ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5881–5900 of 6,188 studies

E3 PreliminaryCohortPEM not requiredObservational

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Lohmann, K, Pröhl, A, Schwarz, E·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·1996

This study looked at 466 people who had neurological symptoms from toxic chemical exposure and found that 136 of them also had Multiple Chemical Sensitivity (MCS)—a condition where people react strongly to low levels of chemicals. The researchers found that wood preservatives, solvents, and formaldehyde were common culprits, and people with MCS were more likely to have chronic fatigue symptoms and allergies than those without MCS.

Pain and Sensitization

E3 PreliminaryCohortPEM not requiredCase-Control

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports.

Ablashi, D V, Levine, P H, De Vinci, C et al.·Biotherapy (Dordrecht, Netherlands)·1996

This small study tested whether a special immune treatment called transfer factor, designed to target HHV-6 (a virus that may be active in some ME/CFS patients), could help. Two ME/CFS patients with active HHV-6 infection received this treatment. One patient improved significantly and returned to normal activities within weeks, but the other patient saw no improvement. The results suggest this treatment might help control HHV-6 in some patients, but more research is needed.

Immune System

E3 PreliminaryCohortPEM unclear

[A case from practice (343). Chronic fatigue syndrome following Lyme borreliosis].

Diamantis, I·Praxis·1996

This case study describes a patient who developed chronic fatigue syndrome (ME/CFS) following a Lyme borreliosis infection (transmitted by tick bite). The report documents one person's experience, showing how a tick-borne infection may have triggered or contributed to the development of ME/CFS symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Research on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?

Wearden, A J, Appleby, L·Journal of psychosomatic research·1996

People with ME/CFS often report problems with memory and concentration, but when researchers test their cognitive abilities in the lab, they don't find major deficits. This review suggests the gap between what patients experience and what tests show might be because lab tests don't measure 'real-world' thinking very well. In ME/CFS, everyday mental tasks may be using up so much energy that patients have less mental flexibility left over for other things.

Cognitive Impairment

E3 PreliminaryBehavioralPEM not requiredCase-Control

EEG biofeedback as a treatment for chronic fatigue syndrome: a controlled case report.

James, L C, Folen, R A·Behavioral medicine (Washington, D.C.)·1996

This study tested whether a brain training technique called EEG neurofeedback could help a person with chronic fatigue syndrome (CFS). The patient received this treatment and was tested before and after using standard cognitive (thinking) tests. The results showed improvements in memory, thinking skills, daily functioning, and overall quality of life.

Cognitive Impairment

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

Crofford, L J, Demitrack, M A·Rheumatic diseases clinics of North America·1996

This study explores how stress-response systems in the brain and body may be broken in people with fibromyalgia and chronic fatigue syndrome (ME/CFS). Both conditions often start after stressful events and get worse during stressful times. The researchers found that the brain's main stress-management system—called the hypothalamic-pituitary-adrenal (HPA) axis—does not work normally in these patients, which could explain why their symptoms worsen with stress.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

[Pathogenicity of fungi in the intestines--current status of the discussion].

Scheurlen, M·Fortschritte der Medizin·1996

Some people believe that yeast infections in the gut, particularly from a fungus called Candida, might cause chronic fatigue syndrome and other long-term illnesses by producing harmful toxins. However, experts disagree about whether this theory is actually true. This editorial explains that while the idea is interesting, there isn't enough solid scientific evidence yet to prove it works or to recommend yeast-fighting treatments based on this theory alone.

Gut MicrobiomeImmune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections.

Marsh, S, Kaplan, M, Asano, Y et al.·Journal of virological methods·1996

Researchers developed a new laboratory test to detect HHV-6, a common virus, in blood and body fluids. This test is faster, cheaper, and easier to use than older methods, and works reliably in clinical settings. They tested it on samples from healthy people, children with fever rashes, and patients with various conditions including chronic fatigue syndrome.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Use of exercise for treatment of chronic fatigue syndrome.

McCully, K K, Sisto, S A, Natelson, B H·Sports medicine (Auckland, N.Z.)·1996

This review looks at whether exercise can help people with ME/CFS feel better. While patients often report getting much sicker after even light activity, most studies find their muscles work normally on standard tests. The authors suggest exercise training might help, but caution that avoiding 'relapses' (crashes) is critical, and more research is needed to understand how exercise affects this illness.

Immune SystemPost-Exertional Malaise

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. Summary of a report of a joint committee of the Royal Colleges of Physicians, Psychiatrists and General Practitioners.

Wessely, S·Journal of the Royal College of Physicians of London·1996

This report from major medical colleges explains that ME/CFS is not caused by a single problem, but rather results from many different factors working together. The condition develops differently in different people, depending on what triggered it initially, what made them vulnerable to it, and what keeps it going. Understanding all these different pieces is important for helping patients recover.

Diagnostics

E3 PreliminaryCommentaryPEM not requiredEditorial

Periodic limb movements of sleep and the restless legs syndrome.

Williams, D C·Virginia medical quarterly : VMQ·1996

This article examines periodic limb movements during sleep and restless legs syndrome, which are not diseases themselves but signs that something is disturbing the nervous system. The author suggests these conditions may be related to ME/CFS and other disorders, and that they arise from problems in a brainstem region that controls smooth sleep and wakefulness. Various treatments can help reduce symptoms and improve sleep quality.

Sleep

E3 PreliminaryCohortPEM unclearCase-Control

A cluster of cases of chronic fatigue and chronic fatigue syndrome: clinical and immunologic studies.

Levine, P H, Dale, J K, Benson-Grigg, E et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1996

This study examined a group of people who developed chronic fatigue syndrome (ME/CFS), looking at their medical histories and immune system patterns to understand what might have caused their illness. Researchers compared patients with ME/CFS to control groups and measured various immune markers in their blood. The goal was to identify common features that might explain why these individuals became ill.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--psychiatric aspects].

Lemke, M R·Fortschritte der Neurologie-Psychiatrie·1996

This editorial discusses how ME/CFS involves both physical symptoms and mental health aspects that need to be understood together. The authors explain that while doctors have focused heavily on physical symptoms, psychiatric factors—such as stress, sleep problems, and how the body's stress system works—play an important role in the syndrome. An effective approach to ME/CFS requires doctors from different specialties to work together.

SleepImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Infectious agents and immunological disturbances in relation to chronic fatigue syndrome.

Tripathy, B K, Agarwal, A K, Sangla, K S et al.·The Journal of the Association of Physicians of India·1996

This review article examines the connection between infections and immune system problems in ME/CFS. The authors looked at existing research to understand whether certain germs or viruses might trigger the condition, and how the immune system behaves differently in people with ME/CFS compared to healthy individuals.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

Sterzl, I, Zamrazil, V·Vnitrni lekarstvi·1996

This review discusses how disorders of the endocrine system (hormone-producing glands) can cause fatigue and other symptoms that overlap with ME/CFS, making them difficult to distinguish. The authors highlight that some patients initially thought to have ME/CFS actually have treatable hormone conditions, particularly autoimmune thyroid disease or other glandular disorders. They also explore how problems with the stress-hormone system (the hypothalamus-pituitary-adrenal axis) might play a role in both endocrine disease and ME/CFS.

Diagnostics

E3 PreliminaryCohortPEM not requiredObservational

[Neural manifestations in Lyme disease (Lyme borreliosis of the nervous system)].

Josević, M, Nikolić, S, Dulović, O et al.·Srpski arhiv za celokupno lekarstvo·1996

This study looked at how Lyme disease can affect the nervous system, a condition called neuroborreliosis. Researchers reviewed 11 patients treated for Lyme disease and found that it can cause various nerve problems including meningitis, facial paralysis, nerve inflammation, and fatigue syndrome. The study helps explain how widely Lyme disease can spread throughout the body and what symptoms patients might experience.

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Rouillon, F, Delhommeau, L, Vinceneux, P·Presse medicale (Paris, France : 1983)·1996

This review examines chronic fatigue syndrome (CFS), a condition where people experience lasting, unexplained tiredness that interferes with daily life. The condition has been recognized for over a century under different names. Currently, doctors and researchers don't fully understand what causes CFS, though it may involve viral infections, immune system problems, or psychiatric factors. Most treatments tested so far have shown limited effectiveness.

Interventions

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Fry, A M, Martin, M·Journal of psychosomatic research·1996

This 1996 study examined whether the extreme tiredness experienced by people with ME/CFS comes from problems in the muscles or the brain's motor control. After reviewing existing research on muscle function and brain activity, the researchers concluded that the fatigue is not caused by physical muscle damage or weakness. Instead, they suggest that the brain may be processing fatigue signals in an unusual way, influenced by how people think about and interpret their symptoms.

Post-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs.

Gold, P W, Licinio, J, Wong, M L et al.·Annals of the New York Academy of Sciences·1995

This research examines how the stress hormone system works differently in people with depression and chronic fatigue syndrome. The study found that while some people with depression have too much cortisol (a stress hormone), others—particularly those with fatigue-related conditions—may have too little activity in the part of the brain that normally triggers this hormone. This suggests that different types of depression and fatigue conditions might involve different problems with the body's stress response system.

Endocrine Disruption

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. 2: Treatment and future research.

Kantrowitz, F G, Farrar, D J, Locke, S E·Behavioral medicine (Washington, D.C.)·1995

This review article examines different ways to treat ME/CFS and outlines important directions for future research. The authors discuss various treatment approaches that have been studied and identify gaps in our current understanding of the condition. The paper emphasizes that while treatment options exist, more research is needed to find more effective therapies.

Sleep

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Evidence browser

[Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports.

[A case from practice (343). Chronic fatigue syndrome following Lyme borreliosis].

Research on cognitive complaints and cognitive functioning in patients with chronic fatigue syndrome (CFS): What conclusions can we draw?

EEG biofeedback as a treatment for chronic fatigue syndrome: a controlled case report.

Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

[Pathogenicity of fungi in the intestines--current status of the discussion].

Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections.

Use of exercise for treatment of chronic fatigue syndrome.

Chronic fatigue syndrome. Summary of a report of a joint committee of the Royal Colleges of Physicians, Psychiatrists and General Practitioners.

Periodic limb movements of sleep and the restless legs syndrome.

A cluster of cases of chronic fatigue and chronic fatigue syndrome: clinical and immunologic studies.

[Chronic fatigue syndrome--psychiatric aspects].

Infectious agents and immunological disturbances in relation to chronic fatigue syndrome.

[Endocrinopathy in the differential diagnosis of chronic fatigue syndrome].

[Neural manifestations in Lyme disease (Lyme borreliosis of the nervous system)].

[Chronic fatigue syndrome].

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs.

Chronic fatigue syndrome. 2: Treatment and future research.

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