health data: a demonstration on data from population-based and tertiary-based samples.

Clinical History Segment Extraction from Chronic Fatigue Syndrome Assessments to Model Disease Trajectories.

Brain Responses in CFS and TMD to Autonomic Challenges: An Exploratory fMRI Study.

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