ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5901–5920 of 6,188 studies

E3 PreliminaryReviewPEM unclearReview-Narrative

Neurasthenia, myalgic encephalitis or cryptogenic chronic fatigue syndrome?

Leitch, A G·QJM : monthly journal of the Association of Physicians·1995

This 1995 paper explores the history and naming of ME/CFS, comparing three different terms used to describe the condition: neurasthenia (an older term), myalgic encephalitis, and chronic fatigue syndrome. The author examines how the same illness has been called different names over time and in different places, which can create confusion about what the condition actually is.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Human herpesvirus-7 (HHV-7): current status.

Ablashi, D V, Berneman, Z N, Kramarsky, B et al.·Clinical and diagnostic virology·1995

This review article summarizes what scientists knew about human herpesvirus-7 (HHV-7) as of 1995, a newly discovered virus related to other common herpesviruses. HHV-7 was found in a chronic fatigue syndrome patient, along with healthy people, and is very common in the population (affecting over 85% of Americans). The virus has been linked to a few childhood rash illnesses and possibly some cases with liver involvement, but scientists had limited information about whether it causes ME/CFS.

Immune System

E3 PreliminaryBehavioralPEM not requiredObservational

Chronic fatigue syndrome: a cognitive approach.

Surawy, C, Hackmann, A, Hawton, K et al.·Behaviour research and therapy·1995

This study looked at what ME/CFS patients were thinking and believing about their symptoms, and how these thoughts might play a role in the condition. Researchers listened to patients' own descriptions of their fatigue and the thoughts that came with it, then tested whether a talking therapy called cognitive behavioural therapy (CBT) could help. The study suggests that the way patients think about their symptoms might be part of what keeps them sick.

E3 PreliminaryReviewPEM unclearReview-Narrative

Chronic fatigue syndrome. 2: Treatment and future research.

Kantrowitz, F G, Farrar, D J, Locke, S E·Behavioral medicine (Washington, D.C.)·1995

This review article examines different ways to treat ME/CFS and outlines important directions for future research. The authors discuss various treatment approaches that have been studied and identify gaps in our current understanding of the condition. The paper emphasizes that while treatment options exist, more research is needed to find more effective therapies.

Sleep

E3 PreliminaryReviewPEM unclearReview-Narrative

New pathogens, and diseases old and new. I) Afipia felis and Rochalimaea. II) Parvovirus B 19. III) herpesvirus 6.

Zannolli, R, Morgese, G·Panminerva medica·1995

This review examines three viruses (Afipia felis, Parvovirus B19, and Herpesvirus 6) that cause common childhood diseases like cat scratch disease and measles-like rashes. The authors note that these same viruses have been suggested as possible causes of chronic fatigue syndrome and other conditions, but proving this connection has been difficult because current tests cannot always tell whether someone has an active infection or just carries the virus from the past.

E3 PreliminaryCohortPEM unclearObservational

Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.

Gascón, J, Marcos, T, Vidal, J et al.·Journal of travel medicine·1995

This study looked at whether two common viruses—cytomegalovirus (CMV) and Epstein-Barr virus (EBV)—might be responsible for causing ME/CFS in people who had traveled to tropical regions. The researchers observed a group of travelers and tracked whether those infected with these viruses developed chronic fatigue symptoms similar to ME/CFS.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Ash-Bernal, R, Wall, C, Komaroff, A L et al.·Acta oto-laryngologica·1995

Many people with ME/CFS experience dizziness and balance problems, but doctors weren't sure where these problems originated in the body. This study tested the balance and inner ear function of 11 ME/CFS patients using specialized equipment and found several abnormalities—particularly difficulty with tests that rely heavily on the inner ear and brain working together. The pattern of results suggested the problem may be in how the brain processes balance signals rather than damage to the inner ear itself.

E3 PreliminaryMechanismPEM not requiredMechanistic

Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome.

Martin, W J, Glass, R T·Pathobiology : journal of immunopathology, molecular and cellular biology·1995

Researchers isolated a virus from a ME/CFS patient and injected it into cats to see what would happen. The cats developed serious neurological illness, and examination of their brain tissue showed viral particles and cell damage. This suggests that a particular type of virus might play a role in ME/CFS-related brain symptoms.

E3 PreliminaryMechanismPEM not requiredMechanistic

Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome.

Bearn, J, Allain, T, Coskeran, P et al.·Biological psychiatry·1995

This study tested whether ME/CFS might be caused by problems with the brain's hormone-control system (the pituitary and adrenal glands). Researchers gave patients and healthy people two different tests—one using low blood sugar and another using a serotonin-stimulating drug—to measure hormone responses. They found that ME/CFS patients had unusual patterns in some hormones, suggesting their glands may not be working normally.

Endocrine Disruption

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome: current perspectives on evaluation and management.

Hickie, I B, Lloyd, A R, Wakefield, D·The Medical journal of Australia·1995

This guideline helps doctors evaluate and treat ME/CFS by reviewing what we know about the condition. The authors found that while many medical and psychological factors can affect recovery, no single infection has been proven to cause ME/CFS. Treatment works best when doctors address all aspects of a patient's health—physical, mental, and social—rather than focusing on just one area.

Diagnostics

E3 PreliminaryReviewPEM not requiredReview-Narrative

Are cytokines associated with neuropsychiatric syndromes in humans?

Hickie, I, Lloyd, A·International journal of immunopharmacology·1995

This paper suggests that immune molecules called cytokines—which your body produces during infections or inflammation—may affect your brain and behavior in ways that look like psychiatric symptoms such as depression, fatigue, loss of appetite, and difficulty thinking clearly. The authors review evidence from various illnesses where these immune-related behavioral changes happen together, including ME/CFS, and propose that cytokines may be the biological link between immune activation and these symptoms.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM not requiredCase-Control

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study examined muscle tissue from CFS patients under a powerful microscope to look for damage to mitochondria (the energy-producing structures in cells). Researchers compared 15 CFS patients with 15 healthy people and found no visible structural differences in the mitochondria between the two groups, even though CFS causes severe fatigue and weakness.

Energy Metabolism

E3 PreliminaryPEM unclear

[The classification of Lyme borreliosis (Lyme disease)].

Lesniak, O M, Belikov, E S·Terapevticheskii arkhiv·1995

This paper proposes a new way to classify and organize Lyme disease based on when it starts (acute, subacute, or chronic), how widespread it is in the body, and whether certain tests are positive or negative. The authors also note that some people develop chronic fatigue syndrome or fibromyalgia after Lyme disease, and they include these complications in their classification system.

E3 PreliminaryReviewPEM unclearReview-Narrative

10 key questions answered on chronic fatigue syndrome.

Gantz, N M·Contemporary internal medicine·1995

This is an editorial article that addresses 10 frequently asked questions about chronic fatigue syndrome (ME/CFS). Rather than reporting new research data, the author discusses common questions patients and doctors have about the condition, its diagnosis, and management. The article aims to help clarify misconceptions and provide practical information about ME/CFS.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Fatigue brought on by malfunction of the central and peripheral nervous systems.

McComas, A J, Miller, R G, Gandevia, S C·Advances in experimental medicine and biology·1995

This review examines why people with nervous system disorders experience extreme tiredness and weakness. The authors looked at several conditions—including post-polio syndrome, multiple sclerosis, spinal cord injury, ALS, and ME/CFS—and found that damage to nerves can make muscles tire much more easily than normal. Lack of physical activity can make this problem worse over time.

E3 PreliminaryMechanismPEM not requiredCross-Sectional

The disease associations of the antibody response against the Epstein-Barr virus transactivator protein ZEBRA can be separated into different epitopes.

Tedeschi, R, Foong, Y T, Cheng, H M et al.·The Journal of general virology·1995

This study looked at antibody patterns against a specific EBV protein called ZEBRA, which becomes active when the virus 'wakes up' from dormancy. Researchers found that different parts of this protein trigger antibodies in different diseases—some patterns were more common in people with nasopharyngeal cancer, others in people with infectious mononucleosis, and some in people with chronic fatigue syndrome. This suggests that the type of EBV reactivation may differ depending on the illness someone has.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Bianchedi, M, Croce, A, Moretti, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1995

Researchers tested a special hearing test on people with ME/CFS to see if it could find differences in how their brainstem (the lower part of the brain) processes sound. They used two types of sound frequencies—slow and fast clicking sounds—while measuring brain electrical activity. The fast clicking test found unusual patterns in about 64% of people with confirmed ME/CFS, but not in people without ME/CFS, suggesting this test might help identify the condition.

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1995

A group of South African medical experts created guidelines to help doctors recognize and treat chronic fatigue syndrome (CFS). The guidelines outline what symptoms and test results might help diagnose CFS, and suggest reasonable ways to manage the condition while keeping costs reasonable. However, the experts disagreed significantly about whether CFS is a real, distinct illness.

Diagnostics

E3 PreliminaryReviewPEM unclearReview-Narrative

Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.

Moldofsky, H·Advances in neuroimmunology·1995

This review examines how sleep problems, immune system dysfunction, and hormone imbalances may be connected in fibromyalgia and ME/CFS. The authors suggest that when the body's internal clock is disrupted, it can trigger a cascade of problems including poor sleep quality, pain, fatigue, and cognitive difficulties. They propose that studying these interconnected systems together—rather than separately—may help explain why these conditions are so disabling.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

[Differential therapy of chronic fatigue syndrome].

Pankow, W, Feddersen, C O, von Wichert, P·Der Internist·1995

This 1995 study examines different treatment approaches for chronic fatigue syndrome. The authors review various therapeutic options that may help ME/CFS patients manage their symptoms. While specific details are limited due to the abstract not being available, this work represents an early clinical discussion of treatment strategies for this complex illness.

Diagnostics

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Evidence browser

Neurasthenia, myalgic encephalitis or cryptogenic chronic fatigue syndrome?

Human herpesvirus-7 (HHV-7): current status.

Chronic fatigue syndrome: a cognitive approach.

Chronic fatigue syndrome. 2: Treatment and future research.

New pathogens, and diseases old and new. I) Afipia felis and Rochalimaea. II) Parvovirus B 19. III) herpesvirus 6.

Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome.

Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome.

Chronic fatigue syndrome: current perspectives on evaluation and management.

Are cytokines associated with neuropsychiatric syndromes in humans?

Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome.

[The classification of Lyme borreliosis (Lyme disease)].

10 key questions answered on chronic fatigue syndrome.

Fatigue brought on by malfunction of the central and peripheral nervous systems.

The disease associations of the antibody response against the Epstein-Barr virus transactivator protein ZEBRA can be separated into different epitopes.

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Chronic fatigue syndrome. Committee for Science and Education, Medical Association of South Africa.

Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.

[Differential therapy of chronic fatigue syndrome].

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