ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5881–5900 of 6,211 studies

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--psychiatric aspects].

Lemke, M R·Fortschritte der Neurologie-Psychiatrie·1996

This editorial discusses how ME/CFS involves both physical symptoms and mental health aspects that need to be understood together. The authors explain that while doctors have focused heavily on physical symptoms, psychiatric factors—such as stress, sleep problems, and how the body's stress system works—play an important role in the syndrome. An effective approach to ME/CFS requires doctors from different specialties to work together.

SleepImmune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Infectious agents and immunological disturbances in relation to chronic fatigue syndrome.

Tripathy, B K, Agarwal, A K, Sangla, K S et al.·The Journal of the Association of Physicians of India·1996

This review article examines the connection between infections and immune system problems in ME/CFS. The authors looked at existing research to understand whether certain germs or viruses might trigger the condition, and how the immune system behaves differently in people with ME/CFS compared to healthy individuals.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Vecchiet, L, Montanari, G, Pizzigallo, E et al.·Neuroscience letters·1996

This study tested whether people with ME/CFS have increased pain sensitivity in their muscles compared to their skin. Researchers found that muscles were significantly more sensitive to pain in ME/CFS patients, while skin sensitivity was normal. They also discovered abnormal structures and damage in muscle cells from ME/CFS patients, including problems with mitochondria (the energy-producing parts of cells) and signs of degeneration.

Pain and Sensitization

E3 PreliminaryReviewPEM unclearReview-Narrative

Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

Crofford, L J, Demitrack, M A·Rheumatic diseases clinics of North America·1996

This study explores how stress-response systems in the brain and body may be broken in people with fibromyalgia and chronic fatigue syndrome (ME/CFS). Both conditions often start after stressful events and get worse during stressful times. The researchers found that the brain's main stress-management system—called the hypothalamic-pituitary-adrenal (HPA) axis—does not work normally in these patients, which could explain why their symptoms worsen with stress.

Endocrine Disruption

E3 PreliminaryBehavioralPEM not requiredCase-Control

EEG biofeedback as a treatment for chronic fatigue syndrome: a controlled case report.

James, L C, Folen, R A·Behavioral medicine (Washington, D.C.)·1996

This study tested whether a brain training technique called EEG neurofeedback could help a person with chronic fatigue syndrome (CFS). The patient received this treatment and was tested before and after using standard cognitive (thinking) tests. The results showed improvements in memory, thinking skills, daily functioning, and overall quality of life.

Cognitive Impairment

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome].

Rouillon, F, Delhommeau, L, Vinceneux, P·Presse medicale (Paris, France : 1983)·1996

This review examines chronic fatigue syndrome (CFS), a condition where people experience lasting, unexplained tiredness that interferes with daily life. The condition has been recognized for over a century under different names. Currently, doctors and researchers don't fully understand what causes CFS, though it may involve viral infections, immune system problems, or psychiatric factors. Most treatments tested so far have shown limited effectiveness.

Interventions

E3 PreliminaryCohortPEM unclear

[A case from practice (343). Chronic fatigue syndrome following Lyme borreliosis].

Diamantis, I·Praxis·1996

This case study describes a patient who developed chronic fatigue syndrome (ME/CFS) following a Lyme borreliosis infection (transmitted by tick bite). The report documents one person's experience, showing how a tick-borne infection may have triggered or contributed to the development of ME/CFS symptoms.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Fry, A M, Martin, M·Journal of psychosomatic research·1996

This 1996 study examined whether the extreme tiredness experienced by people with ME/CFS comes from problems in the muscles or the brain's motor control. After reviewing existing research on muscle function and brain activity, the researchers concluded that the fatigue is not caused by physical muscle damage or weakness. Instead, they suggest that the brain may be processing fatigue signals in an unusual way, influenced by how people think about and interpret their symptoms.

Post-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Are echoviruses still orphans?

Hill, W M·British journal of biomedical science·1996

This review examines echoviruses, a family of common viruses that can cause outbreaks of illness around the world. The authors note that since polio has become rare, doctors have noticed more cases of non-polio enteroviruses (a related group of viruses) being linked to myalgic encephalomyelitis (ME) and post-viral fatigue syndrome. Different types of echoviruses tend to cause different patterns of illness in different populations.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Use of exercise for treatment of chronic fatigue syndrome.

McCully, K K, Sisto, S A, Natelson, B H·Sports medicine (Auckland, N.Z.)·1996

This review looks at whether exercise can help people with ME/CFS feel better. While patients often report getting much sicker after even light activity, most studies find their muscles work normally on standard tests. The authors suggest exercise training might help, but caution that avoiding 'relapses' (crashes) is critical, and more research is needed to understand how exercise affects this illness.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCommentaryPEM unclearCommentary

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Butler, C, Rollnick, S·Family practice·1996

This study examines a conversation between a doctor and a patient who believed they had ME/CFS. Even though the doctor tried to listen carefully, they didn't fully understand what the diagnosis meant to the patient. The study shows that when doctors don't truly understand what patients mean by their diagnosis, it can damage trust and may slow recovery. The authors suggest that doctors should use reflective listening—repeating back what they hear—to make sure they really understand what patients are experiencing.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

Hoffmann, A, Linder, R, Kröger, B et al.·Deutsche medizinische Wochenschrift (1946)·1996

This study compared fibromyalgia syndrome and chronic fatigue syndrome (ME/CFS) to understand how they are similar and how they differ. Researchers examined patients with both conditions to identify shared symptoms and unique characteristics that could help doctors better recognize and distinguish between them.

E3 PreliminaryCommentaryPEM not requiredEditorial

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

Levine, P H·Biotherapy (Dordrecht, Netherlands)·1996

ME/CFS often starts with a viral infection and some people have ongoing herpes virus activity. This article discusses transfer factors—a type of immune therapy—that might help fight these viruses and improve symptoms. The authors explain why we need better-designed studies to test if this treatment actually works.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Neri, G, Bianchedi, M, Croce, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1996

This study tested whether two hearing-related tests could help diagnose ME/CFS. Researchers examined 21 people with suspected ME/CFS using specialized hearing tests that measure how the brainstem processes sound and how the ear muscles respond to loud noises. When both tests were combined, they correctly identified about 82% of people with ME/CFS, suggesting these tests might be useful diagnostic tools.

Biomarkers

E3 PreliminaryMechanismPEM unclearObservational

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

Steinberg, P, Pheley, A, Peterson, P K·The Journal of allergy and clinical immunology·1996

This study looked at how immediate allergic skin reactions (like those that happen within minutes of allergen exposure) might affect delayed allergic reactions (which develop over hours or days) in people with ME/CFS. Researchers were investigating whether the immune system's early response to allergens could influence its later response in this patient population. Understanding these connections may help explain why some ME/CFS patients experience unusual or prolonged allergic reactions.

Immune System

E3 PreliminaryCohortPEM not required

The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient.

Kodama, M, Kodama, T, Murakami, M·In vivo (Athens, Greece)·1996

This pilot study tested whether high-dose vitamin C infusions, combined with a hormone called DHEA, could help one male ME/CFS patient who also had pneumonia-like symptoms. The patient received different types of infusions over 10 months, and his pneumonia-related symptoms improved when the new DHEA-enhanced vitamin C treatment was used alongside antibiotics. The researchers measured increased levels of certain hormones in his urine after treatment.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Drago, F, Ranieri, E, Pastorino, A et al.·The British journal of dermatology·1996

This case report describes a woman with ME/CFS who developed unusual skin lesions (brownish patches and bumps) on her chest and back for 10 years. Doctors found that the Epstein-Barr virus (EBV)—the virus that causes mononucleosis—was active in her skin and other body areas, and abnormal protein deposits were building up in her skin. When she was treated with antiviral medication (acyclovir) and a type of immune-boosting therapy (interferon-alpha), both her skin lesions and other symptoms improved significantly.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmune mechanisms in health and disease: 2. Disease.

Anisman, H, Baines, M G, Berczi, I et al.·CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1996

When your body fights an infection, your immune system releases chemical messengers called cytokines that trigger fatigue, fever, loss of appetite, and inactivity—changes controlled partly by your brain and nervous system. This review explains how problems in the communication between your immune system and brain (particularly an area called the hypothalamus-pituitary-adrenal axis) may contribute to chronic conditions including ME/CFS, fibromyalgia, and autoimmune diseases. Understanding these connections could lead to new treatments using hormones and other brain-signaling molecules.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Neurobiology of chronic fatigue syndrome.

Gonzalez, M B, Cousins, J C, Doraiswamy, P M·Progress in neuro-psychopharmacology & biological psychiatry·1996

This review article examines what happens in the brain and nervous system of people with ME/CFS. Researchers found that ME/CFS involves real biological changes in the brain—not just fatigue—including problems with mood, thinking, and hormone regulation. The study suggests that ME/CFS is a neurological condition with measurable differences in brain function, rather than purely psychological.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

Lieb, K, Dammann, G, Berger, M et al.·Der Nervenarzt·1996

ME/CFS is a disorder that causes persistent tiredness, but doctors cannot diagnose it with a simple blood test or scan. Instead, doctors use specific clinical criteria to identify the condition, while carefully ruling out other illnesses like depression or sleep problems that can look similar. Currently, there is no cure for ME/CFS, so treatment focuses on managing individual symptoms like poor sleep, pain, and mood changes with a combination of medical care and psychological support.

Pain and SensitizationSleepDiagnostics

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Evidence browser

[Chronic fatigue syndrome--psychiatric aspects].

Infectious agents and immunological disturbances in relation to chronic fatigue syndrome.

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

EEG biofeedback as a treatment for chronic fatigue syndrome: a controlled case report.

[Chronic fatigue syndrome].

[A case from practice (343). Chronic fatigue syndrome following Lyme borreliosis].

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Are echoviruses still orphans?

Use of exercise for treatment of chronic fatigue syndrome.

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

The use of transfer factors in chronic fatigue syndrome: prospects and problems.

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient.

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Neuroimmune mechanisms in health and disease: 2. Disease.

Neurobiology of chronic fatigue syndrome.

[Chronic fatigue syndrome. Definition, diagnostic measures and therapeutic possibilities].

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