ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

641–660 of 1,205 studies

E3 PreliminaryCohortPEM unclearCase-Control

A Case of Psoriasis Concurrently Complicated by Sacroiliitis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Iijima, Mami, Miyagaki, Tomomitsu, Nakajima, Kaori et al.·Cureus·2025

This case report describes one patient who developed psoriasis (a skin condition), sacroiliitis (inflammation of joints in the lower back), and ME/CFS all around the same time. The researchers reviewed what is known about how these three conditions might be connected through shared immune system problems. The study suggests that people with psoriasis may be at higher risk of developing ME/CFS, possibly because both conditions involve similar types of inflammatory immune responses.

Immune System

E3 PreliminaryDiagnosticPEM not requiredMethods-Paper

Profiling Antibody Reactivity to Gut Microbes in ME/CFS Patients.

Seton, Katharine A, Carding, Simon R·Methods in molecular biology (Clifton, N.J.)·2025

This study looks at how the immune system of ME/CFS patients reacts to bacteria in the gut. Many ME/CFS patients have changes in their gut bacteria and a leaky gut lining that allows bacteria and their toxic products to enter the bloodstream, potentially triggering widespread inflammation. The researchers developed methods to measure specific immune proteins (antibodies) that ME/CFS patients produce in response to these gut bacteria, compared to healthy household members.

Gut MicrobiomeImmune System

E3 PreliminaryMechanismPEM unclearCross-Sectional

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients.

Shahbaz, Shima, Rezaeifar, Maryam, Syed, Hussein et al.·Brain, behavior, and immunity·2025

Researchers studied blood samples from Long COVID patients with ME/CFS-like symptoms and compared them to healthy controls. They found that certain genes related to immune function and brain health were turned on in the patients, while others were turned off. The study also discovered unusual activation of smell-related genes and changes in immune cell types, suggesting the body remains in a state of ongoing inflammation and stress.

NeuroinflammationBiomarkersImmune System

E3 PreliminaryMechanismPEM requiredMechanistic

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Che, Xiaoyu, Ranjan, Amit, Guo, Cheng et al.·npj metabolic health and disease·2025

This study examined blood samples and immune responses in ME/CFS patients to understand why they experience extreme fatigue and feeling worse after activity. Researchers found that patients' immune systems overreact to germs, their bodies have trouble producing energy efficiently, and they have several chemical imbalances in their blood. These problems got worse after exercise and matched how sick patients felt.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM unclearMechanistic

A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study.

Hung, Li-Yuan, Wu, Chan-Shuo, Chang, Chia-Jung et al.·Frontiers in human neuroscience·2025

Researchers used advanced computer analysis to examine genetic information from people with severe ME/CFS, looking for patterns in how genes work together. They found that ME/CFS involves multiple body systems working incorrectly, particularly the immune and nervous systems, and discovered connections to viral infections like EBV and COVID-19. The study also found clues about why more women than men develop ME/CFS, relating to how estrogen affects the body.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Proposed Mechanistic Axis of Infections and mTOR Hyperactivation: A Multidisciplinary Review of Immune, Rheumatologic, and Psychiatric Links.

Fronticelli Baldelli, Giovanni, Buonsenso, Danilo·Children (Basel, Switzerland)·2025

This review proposes that a protein called mTOR may be the key link between infections and the long-lasting symptoms seen in ME/CFS and similar post-infection illnesses. The authors suggest that when mTOR stays overactive after an infection, it can damage the barrier that protects the brain, allow immune cells to enter brain tissue, and cause ongoing inflammation that affects how the brain works. They outline a step-by-step pathway explaining how this might happen and suggest that targeting mTOR could be a new treatment approach.

NeuroinflammationImmune System

E3 PreliminaryMechanismPEM requiredMechanistic

Gulf War Illness Induced Sex-Specific Transcriptional Differences Under Stressful Conditions.

Frank, Joshua, Tehrani, Lily, Gamer, Jackson et al.·International journal of molecular sciences·2025

Researchers studied how the immune system responds to physical stress in Gulf War veterans with Gulf War Illness (GWI), a condition similar to ME/CFS with fatigue, brain fog, and exhaustion. They found that men and women with GWI have different patterns of immune system activation during and after exercise, suggesting their bodies handle stress differently. These differences could help doctors develop better tests and treatments tailored to each person's sex.

BiomarkersImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Mucosal Viruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Missing Piece of the Puzzle?

Perera, Krishani Dinali, Cameron, Paige, Sarwar, Tayyibah et al.·International journal of molecular sciences·2025

Many people with ME/CFS report that their illness started after a viral infection, but scientists haven't found clear evidence of viruses in their blood. This review suggests researchers have been looking in the wrong places—focusing on blood instead of mucosal tissues (like the throat and gut lining) where viruses naturally enter the body and may hide. The authors propose that viruses could be persisting in these mucosal sites and occasionally reactivating, potentially triggering the ongoing inflammation and symptoms that characterize ME/CFS.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Autoantibody targeting therapies in post COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome.

Wohlrab, Felix, Eltity, Mailam, Ufer, Friederike et al.·Expert opinion on biological therapy·2025

This article reviews how certain immune system proteins called autoantibodies—which the body mistakenly makes against itself—may contribute to both long COVID and ME/CFS. The authors discuss different treatment approaches that aim to reduce or neutralize these harmful autoantibodies. This editorial examines the current evidence and potential of these new therapies to help patients with these conditions.

Immune System

E3 PreliminaryMechanismPEM not requiredMechanistic

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures.

Goshi, Noah, Lam, Doris, Bogguri, Chandrakumar et al.·Frontiers in cellular neuroscience·2025

This study looked at how two inflammatory chemicals (TNF-α and IL-6) that are elevated in ME/CFS and long-COVID patients affect brain cells. Researchers grew human brain cells in the lab and exposed them to these chemicals for several days. They found that these inflammatory chemicals changed how the brain cells communicate with each other, which could help explain why patients experience cognitive problems like brain fog and difficulty concentrating.

Immune System

E3 PreliminaryMechanismPEM not requiredObservational

Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19.

Kwon, Ji-Soo, Chang, Euijin, Jang, Hyeon Mu et al.·The Korean journal of internal medicine·2025

After COVID-19, some people develop long-lasting symptoms like fatigue, brain fog, and difficulty exercising—a condition called long COVID or PASC. This study measured immune system markers (called cytokines) in the blood of 79 people and found that certain symptoms were linked to higher levels of specific immune proteins, suggesting the immune system may stay overactive in some long COVID patients.

Immune SystemPost-Exertional Malaise

E3 PreliminaryDiagnosticPEM requiredMethods-Paper

Stress-Induced Changes in Immune Signatures in ME/CFS Patients Determined by Transcriptome Analysis.

Gamer, Jackson, Van Booven, Derek, Zarnowski, Oskar et al.·Methods in molecular biology (Clifton, N.J.)·2025

Researchers studied how the immune system of ME/CFS patients responds to exercise by examining blood cells before, during, and after a physical challenge. They compared these responses in ME/CFS patients to healthy people using advanced genetic testing. This study is part of ongoing efforts to understand what makes ME/CFS different at a biological level and why exercise can make symptoms worse.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID.

Olivares-Martínez, Elizabeth, Hernández-Ramírez, Diego Francisco, Núñez-Álvarez, Carlos Alberto et al.·International journal of molecular sciences·2025

Researchers tested a treatment called polymerized type I collagen (PTIC) in COVID-19 patients and found it may help reduce excessive inflammation by calming down immune cells called monocytes. The treatment appeared to improve breathing, reduce fatigue, chest pain, and cough in both the acute phase and long-term recovery from COVID-19. This finding could potentially be relevant for patients with long COVID or ME/CFS, which involve similar inflammatory problems.

Immune System

E3 PreliminaryMechanismPEM requiredCase-Control

Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Sasso, Etianne Martini, Er, Teagan S, Eaton-Fitch, Natalie et al.·Frontiers in medicine·2025

This study examined a specific ion channel called TRPM3 in immune cells from people with ME/CFS compared to healthy individuals. Researchers at two different laboratories found that TRPM3 channels work differently in ME/CFS patients—they're less active than in healthy people. Because both labs got the same results independently, this suggests TRPM3 dysfunction could be a reliable biological marker for ME/CFS.

Immune System

E3 PreliminaryMechanismPEM requiredPreprintPreprint

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Che, Xiaoyu, Ranjan, Amit, Guo, Cheng et al.·medRxiv : the preprint server for health sciences·2025

This study found that people with ME/CFS may have an overactive immune system that responds too strongly to germs and infections. The research showed problems with how the body produces energy and manages inflammation, and these problems got worse after exercise in ME/CFS patients but not in healthy people. The findings suggest multiple biological systems are working abnormally in ME/CFS, which could help doctors develop better treatments.

Energy MetabolismImmune SystemPost-Exertional Malaise

E3 PreliminaryReviewPEM unclearReview-Narrative

Core features and inherent diversity of post-acute infection syndromes.

Trautmann, Alain·Frontiers in immunology·2025

This review examines post-acute infection syndromes—long-lasting illnesses that develop after infections don't fully resolve, including ME/CFS. These conditions share common core symptoms like extreme fatigue, brain fog, sleep problems, and pain, but can also include many other varied symptoms that come and go over months or years. The authors propose that these illnesses arise from a combination of persistent infection traces, immune system problems, mitochondrial dysfunction, and changes in how the brain processes body signals, with individual differences determining which symptoms appear.

Immune System

E3 PreliminaryReviewPEM unclearReview-Narrative

Post-COVID-19 Vaccination (or Long Vax) Syndrome: Putative Manifestation, Pathophysiology, and Therapeutic Options.

Yong, Shin Jie, Kenny, Tiff-Annie, Halim, Alice et al.·Reviews in medical virology·2025

This review describes a condition called post-COVID-19 vaccination syndrome (PCVS), where some people develop long-lasting symptoms similar to long COVID after receiving a vaccine. Symptoms typically start within days to weeks after vaccination and can last for months or years, including fatigue, brain fog, and nerve tingling. The study examines what might cause PCVS and discusses possible treatments, though researchers emphasize that much remains unknown about this condition.

Immune SystemPost-Exertional Malaise

E3 PreliminaryMechanismPEM not requiredMechanistic

HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions.

Georgopoulos, Apostolos P, James, Lisa M, Peterson, Philip K·Scientific reports·2025

This study explores why some people develop ME/CFS after viral infections while others don't. Researchers looked at immune system genes (HLA types) and tested how well they recognize and fight nine common human herpes viruses. They found that people with certain HLA types have weak immune recognition of these viruses, potentially allowing the viruses to persist and cause ME/CFS, while people with other HLA types have strong recognition and protection.

Immune System

E3 PreliminaryReviewPEM not requiredReview-Narrative

A new anchor point for gut microbiome to regulate complications of allogeneic hematopoietic stem cell transplantation: oxidative stress.

Bai, Wenxuan, Jiang, Tiebin, Tang, Lanlan et al.·Experimental hematology·2025

This review examines how bone marrow stem cell transplants can cause complications through a process called oxidative stress (cellular damage from harmful molecules). The authors explain how gut bacteria and their chemical byproducts may help protect the body by reducing this oxidative stress, potentially preventing or lessening serious complications like infections, fatigue, and organ damage that can occur after transplantation.

Immune System

E3 PreliminaryDiagnosticPEM unclearMethods-Paper

Quantitative Proteomics on Immune Cells of ME/CFS Patients Using SWATH-MS.

Kumar, Abhishek, Peppercorn, Katie, Kleffmann, Torsten·Methods in molecular biology (Clifton, N.J.)·2025

This study describes a detailed scientific method for examining proteins in immune cells taken from the blood of ME/CFS patients. Researchers used advanced technology called SWATH-MS (a type of mass spectrometry) to identify and measure thousands of proteins at once. The paper explains the step-by-step process they used so that other researchers can use the same method to find protein abnormalities in ME/CFS.

Immune System

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A Case of Psoriasis Concurrently Complicated by Sacroiliitis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Profiling Antibody Reactivity to Gut Microbes in ME/CFS Patients.

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients.

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study.

Proposed Mechanistic Axis of Infections and mTOR Hyperactivation: A Multidisciplinary Review of Immune, Rheumatologic, and Psychiatric Links.

Gulf War Illness Induced Sex-Specific Transcriptional Differences Under Stressful Conditions.

Mucosal Viruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Missing Piece of the Puzzle?

Autoantibody targeting therapies in post COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome.

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures.

Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19.

Stress-Induced Changes in Immune Signatures in ME/CFS Patients Determined by Transcriptome Analysis.

Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID.

Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Core features and inherent diversity of post-acute infection syndromes.

Post-COVID-19 Vaccination (or Long Vax) Syndrome: Putative Manifestation, Pathophysiology, and Therapeutic Options.

HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions.

A new anchor point for gut microbiome to regulate complications of allogeneic hematopoietic stem cell transplantation: oxidative stress.

Quantitative Proteomics on Immune Cells of ME/CFS Patients Using SWATH-MS.

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