ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5141–5160 of 6,211 studies

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Efficiency evaluation of autonomic heart control by using the principal component analysis of ECG P-wave.

Krisciukaitis, A, Simoliuniene, R, Tamosiunas, M et al.·Methods of information in medicine·2010

This study developed a new computer method to measure how well the heart's nerves (autonomic nervous system) work by analyzing changes in the electrical activity of the heart during a simple tilt test, where a person moves from lying down to standing up. The researchers tested this method in healthy people and those with heart rhythm problems, and found it could detect differences in how the heart responds to position changes. This type of measurement might eventually help doctors diagnose problems with heart control earlier.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV.

Sato, Eiji, Furuta, Rika A, Miyazawa, Takayuki·Retrovirology·2010

Researchers testing for a virus called XMRV in ME/CFS patients discovered that one commercial laboratory test kit was contaminated with mouse virus DNA. This contamination meant that positive results from this kit could not be trusted, since the positive signal came from the kit itself rather than from patient samples. The researchers are warning other scientists to carefully check their test kits for this contamination before using them in studies.

E3 PreliminaryMechanismPEM unclearMechanistic

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

Groom, Harriet C T, Yap, Melvyn W, Galão, Rui Pedro et al.·Proceedings of the National Academy of Sciences of the United States of America·2010

Scientists studied a virus called XMRV that had been linked to ME/CFS to understand how it survives in human cells. They discovered that the body's natural antiviral defense proteins can block this virus, but XMRV does not appear to have developed ways to escape these defenses like some other viruses do. This finding helps researchers understand which cells XMRV can infect and how to design better laboratory studies of this virus.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[The chronic asthenia syndrome: a clinical approach].

Young, Pablo, Finn, Bárbara C, Bruetman, Julio et al.·Medicina·2010

Fatigue is one of the most common reasons people visit doctors, affecting about 30% of patients. This article explains how doctors should think about different types of fatigue—including chronic fatigue syndrome (ME/CFS), which affects 0.2–0.7% of people. The authors emphasize that finding and treating the underlying cause is the best approach, though about 20% of patients never get a clear diagnosis.

Diagnostics

E3 PreliminaryMechanismPEM unclearObservational

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

White, Andrea T, Light, Alan R, Hughen, Ronald W et al.·Psychophysiology·2010

This study looked at why some people with ME/CFS feel much worse after exercise. Researchers measured immune chemicals in the blood before and after moderate exercise in people with ME/CFS and healthy controls. They found that patients who experienced severe symptom flare had increased levels of certain immune chemicals 8 hours after exercise, while those with mild flare or healthy people did not show this pattern.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome.

Sachdeva, Anand Kamal, Kuhad, Anurag, Tiwari, Vinod et al.·Basic & clinical pharmacology & toxicology·2010

This study tested whether a compound from green tea called EGCG could help reduce fatigue in mice exposed to stress. Researchers induced fatigue-like symptoms in mice through daily forced swimming, then gave some mice EGCG supplements. The treatment appeared to reduce the mice's fatigue and also lowered harmful inflammation markers in their brains.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Lacerda, Eliana M, Nacul, Luis, Pheby, Derek et al.·Journal of clinical pathology·2010

This study explored whether it would be possible and acceptable to create a tissue bank in the UK specifically for ME/CFS—a place where donated tissues from people with ME/CFS could be studied after death to better understand the disease. Researchers interviewed patients, held discussion groups, and consulted experts to find out what people thought about this idea. The findings show that both patients and experts believe such a tissue bank would be valuable and could work in practice, as long as certain concerns were properly addressed.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Clauson, Kevin A, Zeng-Treitler, Qing, Kandula, Sasikiran·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study examined whether instruction sheets about dietary supplements for diabetes and ME/CFS are written in a way that patients can easily understand. Researchers found that most of these leaflets are written at a college level (13th grade), far harder than the recommended 6th-grade level. This difficulty may make it harder for patients to understand important information and follow recommendations.

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Decker, Michael J, Eyal, Shulamit, Shinar, Zvika et al.·Sleep & breathing = Schlaf & Atmung·2010

Researchers tested a new computer method that analyzes heart rate patterns to measure sleep quality and breathing problems during sleep, comparing it to the traditional gold-standard method of manually reviewing sleep recordings. The new method worked very well for measuring overall sleep time, wake time, and most sleep stages, though it was less accurate at distinguishing between deep and light sleep. This could eventually allow easier and cheaper sleep testing for patients with ME/CFS who often have sleep problems.

Sleep

E3 PreliminaryMechanismPEM not requiredMechanistic

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

Stieler, Kristin, Schulz, Claudia, Lavanya, Madakasira et al.·Virology·2010

This study examined how XMRV, a virus found in some ME/CFS patients' blood cells, infects different types of human cells. Researchers tested which cells the virus could enter and grow in, finding that it could infect various cell types including immune cells and prostate cells. The virus appeared to replicate most efficiently in prostate tissue, suggesting the virus may have preferred targets in the body.

E3 PreliminaryCohortPEM unclearCross-Sectional

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

Guise, Jennie, McVittie, Chris, McKinlay, Andy·Journal of health psychology·2010

This study looked at how ME/CFS patients describe their experiences when talking to doctors. Researchers analyzed conversations from an online support group and found that patients often feel their doctors don't listen to them or take their condition seriously. Interestingly, patients were careful about how they complained, trying to focus on practical issues rather than seeming like they were just complaining.

Diagnostics

E3 PreliminaryMechanismPEM requiredMechanistic

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Van Oosterwijck, J, Nijs, J, Meeus, M et al.·Journal of internal medicine·2010

This study compared how the body's pain-relief systems work in people with ME/CFS versus healthy people during exercise. Researchers found that after exercise, people with ME/CFS became more sensitive to pain (their pain thresholds decreased), while healthy people became less sensitive to pain. The ME/CFS group also experienced worsening symptoms after both types of exercise they tried.

Post-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Vermeulen, Ruud C W, Kurk, Ruud M, Visser, Frans C et al.·Journal of translational medicine·2010

This study compared how well people with ME/CFS and healthy controls performed during two exercise tests done 24 hours apart. Patients became exhausted at much lower exercise levels than controls, and performed even worse on the second test. Surprisingly, when researchers tested the energy-producing structures (mitochondria) in patients' blood cells, they appeared to work normally, suggesting the problem may lie elsewhere in the energy production process.

Post-Exertional Malaise

E3 PreliminaryCohortPEM unclearCase-Control

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

Chia, J, Chia, A, Voeller, M et al.·Journal of clinical pathology·2010

This study tracked patients who had acute enterovirus infections (common viral illnesses) and then developed ME/CFS symptoms. Researchers found that in three patients, the virus persisted in their stomach tissue years after the initial infection. This suggests that some ME/CFS cases may be triggered by enterovirus infections that don't fully clear from the body.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

The Beliefs about Emotions Scale: validity, reliability and sensitivity to change.

Rimes, Katharine A, Chalder, Trudie·Journal of psychosomatic research·2010

Researchers created a new questionnaire called the Beliefs about Emotions Scale to measure how much people with ME/CFS tend to think negative emotions are unacceptable or shouldn't be expressed. They found that people with ME/CFS had much higher scores on this scale than healthy people, and that the scores improved after cognitive behavioral therapy (CBT), suggesting the scale can detect real changes in these unhelpful beliefs.

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Oakes, Brendan, Tai, Albert K, Cingöz, Oya et al.·Retrovirology·2010

Researchers tested blood samples from ME/CFS patients and healthy people for a virus called XMRV. They discovered that when using very sensitive testing methods, they were getting false positive results because mouse DNA was contaminating the samples, not because patients actually had the virus. This study shows why careful testing procedures are essential when looking for viruses in patient samples.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neuroendocrine and immune contributors to fatigue.

Silverman, Marni N, Heim, Christine M, Nater, Urs M et al.·PM & R : the journal of injury, function, and rehabilitation·2010

This review explores how three body systems—the stress response system, the nervous system, and the immune system—may work together to cause the overwhelming tiredness experienced in ME/CFS. The researchers found that people with chronic fatigue often have an underactive stress-response system, an overactive fight-or-flight response, and immune system imbalances. Understanding how these systems interact may help explain why rest alone doesn't always resolve the fatigue.

Autonomic Nervous SystemImmune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

Immune and hemorheological changes in chronic fatigue syndrome.

Brenu, Ekua W, Staines, Donald R, Baskurt, Oguz K et al.·Journal of translational medicine·2010

This study looked at immune system cells and blood cell properties in people with ME/CFS compared to healthy people. Researchers found that ME/CFS patients had weaker immune responses in certain white blood cells (neutrophils and NK cells) but normal blood cell flexibility and clumping. These immune differences might help explain why people with ME/CFS feel so tired and unwell.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Human herpesvirus 6].

Ongrádi, József, Kövesdi, Valéria, Medveczky, G Péter·Orvosi hetilap·2010

Human herpesvirus 6 (HHV-6) is a common virus that most people catch in early childhood, usually causing mild symptoms or no symptoms at all. The virus stays dormant in your body for life but can reactivate, especially if your immune system is weakened. Research suggests HHV-6 may play a role in ME/CFS and other serious conditions, possibly by changing how your immune system produces certain signaling molecules.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

De Luca, C, Scordo, G, Cesareo, E et al.·Indian journal of experimental biology·2010

Some people with ME/CFS and related conditions may have difficulty processing chemicals, metals, and other substances they encounter in the environment because of inherited or acquired differences in how their bodies handle these toxins. This review suggests that genetic variations affecting enzymes responsible for detoxifying chemicals, combined with problems in the body's antioxidant systems, might explain why some people react strongly to very small amounts of environmental exposures. Understanding these biological mechanisms could help develop personalized treatments.

Pain and Sensitization

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Efficiency evaluation of autonomic heart control by using the principal component analysis of ECG P-wave.

An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR kit is amplified using standard primers for XMRV.

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.

[The chronic asthenia syndrome: a clinical approach].

Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome.

Exploring the feasibility of establishing a disease-specific post-mortem tissue bank in the UK: a case study in ME/CFS.

Readability of patient and health care professional targeted dietary supplement leaflets used for diabetes and chronic fatigue syndrome.

Validation of ECG-derived sleep architecture and ventilation in sleep apnea and chronic fatigue syndrome.

Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.

A discourse analytic study of ME/CFS (Chronic Fatigue Syndrome) sufferers' experiences of interactions with doctors.

Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study.

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity.

Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.

The Beliefs about Emotions Scale: validity, reliability and sensitivity to change.

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequences.

Neuroendocrine and immune contributors to fatigue.

Immune and hemorheological changes in chronic fatigue syndrome.

[Human herpesvirus 6].

Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine.

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