ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

5921–5940 of 6,188 studies

E3 PreliminaryMechanismPEM not requiredMechanistic

Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome.

Bearn, J, Allain, T, Coskeran, P et al.·Biological psychiatry·1995

This study tested whether ME/CFS might be caused by problems with the brain's hormone-control system (the pituitary and adrenal glands). Researchers gave patients and healthy people two different tests—one using low blood sugar and another using a serotonin-stimulating drug—to measure hormone responses. They found that ME/CFS patients had unusual patterns in some hormones, suggesting their glands may not be working normally.

Endocrine Disruption

E3 PreliminaryPEM unclear

[The classification of Lyme borreliosis (Lyme disease)].

Lesniak, O M, Belikov, E S·Terapevticheskii arkhiv·1995

This paper proposes a new way to classify and organize Lyme disease based on when it starts (acute, subacute, or chronic), how widespread it is in the body, and whether certain tests are positive or negative. The authors also note that some people develop chronic fatigue syndrome or fibromyalgia after Lyme disease, and they include these complications in their classification system.

E3 PreliminaryReviewPEM unclearReview-Narrative

[Clinical aspects and neurologic expert assessment in sequelae of whiplash injury to the cervical spine].

Jenzer, G·Der Nervenarzt·1995

This review examined whiplash injuries to the neck and the long-term complications some patients develop, called chronic whiplash syndrome. The authors found that whiplash injuries can cause a complex mix of symptoms similar to those seen in chronic fatigue syndrome and fibromyalgia, making diagnosis challenging. Most people recover well from whiplash, though some experience prolonged difficulties.

Diagnostics

E3 PreliminaryCohortPEM requiredCase-Control

Is neurally mediated hypotension an unrecognised cause of chronic fatigue?

Rowe, P C, Bou-Holaigah, I, Kan, J S et al.·Lancet (London, England)·1995

This study looked at whether a condition called neurally mediated hypotension—where blood pressure drops suddenly when standing up—might be causing chronic fatigue in some patients. Researchers tested seven teenagers with severe fatigue using a tilt-table test (which gradually tilts the body upright) and found that all seven experienced significant drops in blood pressure. Four of these patients improved when treated with specific heart medications, suggesting this condition may contribute to some cases of ME/CFS.

Autonomic Nervous System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Determination of observer-rated alpha activity during sleep.

Flanigan, M J, Morehouse, R L, Shapiro, C M·Sleep·1995

Many ME/CFS patients have been reported to show a particular brain wave pattern called 'alpha intrusion' during sleep, which may contribute to poor sleep quality. This study examined whether the way researchers measure brain waves during sleep affects whether they can detect this pattern. The researchers found that the type of electrode placement and reference point used significantly influenced whether alpha waves were observed, suggesting that previous findings about alpha intrusion in ME/CFS patients may depend heavily on the measurement method used.

Sleep

E3 PreliminaryCommentaryPEM unclearEditorial

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

Goldenberg, D L·Current opinion in rheumatology·1995

This review article examines fibromyalgia, chronic fatigue syndrome, and related muscle pain conditions. Research using specialized magnetic imaging showed that muscle damage is not the main problem in fibromyalgia. Scientists are now focusing on how the brain and nervous system may be involved in these conditions, using new technologies to better understand what causes them.

E3 PreliminaryReviewPEM unclearReview-Narrative

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Clauw, D J·Medical hypotheses·1995

This paper reviews what doctors and researchers knew in 1995 about fibromyalgia and similar conditions that cause chronic pain and tiredness. The authors noticed that fibromyalgia overlaps significantly with chronic fatigue syndrome, migraines, irritable bowel syndrome, and mood disorders, suggesting these conditions may share common underlying causes rather than being completely separate diseases.

SleepAutonomic Nervous System

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Ash-Bernal, R, Wall, C, Komaroff, A L et al.·Acta oto-laryngologica·1995

Many people with ME/CFS experience dizziness and balance problems, but doctors weren't sure where these problems originated in the body. This study tested the balance and inner ear function of 11 ME/CFS patients using specialized equipment and found several abnormalities—particularly difficulty with tests that rely heavily on the inner ear and brain working together. The pattern of results suggested the problem may be in how the brain processes balance signals rather than damage to the inner ear itself.

E3 PreliminaryMechanismPEM not requiredMechanistic

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Galbraith, D N, Nairn, C, Clements, G B·The Journal of general virology·1995

Researchers looked for enterovirus genetic material in ME/CFS patients and compared it to viruses found in people with acute infections. Using genetic analysis, they found that most of the virus sequences from ME/CFS patients were novel and distinct from known enteroviruses. This suggests that some ME/CFS patients may have persistent enterovirus infections that are different from typical acute infections.

E3 PreliminaryCohortPEM unclearObservational

Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.

Gascón, J, Marcos, T, Vidal, J et al.·Journal of travel medicine·1995

This study looked at whether two common viruses—cytomegalovirus (CMV) and Epstein-Barr virus (EBV)—might be responsible for causing ME/CFS in people who had traveled to tropical regions. The researchers observed a group of travelers and tracked whether those infected with these viruses developed chronic fatigue symptoms similar to ME/CFS.

E3 PreliminaryMechanismPEM not requiredMechanistic

Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome.

Martin, W J, Glass, R T·Pathobiology : journal of immunopathology, molecular and cellular biology·1995

Researchers isolated a virus from a ME/CFS patient and injected it into cats to see what would happen. The cats developed serious neurological illness, and examination of their brain tissue showed viral particles and cell damage. This suggests that a particular type of virus might play a role in ME/CFS-related brain symptoms.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Are cytokines associated with neuropsychiatric syndromes in humans?

Hickie, I, Lloyd, A·International journal of immunopharmacology·1995

This paper suggests that immune molecules called cytokines—which your body produces during infections or inflammation—may affect your brain and behavior in ways that look like psychiatric symptoms such as depression, fatigue, loss of appetite, and difficulty thinking clearly. The authors review evidence from various illnesses where these immune-related behavioral changes happen together, including ME/CFS, and propose that cytokines may be the biological link between immune activation and these symptoms.

NeuroinflammationImmune System

E3 PreliminaryGuidelinePEM not requiredGuideline

Chronic fatigue syndrome: current perspectives on evaluation and management.

Hickie, I B, Lloyd, A R, Wakefield, D·The Medical journal of Australia·1995

This guideline helps doctors evaluate and treat ME/CFS by reviewing what we know about the condition. The authors found that while many medical and psychological factors can affect recovery, no single infection has been proven to cause ME/CFS. Treatment works best when doctors address all aspects of a patient's health—physical, mental, and social—rather than focusing on just one area.

Diagnostics

E3 PreliminaryMechanismPEM not requiredCross-Sectional

The disease associations of the antibody response against the Epstein-Barr virus transactivator protein ZEBRA can be separated into different epitopes.

Tedeschi, R, Foong, Y T, Cheng, H M et al.·The Journal of general virology·1995

This study looked at antibody patterns against a specific EBV protein called ZEBRA, which becomes active when the virus 'wakes up' from dormancy. Researchers found that different parts of this protein trigger antibodies in different diseases—some patterns were more common in people with nasopharyngeal cancer, others in people with infectious mononucleosis, and some in people with chronic fatigue syndrome. This suggests that the type of EBV reactivation may differ depending on the illness someone has.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome--a review of the literature].

Hamre, H J·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1995

ME/CFS is a real medical condition that causes extreme tiredness, low-grade fevers, sore throats, and pain in joints and muscles, often starting after a flu-like illness. Exercise makes symptoms significantly worse. While doctors don't yet have a single blood test to diagnose it, research shows patients may have problems with brain blood flow, immune system issues, and mitochondrial (cellular energy) abnormalities.

Immune SystemPost-Exertional Malaise

E3 PreliminaryCohortPEM not requiredCross-Sectional

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Bianchedi, M, Croce, A, Moretti, A et al.·Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·1995

Researchers tested a special hearing test on people with ME/CFS to see if it could find differences in how their brainstem (the lower part of the brain) processes sound. They used two types of sound frequencies—slow and fast clicking sounds—while measuring brain electrical activity. The fast clicking test found unusual patterns in about 64% of people with confirmed ME/CFS, but not in people without ME/CFS, suggesting this test might help identify the condition.

E3 PreliminaryReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

Rebora, A, Drago, F·Dermatology (Basel, Switzerland)·1994

This study describes skin problems that appear in some ME/CFS patients, occurring in about 10-35% of cases. Researchers found that patients sometimes develop mouth sores or skin rashes, possibly related to Epstein-Barr virus (EBV) infection. The study emphasizes that ME/CFS is diagnosed when someone has severe, disabling fatigue lasting at least 6 months with no other medical condition explaining it.

E3 PreliminaryReviewPEM unclearReview-Narrative

[The chronic fatigue syndrome].

Artsimovich, N G, Chugunov, V S, Kornev, A V et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·1994

ME/CFS is a serious condition that causes extreme tiredness, brain fog, and flu-like symptoms that can last for months or years. The condition affects people of all ages, but is most common in women under 45. Researchers believe the immune system is not working properly in people with ME/CFS, though the exact problem is still unclear.

Immune System

E3 PreliminaryCohortPEM not requiredCross-Sectional

The ocular signs and symptoms of chronic fatigue syndrome.

Caffery, B E, Josephson, J E, Samek, M J·Journal of the American Optometric Association·1994

This study looked at eye problems in 25 people with ME/CFS and found that all of them experienced some eye-related symptoms. The most common issues were problems with tears and the eye's surface, as well as difficulty focusing on close objects. Eye doctors should be aware of these issues when examining ME/CFS patients.

Pain and Sensitization

E3 PreliminaryMechanismPEM not requiredCross-Sectional

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

Patarca, R, Klimas, N G, Lugtendorf, S et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study tested blood samples from 70 ME/CFS patients and compared them to healthy people. Researchers found that about 60% of ME/CFS patients had unusually high levels of immune chemicals called cytokines, particularly two types called TNF-alpha and TNF-beta. These chemicals are normally released by the body to fight infections, but in ME/CFS patients they appeared to be abnormally activated even without an active infection.

Immune System

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Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome.

[The classification of Lyme borreliosis (Lyme disease)].

[Clinical aspects and neurologic expert assessment in sequelae of whiplash injury to the cervical spine].

Is neurally mediated hypotension an unrecognised cause of chronic fatigue?

Determination of observer-rated alpha activity during sleep.

Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome.

The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia.

Vestibular function test anomalies in patients with chronic fatigue syndrome.

Phylogenetic analysis of short enteroviral sequences from patients with chronic fatigue syndrome.

Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.

Acute encephalopathy induced in cats with a stealth virus isolated from a patient with chronic fatigue syndrome.

Are cytokines associated with neuropsychiatric syndromes in humans?

Chronic fatigue syndrome: current perspectives on evaluation and management.

The disease associations of the antibody response against the Epstein-Barr virus transactivator protein ZEBRA can be separated into different epitopes.

[Chronic fatigue syndrome--a review of the literature].

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome].

Chronic fatigue syndrome: a novel disorder with cutaneous manifestations.

[The chronic fatigue syndrome].

The ocular signs and symptoms of chronic fatigue syndrome.

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression.

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