ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5901–5920 of 6,211 studies

The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient.

Kodama, M, Kodama, T, Murakami, M·In vivo (Athens, Greece)·1996

This pilot study tested whether high-dose vitamin C infusions, combined with a hormone called DHEA, could help one male ME/CFS patient who also had pneumonia-like symptoms. The patient received different types of infusions over 10 months, and his pneumonia-related symptoms improved when the new DHEA-enhanced vitamin C treatment was used alongside antibiotics. The researchers measured increased levels of certain hormones in his urine after treatment.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

Hoffmann, A, Linder, R, Kröger, B et al.·Deutsche medizinische Wochenschrift (1946)·1996

This study compared fibromyalgia syndrome and chronic fatigue syndrome (ME/CFS) to understand how they are similar and how they differ. Researchers examined patients with both conditions to identify shared symptoms and unique characteristics that could help doctors better recognize and distinguish between them.

E3 PreliminaryCohortPEM not requiredCross-Sectional

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Neri, G, Bianchedi, M, Croce, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1996

This study tested whether two hearing-related tests could help diagnose ME/CFS. Researchers examined 21 people with suspected ME/CFS using specialized hearing tests that measure how the brainstem processes sound and how the ear muscles respond to loud noises. When both tests were combined, they correctly identified about 82% of people with ME/CFS, suggesting these tests might be useful diagnostic tools.

Biomarkers

E3 PreliminaryMechanismPEM unclearObservational

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

Steinberg, P, Pheley, A, Peterson, P K·The Journal of allergy and clinical immunology·1996

This study looked at how immediate allergic skin reactions (like those that happen within minutes of allergen exposure) might affect delayed allergic reactions (which develop over hours or days) in people with ME/CFS. Researchers were investigating whether the immune system's early response to allergens could influence its later response in this patient population. Understanding these connections may help explain why some ME/CFS patients experience unusual or prolonged allergic reactions.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Neuroimmune mechanisms in health and disease: 2. Disease.

Anisman, H, Baines, M G, Berczi, I et al.·CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1996

When your body fights an infection, your immune system releases chemical messengers called cytokines that trigger fatigue, fever, loss of appetite, and inactivity—changes controlled partly by your brain and nervous system. This review explains how problems in the communication between your immune system and brain (particularly an area called the hypothalamus-pituitary-adrenal axis) may contribute to chronic conditions including ME/CFS, fibromyalgia, and autoimmune diseases. Understanding these connections could lead to new treatments using hormones and other brain-signaling molecules.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Drago, F, Ranieri, E, Pastorino, A et al.·The British journal of dermatology·1996

This case report describes a woman with ME/CFS who developed unusual skin lesions (brownish patches and bumps) on her chest and back for 10 years. Doctors found that the Epstein-Barr virus (EBV)—the virus that causes mononucleosis—was active in her skin and other body areas, and abnormal protein deposits were building up in her skin. When she was treated with antiviral medication (acyclovir) and a type of immune-boosting therapy (interferon-alpha), both her skin lesions and other symptoms improved significantly.

Immune System

E3 PreliminaryCommentaryPEM unclearCommentary

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Butler, C, Rollnick, S·Family practice·1996

This study examines a conversation between a doctor and a patient who believed they had ME/CFS. Even though the doctor tried to listen carefully, they didn't fully understand what the diagnosis meant to the patient. The study shows that when doctors don't truly understand what patients mean by their diagnosis, it can damage trust and may slow recovery. The authors suggest that doctors should use reflective listening—repeating back what they hear—to make sure they really understand what patients are experiencing.

E3 PreliminaryMechanismPEM not requiredMechanistic

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

Vecchiet, L, Montanari, G, Pizzigallo, E et al.·Neuroscience letters·1996

This study tested whether people with ME/CFS have increased pain sensitivity in their muscles compared to their skin. Researchers found that muscles were significantly more sensitive to pain in ME/CFS patients, while skin sensitivity was normal. They also discovered abnormal structures and damage in muscle cells from ME/CFS patients, including problems with mitochondria (the energy-producing parts of cells) and signs of degeneration.

Pain and Sensitization

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--psychiatric aspects].

Lemke, M R·Fortschritte der Neurologie-Psychiatrie·1996

This editorial discusses how ME/CFS involves both physical symptoms and mental health aspects that need to be understood together. The authors explain that while doctors have focused heavily on physical symptoms, psychiatric factors—such as stress, sleep problems, and how the body's stress system works—play an important role in the syndrome. An effective approach to ME/CFS requires doctors from different specialties to work together.

SleepImmune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

Use of exercise for treatment of chronic fatigue syndrome.

McCully, K K, Sisto, S A, Natelson, B H·Sports medicine (Auckland, N.Z.)·1996

This review looks at whether exercise can help people with ME/CFS feel better. While patients often report getting much sicker after even light activity, most studies find their muscles work normally on standard tests. The authors suggest exercise training might help, but caution that avoiding 'relapses' (crashes) is critical, and more research is needed to understand how exercise affects this illness.

Immune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM not requiredReview-Narrative

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Fry, A M, Martin, M·Journal of psychosomatic research·1996

This 1996 study examined whether the extreme tiredness experienced by people with ME/CFS comes from problems in the muscles or the brain's motor control. After reviewing existing research on muscle function and brain activity, the researchers concluded that the fatigue is not caused by physical muscle damage or weakness. Instead, they suggest that the brain may be processing fatigue signals in an unusual way, influenced by how people think about and interpret their symptoms.

Post-Exertional Malaise

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. Summary of a report of a joint committee of the Royal Colleges of Physicians, Psychiatrists and General Practitioners.

Wessely, S·Journal of the Royal College of Physicians of London·1996

This report from major medical colleges explains that ME/CFS is not caused by a single problem, but rather results from many different factors working together. The condition develops differently in different people, depending on what triggered it initially, what made them vulnerable to it, and what keeps it going. Understanding all these different pieces is important for helping patients recover.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

[Pathogenicity of fungi in the intestines--current status of the discussion].

Scheurlen, M·Fortschritte der Medizin·1996

Some people believe that yeast infections in the gut, particularly from a fungus called Candida, might cause chronic fatigue syndrome and other long-term illnesses by producing harmful toxins. However, experts disagree about whether this theory is actually true. This editorial explains that while the idea is interesting, there isn't enough solid scientific evidence yet to prove it works or to recommend yeast-fighting treatments based on this theory alone.

Gut MicrobiomeImmune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections.

Marsh, S, Kaplan, M, Asano, Y et al.·Journal of virological methods·1996

Researchers developed a new laboratory test to detect HHV-6, a common virus, in blood and body fluids. This test is faster, cheaper, and easier to use than older methods, and works reliably in clinical settings. They tested it on samples from healthy people, children with fever rashes, and patients with various conditions including chronic fatigue syndrome.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Investigation by polymerase chain reaction of enteroviral infection in patients with chronic fatigue syndrome.

McArdle, A, McArdle, F, Jackson, M J et al.·Clinical science (London, England : 1979)·1996

Researchers wanted to test whether a virus called enterovirus might be hiding in the muscles of people with ME/CFS and causing the fatigue and pain. They took muscle samples from 34 patients and looked carefully for signs of enteroviral infection, but found none. However, they did find that muscle tissue showed signs of reduced activity, including lower levels of the building blocks that muscle cells need to function properly.

Energy Metabolism

E3 PreliminaryCohortPEM not requiredCase-Control

Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

This study looked at three patients who started with symptoms similar to ME/CFS and then developed severe brain inflammation. Brain tissue samples showed signs of unusual viral infection with damaged cells, but without the typical immune response usually seen in brain infections. Two patients partially recovered over time, while one remained severely disabled for years.

E3 PreliminaryCohortPEM not requiredObservational

[Neural manifestations in Lyme disease (Lyme borreliosis of the nervous system)].

Josević, M, Nikolić, S, Dulović, O et al.·Srpski arhiv za celokupno lekarstvo·1996

This study looked at how Lyme disease can affect the nervous system, a condition called neuroborreliosis. Researchers reviewed 11 patients treated for Lyme disease and found that it can cause various nerve problems including meningitis, facial paralysis, nerve inflammation, and fatigue syndrome. The study helps explain how widely Lyme disease can spread throughout the body and what symptoms patients might experience.

E3 PreliminaryCohortPEM not requiredCase-Control

Simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy.

Martin, W J·Pathobiology : journal of immunopathology, molecular and cellular biology·1996

Researchers found an unusual virus in the spinal fluid of a patient with severe brain inflammation and psychiatric symptoms. This virus was similar to one previously found in a chronic fatigue syndrome patient. The study suggests that certain viruses might be responsible for various brain-related illnesses.

E3 PreliminaryCohortPEM unclearCross-Sectional

Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

Nakaya, T, Takahashi, H, Nakamura, Y et al.·FEBS letters·1996

Researchers tested blood cells from 25 Japanese patients with chronic fatigue syndrome (ME/CFS) to see if a virus called Borna disease virus (BDV) was present. They found evidence of BDV in 3 patients' blood cells and antibodies (immune markers) against BDV in 6 patients, suggesting about 32% of their study group may have been exposed to or infected with this virus. This finding raised the possibility that BDV might be connected to ME/CFS in Japanese patients.

Immune System

E3 PreliminaryCohortPEM not requiredCase-Control

Possible relationship between chronic fatigue and postural tachycardia syndromes.

De Lorenzo, F, Hargreaves, J, Kakkar, V V·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1996

This study looked at five people with ME/CFS who experienced symptoms like dizziness, blurred vision, and heart palpitations when standing up. When these patients were tested while lying on a tilting table that slowly moved them upright, researchers found that their blood pressure dropped and heart rate increased significantly. This suggests that some ME/CFS patients may have a condition called postural tachycardia syndrome, which affects how the body manages blood pressure during position changes.

Autonomic Nervous System

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The value of the dehydroepiandrosterone-annexed vitamin C infusion treatment in the clinical control of chronic fatigue syndrome (CFS). I. A Pilot study of the new vitamin C infusion treatment with a volunteer CFS patient.

[Fibromyalgia syndrome and chronic fatigue syndrome. Similarities and differences].

["Prolonged" decay test and auditory brainstem responses in the clinical diagnosis of the chronic fatigue syndrome].

Influence of immediate hypersensitivity skin reactions on delayed reactions in patients with chronic fatigue syndrome.

Neuroimmune mechanisms in health and disease: 2. Disease.

Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha.

Missing the meaning and provoking resistance; a case of myalgic encephalomyelitis.

Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome.

[Chronic fatigue syndrome--psychiatric aspects].

Use of exercise for treatment of chronic fatigue syndrome.

Fatigue in the chronic fatigue syndrome: a cognitive phenomenon?

Chronic fatigue syndrome. Summary of a report of a joint committee of the Royal Colleges of Physicians, Psychiatrists and General Practitioners.

[Pathogenicity of fungi in the intestines--current status of the discussion].

Development and application of HHV-6 antigen capture assay for the detection of HHV-6 infections.

Investigation by polymerase chain reaction of enteroviral infection in patients with chronic fatigue syndrome.

Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.

[Neural manifestations in Lyme disease (Lyme borreliosis of the nervous system)].

Simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy.

Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

Possible relationship between chronic fatigue and postural tachycardia syndromes.

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