ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

61–80 of 360 studies

E2 ModerateCohortPEM unclearCross-Sectional

Sex- and menopause-related differences in immune and gastrointestinal symptom architecture in ME/CFS: evidence from factor analysis and structural equation modeling.

Habermann-Horstmeier, Lotte, Horstmeier, Lukas M·Journal of translational medicine·2026

This study examined how immune and gut symptoms are organized differently in women and men with ME/CFS, and whether menopause affects these patterns. Researchers analyzed data from 748 people with ME/CFS and observed that women tend to have two somewhat separate symptom clusters (immune-related and gut-related), while men showed these symptoms more integrated together. Among women, flu-like symptoms were reported more frequently before menopause than after, while gut symptoms remained stable across menopause. These are early findings from a single cross-sectional analysis and require confirmation in future studies.

Endocrine DisruptionGut MicrobiomeAutonomic Nervous SystemImmune System

E2 ModerateCohortPEM unclearCross-Sectional

Provocation of brachial plexus and systemic symptoms during the elevated arm stress test in individuals with myalgic encephalomyelitis/chronic fatigue syndrome or idiopathic chronic fatigue.

Edwards, Charles C, Byrnes, Julia M, Broussard, Camille A et al.·Journal of translational medicine·2025

Researchers tested whether a simple arm position exercise (holding arms overhead and opening/closing fists) could trigger symptoms in ME/CFS patients who struggle with overhead activities. They found that nearly all patients (97%) developed arm symptoms like pain, numbness, or heaviness during the test, and 41% also experienced whole-body symptoms like dizziness, brain fog, or a racing heart. This suggests that some ME/CFS patients may have nerve compression issues in their shoulders or neck that worsen with certain arm positions.

Evidence Atlas

Evidence browser

Sex- and menopause-related differences in immune and gastrointestinal symptom architecture in ME/CFS: evidence from factor analysis and structural equation modeling.

Provocation of brachial plexus and systemic symptoms during the elevated arm stress test in individuals with myalgic encephalomyelitis/chronic fatigue syndrome or idiopathic chronic fatigue.

Autonomic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Findings from the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study in the USA.

Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID: Self-reported Data From the LISTEN Study.

Autonomic symptom burden, comorbidities and quality of life in women with Hypermobility Spectrum Disorders and hypermobile Ehlers-Danlos syndrome.

Cross-Sectional Study Evaluating the Role of Autonomic Nervous System Functional Diagnostics in Differentiating Post-Infectious Syndromes: Post-COVID Syndrome, Chronic Fatigue Syndrome, and Lyme Disease.

Assessment of Autonomic Nervous System Function in Patients with Chronic Fatigue Syndrome and Post-COVID-19 Syndrome Presenting with Recurrent Syncope.

Small fiber neuropathy in the post-COVID condition and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical significance and diagnostic challenges.

The Diagnostic Journey of Dysautonomia Patients: Insights from a Patient-Reported Outcome Study.

Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

Comprehensive Assessment of Autonomic Nervous System Profiles in Postural Orthostatic Tachycardia Syndrome Among Syncope, Chronic Fatigue, and Post-COVID-19 Patients.

Diagnosis of chronic fatigue syndrome using beat-to-beat autonomic measurements.

The Relation Between Cardiac Output and Cerebral Blood Flow in ME/CFS Patients with a POTS Response During a Tilt Test.

Comparing autonomic nervous system function in patients with functional somatic syndromes, stress-related syndromes and healthy controls.

Low Vasopressin in Myalgic Encephalomyelitise/Chronic Fatigue Syndrome.

Autonomic Dysfunction and Low Cardio-Respiratory Fitness in Long-Term Post-COVID-19 Syndrome.

Autonomic Dysfunction in Patients with Acute Infection with Coxiella burnetii.

Nonpelvic comorbid symptoms of 45 patients with pain of pelvic venous origin, before and after treatment.

The Relationship Between Hemodynamic Responses During Head-Up Tilt Testing and Parameters of Infection in Post-COVID Syndrome, Chronic Fatigue Syndrome, and Late-Stage Lyme Disease.

Awareness and Perception of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome Among Pain Specialists: A Questionnaire-Based Study.

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