ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

61–80 of 266 studies

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Chronic fatigue syndrome in caregivers of children with cerebral palsy and affecting factors.

Pasin, Tugce, Karatekin, Bilinc Dogruoz, Pasin, Ozge·Northern clinics of Istanbul·2023

This study looked at mothers caring for children with cerebral palsy to see how many developed ME/CFS and what factors affected them. The researchers found that about 80% of the mothers met the clinical criteria for ME/CFS, with mothers who stayed home having more severe fatigue than those who worked full-time. The child's hand and arm function appeared to be an important factor in how severe the mother's fatigue became.

Sleep

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Pediatric Post-Acute Sequelae of SARS-CoV-2 Infection.

Jason, Leonard A, Johnson, Madeline, Torres, Chelsea·Fatigue : biomedicine, health & behavior·2023

This study compared young people recovering from long COVID (PASC) with young people who have ME/CFS to understand how their symptoms differ. Researchers asked 19 parents about their child's symptoms during initial COVID infection and again later, then compared these to 19 young people with ME/CFS. Most PASC symptoms improved over time, but fatigue and sleep problems stayed high—similar to what ME/CFS patients experience.

SleepPost-Exertional Malaise

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Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan.

Nakano, Yasuhiro, Otsuka, Yuki, Honda, Hiroyuki et al.·Medicina (Kaunas, Lithuania)·2022

This study compared long COVID symptoms in patients infected with different COVID-19 variants (Delta vs. Omicron) in Japan. Patients infected with Omicron had milder initial illness but were more likely to experience fatigue, sleep problems, and ongoing cough. Those infected with Delta were more likely to lose their sense of taste or smell and experience hair loss.

Sleep

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Key Features of a Multi-Disciplinary Hospital-Based Rehabilitation Program for Children and Adolescents with Moderate to Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS.

Hiremath, Sonya, Doukrou, Montserrat, Flannery, Halina et al.·International journal of environmental research and public health·2022

This study looked at 27 children and teenagers with moderate to severe ME/CFS who stayed in a hospital and received coordinated care from multiple medical professionals. Most patients (85%) showed improvement in at least one important area of their lives, such as being able to move around better, return to school, sleep better, or enjoy social activities. These results suggest that hospital-based rehabilitation programs can help young people with severe ME/CFS improve their quality of life.

Sleep

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Tai Chi increases functional connectivity and decreases chronic fatigue syndrome: A pilot intervention study with machine learning and fMRI analysis.

Wu, Kang, Li, Yuanyuan, Zou, Yihuai et al.·PloS one·2022

This study tested whether Tai Chi exercise could help people with ME/CFS by looking at brain activity patterns. Researchers compared 20 ME/CFS patients with 20 healthy people, teaching both groups Tai Chi for one month. They found that Tai Chi improved fatigue, sleep quality, and overall health, and that specific brain networks became better connected after the training.

Sleep

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A description of the current status of chronic fatigue syndrome and associated factors among university students in Wuhan, China.

Luo, Lunbing, Zhang, Yutong, Huang, Tao et al.·Frontiers in psychiatry·2022

This study surveyed over 1,800 university students in Wuhan, China to understand how common ME/CFS is and what factors might contribute to it. Researchers found that about 6 in 100 students had ME/CFS, and identified several factors linked to the condition: pulling all-nighters, overeating, anxiety, and poor sleep quality increased risk, while being actively engaged in learning appeared protective. The study highlights that lifestyle and mental health factors may play important roles in ME/CFS among young adults.

Sleep

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Assessing sleep and pain among adults with myalgic encephalomyelitis/chronic fatigue syndrome: psychometric evaluation of the PROMIS® sleep and pain short forms.

Yang, Manshu, Keller, San, Lin, Jin-Mann S·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2022

This study tested whether two questionnaires (PROMIS scales) accurately measure sleep problems and pain in people with ME/CFS. Researchers surveyed over 600 ME/CFS patients and 338 healthy people at seven clinics across the USA. The questionnaires worked well—they consistently measured what they were supposed to measure, and they clearly showed the difference between ME/CFS patients (who had worse sleep and pain) and healthy controls.

Pain and SensitizationSleep

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The Impact of Micro RNA-320a Serum Level on Severity of Symptoms and Cerebral Processing of Pain in Patients with Fibromyalgia.

Hussein, Mona, Fathy, Wael, Abdelaleem, Enas A et al.·Pain medicine (Malden, Mass.)·2022

Researchers measured a molecule called miR-320a in the blood of people with fibromyalgia and compared it to healthy people. They found that fibromyalgia patients had higher levels of this molecule, and those with higher levels tended to have worse symptoms like pain, fatigue, sleep problems, and depression. However, this molecule did not appear to affect how the brain processes pain signals.

Pain and SensitizationSleep

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The Fatigue-Related Symptoms Post-Acute SARS-CoV-2: A Preliminary Comparative Study.

Thomas, Marie·International journal of environmental research and public health·2022

This study compared fatigue and related symptoms in 26 people experiencing Long COVID with two groups: people without fatigue and people with ME/CFS. The Long COVID group reported severe fatigue, brain fog, sleep problems, and difficulty concentrating—similar to what people with ME/CFS experience. The findings suggest Long COVID and ME/CFS may share some common features.

SleepCognitive Impairment

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Somatic symptom disorder in patients with post-COVID-19 neurological symptoms: a preliminary report from the somatic study (Somatic Symptom Disorder Triggered by COVID-19).

Kachaner, Alexandra, Lemogne, Cédric, Dave, Julie et al.·Journal of neurology, neurosurgery, and psychiatry·2022

This study examined whether patients with long-lasting neurological symptoms after COVID-19 meet diagnostic criteria for somatic symptom disorder (SSD), a condition where psychological distress can amplify physical symptoms. Researchers evaluated 50 patients and found that about two-thirds met SSD criteria, though brain imaging and standard neurological tests were mostly normal. Most patients also had fatigue meeting chronic fatigue syndrome criteria, sleep problems, and significant work loss.

Sleep

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Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan.

Sunada, Naruhiko, Nakano, Yasuhiro, Otsuka, Yuki et al.·Journal of clinical medicine·2022

This study looked at sleep problems in 363 long COVID patients in Japan and found that about 16.5% had significant sleep disturbance. People infected during the Omicron wave were twice as likely to have sleep problems compared to those infected during the Delta wave. Patients with sleep disturbance also reported more fatigue, brain fog, headaches, and anxiety, and had abnormal stress hormone levels suggesting their bodies were under persistent stress.

SleepCognitive Impairment

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Associations of physical and psychiatric conditions with chronic fatigue syndrome in Germany: an exploratory case-control study.

Jacob, Louis, Haro, Josep Maria, Kostev, Karel·Psychological medicine·2022

Researchers in Germany studied nearly 20,000 adults to see which health conditions are linked to developing ME/CFS. They compared people newly diagnosed with ME/CFS to similar people without it, looking at health problems they had in the year before diagnosis. They found that cancer, sleep disorders, and depression were the conditions most strongly associated with ME/CFS.

Sleep

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Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms: An Australian Longitudinal Study.

Balinas, Cassandra, Eaton-Fitch, Natalie, Maksoud, Rebekah et al.·International journal of environmental research and public health·2021

This Australian study followed 36 ME/CFS patients over five months to see how life stressors affected their symptoms. The researchers found that major life changes like work disruptions or money problems were linked to worsening symptoms like brain fog, stomach issues, pain, and sleep problems. Interestingly, patients who had better access to healthcare and support services experienced fewer severe symptoms.

Pain and SensitizationSleep

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Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation.

Harenwall, Sari, Heywood-Everett, Suzanne, Henderson, Rebecca et al.·Journal of primary care & community health·2021

Researchers created a 7-week online rehabilitation program for people recovering from long COVID, led by psychologists and a team of other health professionals. The program covered topics like managing fatigue, improving sleep, nutrition, stress management, and activity pacing. Among 76 participants who completed the program and filled out quality-of-life surveys, people reported significant improvements in their ability to move around, care for themselves, do daily activities, and manage pain and mood.

Sleep

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Sarcoidosis among US Hispanics in a Nationwide Registry.

Innabi, Ayoub, Alzghoul, Bashar N, Kalra, Saminder et al.·Respiratory medicine·2021

This study looked at how sarcoidosis (a disease that causes inflammation in the body) affects Hispanic patients in the United States compared to non-Hispanic patients. Researchers surveyed nearly 3,835 people and found that Hispanic patients with sarcoidosis experience more depression, chronic pain, sleep problems, and job loss than non-Hispanic patients. The findings suggest that doctors may need to approach treatment differently for Hispanic patients with this condition.

Pain and SensitizationSleep

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Chronic fatigue syndrome (CFS)/Myalgic Encephalomyelitis (ME) and Fibromyalgia (FM): the foundation of a relationship.

Mckay, Pamela G, Martin, Colin R, Walker, Helen et al.·British journal of pain·2021

This study compared people with ME/CFS and fibromyalgia (FM) to see if these two conditions share similar symptoms and severity. Researchers asked 208 participants from each group to complete questionnaires about their pain, fatigue, sleep quality, mood, and how much these symptoms affected their daily lives. The study found that both groups experienced similarly debilitating symptoms and poor quality of life, suggesting these conditions may be connected in important ways.

Pain and SensitizationSleep

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Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Aly, Menna A E G, Saber, Heba G·International journal of clinical practice·2021

This study looked at 115 elderly women in Egypt who had recovered from COVID-19 to see if their lingering symptoms might lead to chronic fatigue syndrome (ME/CFS). Most women reported problems like fatigue, muscle pain, and sleep trouble after COVID, and the study found that stress, sadness, and poor sleep were most strongly linked to developing CFS-like symptoms. Only one person in the study actually met full criteria for probable CFS, but the researchers suggest doctors should watch for these warning signs in long COVID patients.

SleepCognitive Impairment

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The Epidemiology of Insomnia and Sleep Duration Across Mental and Physical Health: The SHoT Study.

Sivertsen, Børge, Hysing, Mari, Harvey, Allison G et al.·Frontiers in psychology·2021

This study looked at sleep problems in over 50,000 Norwegian college students and found that insomnia (difficulty sleeping) is much more common in people with both mental and physical health conditions. Students with ME/CFS had particularly high rates of insomnia—about 65% of women and an unspecified percentage of men experienced insomnia when they also had ME/CFS. The study also found that people with these conditions slept shorter amounts overall.

Sleep

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Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Krumina, Angelika, Vecvagare, Katrine, Svirskis, Simons et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at 65 people with ME/CFS in Latvia to understand their main symptoms and how the condition differs from simple tiredness. Researchers found that people with ME/CFS commonly experience fatigue, muscle pain, joint pain, and sleep problems—more often than people without ME/CFS. When patients had other health conditions alongside ME/CFS, their symptoms tended to be more severe.

Pain and SensitizationSleepDiagnostics

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Fatigue-Related Cognitive-Behavioral Factors in Survivors of Childhood Cancer: Comparison with Chronic Fatigue Syndrome and Survivors of Adult-Onset Cancer.

van Deuren, Sylvia, van Dulmen-den Broeder, Eline, Boonstra, Amilie et al.·Journal of adolescent and young adult oncology·2021

This study compared how fatigue affects three groups: people who had cancer as children, people with ME/CFS, and people who had cancer as adults. Researchers looked at thinking patterns and behaviors that might keep fatigue going, like how people cope, sleep habits, and beliefs about their illness. They found many similarities between the groups, but some differences in how people explained their fatigue and how much support they had.

Sleep

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Chronic fatigue syndrome in caregivers of children with cerebral palsy and affecting factors.

Pediatric Post-Acute Sequelae of SARS-CoV-2 Infection.

Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan.

Key Features of a Multi-Disciplinary Hospital-Based Rehabilitation Program for Children and Adolescents with Moderate to Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS.

Tai Chi increases functional connectivity and decreases chronic fatigue syndrome: A pilot intervention study with machine learning and fMRI analysis.

A description of the current status of chronic fatigue syndrome and associated factors among university students in Wuhan, China.

Assessing sleep and pain among adults with myalgic encephalomyelitis/chronic fatigue syndrome: psychometric evaluation of the PROMIS® sleep and pain short forms.

The Impact of Micro RNA-320a Serum Level on Severity of Symptoms and Cerebral Processing of Pain in Patients with Fibromyalgia.

The Fatigue-Related Symptoms Post-Acute SARS-CoV-2: A Preliminary Comparative Study.

Somatic symptom disorder in patients with post-COVID-19 neurological symptoms: a preliminary report from the somatic study (Somatic Symptom Disorder Triggered by COVID-19).

Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan.

Associations of physical and psychiatric conditions with chronic fatigue syndrome in Germany: an exploratory case-control study.

Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms: An Australian Longitudinal Study.

Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation.

Sarcoidosis among US Hispanics in a Nationwide Registry.

Chronic fatigue syndrome (CFS)/Myalgic Encephalomyelitis (ME) and Fibromyalgia (FM): the foundation of a relationship.

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

The Epidemiology of Insomnia and Sleep Duration Across Mental and Physical Health: The SHoT Study.

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Fatigue-Related Cognitive-Behavioral Factors in Survivors of Childhood Cancer: Comparison with Chronic Fatigue Syndrome and Survivors of Adult-Onset Cancer.

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